Symptoms of overdose include drowsiness, loss of or impaired muscle coordination, nausea, visual disturbance, and, at very high doses, coma.
Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin is no longer commonly used.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aripiprazole | The metabolism of Aripiprazole can be increased when combined with Ethotoin. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be increased when combined with Ethotoin. |
| Buprenorphine | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ethotoin. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethotoin. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Ethotoin. |
| Hydrocodone | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ethotoin. |
| Magnesium sulfate | The therapeutic efficacy of Ethotoin can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Ethotoin may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Ethotoin. |
| Mirtazapine | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Ethotoin. |
| Orphenadrine | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Pramipexole | Ethotoin may increase the sedative activities of Pramipexole. |
| Ropinirole | Ethotoin may increase the sedative activities of Ropinirole. |
| Rotigotine | Ethotoin may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Ethotoin. |
| Sodium oxybate | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ethotoin. |
| Thalidomide | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Mefloquine | The therapeutic efficacy of Ethotoin can be decreased when used in combination with Mefloquine. |
| Mianserin | The therapeutic efficacy of Ethotoin can be decreased when used in combination with Mianserin. |
| Orlistat | Orlistat can cause a decrease in the absorption of Ethotoin resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Topotecan | Ethotoin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Ethotoin. |
| Ifosfamide | The metabolism of Ifosfamide can be increased when combined with Ethotoin. |
| Perampanel | The metabolism of Perampanel can be increased when combined with Ethotoin. |
| R,S-Warfarin alcohol | The metabolism of R,S-Warfarin alcohol can be increased when combined with Ethotoin. |
| S,R-Warfarin alcohol | The metabolism of S,R-Warfarin alcohol can be increased when combined with Ethotoin. |
| Dicoumarol | The therapeutic efficacy of Dicoumarol can be increased when used in combination with Ethotoin. |
| Phenindione | The therapeutic efficacy of Phenindione can be increased when used in combination with Ethotoin. |
| Warfarin | The therapeutic efficacy of Warfarin can be increased when used in combination with Ethotoin. |
| Phenprocoumon | The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Ethotoin. |
| Acenocoumarol | The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Ethotoin. |
| 4-hydroxycoumarin | The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Ethotoin. |
| Coumarin | The therapeutic efficacy of Coumarin can be increased when used in combination with Ethotoin. |
| (R)-warfarin | The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Ethotoin. |
| Ethyl biscoumacetate | The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Ethotoin. |
| Fluindione | The therapeutic efficacy of Fluindione can be increased when used in combination with Ethotoin. |
| Clorindione | The therapeutic efficacy of Clorindione can be increased when used in combination with Ethotoin. |
| Diphenadione | The therapeutic efficacy of Diphenadione can be increased when used in combination with Ethotoin. |
| Tioclomarol | The therapeutic efficacy of Tioclomarol can be increased when used in combination with Ethotoin. |
| (S)-Warfarin | The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Ethotoin. |
| Tetracosactide | The risk or severity of liver damage can be increased when Tetracosactide is combined with Ethotoin. |
| Ethanol | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Ethotoin. |
| Fluvoxamine | The risk or severity of adverse effects can be increased when Ethotoin is combined with Fluvoxamine. |
| Citalopram | The risk or severity of adverse effects can be increased when Ethotoin is combined with Citalopram. |
| Duloxetine | The risk or severity of adverse effects can be increased when Ethotoin is combined with Duloxetine. |
| Trazodone | The risk or severity of adverse effects can be increased when Ethotoin is combined with Trazodone. |
| Paroxetine | The risk or severity of adverse effects can be increased when Ethotoin is combined with Paroxetine. |
