LD50=808mg/kg (orally in mice)
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.
The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use containing tetracycline in a concentration greater than 25 mg/ml.L43942 Other formulations of tetracycline continue to be used.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Tetracycline. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Tetracycline. |
| Succinylcholine | The therapeutic efficacy of Succinylcholine can be increased when used in combination with Tetracycline. |
| Metocurine iodide | The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Tetracycline. |
| Gallamine triethiodide | The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Tetracycline. |
| Cisatracurium | Tetracycline may increase the neuromuscular blocking activities of Cisatracurium. |
| Rocuronium | The therapeutic efficacy of Rocuronium can be increased when used in combination with Tetracycline. |
| Atracurium besylate | The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Tetracycline. |
| Doxacurium | The therapeutic efficacy of Doxacurium can be increased when used in combination with Tetracycline. |
| Mivacurium | The therapeutic efficacy of Mivacurium can be increased when used in combination with Tetracycline. |
| Decamethonium | The therapeutic efficacy of Decamethonium can be increased when used in combination with Tetracycline. |
| Metocurine | The therapeutic efficacy of Metocurine can be increased when used in combination with Tetracycline. |
| Pancuronium | The therapeutic efficacy of Pancuronium can be increased when used in combination with Tetracycline. |
| Pipecuronium | The therapeutic efficacy of Pipecuronium can be increased when used in combination with Tetracycline. |
| Vecuronium | The therapeutic efficacy of Vecuronium can be increased when used in combination with Tetracycline. |
| Rapacuronium | The therapeutic efficacy of Rapacuronium can be increased when used in combination with Tetracycline. |
| Pyrantel | The therapeutic efficacy of Pyrantel can be increased when used in combination with Tetracycline. |
| Neosaxitoxin | The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Tetracycline. |
| Atracurium | The therapeutic efficacy of Atracurium can be increased when used in combination with Tetracycline. |
| Gallamine | The therapeutic efficacy of Gallamine can be increased when used in combination with Tetracycline. |
| Alcuronium | The therapeutic efficacy of Alcuronium can be increased when used in combination with Tetracycline. |
| Tubocurarine | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Tetracycline. |
| Cilostazol | The metabolism of Cilostazol can be decreased when combined with Tetracycline. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Tetracycline. |
| Fentanyl | Tetracycline may decrease the excretion rate of Fentanyl which could result in a higher serum level. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Tetracycline. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Tetracycline. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Tetracycline. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Tetracycline. |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with Tetracycline. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Tetracycline. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with Tetracycline. |
| Bismuth subsalicylate | The serum concentration of Tetracycline can be decreased when it is combined with Bismuth subsalicylate. |
| Mecamylamine | Tetracycline may increase the neuromuscular blocking activities of Mecamylamine. |
| Mipomersen | Tetracycline may increase the hepatotoxic activities of Mipomersen. |
| Quinapril | Quinapril can cause a decrease in the absorption of Tetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Sucralfate | Sucralfate can cause a decrease in the absorption of Tetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Iron sucrose | The serum concentration of Tetracycline can be decreased when it is combined with Iron sucrose. |
| Alfuzosin | The metabolism of Alfuzosin can be decreased when combined with Tetracycline. |
| Flucloxacillin | The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Tetracycline. |
| Piperacillin | The therapeutic efficacy of Piperacillin can be decreased when used in combination with Tetracycline. |
| Ampicillin | The therapeutic efficacy of Ampicillin can be decreased when used in combination with Tetracycline. |
| Phenoxymethylpenicillin | The therapeutic efficacy of Phenoxymethylpenicillin can be decreased when used in combination with Tetracycline. |
| Dicloxacillin | The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Tetracycline. |
| Carbenicillin | The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Tetracycline. |
| Nafcillin | The therapeutic efficacy of Nafcillin can be decreased when used in combination with Tetracycline. |
| Oxacillin | The therapeutic efficacy of Oxacillin can be decreased when used in combination with Tetracycline. |
| Hetacillin | The therapeutic efficacy of Hetacillin can be decreased when used in combination with Tetracycline. |
| Benzylpenicilloyl polylysine | The therapeutic efficacy of Benzylpenicilloyl polylysine can be decreased when used in combination with Tetracycline. |
| Mezlocillin | The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Tetracycline. |
