Peringatan Keamanan

Oral LD50 in rat and mouse is 1400 mg/kg and 660 mg/kg, respectively.

Diethylcarbamazine

DB00711

small molecule approved investigational vet_approved

Deskripsi

An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Struktur Molekul 2D

Berat 199.2932
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 8 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Readily absorbed following oral administration.

Metabolisme

Partially metabolized to diethylcarbamazine N-oxide.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take after a meal.

Interaksi Obat

292 Data
Dipyridamole The therapeutic efficacy of Diethylcarbamazine can be decreased when used in combination with Dipyridamole.
Ephedrine Diethylcarbamazine may increase the neuromuscular blocking activities of Ephedrine.
Bambuterol Diethylcarbamazine may increase the neuromuscular blocking activities of Bambuterol.
Clevidipine Diethylcarbamazine may increase the neuromuscular blocking activities of Clevidipine.
Sar9, Met (O2)11-Substance P Diethylcarbamazine may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P.
Mirabegron Diethylcarbamazine may increase the neuromuscular blocking activities of Mirabegron.
Moxisylyte Diethylcarbamazine may increase the neuromuscular blocking activities of Moxisylyte.
Propacetamol Diethylcarbamazine may increase the neuromuscular blocking activities of Propacetamol.
Procaine Diethylcarbamazine may increase the neuromuscular blocking activities of Procaine.
Cocaine Diethylcarbamazine may increase the neuromuscular blocking activities of Cocaine.
Trimethaphan Diethylcarbamazine may increase the neuromuscular blocking activities of Trimethaphan.
Doxacurium Diethylcarbamazine may increase the neuromuscular blocking activities of Doxacurium.
Chloroprocaine Diethylcarbamazine may increase the neuromuscular blocking activities of Chloroprocaine.
Tubocurarine Diethylcarbamazine may increase the neuromuscular blocking activities of Tubocurarine.
Aclidinium Diethylcarbamazine may increase the neuromuscular blocking activities of Aclidinium.
Butyrylthiocholine Diethylcarbamazine may increase the neuromuscular blocking activities of Butyrylthiocholine.
Oxybuprocaine Diethylcarbamazine may increase the neuromuscular blocking activities of Oxybuprocaine.
Benzonatate Diethylcarbamazine may increase the neuromuscular blocking activities of Benzonatate.
Succinylcholine The metabolism of Succinylcholine can be decreased when combined with Diethylcarbamazine.
Tramadol The therapeutic efficacy of Tramadol can be decreased when used in combination with Diethylcarbamazine.
Trospium The therapeutic efficacy of Trospium can be decreased when used in combination with Diethylcarbamazine.
Oxyphenonium The therapeutic efficacy of Oxyphenonium can be decreased when used in combination with Diethylcarbamazine.
Butabarbital The therapeutic efficacy of Butabarbital can be decreased when used in combination with Diethylcarbamazine.
Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Diethylcarbamazine.
Benzatropine The therapeutic efficacy of Benzatropine can be decreased when used in combination with Diethylcarbamazine.
Ziprasidone The therapeutic efficacy of Ziprasidone can be decreased when used in combination with Diethylcarbamazine.
Disopyramide The therapeutic efficacy of Disopyramide can be decreased when used in combination with Diethylcarbamazine.
Talbutal The therapeutic efficacy of Talbutal can be decreased when used in combination with Diethylcarbamazine.
Pentobarbital The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Diethylcarbamazine.
Amitriptyline The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Diethylcarbamazine.
Ipratropium The therapeutic efficacy of Ipratropium can be decreased when used in combination with Diethylcarbamazine.
Methadone The therapeutic efficacy of Methadone can be decreased when used in combination with Diethylcarbamazine.
Olanzapine The therapeutic efficacy of Olanzapine can be decreased when used in combination with Diethylcarbamazine.
Metixene The therapeutic efficacy of Metixene can be decreased when used in combination with Diethylcarbamazine.
Terfenadine The therapeutic efficacy of Terfenadine can be decreased when used in combination with Diethylcarbamazine.
Buclizine The therapeutic efficacy of Buclizine can be decreased when used in combination with Diethylcarbamazine.
Clozapine The therapeutic efficacy of Clozapine can be decreased when used in combination with Diethylcarbamazine.
Doxylamine The therapeutic efficacy of Doxylamine can be decreased when used in combination with Diethylcarbamazine.
Trihexyphenidyl The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Diethylcarbamazine.
Oxyphencyclimine The therapeutic efficacy of Oxyphencyclimine can be decreased when used in combination with Diethylcarbamazine.
Procyclidine The therapeutic efficacy of Procyclidine can be decreased when used in combination with Diethylcarbamazine.
Profenamine The therapeutic efficacy of Profenamine can be decreased when used in combination with Diethylcarbamazine.
Secobarbital The therapeutic efficacy of Secobarbital can be decreased when used in combination with Diethylcarbamazine.
Promazine The therapeutic efficacy of Promazine can be decreased when used in combination with Diethylcarbamazine.
Hyoscyamine The therapeutic efficacy of Hyoscyamine can be decreased when used in combination with Diethylcarbamazine.