| Sertraline | The risk or severity of adverse effects can be increased when Ethotoin is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Ethotoin is combined with Sibutramine. |
| Nefazodone | The risk or severity of adverse effects can be increased when Ethotoin is combined with Nefazodone. |
| Escitalopram | The risk or severity of adverse effects can be increased when Ethotoin is combined with Escitalopram. |
| Zimelidine | The risk or severity of adverse effects can be increased when Ethotoin is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Ethotoin is combined with Dapoxetine. |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Ethotoin is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Ethotoin is combined with Seproxetine. |
| Indalpine | The risk or severity of adverse effects can be increased when Ethotoin is combined with Indalpine. |
| Ritanserin | The risk or severity of adverse effects can be increased when Ethotoin is combined with Ritanserin. |
| Alaproclate | The risk or severity of adverse effects can be increased when Ethotoin is combined with Alaproclate. |
| Erlotinib | The serum concentration of Erlotinib can be decreased when it is combined with Ethotoin. |
| Cyproheptadine | The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Ethotoin. |
| Amoxapine | The risk or severity of CNS depression can be increased when Amoxapine is combined with Ethotoin. |
| Propiomazine | The risk or severity of CNS depression can be increased when Ethotoin is combined with Propiomazine. |
| Maprotiline | The risk or severity of CNS depression can be increased when Ethotoin is combined with Maprotiline. |
| Desipramine | The risk or severity of CNS depression can be increased when Ethotoin is combined with Desipramine. |
| Pizotifen | The risk or severity of CNS depression can be increased when Ethotoin is combined with Pizotifen. |
| Dosulepin | The risk or severity of CNS depression can be increased when Ethotoin is combined with Dosulepin. |
| Cocaine | The risk or severity of methemoglobinemia can be increased when Ethotoin is combined with Cocaine. |
| Quetiapine | The risk or severity of CNS depression can be increased when Ethotoin is combined with Quetiapine. |
| Amitriptyline | The risk or severity of CNS depression can be increased when Amitriptyline is combined with Ethotoin. |
| Imipramine | The risk or severity of CNS depression can be increased when Imipramine is combined with Ethotoin. |
| Doxepin | The risk or severity of CNS depression can be increased when Ethotoin is combined with Doxepin. |
| Clozapine | The serum concentration of Clozapine can be decreased when it is combined with Ethotoin. |
| Nortriptyline | The risk or severity of CNS depression can be increased when Nortriptyline is combined with Ethotoin. |
| Quinidine | The therapeutic efficacy of Ethotoin can be decreased when used in combination with Quinidine. |
| Zopiclone | The risk or severity of adverse effects can be increased when Ethotoin is combined with Zopiclone. |
| Botulinum toxin type B | The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Ethotoin. |
| Botulinum toxin type A | The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Ethotoin. |
| Tryptophan | The risk or severity of CNS depression can be increased when Tryptophan is combined with Ethotoin. |
| Baclofen | Baclofen may increase the central nervous system depressant (CNS depressant) activities of Ethotoin. |
| Lorazepam | The risk or severity of CNS depression can be increased when Lorazepam is combined with Ethotoin. |
| Ethchlorvynol | The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Ethotoin. |
| Succinylcholine | The risk or severity of CNS depression can be increased when Succinylcholine is combined with Ethotoin. |
| Reserpine | The risk or severity of CNS depression can be increased when Reserpine is combined with Ethotoin. |
| Enflurane | The risk or severity of CNS depression can be increased when Enflurane is combined with Ethotoin. |
| Temazepam | The risk or severity of CNS depression can be increased when Temazepam is combined with Ethotoin. |
| Reboxetine | The risk or severity of CNS depression can be increased when Reboxetine is combined with Ethotoin. |
| Butabarbital | The risk or severity of CNS depression can be increased when Butabarbital is combined with Ethotoin. |
| Butalbital | The risk or severity of CNS depression can be increased when Butalbital is combined with Ethotoin. |
| Topiramate | The risk or severity of CNS depression can be increased when Topiramate is combined with Ethotoin. |
| Clemastine | The risk or severity of CNS depression can be increased when Clemastine is combined with Ethotoin. |