Peringatan Keamanan

Data regarding acute overdoses of glucocorticoids are rare.L10529,L10532,L10535,L10538,L7772,L7321 Chronic high doses of glucocorticoids can lead to the development of cataract, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression, and secondary adrenal insufficiency.A188405 Overdose may be treated by adjusting the dose or stopping the corticosteroid as well as initiating symptomatic and supportive treatment.A188405

Hydrocortisone

DB00741

small molecule approved vet_approved

Deskripsi

Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.A188387 Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.L10529,L10532,L10535,L10538,L7772,L7321 It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.A188420

Hydrocortisone was granted FDA approval on 5 August 1952.L10574

Struktur Molekul 2D

Berat 362.4599
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Total hydrocortisone via the oral route has a half life of 2.15h while the free fraction has a half life of 1.39h.[A188354] A 20mg IV dose of hydrocortisone has a terminal half life of 1.9±0.4h.[A188381]
Volume Distribusi Total hydrocortisone has a volume of distribution of 39.82L, while the free fraction has a volume of distribution of 474.38L.[A188354]
Klirens (Clearance) Total hydrocortisone by the oral route has a mean clearance of 12.85L/h, while the free fraction has a mean clearance of 235.78L/h.[A188354] A 20mg IV dose of hydrocortisone has a clearance of 18.2±4.2L/h.[A188381]

Absorpsi

The pharmacokinetics of hydrocortisone can vary by 10 times from patient to patient.A188354 Following the oral administration of hydrocortisone at a dose of 0.2-0.3 mg/kg/day, the mean Cmax and AUC of plasma free cortisol were 32.69 nmol/L and 90.63 h x nmol/L, respectively.A188354 The mean Cmax and AUC of plasma total cortisol were 514.47 nmol/L and 1743.93 h x nmol/L, respectively.A188354 Following the dose of 0.4-0.6 mg/kg/day, the mean Cmax and AUC of plasma free cortisol were 70.81 nmol/L and 199.11 h x nmol/L.A188354 The mean Cmax and AUC of plasma total cortisol were 754.94 nmol/L and 2533.02 h x nmol/L, respectively.A188354 Topical hydrocortisone cream is 4-19% bioavailable A188375 with a Tmax of 24h.A188372 Hydrocortisone retention enemas have a bioavailability of 0.810 for slow absorbers and 0.502 for rapid absorbers.A188378 Slow absorbers take up hydrocortisone at a rate of 0.361±0.255/h while fast absorbers take up hydrocortisone at a rate of 1.05±0.255/h.A188378 A 20mg IV dose of hydrocortisone has an AUC of 1163±277ng\*h/mL.A188381

Metabolisme

Hydrocortisone is metabolised to 6-beta hydrocortisol via CYP3A, 5-beta tetrahydrocortisol via 3-oxo-5-beta-steroid 4-dehydrogenase, 5-alpha tetrahydrocortisol via 3-oxo-5-alpha-steroid 4-dehydrogenase 2, cortisone via Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticosteroid 11-beta-dehydrogenase isozyme 2, and glucuronide products.A188321,A188318 Cortisone is further metabolized to tetrahydrocortisone and dihydrocortisol.A188321,A188318

Rute Eliminasi

Corticosteroids are eliminated predominantly in the urine.A187436 However, data regarding the exact proportion is not readily available.A188387

