Procaine

DB00721

small molecule approved investigational vet_approved

Deskripsi

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also been investigated as an oral entry inhibitor in treatment-experienced HIV patients L1215.

Struktur Molekul 2D

Berat 236.3101
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 7.7 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hydrolysis by plasma esterases to PABA

Rute Eliminasi

With normal kidney function, the drug is excreted rapidly by tubular excretion.

Interaksi Obat

2345 Data
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Procaine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Procaine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Procaine.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Procaine.
Magnesium sulfate The therapeutic efficacy of Procaine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Procaine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Procaine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Procaine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Procaine.
Orphenadrine Procaine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Procaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Procaine.
Pramipexole Procaine may increase the sedative activities of Pramipexole.
Ropinirole Procaine may increase the sedative activities of Ropinirole.
Rotigotine Procaine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Procaine.
Sodium oxybate The risk or severity of CNS depression can be increased when Procaine is combined with Sodium oxybate.
Suvorexant Procaine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Procaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Procaine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Procaine is combined with Prilocaine.
Hyaluronidase (ovine) Hyaluronidase (ovine) can cause an increase in the absorption of Procaine resulting in an increased serum concentration and potentially a worsening of adverse effects.
Hyaluronidase (human recombinant) Hyaluronidase (human recombinant) can cause an increase in the absorption of Procaine resulting in an increased serum concentration and potentially a worsening of adverse effects.
Hyaluronidase Hyaluronidase can cause an increase in the absorption of Procaine resulting in an increased serum concentration and potentially a worsening of adverse effects.
Memantine The risk or severity of adverse effects can be increased when Procaine is combined with Memantine.
Dipyridamole The therapeutic efficacy of Procaine can be decreased when used in combination with Dipyridamole.
Irinotecan The risk or severity of methemoglobinemia can be increased when Irinotecan is combined with Procaine.
Ephedrine Procaine may increase the neuromuscular blocking activities of Ephedrine.
Sar9, Met (O2)11-Substance P Procaine may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P.
Mirabegron Procaine may increase the neuromuscular blocking activities of Mirabegron.
Moxisylyte Procaine may increase the neuromuscular blocking activities of Moxisylyte.
Propacetamol Procaine may increase the neuromuscular blocking activities of Propacetamol.
Pegvisomant Pegvisomant may increase the neuromuscular blocking activities of Procaine.
Mefloquine The risk or severity of methemoglobinemia can be increased when Mefloquine is combined with Procaine.
Tacrine Tacrine may increase the neuromuscular blocking activities of Procaine.
Sulpiride Sulpiride may increase the neuromuscular blocking activities of Procaine.
Profenamine Profenamine may increase the neuromuscular blocking activities of Procaine.
Gallamine triethiodide Gallamine triethiodide may increase the neuromuscular blocking activities of Procaine.
Cisplatin The risk or severity of methemoglobinemia can be increased when Cisplatin is combined with Procaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Cinchocaine is combined with Procaine.
Pyridostigmine Pyridostigmine may increase the neuromuscular blocking activities of Procaine.
Nizatidine Nizatidine may increase the neuromuscular blocking activities of Procaine.
Galantamine Galantamine may increase the neuromuscular blocking activities of Procaine.
Isoflurophate Isoflurophate may increase the neuromuscular blocking activities of Procaine.
Diethylcarbamazine Diethylcarbamazine may increase the neuromuscular blocking activities of Procaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Procaine is combined with Cocaine.
Hexafluronium Hexafluronium may increase the neuromuscular blocking activities of Procaine.
Trimethaphan Procaine may increase the neuromuscular blocking activities of Trimethaphan.
Doxacurium Procaine may increase the neuromuscular blocking activities of Doxacurium.
Chloroprocaine The risk or severity of adverse effects can be increased when Procaine is combined with Chloroprocaine.
Tubocurarine Procaine may increase the neuromuscular blocking activities of Tubocurarine.
Pancuronium Pancuronium may increase the neuromuscular blocking activities of Procaine.
Pipecuronium Pipecuronium may increase the neuromuscular blocking activities of Procaine.
Aclidinium Procaine may increase the neuromuscular blocking activities of Aclidinium.
Terbutaline Terbutaline may increase the neuromuscular blocking activities of Procaine.
Mechlorethamine The risk or severity of methemoglobinemia can be increased when Mechlorethamine is combined with Procaine.
Demecarium Demecarium may increase the neuromuscular blocking activities of Procaine.
Physostigmine Physostigmine may increase the neuromuscular blocking activities of Procaine.
Rivastigmine Rivastigmine may increase the neuromuscular blocking activities of Procaine.
Edrophonium Edrophonium may increase the neuromuscular blocking activities of Procaine.
Procainamide Procainamide may increase the neuromuscular blocking activities of Procaine.
Ambenonium Ambenonium may increase the neuromuscular blocking activities of Procaine.
Ketamine Ketamine may increase the neuromuscular blocking activities of Procaine.
Decamethonium Decamethonium may increase the neuromuscular blocking activities of Procaine.
Ginkgo biloba Ginkgo biloba may increase the neuromuscular blocking activities of Procaine.
Neostigmine Neostigmine may increase the neuromuscular blocking activities of Procaine.
Bambuterol Procaine may increase the neuromuscular blocking activities of Bambuterol.
1,10-Phenanthroline 1,10-Phenanthroline may increase the neuromuscular blocking activities of Procaine.
Thiotepa The risk or severity of methemoglobinemia can be increased when Thiotepa is combined with Procaine.
Huperzine A Huperzine A may increase the neuromuscular blocking activities of Procaine.
Phenserine Phenserine may increase the neuromuscular blocking activities of Procaine.
Regramostim Regramostim may increase the neuromuscular blocking activities of Procaine.
Aprotinin Aprotinin may increase the neuromuscular blocking activities of Procaine.
Betaine Betaine may increase the neuromuscular blocking activities of Procaine.
Capsaicin The risk or severity of methemoglobinemia can be increased when Procaine is combined with Capsaicin.
Coumaphos Coumaphos may increase the neuromuscular blocking activities of Procaine.
Dichlorvos Dichlorvos may increase the neuromuscular blocking activities of Procaine.
Fenthion Fenthion may increase the neuromuscular blocking activities of Procaine.
Metrifonate Metrifonate may increase the neuromuscular blocking activities of Procaine.
Acotiamide Acotiamide may increase the neuromuscular blocking activities of Procaine.
Methanesulfonyl Fluoride Methanesulfonyl Fluoride may increase the neuromuscular blocking activities of Procaine.
Paraoxon Paraoxon may increase the neuromuscular blocking activities of Procaine.
Tyrothricin The risk or severity of methemoglobinemia can be increased when Tyrothricin is combined with Procaine.
Ipidacrine Ipidacrine may increase the neuromuscular blocking activities of Procaine.
Distigmine Distigmine may increase the neuromuscular blocking activities of Procaine.
Tretamine The risk or severity of methemoglobinemia can be increased when Tretamine is combined with Procaine.
Posiphen Posiphen may increase the neuromuscular blocking activities of Procaine.
Butyrylthiocholine Procaine may increase the neuromuscular blocking activities of Butyrylthiocholine.
Methylphosphinic Acid Methylphosphinic Acid may increase the neuromuscular blocking activities of Procaine.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Procaine is combined with Oxybuprocaine.
Benzonatate Procaine may increase the neuromuscular blocking activities of Benzonatate.
Apraclonidine Procaine may increase the alpha-adrenergic activities of Apraclonidine.
Atomoxetine The risk or severity of adverse effects can be increased when Procaine is combined with Atomoxetine.
Betahistine The metabolism of Betahistine can be decreased when combined with Procaine.
Bezafibrate Procaine may increase the hepatotoxic activities of Bezafibrate.
Buprenorphine Procaine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Bupropion The risk or severity of adverse effects can be increased when Procaine is combined with Bupropion.
Buspirone The risk or severity of hypertension can be increased when Procaine is combined with Buspirone.
Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Procaine.

Target Protein

Sodium channel protein type 10 subunit alpha SCN10A
Glutamate receptor ionotropic, NMDA 3A GRIN3A
5-hydroxytryptamine receptor 3A HTR3A
Sodium-dependent dopamine transporter SLC6A3
Neuronal acetylcholine receptor subunit alpha-2 CHRNA2
Calcium-activated potassium channel KCNMA1
Cytosolic phospholipase A2 PLA2G4A
60 kDa lysophospholipase ASPG
Monoamine oxidase MAOA
DNA (cytosine-5)-methyltransferase 1 DNMT1
DNA (cytosine-5)-methyltransferase 3A DNMT3A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 11714893
    Gentry CL, Lukas RJ: Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299(3):1038-48.

Contoh Produk & Brand

Produk: 7 • International brands: 0
Produk
  • Novocain
    Injection, solution • 10 mg/1mL • Infiltration • US • Approved
  • Novocain
    Injection, solution • 10 mg/1mL • Infiltration • US • Approved
  • Novocain
    Injection, solution • 20 mg/1mL • Infiltration • US • Approved
  • Novocain 20 mg/ml
    Solution • 2 % • Infiltration • Canada • Approved
  • Novocain Liq 2%
    Liquid • 2 % • Infiltration • Canada • Approved
  • Novocaine
    Injection, solution • 100 mg/1mL • Intraspinal; Intrathecal; Subarachnoid • US • Approved
  • Procaine Hydrochloride
    Crystal • 1 g/1g • Not applicable • US

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul