Peringatan Keamanan

Side effects include agitation, coma, confusion, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high fever, irregular heart rate, low body temperature, muscle rigidity, overactive reflexes, severely low blood pressure, stupor, vomiting

Trimipramine

DB00726

small molecule approved

Deskripsi

Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.

Struktur Molekul 2D

Berat 294.4338
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 11-18 hrs
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapid absorption

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Farmakogenomik

8 Varian
CYP2D6 (rs35742686)

The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.

CYP2D6 (rs3892097)

The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.

CYP2D6 (None)

The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.

CYP2D6 (rs5030655)

The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.

CYP2C19 (rs4244285)

The presence of this polymorphism in CYP2C19 is associated with poor metabolism of trimipramine.

CYP2C19 (rs4986893)

The presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of trimipramine.

CYP2D6 (rs1135824)

The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.

CYP2D6 (rs28371733)

The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.

Interaksi Makanan

1 Data
  • 1. Avoid alcohol. Ingesting alcohol may increase the risk of adverse effects of trimipramine such as sedation and orthostatic hypotension.

Interaksi Obat

1902 Data
Ramipril Trimipramine may decrease the antihypertensive activities of Ramipril.
Remikiren Trimipramine may decrease the antihypertensive activities of Remikiren.
Guanadrel Trimipramine may decrease the antihypertensive activities of Guanadrel.
Olmesartan Trimipramine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Trimipramine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Trimipramine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Trimipramine may decrease the antihypertensive activities of Minoxidil.
Bendroflumethiazide Trimipramine may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Trimipramine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Trimipramine may decrease the antihypertensive activities of Trandolapril.
Metolazone Trimipramine may decrease the antihypertensive activities of Metolazone.
Benazepril Trimipramine may decrease the antihypertensive activities of Benazepril.
Cyclothiazide Trimipramine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Trimipramine may decrease the antihypertensive activities of Candoxatril.
Lisinopril Trimipramine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Trimipramine may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Trimipramine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Trimipramine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Trimipramine may decrease the antihypertensive activities of Perindopril.
Fenoldopam Trimipramine may decrease the antihypertensive activities of Fenoldopam.
Eprosartan Trimipramine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Trimipramine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Trimipramine may decrease the antihypertensive activities of Quinapril.
Trichlormethiazide Trimipramine may decrease the antihypertensive activities of Trichlormethiazide.
Deserpidine Trimipramine may decrease the antihypertensive activities of Deserpidine.
Diazoxide Trimipramine may decrease the antihypertensive activities of Diazoxide.
Epoprostenol Trimipramine may decrease the antihypertensive activities of Epoprostenol.
Polythiazide Trimipramine may decrease the antihypertensive activities of Polythiazide.
Saprisartan Trimipramine may decrease the antihypertensive activities of Saprisartan.
Spirapril Trimipramine may decrease the antihypertensive activities of Spirapril.
Diethylnorspermine Trimipramine may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Trimipramine may decrease the antihypertensive activities of Temocapril.
Rauwolfia serpentina root Trimipramine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Trimipramine may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Trimipramine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Trimipramine may decrease the antihypertensive activities of Imidapril.
BQ-123 Trimipramine may decrease the antihypertensive activities of BQ-123.
Dihydralazine Trimipramine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Trimipramine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Trimipramine may decrease the antihypertensive activities of Guanoxan.
Delapril Trimipramine may decrease the antihypertensive activities of Delapril.
Vincamine Trimipramine may decrease the antihypertensive activities of Vincamine.
Linsidomine Trimipramine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Trimipramine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Trimipramine may decrease the antihypertensive activities of Tolonidine.
Endralazine Trimipramine may decrease the antihypertensive activities of Endralazine.
Cadralazine Trimipramine may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Trimipramine may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Trimipramine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Trimipramine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Trimipramine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Trimipramine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Trimipramine may decrease the antihypertensive activities of Muzolimine.
Xipamide Trimipramine may decrease the antihypertensive activities of Xipamide.
Tocopherylquinone Trimipramine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Trimipramine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Trimipramine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Trimipramine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Trimipramine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Trimipramine may decrease the antihypertensive activities of Quinaprilat.
Furosemide Trimipramine may decrease the antihypertensive activities of Furosemide.
Eplerenone Trimipramine may decrease the antihypertensive activities of Eplerenone.
Guanethidine Trimipramine may decrease the antihypertensive activities of Guanethidine.
Hydralazine Trimipramine may decrease the antihypertensive activities of Hydralazine.
Pinacidil Trimipramine may decrease the antihypertensive activities of Pinacidil.
Riociguat The serum concentration of Trimipramine can be increased when it is combined with Riociguat.
Macitentan Trimipramine may decrease the antihypertensive activities of Macitentan.
Aliskiren Trimipramine may decrease the antihypertensive activities of Aliskiren.
Enalapril Trimipramine may decrease the antihypertensive activities of Enalapril.
Captopril Trimipramine may decrease the antihypertensive activities of Captopril.
Cilazapril Trimipramine may decrease the antihypertensive activities of Cilazapril.
Levamlodipine Trimipramine may decrease the antihypertensive activities of Levamlodipine.
Buthiazide Trimipramine may decrease the antihypertensive activities of Buthiazide.
Azilsartan medoxomil Trimipramine may decrease the antihypertensive activities of Azilsartan medoxomil.
Buprenorphine Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
Hydrocodone Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Trimipramine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
Orphenadrine Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
Pramipexole Trimipramine may increase the sedative activities of Pramipexole.
Ropinirole Trimipramine may increase the sedative activities of Ropinirole.
Rotigotine Trimipramine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Trimipramine.
Sodium oxybate Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
Thalidomide Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Trimipramine.
Phenmetrazine The risk or severity of hypertension can be increased when Trimipramine is combined with Phenmetrazine.
Omapatrilat Trimipramine may decrease the antihypertensive activities of Omapatrilat.
Dopamine The risk or severity of hypertension can be increased when Trimipramine is combined with Dopamine.
Rescinnamine Trimipramine may decrease the antihypertensive activities of Rescinnamine.