Interaksi Makanan

1 Data
  • 1. Avoid alcohol.

Interaksi Obat

1225 Data
Natalizumab The risk or severity of immunosuppression can be increased when Hydrocortisone is combined with Natalizumab.
Pimecrolimus The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Hydrocortisone.
Roflumilast Roflumilast may increase the immunosuppressive activities of Hydrocortisone.
Sipuleucel-T The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Hydrocortisone.
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Hydrocortisone.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Hydrocortisone.
Ceritinib The risk or severity of hyperglycemia can be increased when Hydrocortisone is combined with Ceritinib.
Corticorelin ovine triflutate The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Hydrocortisone.
Deferasirox The risk or severity of gastrointestinal ulceration and gastrointestinal irritation can be increased when Hydrocortisone is combined with Deferasirox.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Hydrocortisone.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Hydrocortisone.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Hydrocortisone.
Amphotericin B The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Amphotericin B.
Isoetharine The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Isoetharine.
Norepinephrine The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Norepinephrine.
Phenylpropanolamine The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Phenylpropanolamine.
Epinephrine The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Epinephrine.
Orciprenaline The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Orciprenaline.
Dobutamine The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Dobutamine.
Ritodrine The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Ritodrine.
Bitolterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Bitolterol.
Salmeterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Salmeterol.
Formoterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Formoterol.
Albuterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Salbutamol.
Isoprenaline The therapeutic efficacy of Isoprenaline can be decreased when used in combination with Hydrocortisone.
Arbutamine The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Arbutamine.
Arformoterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Arformoterol.
Fenoterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Fenoterol.
Pirbuterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Ephedra sinica root.
Procaterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Procaterol.
Clenbuterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Clenbuterol.
Celiprolol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Celiprolol.
Indacaterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Indacaterol.
Droxidopa The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Droxidopa.
Protokylol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Protokylol.
Hexoprenaline The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Hexoprenaline.
Olodaterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Olodaterol.
Doxofylline The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Doxofylline.
Racepinephrine The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Racepinephrine.
Etafedrine The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Etafedrine.
PF-00610355 The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with PF-00610355.
Abediterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Abediterol.
Batefenterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Batefenterol.
Levosalbutamol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Levosalbutamol.
Vilanterol The risk or severity of hypokalemia can be increased when Hydrocortisone is combined with Vilanterol.
Mitotane The serum concentration of Hydrocortisone can be decreased when it is combined with Mitotane.
Dicoumarol Hydrocortisone may increase the anticoagulant activities of Dicoumarol.
Phenindione Hydrocortisone may increase the anticoagulant activities of Phenindione.
Phenprocoumon Hydrocortisone may increase the anticoagulant activities of Phenprocoumon.
4-hydroxycoumarin Hydrocortisone may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Hydrocortisone may increase the anticoagulant activities of Coumarin.
Ethyl biscoumacetate Hydrocortisone may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Hydrocortisone may increase the anticoagulant activities of Fluindione.
Clorindione Hydrocortisone may increase the anticoagulant activities of Clorindione.
Diphenadione Hydrocortisone may increase the anticoagulant activities of Diphenadione.
Tioclomarol Hydrocortisone may increase the anticoagulant activities of Tioclomarol.
Aspartame The excretion of Hydrocortisone can be decreased when combined with Aspartame.
Cefotiam The excretion of Hydrocortisone can be decreased when combined with Cefotiam.
Liothyronine The excretion of Hydrocortisone can be decreased when combined with Liothyronine.
Aminohippuric acid The excretion of Hydrocortisone can be decreased when combined with Aminohippuric acid.
Cefalotin The excretion of Hydrocortisone can be decreased when combined with Cefalotin.
Cefotaxime The excretion of Hydrocortisone can be decreased when combined with Cefotaxime.
Guanidine The excretion of Hydrocortisone can be decreased when combined with Guanidine.
Cephalexin The excretion of Hydrocortisone can be decreased when combined with Cephalexin.
Oxytetracycline The excretion of Hydrocortisone can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Hydrocortisone can be decreased when combined with Leucovorin.
Furosemide The excretion of Hydrocortisone can be decreased when combined with Furosemide.
Acyclovir The excretion of Hydrocortisone can be decreased when combined with Acyclovir.
Cefaclor The excretion of Hydrocortisone can be decreased when combined with Cefaclor.
Bumetanide The excretion of Hydrocortisone can be decreased when combined with Bumetanide.
Dinoprostone The excretion of Hydrocortisone can be decreased when combined with Dinoprostone.
Famotidine The excretion of Hydrocortisone can be decreased when combined with Famotidine.
Ganciclovir The excretion of Hydrocortisone can be decreased when combined with Ganciclovir.
Minocycline The excretion of Hydrocortisone can be decreased when combined with Minocycline.
Probenecid The excretion of Hydrocortisone can be decreased when combined with Probenecid.
Novobiocin The excretion of Hydrocortisone can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Hydrocortisone can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Hydrocortisone can be decreased when combined with Melatonin.
Ouabain The excretion of Hydrocortisone can be decreased when combined with Ouabain.
Cefadroxil The excretion of Hydrocortisone can be decreased when combined with Cefadroxil.
Cefamandole The excretion of Hydrocortisone can be decreased when combined with Cefamandole.
Cefazolin The excretion of Hydrocortisone can be decreased when combined with Cefazolin.
Ceftizoxime The excretion of Hydrocortisone can be decreased when combined with Ceftizoxime.
Cefacetrile The excretion of Hydrocortisone can be decreased when combined with Cefacetrile.
Ceftibuten The excretion of Hydrocortisone can be decreased when combined with Ceftibuten.
Cilastatin The excretion of Hydrocortisone can be decreased when combined with Cilastatin.
Tazobactam The excretion of Hydrocortisone can be decreased when combined with Tazobactam.
trans-2-hydroxycinnamic acid The excretion of Hydrocortisone can be decreased when combined with trans-2-hydroxycinnamic acid.
Topiroxostat The excretion of Hydrocortisone can be decreased when combined with Topiroxostat.
Cholic Acid The excretion of Hydrocortisone can be decreased when combined with Cholic Acid.
Glutaric Acid The excretion of Hydrocortisone can be decreased when combined with Glutaric Acid.
Caprylic acid The excretion of Hydrocortisone can be decreased when combined with Caprylic acid.
Ataluren The excretion of Hydrocortisone can be decreased when combined with Ataluren.
Cefaloridine The excretion of Hydrocortisone can be decreased when combined with Cefaloridine.
Cabotegravir The excretion of Hydrocortisone can be decreased when combined with Cabotegravir.
Pradigastat The excretion of Hydrocortisone can be decreased when combined with Pradigastat.
Mercaptopurine The excretion of Hydrocortisone can be decreased when combined with Mercaptopurine.
Gemfibrozil The excretion of Hydrocortisone can be decreased when combined with Gemfibrozil.
Liotrix The excretion of Hydrocortisone can be decreased when combined with Liotrix.

Target Protein

Glucocorticoid receptor NR3C1
Annexin A1 ANXA1

Referensi & Sumber

Synthesis reference: Manfred Baumgarth, Dieter Orth, Jurgen Harting, Hans Schaefer, Achim Zesch, "Hydrocortisone orthoesters, pharmaceutical formulations thereof and processes for the preparation thereof." U.S. Patent US4264584, issued March, 1974.
Artikel (PubMed)
  • PMID: 28521880
    Werumeus Buning J, Touw DJ, Brummelman P, Dullaart RPF, van den Berg G, van der Klauw MM, Kamp J, Wolffenbuttel BHR, van Beek AP: Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism. 2017 Jun;71:7-16. doi: 10.1016/j.metabol.2017.02.005. Epub 2017 Feb 13.
  • PMID: 7547394
    Aalto-Korte K, Turpeinen M: Pharmacokinetics of topical hydrocortisone at plasma level after applications once or twice daily in patients with widespread dermatitis. Br J Dermatol. 1995 Aug;133(2):259-63. doi: 10.1111/j.1365-2133.1995.tb02625.x.
  • PMID: 8546995
    Aalto-Korte K, Turpeinen M: Quantifying systemic absorption of topical hydrocortisone in erythroderma. Br J Dermatol. 1995 Sep;133(3):403-8. doi: 10.1111/j.1365-2133.1995.tb02668.x.
  • PMID: 7398193
    Lima JJ, Jusko WJ: Bioavailability of hydrocortisone retention enemas in relation to absorption kinetics. Clin Pharmacol Ther. 1980 Aug;28(2):262-9. doi: 10.1038/clpt.1980.159.
  • PMID: 13700365
    FLORINI JR, BUYSKE DA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. J Biol Chem. 1961 Jan;236:247-51.
  • PMID: 2050835
    Derendorf H, Mollmann H, Barth J, Mollmann C, Tunn S, Krieg M: Pharmacokinetics and oral bioavailability of hydrocortisone. J Clin Pharmacol. 1991 May;31(5):473-6. doi: 10.1002/j.1552-4604.1991.tb01906.x.
  • PMID: 25425285
    Jung C, Greco S, Nguyen HH, Ho JT, Lewis JG, Torpy DJ, Inder WJ: Plasma, salivary and urinary cortisol levels following physiological and stress doses of hydrocortisone in normal volunteers. BMC Endocr Disord. 2014 Nov 26;14:91. doi: 10.1186/1472-6823-14-91.
  • PMID: 24347992
    Ciriaco M, Ventrice P, Russo G, Scicchitano M, Mazzitello G, Scicchitano F, Russo E: Corticosteroid-related central nervous system side effects. J Pharmacol Pharmacother. 2013 Dec;4(Suppl 1):S94-8. doi: 10.4103/0976-500X.120975.
Menampilkan 8 dari 13 artikel.

Contoh Produk & Brand

Produk: 1091 • International brands: 32
Produk
  • 1% Hydrocortisone
    Cream • 1 g/100g • Topical • US • OTC
  • 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
    Emulsion • - • Topical • US
  • 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025%
    Emulsion • - • Topical • US
  • 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025%
    Emulsion • - • Topical • US
  • 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025%
    Emulsion • - • Topical • US
  • 999 Itch Relieving
    Ointment • 1 g/100g • Topical • US • OTC
  • 999 Itch Relieving
    Ointment • 1 g/100g • Topical • US • OTC
  • Acetasol HC
    Solution • - • Auricular (otic) • US • Generic • Approved
Menampilkan 8 dari 1091 produk.
International Brands
  • Acticort
  • Aeroseb HC
  • Ala-Scalp
  • Algicirtis
  • Beta-HC
  • Cetacort
  • Cortaid
  • Delacort
  • Ficortril
  • Genacort

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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