Peringatan Keamanan

Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.

Pentamidine

DB00738

small molecule approved investigational

Deskripsi

Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.

Struktur Molekul 2D

Berat 340.4195
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 9.1-13.2 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1709 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Pentamidine.
Pegvisomant The risk or severity of hypoglycemia can be increased when Pegvisomant is combined with Pentamidine.
Dabrafenib The serum concentration of Pentamidine can be decreased when it is combined with Dabrafenib.
Luliconazole The serum concentration of Pentamidine can be increased when it is combined with Luliconazole.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Pentamidine.
Tenofovir disoproxil Pentamidine may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Pentamidine may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Pentamidine may increase the nephrotoxic activities of Tenofovir.
Foscarnet The risk or severity of adverse effects can be increased when Pentamidine is combined with Foscarnet.
Mirabegron The serum concentration of Pentamidine can be increased when it is combined with Mirabegron.
Lipoic acid The risk or severity of hypoglycemia can be increased when Lipoic acid is combined with Pentamidine.
Moxifloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Moxifloxacin.
Enoxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Enoxacin.
Pefloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Pefloxacin.
Ciprofloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Ciprofloxacin.
Nalidixic acid The therapeutic efficacy of Pentamidine can be increased when used in combination with Nalidixic acid.
Rosoxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Rosoxacin.
Cinoxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Cinoxacin.
Lomefloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Lomefloxacin.
Gatifloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Gatifloxacin.
Norfloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Norfloxacin.
Levofloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Levofloxacin.
Gemifloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Gemifloxacin.
Ofloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Ofloxacin.
Fleroxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Fleroxacin.
Technetium Tc-99m ciprofloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Technetium Tc-99m ciprofloxacin.
Garenoxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Garenoxacin.
Nemonoxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Nemonoxacin.
Flumequine The therapeutic efficacy of Pentamidine can be increased when used in combination with Flumequine.
Enrofloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Enrofloxacin.
Orbifloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Orbifloxacin.
Sarafloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Sarafloxacin.
Difloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Difloxacin.
Pazufloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Pazufloxacin.
Prulifloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Prulifloxacin.
Delafloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Delafloxacin.
Sitafloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Sitafloxacin.
Oxolinic acid The therapeutic efficacy of Pentamidine can be increased when used in combination with Oxolinic acid.
Rufloxacin The therapeutic efficacy of Pentamidine can be increased when used in combination with Rufloxacin.
Pipemidic acid The therapeutic efficacy of Pentamidine can be increased when used in combination with Pipemidic acid.
Methyclothiazide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Methyclothiazide.
Chlorthalidone The therapeutic efficacy of Pentamidine can be decreased when used in combination with Chlorthalidone.
Bendroflumethiazide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Bendroflumethiazide.
Metolazone The therapeutic efficacy of Pentamidine can be decreased when used in combination with Metolazone.
Benzthiazide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Benzthiazide.
Hydroflumethiazide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Hydroflumethiazide.
Indapamide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Indapamide.
Chlorothiazide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Chlorothiazide.
Hydrochlorothiazide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Hydrochlorothiazide.
Trichlormethiazide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Trichlormethiazide.
Polythiazide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Polythiazide.
Quinethazone The therapeutic efficacy of Pentamidine can be decreased when used in combination with Quinethazone.
Cyclopenthiazide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Cyclopenthiazide.
Epitizide The therapeutic efficacy of Pentamidine can be decreased when used in combination with Epitizide.
Lumacaftor The serum concentration of Pentamidine can be decreased when it is combined with Lumacaftor.
Amineptine Amineptine may decrease the hypoglycemic activities of Pentamidine.
Butriptyline Butriptyline may decrease the hypoglycemic activities of Pentamidine.
Tianeptine Tianeptine may decrease the hypoglycemic activities of Pentamidine.
Oxaprotiline Oxaprotiline may decrease the hypoglycemic activities of Pentamidine.
Amitriptylinoxide Amitriptylinoxide may decrease the hypoglycemic activities of Pentamidine.
Dibenzepin Dibenzepin may decrease the hypoglycemic activities of Pentamidine.
Quinupramine Quinupramine may decrease the hypoglycemic activities of Pentamidine.
Melitracen Melitracen may decrease the hypoglycemic activities of Pentamidine.
Lofepramine Lofepramine may decrease the hypoglycemic activities of Pentamidine.
Iprindole Iprindole may decrease the hypoglycemic activities of Pentamidine.
Imipramine oxide Imipramine oxide may decrease the hypoglycemic activities of Pentamidine.
Protriptyline Protriptyline may decrease the hypoglycemic activities of Pentamidine.
Dimetacrine Dimetacrine may decrease the hypoglycemic activities of Pentamidine.
Opipramol Opipramol may decrease the hypoglycemic activities of Pentamidine.
Doxepin Doxepin may decrease the hypoglycemic activities of Pentamidine.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Pentamidine.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Pentamidine.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Pentamidine.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Pentamidine.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Pentamidine.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Pentamidine.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Pentamidine.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Pentamidine.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Pentamidine.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Pentamidine.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Pentamidine.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Pentamidine.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Pentamidine.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Pentamidine.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Pentamidine.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Pentamidine.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Pentamidine.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Pentamidine.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Pentamidine.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Pentamidine.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Pentamidine.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Phenylbutazone.
Carprofen The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Carprofen.
Ceforanide The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Ceforanide.
Cefditoren The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefditoren.
Colistimethate The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Colistimethate.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefuroxime.
Cefapirin The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefapirin.
Cefprozil The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefprozil.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Lumiracoxib.

Target Protein

Tryptase alpha/beta-1 TPSAB1
tRNA (cytosine(38)-C(5))-methyltransferase TRDMT1
DNA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17191940
    Nguewa PA, Fuertes MA, Cepeda V, Iborra S, Carrion J, Valladares B, Alonso C, Perez JM: Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers. 2005 Oct;2(10):1387-400.

Contoh Produk & Brand

Produk: 12 • International brands: 4
Produk
  • NebuPent
    Inhalant • 300 mg/6mL • Respiratory (inhalation) • US • Approved
  • NebuPent
    Inhalant • 300 mg/6mL • Respiratory (inhalation) • US • Approved
  • Pentacarinat 300 Inj Pws 300mg/vial
    Powder, for solution • 300 mg / vial • Intramuscular; Intravenous; Respiratory (inhalation) • Canada • Approved
  • Pentam 300
    Injection, powder, lyophilized, for solution • 300 mg/3mL • Intramuscular; Intravenous • US • Approved
  • Pentamidine Isethionate
    Injection, powder, lyophilized, for solution • 300 mg/300mg • Intramuscular; Intravenous • US • Generic • Approved
  • Pentamidine Isethionate
    Inhalant • 300 mg/300mg • Respiratory (inhalation) • US • Generic • Approved
  • Pentamidine Isethionate
    Injection, powder, lyophilized, for solution • 300 mg/300mg • Intramuscular; Intravenous • US • Generic • Approved
  • Pentamidine Isethionate
    Injection, powder, lyophilized, for solution • 300 mg/3mL • Intramuscular; Intravenous • US • Generic • Approved
Menampilkan 8 dari 12 produk.
International Brands
  • Pentacarinat — Sanofi-Aventis
  • Pentacrinat — Abbot
  • Pentam — Abbot
  • Pneumopent

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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