Peringatan Keamanan

Selective COX-2 inhibitors have been associated with increased risk of serious cardiovascular events (e.g. myocardial infarction, stroke) in some patients. Current data is insufficient to assess the cardiovascular risk of etodolac. Etodolac may increase blood pressure and/or cause fluid retention and edema. Risk of GI toxicity including bleeding, ulceration and perforation. Risk of direct renal injury, including renal papillary necrosis. Anaphylactoid and serious skin reactions (e.g. exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) have been reported. Common adverse events include abdominal pain, constipation, diarrhea, dyspepsia, flatulence, GI bleeding, GI perforation, nausea, peptic ulcer, vomiting, renal function abnormalities, anemia, dizziness, edema, liver function test abnormalities, headache, prolonged bleeding time, pruritus, rash, tinnitus. Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.

Etodolac

DB00749

small molecule approved investigational vet_approved

Deskripsi

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.

Struktur Molekul 2D

Berat 287.3535
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Terminal t<sub>1/2</sub>, 7.3 &plusmn; 4.0 hours. Distribution t<sub>1/2</sub>, 0.71 &plusmn; 0.50 hours
Volume Distribusi * 390 mL/kg
Klirens (Clearance) * Oral cl=49.1 mL/h/kg [Normal healthy adults] * Oral cl=49.4 mL/h/kg [Healthy males (18-65 years)] * Oral cl=35.7 mL/h/kg [Healthy females (27-65 years)] * Oral cl=45.7 mL/h/kg [Eldery (>65 years)] * Oral cl=58.3 mL/h/kg [Renal impairement (46-73 years)] * Oral cl=42.0 mL/h/kg [Hepatic impairement (34-60 years)]

Absorpsi

Based on mass balance studies, the systemic bioavailability of etodolac from either the tablet or capsule formulation is at least 80%.

Metabolisme

Etodolac is extensively metabolized in the liver. Renal elimination of etodolac and its metabolites is the primary route of excretion (72%). Metabolites found in urine (with percents of the administered dose) are: unchanged etodolac (1%), etodolac glucuronide (13%), hydroxylated metabolites (6-, 7-, and 8-OH; 5%), hydroxylated metabolite glucuronides (20%), and unidentified metabolites (33%). Fecal excretion accounts for 16% of its elimination.

Rute Eliminasi

It is not known whether etodolac is excreted in human milk; however, based on its physical-chemical properties, excretion into breast milk is expected. Etodolac is extensively metabolized in the liver. The hydroxylated-etodolac metabolites undergo further glucuronidation followed by renal excretion and partial elimination in the feces (16% of dose). Approximately 1% of a etodolac dose is excreted unchanged in the urine with 72% of the dose excreted into urine as parent drug plus metabolite.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food. Food reduces irritation.