Target Protein

Sodium-dependent serotonin transporter SLC6A4
Sodium-dependent noradrenaline transporter SLC6A2
Sodium-dependent dopamine transporter SLC6A3
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 1A HTR1A
Alpha-1A adrenergic receptor ADRA1A
Alpha-1B adrenergic receptor ADRA1B
D(2) dopamine receptor DRD2
Alpha-2B adrenergic receptor ADRA2B
Histamine H1 receptor HRH1
5-hydroxytryptamine receptor 2C HTR2C
5-hydroxytryptamine receptor 3A HTR3A
5-hydroxytryptamine receptor 1D HTR1D
Alpha-2A adrenergic receptor ADRA2A
D(1) dopamine receptor DRD1
Beta adrenergic receptor ADRB1
Muscarinic acetylcholine receptor CHRM1
5-hydroxytryptamine receptor 2C Htr2c

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 59 • International brands: 7
Produk
  • Apo-trimipramine
    Tablet • 12.5 mg • Oral • Canada • Generic • Approved
  • Apo-trimipramine
    Tablet • 25 mg • Oral • Canada • Generic • Approved
  • Apo-trimipramine
    Tablet • 50 mg • Oral • Canada • Generic • Approved
  • Apo-trimipramine
    Tablet • 100 mg • Oral • Canada • Generic • Approved
  • Apo-trimipramine
    Capsule • 75 mg • Oral • Canada • Generic • Approved
  • Novo-tripramine Tab 100mg BP
    Tablet • 100 mg • Oral • Canada • Generic • Approved
  • Novo-tripramine Tab 25mg BP
    Tablet • 25 mg • Oral • Canada • Generic • Approved
  • Novo-tripramine Tab 50mg BP
    Tablet • 50 mg • Oral • Canada • Generic • Approved
Menampilkan 8 dari 59 produk.
International Brands
  • Herphonal — Temmler
  • Sapilent — ExtractumPharma
  • Stangyl — Sanofi-Aventis
  • Trimidura — Mylan dura
  • Trimineurin — Hexal
  • Tripress — Mylan
  • Tydamine — Aspen Pharmacare

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul