Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
Patients with this genotype have reduced improvement in vigor and well-being with modafinil.
Patients with this genotype have increased improvement in vigor and well-being with modafinil.
| Dofetilide | The metabolism of Dofetilide can be increased when combined with Modafinil. |
| Theophylline | The metabolism of Theophylline can be increased when combined with Modafinil. |
| Carbamazepine | The metabolism of Carbamazepine can be increased when combined with Modafinil. |
| Warfarin | The metabolism of Warfarin can be increased when combined with Modafinil. |
| Tacrolimus | The metabolism of Tacrolimus can be increased when combined with Modafinil. |
| Sirolimus | The metabolism of Sirolimus can be increased when combined with Modafinil. |
| Quinidine | The metabolism of Quinidine can be increased when combined with Modafinil. |
| Phenprocoumon | The metabolism of Phenprocoumon can be increased when combined with Modafinil. |
| Busulfan | The metabolism of Busulfan can be increased when combined with Modafinil. |
| Pimozide | The metabolism of Pimozide can be increased when combined with Modafinil. |
| Aminophylline | The metabolism of Aminophylline can be increased when combined with Modafinil. |
| Paclitaxel | The metabolism of Paclitaxel can be increased when combined with Modafinil. |
| Dasatinib | The metabolism of Dasatinib can be increased when combined with Modafinil. |
| Fosphenytoin | The metabolism of Fosphenytoin can be increased when combined with Modafinil. |
| Digitoxin | The metabolism of Digitoxin can be increased when combined with Modafinil. |
| Acenocoumarol | The metabolism of Acenocoumarol can be increased when combined with Modafinil. |
| Everolimus | The metabolism of Everolimus can be increased when combined with Modafinil. |
| Dronedarone | The metabolism of Dronedarone can be increased when combined with Modafinil. |
| Temsirolimus | The metabolism of Temsirolimus can be increased when combined with Modafinil. |
| Tianeptine | The metabolism of Tianeptine can be increased when combined with Modafinil. |
| Sorafenib | The metabolism of Sorafenib can be increased when combined with Modafinil. |
| Teniposide | The metabolism of Teniposide can be increased when combined with Modafinil. |
| Vincristine | The metabolism of Vincristine can be increased when combined with Modafinil. |
| Irinotecan | The metabolism of Irinotecan can be increased when combined with Modafinil. |
| Etoposide | The metabolism of Etoposide can be increased when combined with Modafinil. |
| Docetaxel | The metabolism of Docetaxel can be increased when combined with Modafinil. |
| Sunitinib | The metabolism of Sunitinib can be increased when combined with Modafinil. |
| Trastuzumab emtansine | The metabolism of Trastuzumab emtansine can be increased when combined with Modafinil. |
| Romidepsin | The metabolism of Romidepsin can be increased when combined with Modafinil. |
| Cabazitaxel | The metabolism of Cabazitaxel can be increased when combined with Modafinil. |
| Crizotinib | The metabolism of Crizotinib can be increased when combined with Modafinil. |
| Ponatinib | The metabolism of Ponatinib can be increased when combined with Modafinil. |
| Olaparib | The metabolism of Olaparib can be increased when combined with Modafinil. |
| Copanlisib | The metabolism of Copanlisib can be increased when combined with Modafinil. |
| Cobimetinib | The metabolism of Cobimetinib can be increased when combined with Modafinil. |
| Ceritinib | The metabolism of Ceritinib can be increased when combined with Modafinil. |
| Osimertinib | The metabolism of Osimertinib can be increased when combined with Modafinil. |
| Dacomitinib | The metabolism of Dacomitinib can be increased when combined with Modafinil. |
| Alpelisib | The metabolism of Alpelisib can be increased when combined with Modafinil. |
| Bortezomib | The metabolism of Bortezomib can be increased when combined with Modafinil. |
| Pazopanib | The metabolism of Pazopanib can be increased when combined with Modafinil. |
| Pomalidomide | The metabolism of Pomalidomide can be increased when combined with Modafinil. |
| Enasidenib | The metabolism of Enasidenib can be increased when combined with Modafinil. |
| Trabectedin | The metabolism of Trabectedin can be increased when combined with Modafinil. |
| Astemizole | The metabolism of Astemizole can be increased when combined with Modafinil. |
| Lomitapide | The metabolism of Lomitapide can be increased when combined with Modafinil. |
| Siponimod | The metabolism of Siponimod can be increased when combined with Modafinil. |
| Clonidine | The metabolism of Clonidine can be increased when combined with Modafinil. |
| Methotrexate | The metabolism of Methotrexate can be increased when combined with Modafinil. |
| Vinorelbine | The metabolism of Vinorelbine can be increased when combined with Modafinil. |
| Vinblastine | The metabolism of Vinblastine can be increased when combined with Modafinil. |
| Doxorubicin | The serum concentration of Doxorubicin can be decreased when it is combined with Modafinil. |
| Thiotepa | The metabolism of Thiotepa can be increased when combined with Modafinil. |
| Vandetanib | The metabolism of Vandetanib can be increased when combined with Modafinil. |
| Vemurafenib | The metabolism of Vemurafenib can be increased when combined with Modafinil. |
| Alectinib | The metabolism of Alectinib can be increased when combined with Modafinil. |
| Venetoclax | The metabolism of Venetoclax can be increased when combined with Modafinil. |
| Vinflunine | The metabolism of Vinflunine can be increased when combined with Modafinil. |
| Acalabrutinib | The metabolism of Acalabrutinib can be increased when combined with Modafinil. |
| Cabergoline | The metabolism of Cabergoline can be increased when combined with Modafinil. |
| Vindesine | The metabolism of Vindesine can be increased when combined with Modafinil. |
| Ixabepilone | The metabolism of Ixabepilone can be increased when combined with Modafinil. |
| Panobinostat | The metabolism of Panobinostat can be increased when combined with Modafinil. |
| Bosutinib | The metabolism of Bosutinib can be increased when combined with Modafinil. |
| Brentuximab vedotin | The metabolism of Brentuximab vedotin can be increased when combined with Modafinil. |
| Ruxolitinib | The metabolism of Ruxolitinib can be increased when combined with Modafinil. |
| Dabrafenib | The serum concentration of Modafinil can be decreased when it is combined with Dabrafenib. |
| Palbociclib | The metabolism of Palbociclib can be increased when combined with Modafinil. |
| Sonidegib | The metabolism of Sonidegib can be increased when combined with Modafinil. |
| Neratinib | The metabolism of Neratinib can be increased when combined with Modafinil. |
| Brigatinib | The metabolism of Brigatinib can be increased when combined with Modafinil. |
| Pexidartinib | The metabolism of Pexidartinib can be increased when combined with Modafinil. |
| Ivosidenib | The metabolism of Modafinil can be increased when combined with Ivosidenib. |
| Idelalisib | The metabolism of Idelalisib can be increased when combined with Modafinil. |
| Ixazomib | The metabolism of Ixazomib can be increased when combined with Modafinil. |
| Tolvaptan | The metabolism of Tolvaptan can be increased when combined with Modafinil. |
| Regorafenib | The metabolism of Regorafenib can be increased when combined with Modafinil. |
| Abemaciclib | The metabolism of Abemaciclib can be increased when combined with Modafinil. |
| Dihydroergotamine | The metabolism of Dihydroergotamine can be increased when combined with Modafinil. |
| Bicalutamide | The metabolism of Bicalutamide can be increased when combined with Modafinil. |
| Nortriptyline | The metabolism of Nortriptyline can be increased when combined with Modafinil. |
| Levacetylmethadol | The metabolism of Levacetylmethadol can be increased when combined with Modafinil. |
| Cyclosporine | The serum concentration of Cyclosporine can be decreased when it is combined with Modafinil. |
| Aripiprazole | The metabolism of Aripiprazole can be increased when combined with Modafinil. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be increased when combined with Modafinil. |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Modafinil. |
| Daclatasvir | The metabolism of Daclatasvir can be increased when combined with Modafinil. |
| Ifosfamide | The metabolism of Ifosfamide can be increased when combined with Modafinil. |
| Perampanel | The metabolism of Perampanel can be increased when combined with Modafinil. |
| R,S-Warfarin alcohol | The metabolism of R,S-Warfarin alcohol can be increased when combined with Modafinil. |
| S,R-Warfarin alcohol | The metabolism of S,R-Warfarin alcohol can be increased when combined with Modafinil. |
| Rolapitant | The metabolism of Rolapitant can be increased when combined with Modafinil. |
| Erlotinib | The serum concentration of Erlotinib can be decreased when it is combined with Modafinil. |
| Diethylstilbestrol | The metabolism of Diethylstilbestrol can be increased when combined with Modafinil. |
| Etonogestrel | The metabolism of Etonogestrel can be increased when combined with Modafinil. |
| Desogestrel | The metabolism of Desogestrel can be increased when combined with Modafinil. |
| Megestrol acetate | The metabolism of Megestrol acetate can be increased when combined with Modafinil. |
| Levonorgestrel | The metabolism of Levonorgestrel can be increased when combined with Modafinil. |
| Medroxyprogesterone acetate | The metabolism of Medroxyprogesterone acetate can be increased when combined with Modafinil. |
| Norethisterone | The metabolism of Norethisterone can be increased when combined with Modafinil. |