Interaksi Obat

1608 Data
Amlodipine The metabolism of Etodolac can be decreased when combined with Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Etodolac.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Etodolac.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Etodolac.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Etodolac.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Etodolac.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Etodolac.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Etodolac.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Etodolac.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Etodolac.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Etodolac.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Etodolac.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Etodolac.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Etodolac.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Etodolac.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Etodolac.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Etodolac.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Etodolac.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Etodolac.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Etodolac.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Etodolac.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Etodolac.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Etodolac.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Etodolac.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Etodolac.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Etodolac.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Etodolac.
Isoflurane The risk or severity of hypertension can be increased when Etodolac is combined with Isoflurane.
Propiomazine The risk or severity of hypertension can be increased when Etodolac is combined with Propiomazine.
Alfentanil The risk or severity of hypertension can be increased when Etodolac is combined with Alfentanil.
Minaprine The risk or severity of hypertension can be increased when Etodolac is combined with Minaprine.
Orciprenaline The risk or severity of hypertension can be increased when Etodolac is combined with Orciprenaline.
Phenmetrazine The risk or severity of hypertension can be increased when Etodolac is combined with Phenmetrazine.
Trifluoperazine The risk or severity of hypertension can be increased when Etodolac is combined with Trifluoperazine.
Pseudoephedrine The risk or severity of hypertension can be increased when Etodolac is combined with Pseudoephedrine.
Benzphetamine The risk or severity of hypertension can be increased when Etodolac is combined with Benzphetamine.
Ritodrine The risk or severity of hypertension can be increased when Etodolac is combined with Ritodrine.
Flupentixol The risk or severity of hypertension can be increased when Etodolac is combined with Flupentixol.
Remifentanil The risk or severity of hypertension can be increased when Etodolac is combined with Remifentanil.
Bitolterol The risk or severity of hypertension can be increased when Etodolac is combined with Bitolterol.
Oxymetazoline The risk or severity of hypertension can be increased when Etodolac is combined with Oxymetazoline.
Diethylpropion The risk or severity of hypertension can be increased when Etodolac is combined with Diethylpropion.
Salmeterol The risk or severity of hypertension can be increased when Etodolac is combined with Salmeterol.
Naratriptan The risk or severity of hypertension can be increased when Etodolac is combined with Naratriptan.
Frovatriptan The risk or severity of hypertension can be increased when Etodolac is combined with Frovatriptan.
Ergoloid mesylate The risk or severity of hypertension can be increased when Etodolac is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Etodolac is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Etodolac is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Etodolac is combined with Dutasteride.
Pergolide The risk or severity of hypertension can be increased when Etodolac is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Etodolac is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Etodolac is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Etodolac is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Etodolac is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Etodolac is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Etodolac is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Etodolac is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Etodolac is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Etodolac is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Etodolac is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Etodolac is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Etodolac is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Etodolac is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Etodolac is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Etodolac is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Etodolac is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Etodolac is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Etodolac is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Etodolac is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Etodolac is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Etodolac is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Etodolac is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Etodolac is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Etodolac is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Etodolac is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Etodolac is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Etodolac is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Etodolac is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Etodolac is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Etodolac is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Etodolac is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Etodolac is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Etodolac is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Etodolac is combined with 1-benzylimidazole.
Nialamide The risk or severity of hypertension can be increased when Etodolac is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Etodolac is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Etodolac is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Etodolac is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Etodolac is combined with Iloperidone.
Indacaterol The risk or severity of hypertension can be increased when Etodolac is combined with Indacaterol.
Rotigotine The risk or severity of hypertension can be increased when Etodolac is combined with Rotigotine.
Amibegron The risk or severity of hypertension can be increased when Etodolac is combined with Amibegron.
Naluzotan The risk or severity of hypertension can be increased when Etodolac is combined with Naluzotan.
Cariprazine The risk or severity of hypertension can be increased when Etodolac is combined with Cariprazine.
Mianserin The risk or severity of hypertension can be increased when Etodolac is combined with Mianserin.
Pizotifen The risk or severity of hypertension can be increased when Etodolac is combined with Pizotifen.
Solabegron The risk or severity of hypertension can be increased when Etodolac is combined with Solabegron.
Asenapine The risk or severity of hypertension can be increased when Etodolac is combined with Asenapine.
Esmirtazapine The risk or severity of hypertension can be increased when Etodolac is combined with Esmirtazapine.
Vilazodone The risk or severity of hypertension can be increased when Etodolac is combined with Vilazodone.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1
Retinoic acid receptor RXR-alpha RXRA

Referensi & Sumber

Synthesis reference: Christopher A. Demerson, Leslie G. Humber, "Process for preparing 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)-indole-1-acetic acid, etodolac." U.S. Patent US4585877, issued May, 1977.

Contoh Produk & Brand

Produk: 247 • International brands: 27
Produk
  • Etodolac
    Tablet, film coated • 400 mg/1 • Oral • US • Generic • Approved
  • Etodolac
    Tablet, film coated, extended release • 400 mg/1 • Oral • US • Generic • Approved
  • Etodolac
    Tablet, film coated, extended release • 500 mg/1 • Oral • US • Generic • Approved
  • Etodolac
    Tablet, film coated, extended release • 600 mg/1 • Oral • US • Generic • Approved
  • Etodolac
    Capsule • 300 mg/1 • Oral • US • Generic • Approved
  • Etodolac
    Capsule • 200 mg/1 • Oral • US • Generic • Approved
  • Etodolac
    Tablet, film coated • 400 mg/1 • Oral • US • Generic • Approved
  • Etodolac
    Tablet, film coated • 500 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 247 produk.
International Brands
  • Bodopine — Yuan Chou
  • Dolarit — Drogsan
  • Dolchis — Korea United Pharm
  • Doloc — Unifarma
  • Dualgan — ITF
  • Eccoxolac — Meda
  • Edolar Fort — Pfizer
  • Edopain — Incepta
  • Edopain ER — Incepta
  • Elac — Royal

Sekuens Gen/Protein (FASTA)

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