Peringatan Keamanan

The oral and subcutaneous LD50 in rats is >8500mg/kg and in mice is >9100mg/kg.L8399 The oral LDLO in women is 1200µg/kg/16D and in men is 43mg/kg/43W.L8399

Patients experiencing an overdose of lisinopril may present with hypotension.L8384,L8387,L8390 Patients should be treated with intravenous saline to restore blood pressure.L8384,L8387,L8390 Lisinopril can be removed from the blood by hemodialysis due to it not being protein bound.L8384,L8387,L8390

Lisinopril

DB00722

small molecule approved investigational

Deskripsi

Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.L8384,L8387,L8390 Lisinopril and captopril are the only ACEIs that are not prodrugs.A184853 It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.A184781,A184808,A184817 ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.A184844

Lisinopril was granted FDA approval on 29 December 1987.L8384

Struktur Molekul 2D

Berat 405.4879
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Lisinopril has an effective half life of accumulation of 12.6h[A184754,L8384,L8387,L8390] and a terminal half life of 46.7h.[A184754]
Volume Distribusi The apparent volume of distribution of lisinopril is 124L.[A184781]
Klirens (Clearance) A 30kg child has a typical clearance of 10L/h, which increases with renal function.[L8384,L8387] The mean renal clearance of lisinopril in healthy adult males is 121mL/min.[A184754]

Absorpsi

Lisinopril is 6-60% orally bioavailable with an average of 25% bioavailability.A184754,L8384,L8387,L8390 Lisinopril reaches a Cmax of 58ng/mL with a Tmax of 6-8h.A184754 Lisinopril's absorption is not affected by food.A184754

Metabolisme

Lisinopril is not metabolized and is excreted as the unchanged drug.L8384,L8387,L8390

Rute Eliminasi

Lisinopril is entirely eliminated exclusively in the urine.L8384,L8387,L8390

Interaksi Makanan

4 Data
  • 1. Avoid hypertensive herbs (e.g. bayberry, blue cohosh, cayenne, ephedra, and licorice).
  • 2. Avoid potassium-containing products. Potassium products increase the risk of hyperkalemia.
  • 3. Limit salt intake. Salt may attenuate the antihypertensive effect.
  • 4. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1304 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Lisinopril is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Lisinopril is combined with Levodopa.
Risperidone Lisinopril may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Lisinopril.
Amifostine Lisinopril may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Lisinopril.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Lisinopril.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Lisinopril.
Obinutuzumab Lisinopril may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Lisinopril.
Rituximab Lisinopril may increase the hypotensive activities of Rituximab.
Phentermine Phentermine may decrease the antihypertensive activities of Lisinopril.
Midodrine Midodrine may decrease the antihypertensive activities of Lisinopril.
Eletriptan Eletriptan may decrease the antihypertensive activities of Lisinopril.
Isoetharine Isoetharine may decrease the antihypertensive activities of Lisinopril.
Methysergide Methysergide may decrease the antihypertensive activities of Lisinopril.
Cabergoline Cabergoline may decrease the antihypertensive activities of Lisinopril.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Lisinopril.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Lisinopril.
Protriptyline Protriptyline may decrease the antihypertensive activities of Lisinopril.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Lisinopril.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Lisinopril.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Lisinopril.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Lisinopril.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Lisinopril.
Promazine Promazine may decrease the antihypertensive activities of Lisinopril.
Droperidol Droperidol may decrease the antihypertensive activities of Lisinopril.
Nortriptyline Nortriptyline may decrease the antihypertensive activities of Lisinopril.
Amoxapine Amoxapine may decrease the antihypertensive activities of Lisinopril.
Doxapram Doxapram may decrease the antihypertensive activities of Lisinopril.
Atropine Atropine may decrease the antihypertensive activities of Lisinopril.
Lisuride Lisuride may decrease the antihypertensive activities of Lisinopril.
Metaraminol Metaraminol may decrease the antihypertensive activities of Lisinopril.
Trazodone Trazodone may decrease the antihypertensive activities of Lisinopril.
Epinephrine Epinephrine may decrease the antihypertensive activities of Lisinopril.
Ergotamine Ergotamine may decrease the antihypertensive activities of Lisinopril.
Nicergoline Nicergoline may decrease the antihypertensive activities of Lisinopril.
Methoxamine Methoxamine may decrease the antihypertensive activities of Lisinopril.
Trimipramine Trimipramine may decrease the antihypertensive activities of Lisinopril.
Propiomazine Propiomazine may decrease the antihypertensive activities of Lisinopril.
Alfentanil Alfentanil may decrease the antihypertensive activities of Lisinopril.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Lisinopril.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Lisinopril.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Lisinopril.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Lisinopril.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Lisinopril.
Ritodrine Ritodrine may decrease the antihypertensive activities of Lisinopril.
Flupentixol Flupentixol may decrease the antihypertensive activities of Lisinopril.
Bitolterol Bitolterol may decrease the antihypertensive activities of Lisinopril.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Lisinopril.
Salmeterol Salmeterol may decrease the antihypertensive activities of Lisinopril.
Naratriptan Naratriptan may decrease the antihypertensive activities of Lisinopril.
Formoterol Formoterol may decrease the antihypertensive activities of Lisinopril.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Lisinopril.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Lisinopril.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Lisinopril.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Lisinopril.
Arbutamine Arbutamine may decrease the antihypertensive activities of Lisinopril.
Dutasteride Dutasteride may decrease the antihypertensive activities of Lisinopril.
Pergolide Pergolide may decrease the antihypertensive activities of Lisinopril.
Finasteride Finasteride may decrease the antihypertensive activities of Lisinopril.
Ergometrine Ergometrine may decrease the antihypertensive activities of Lisinopril.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Lisinopril.
Fenoterol Fenoterol may decrease the antihypertensive activities of Lisinopril.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Lisinopril.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Lisinopril.
Ephedrine Ephedrine may decrease the antihypertensive activities of Lisinopril.
Mephentermine Mephentermine may decrease the antihypertensive activities of Lisinopril.
Procaterol Procaterol may decrease the antihypertensive activities of Lisinopril.
Yohimbine Yohimbine may decrease the antihypertensive activities of Lisinopril.
Methotrimeprazine Methotrimeprazine may decrease the antihypertensive activities of Lisinopril.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Lisinopril.
Bambuterol Bambuterol may decrease the antihypertensive activities of Lisinopril.
MMDA MMDA may decrease the antihypertensive activities of Lisinopril.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Lisinopril.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Lisinopril.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Lisinopril.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Lisinopril.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Lisinopril.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Lisinopril.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Lisinopril.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Lisinopril.
Solifenacin Solifenacin may decrease the antihypertensive activities of Lisinopril.
Periciazine Periciazine may decrease the antihypertensive activities of Lisinopril.
Acepromazine Acepromazine may decrease the antihypertensive activities of Lisinopril.
Thioproperazine Thioproperazine may decrease the antihypertensive activities of Lisinopril.
Zuclopenthixol Zuclopenthixol may decrease the antihypertensive activities of Lisinopril.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Lisinopril.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Lisinopril.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Lisinopril.
Amineptine Amineptine may decrease the antihypertensive activities of Lisinopril.
Dronedarone Dronedarone may decrease the antihypertensive activities of Lisinopril.
Flibanserin Flibanserin may decrease the antihypertensive activities of Lisinopril.
Iloperidone Iloperidone may decrease the antihypertensive activities of Lisinopril.
Indacaterol Indacaterol may decrease the antihypertensive activities of Lisinopril.
Amibegron Amibegron may decrease the antihypertensive activities of Lisinopril.
Naluzotan Naluzotan may decrease the antihypertensive activities of Lisinopril.
Cariprazine Cariprazine may decrease the antihypertensive activities of Lisinopril.
Mianserin Mianserin may decrease the antihypertensive activities of Lisinopril.
Pizotifen Pizotifen may decrease the antihypertensive activities of Lisinopril.

Target Protein

Angiotensin-converting enzyme ACE
Renin REN

Referensi & Sumber

Synthesis reference: Vincenzo Cannata, Valeriano Merli, Stefano Saguatti, "Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril." U.S. Patent US6166217, issued September, 1972.
Artikel (PubMed)
  • PMID: 2539850
    Thomson AH, Kelly JG, Whiting B: Lisinopril population pharmacokinetics in elderly and renal disease patients with hypertension. Br J Clin Pharmacol. 1989 Jan;27(1):57-65. doi: 10.1111/j.1365-2125.1989.tb05335.x.
  • PMID: 2844083
    Beermann B: Pharmacokinetics of lisinopril. Am J Med. 1988 Sep 23;85(3B):25-30. doi: 10.1016/0002-9343(88)90346-4.
  • PMID: 8891468
    Goa KL, Balfour JA, Zuanetti G: Lisinopril. A review of its pharmacology and clinical efficacy in the early management of acute myocardial infarction. Drugs. 1996 Oct;52(4):564-88. doi: 10.2165/00003495-199652040-00011.
  • PMID: 28780421
    Laurent S: Antihypertensive drugs. Pharmacol Res. 2017 Oct;124:116-125. doi: 10.1016/j.phrs.2017.07.026. Epub 2017 Aug 2.
  • PMID: 25767283
    Te Riet L, van Esch JH, Roks AJ, van den Meiracker AH, Danser AH: Hypertension: renin-angiotensin-aldosterone system alterations. Circ Res. 2015 Mar 13;116(6):960-75. doi: 10.1161/CIRCRESAHA.116.303587.
  • PMID: 29667175
    Wright JM, Musini VM, Gill R: First-line drugs for hypertension. Cochrane Database Syst Rev. 2018 Apr 18;4:CD001841. doi: 10.1002/14651858.CD001841.pub3.
  • PMID: 28613705
    Herman LL, Bashir K: Angiotensin Converting Enzyme Inhibitors (ACEI) .

Contoh Produk & Brand

Produk: 1438 • International brands: 20
Produk
  • Act Lisinopril
    Tablet • 5 mg • Oral • Canada • Approved
  • Act Lisinopril
    Tablet • 10 mg • Oral • Canada • Approved
  • Act Lisinopril
    Tablet • 20 mg • Oral • Canada • Approved
  • Apo-lisinopril
    Tablet • 5 mg • Oral • Canada • Generic • Approved
  • Apo-lisinopril
    Tablet • 10 mg • Oral • Canada • Generic • Approved
  • Apo-lisinopril
    Tablet • 20 mg • Oral • Canada • Generic • Approved
  • Apo-lisinopril Tablet (type P) - 10mg
    Tablet • 10 mg • Oral • Canada • Generic • Approved
  • Apo-lisinopril Tablet (type P) - 20mg
    Tablet • 20 mg • Oral • Canada • Generic • Approved
Menampilkan 8 dari 1438 produk.
International Brands
  • Acebitor — GlaxoSmithKline
  • Acemin — AstraZeneca
  • Acerbon — AstraZeneca
  • Acinopril — sanofi-aventis
  • Bellisin — Ranbaxy
  • Biopril — Biochem
  • Dapril — Medochemie
  • Fibsol — Sigma
  • Fisopril — Sanofi-Aventis
  • Hipril — Micro Labs

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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