Peringatan Keamanan

LC50=15300 ppm/3 hrs (inhalation by rat)

Isoflurane

DB00753

small molecule approved vet_approved

Deskripsi

A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Struktur Molekul 2D

Berat 184.492
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Minimal

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1615 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Isoflurane is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Isoflurane is combined with Levodopa.
Risperidone Isoflurane may increase the hypotensive activities of Risperidone.
Furosemide Isoflurane may decrease the antihypertensive activities of Furosemide.
Valsartan Isoflurane may decrease the antihypertensive activities of Valsartan.
Remikiren Isoflurane may decrease the antihypertensive activities of Remikiren.
Torasemide Isoflurane may decrease the antihypertensive activities of Torasemide.
Bethanidine Isoflurane may decrease the antihypertensive activities of Bethanidine.
Guanadrel Isoflurane may decrease the antihypertensive activities of Guanadrel.
Metoprolol Isoflurane may decrease the antihypertensive activities of Metoprolol.
Olmesartan Isoflurane may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Isoflurane may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Isoflurane may decrease the antihypertensive activities of Nitroprusside.
Atenolol Isoflurane may decrease the antihypertensive activities of Atenolol.
Minoxidil Isoflurane may decrease the antihypertensive activities of Minoxidil.
Nisoldipine Isoflurane may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Isoflurane may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Isoflurane may decrease the antihypertensive activities of Prazosin.
Fosinopril Isoflurane may decrease the antihypertensive activities of Fosinopril.
Trandolapril Isoflurane may decrease the antihypertensive activities of Trandolapril.
Metolazone Isoflurane may decrease the antihypertensive activities of Metolazone.
Lercanidipine Isoflurane may decrease the antihypertensive activities of Lercanidipine.
Benazepril Isoflurane may decrease the antihypertensive activities of Benazepril.
Bosentan Isoflurane may decrease the antihypertensive activities of Bosentan.
Enalapril Isoflurane may decrease the antihypertensive activities of Enalapril.
Doxazosin Isoflurane may decrease the antihypertensive activities of Doxazosin.
Labetalol Isoflurane may decrease the antihypertensive activities of Labetalol.
Cyclothiazide Isoflurane may decrease the antihypertensive activities of Cyclothiazide.
Bisoprolol Isoflurane may decrease the antihypertensive activities of Bisoprolol.
Candoxatril Isoflurane may decrease the antihypertensive activities of Candoxatril.
Guanabenz Isoflurane may decrease the antihypertensive activities of Guanabenz.
Mecamylamine Isoflurane may decrease the antihypertensive activities of Mecamylamine.
Phentolamine Isoflurane may decrease the antihypertensive activities of Phentolamine.
Eplerenone Isoflurane may decrease the antihypertensive activities of Eplerenone.
Lisinopril Isoflurane may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Isoflurane may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Isoflurane may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Isoflurane may decrease the antihypertensive activities of Cryptenamine.
Candesartan cilexetil Isoflurane may decrease the antihypertensive activities of Candesartan cilexetil.
Tolazoline Isoflurane may decrease the antihypertensive activities of Tolazoline.
Fenoldopam Isoflurane may decrease the antihypertensive activities of Fenoldopam.
Tadalafil Isoflurane may decrease the antihypertensive activities of Tadalafil.
Eprosartan Isoflurane may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Isoflurane may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Isoflurane may decrease the antihypertensive activities of Quinapril.
Omapatrilat Isoflurane may decrease the antihypertensive activities of Omapatrilat.
Phenoxybenzamine Isoflurane may decrease the antihypertensive activities of Phenoxybenzamine.
Telmisartan Isoflurane may decrease the antihypertensive activities of Telmisartan.
Methyldopa Isoflurane may decrease the antihypertensive activities of Methyldopa.
Trichlormethiazide Isoflurane may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Isoflurane may decrease the antihypertensive activities of Irbesartan.
Deserpidine Isoflurane may decrease the antihypertensive activities of Deserpidine.
Pentolinium Isoflurane may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Isoflurane may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Isoflurane may decrease the antihypertensive activities of Diazoxide.
Terazosin Isoflurane may decrease the antihypertensive activities of Terazosin.
Guanethidine Isoflurane may decrease the antihypertensive activities of Guanethidine.
Rescinnamine Isoflurane may decrease the antihypertensive activities of Rescinnamine.
Captopril Isoflurane may decrease the antihypertensive activities of Captopril.
Nadolol Isoflurane may decrease the antihypertensive activities of Nadolol.
Epoprostenol Isoflurane may decrease the antihypertensive activities of Epoprostenol.
Hydralazine Isoflurane may decrease the antihypertensive activities of Hydralazine.
Bevantolol Isoflurane may decrease the antihypertensive activities of Bevantolol.
Practolol Isoflurane may decrease the antihypertensive activities of Practolol.
Polythiazide Isoflurane may decrease the antihypertensive activities of Polythiazide.
Cilazapril Isoflurane may decrease the antihypertensive activities of Cilazapril.
Saprisartan Isoflurane may decrease the antihypertensive activities of Saprisartan.
Spirapril Isoflurane may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Isoflurane may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid Isoflurane may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Isoflurane may decrease the antihypertensive activities of Debrisoquine.
Nebivolol Isoflurane may decrease the antihypertensive activities of Nebivolol.
Sitaxentan Isoflurane may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Isoflurane may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Isoflurane may decrease the antihypertensive activities of Diethylnorspermine.
Pinacidil Isoflurane may decrease the antihypertensive activities of Pinacidil.
Temocapril Isoflurane may decrease the antihypertensive activities of Temocapril.
Riociguat Isoflurane may decrease the antihypertensive activities of Riociguat.
Macitentan Isoflurane may decrease the antihypertensive activities of Macitentan.
Indoramin Isoflurane may decrease the antihypertensive activities of Indoramin.
Aliskiren Isoflurane may decrease the antihypertensive activities of Aliskiren.
Trimazosin Isoflurane may decrease the antihypertensive activities of Trimazosin.
Moxonidine Isoflurane may decrease the antihypertensive activities of Moxonidine.
Rauwolfia serpentina root Isoflurane may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Isoflurane may decrease the antihypertensive activities of Enalaprilat.
Selexipag Isoflurane may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Isoflurane may decrease the antihypertensive activities of Angiotensin 1-7.
Rilmenidine Isoflurane may decrease the antihypertensive activities of Rilmenidine.
Imidapril Isoflurane may decrease the antihypertensive activities of Imidapril.
BQ-123 Isoflurane may decrease the antihypertensive activities of BQ-123.
Naftopidil Isoflurane may decrease the antihypertensive activities of Naftopidil.
Landiolol Isoflurane may decrease the antihypertensive activities of Landiolol.
Dihydralazine Isoflurane may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Isoflurane may decrease the antihypertensive activities of Zofenopril.
Guanoxan Isoflurane may decrease the antihypertensive activities of Guanoxan.
Delapril Isoflurane may decrease the antihypertensive activities of Delapril.
Vincamine Isoflurane may decrease the antihypertensive activities of Vincamine.
Linsidomine Isoflurane may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Isoflurane may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Isoflurane may decrease the antihypertensive activities of Tolonidine.

Target Protein

Gamma-aminobutyric acid receptor subunit alpha-1 GABRA1
Calcium-transporting ATPase type 2C member 1 ATP2C1
Glycine receptor subunit alpha-1 GLRA1
Glutamate receptor 1 GRIA1
Potassium voltage-gated channel subfamily A member 1 KCNA1
GABA(A) Receptor GABRA1
ATP synthase subunit delta, mitochondrial ATP5F1D
Neuronal acetylcholine receptor subunit alpha-4 CHRNA4
Neuronal acetylcholine receptor subunit beta-2 CHRNB2
Calmodulin CALM1

Referensi & Sumber

Synthesis reference: Leonid A. Rozov, Fernando Quiroz, Gerald G. Vernice, "Preparation of isoflurane." U.S. Patent US5416244, issued March, 1973.

Contoh Produk & Brand

Produk: 13 • International brands: 4
Produk
  • Forane
    Inhalant • 1 mL/1mL • Respiratory (inhalation) • US • Approved
  • Forane
    Liquid • 100 % • Respiratory (inhalation) • Canada • Approved
  • Forane Liq Inh
    Liquid • 100 % • Respiratory (inhalation) • Canada • Approved
  • Isoflurane
    Liquid • 1 mL/1mL • Respiratory (inhalation) • US • Generic • Approved
  • Isoflurane
    Liquid • 1 mL/1mL • Respiratory (inhalation) • US • Generic • Approved
  • Isoflurane
    Liquid • 1 mL/1mL • Respiratory (inhalation) • US • Generic • Approved
  • Isoflurane
    Liquid • 1 mL/1mL • Respiratory (inhalation) • US • Generic • Approved
  • Isoflurane USP
    Liquid • 99.9 % • Respiratory (inhalation) • Canada • Approved
Menampilkan 8 dari 13 produk.
International Brands
  • Aerrane — Baxter
  • Forene — Abbott
  • Isocane — Lunan
  • Isorane — Abbott

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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