| Cyclacillin | The therapeutic efficacy of Cyclacillin can be decreased when used in combination with Tetracycline. |
| Benzylpenicillin | The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Tetracycline. |
| Amoxicillin | The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Tetracycline. |
| Azlocillin | The therapeutic efficacy of Azlocillin can be decreased when used in combination with Tetracycline. |
| Cloxacillin | The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Tetracycline. |
| Amdinocillin | The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Tetracycline. |
| Bacampicillin | The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Tetracycline. |
| Meticillin | The therapeutic efficacy of Meticillin can be decreased when used in combination with Tetracycline. |
| Pivampicillin | The therapeutic efficacy of Pivampicillin can be decreased when used in combination with Tetracycline. |
| Pivmecillinam | The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Tetracycline. |
| Ticarcillin | The therapeutic efficacy of Ticarcillin can be decreased when used in combination with Tetracycline. |
| Azidocillin | The therapeutic efficacy of Azidocillin can be decreased when used in combination with Tetracycline. |
| Carindacillin | The therapeutic efficacy of Carindacillin can be decreased when used in combination with Tetracycline. |
| Procaine benzylpenicillin | The therapeutic efficacy of Procaine benzylpenicillin can be decreased when used in combination with Tetracycline. |
| Sultamicillin | The therapeutic efficacy of Sultamicillin can be decreased when used in combination with Tetracycline. |
| Temocillin | The therapeutic efficacy of Temocillin can be decreased when used in combination with Tetracycline. |
| Epicillin | The therapeutic efficacy of Epicillin can be decreased when used in combination with Tetracycline. |
| Pheneticillin | The therapeutic efficacy of Pheneticillin can be decreased when used in combination with Tetracycline. |
| Carfecillin | The therapeutic efficacy of Carfecillin can be decreased when used in combination with Tetracycline. |
| Propicillin | The therapeutic efficacy of Propicillin can be decreased when used in combination with Tetracycline. |
| Clometocillin | The therapeutic efficacy of Clometocillin can be decreased when used in combination with Tetracycline. |
| Sulbenicillin | The therapeutic efficacy of Sulbenicillin can be decreased when used in combination with Tetracycline. |
| Penamecillin | The therapeutic efficacy of Penamecillin can be decreased when used in combination with Tetracycline. |
| Talampicillin | The therapeutic efficacy of Talampicillin can be decreased when used in combination with Tetracycline. |
| Aspoxicillin | The therapeutic efficacy of Aspoxicillin can be decreased when used in combination with Tetracycline. |
| Metampicillin | The therapeutic efficacy of Metampicillin can be decreased when used in combination with Tetracycline. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Tetracycline. |
| Quinine | The serum concentration of Quinine can be increased when it is combined with Tetracycline. |
| Quinidine | The serum concentration of Quinidine can be increased when it is combined with Tetracycline. |
| Aspartame | The excretion of Tetracycline can be decreased when combined with Aspartame. |
| Aminohippuric acid | The excretion of Tetracycline can be decreased when combined with Aminohippuric acid. |
| Guanidine | The excretion of Tetracycline can be decreased when combined with Guanidine. |
| Oxytetracycline | The excretion of Tetracycline can be decreased when combined with Oxytetracycline. |
| Leucovorin | The excretion of Tetracycline can be decreased when combined with Leucovorin. |
| Succinic acid | The excretion of Succinic acid can be decreased when combined with Tetracycline. |
| Citrulline | The excretion of Citrulline can be decreased when combined with Tetracycline. |
| Cefdinir | The excretion of Cefdinir can be decreased when combined with Tetracycline. |
| Fluorescein | The excretion of Fluorescein can be decreased when combined with Tetracycline. |
| Dinoprostone | The excretion of Dinoprostone can be decreased when combined with Tetracycline. |
| Famotidine | The excretion of Famotidine can be decreased when combined with Tetracycline. |
| Rosuvastatin | The excretion of Rosuvastatin can be decreased when combined with Tetracycline. |
| Tazobactam | The excretion of Tazobactam can be decreased when combined with Tetracycline. |
| Cyclic adenosine monophosphate | The excretion of Cyclic adenosine monophosphate can be decreased when combined with Tetracycline. |
| Cholic Acid | The excretion of Cholic Acid can be decreased when combined with Tetracycline. |
| Glutaric Acid | The excretion of Glutaric Acid can be decreased when combined with Tetracycline. |
| Oxalic Acid | The excretion of Oxalic Acid can be decreased when combined with Tetracycline. |
| Saxagliptin | The excretion of Saxagliptin can be decreased when combined with Tetracycline. |
| Ellagic acid | The excretion of Ellagic acid can be decreased when combined with Tetracycline. |
| Avibactam | The excretion of Avibactam can be decreased when combined with Tetracycline. |
| Eluxadoline | The excretion of Eluxadoline can be decreased when combined with Tetracycline. |