Cyproheptadine The therapeutic efficacy of Cyproheptadine can be decreased when used in combination with Diethylcarbamazine.
Imipramine The therapeutic efficacy of Imipramine can be decreased when used in combination with Diethylcarbamazine.
Methscopolamine bromide The therapeutic efficacy of Methscopolamine bromide can be decreased when used in combination with Diethylcarbamazine.
Metharbital The therapeutic efficacy of Metharbital can be decreased when used in combination with Diethylcarbamazine.
Fluoxetine The therapeutic efficacy of Fluoxetine can be decreased when used in combination with Diethylcarbamazine.
Chlorpromazine The therapeutic efficacy of Chlorpromazine can be decreased when used in combination with Diethylcarbamazine.
Darifenacin The therapeutic efficacy of Darifenacin can be decreased when used in combination with Diethylcarbamazine.
Tridihexethyl The therapeutic efficacy of Tridihexethyl can be decreased when used in combination with Diethylcarbamazine.
Triflupromazine The therapeutic efficacy of Triflupromazine can be decreased when used in combination with Diethylcarbamazine.
Dextromethorphan The therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Diethylcarbamazine.
Anisotropine methylbromide The therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with Diethylcarbamazine.
Nortriptyline The therapeutic efficacy of Nortriptyline can be decreased when used in combination with Diethylcarbamazine.
Amoxapine The therapeutic efficacy of Amoxapine can be decreased when used in combination with Diethylcarbamazine.
Atropine The therapeutic efficacy of Atropine can be decreased when used in combination with Diethylcarbamazine.
Thiopental The therapeutic efficacy of Thiopental can be decreased when used in combination with Diethylcarbamazine.
Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Diethylcarbamazine.
Mecamylamine The therapeutic efficacy of Mecamylamine can be decreased when used in combination with Diethylcarbamazine.
Pirenzepine The therapeutic efficacy of Pirenzepine can be decreased when used in combination with Diethylcarbamazine.
Paroxetine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Diethylcarbamazine.
Homatropine methylbromide The therapeutic efficacy of Homatropine methylbromide can be decreased when used in combination with Diethylcarbamazine.
Scopolamine The therapeutic efficacy of Scopolamine can be decreased when used in combination with Diethylcarbamazine.
Isoflurane The therapeutic efficacy of Isoflurane can be decreased when used in combination with Diethylcarbamazine.
Benzquinamide The therapeutic efficacy of Benzquinamide can be decreased when used in combination with Diethylcarbamazine.
Clidinium The therapeutic efficacy of Clidinium can be decreased when used in combination with Diethylcarbamazine.
Propiomazine The therapeutic efficacy of Propiomazine can be decreased when used in combination with Diethylcarbamazine.
Propantheline The therapeutic efficacy of Propantheline can be decreased when used in combination with Diethylcarbamazine.
Primidone The therapeutic efficacy of Primidone can be decreased when used in combination with Diethylcarbamazine.
Dicyclomine The therapeutic efficacy of Dicyclomine can be decreased when used in combination with Diethylcarbamazine.
Biperiden The therapeutic efficacy of Biperiden can be decreased when used in combination with Diethylcarbamazine.
Brompheniramine The therapeutic efficacy of Brompheniramine can be decreased when used in combination with Diethylcarbamazine.
Methylphenobarbital The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Diethylcarbamazine.
Quinidine The therapeutic efficacy of Quinidine can be decreased when used in combination with Diethylcarbamazine.
Amantadine The therapeutic efficacy of Amantadine can be decreased when used in combination with Diethylcarbamazine.
Maprotiline The therapeutic efficacy of Maprotiline can be decreased when used in combination with Diethylcarbamazine.
Methantheline The therapeutic efficacy of Methantheline can be decreased when used in combination with Diethylcarbamazine.
Hexafluronium The therapeutic efficacy of Hexafluronium can be decreased when used in combination with Diethylcarbamazine.
Cycrimine The therapeutic efficacy of Cycrimine can be decreased when used in combination with Diethylcarbamazine.
Desloratadine The therapeutic efficacy of Desloratadine can be decreased when used in combination with Diethylcarbamazine.
Glycopyrronium The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Diethylcarbamazine.
Tolterodine The therapeutic efficacy of Tolterodine can be decreased when used in combination with Diethylcarbamazine.
Oxybutynin The therapeutic efficacy of Oxybutynin can be decreased when used in combination with Diethylcarbamazine.
Promethazine The therapeutic efficacy of Promethazine can be decreased when used in combination with Diethylcarbamazine.
Diphenhydramine The therapeutic efficacy of Diphenhydramine can be decreased when used in combination with Diethylcarbamazine.
Pentolinium The therapeutic efficacy of Pentolinium can be decreased when used in combination with Diethylcarbamazine.
Doxepin The therapeutic efficacy of Doxepin can be decreased when used in combination with Diethylcarbamazine.
Flavoxate The therapeutic efficacy of Flavoxate can be decreased when used in combination with Diethylcarbamazine.
Desipramine The therapeutic efficacy of Desipramine can be decreased when used in combination with Diethylcarbamazine.
Orphenadrine The therapeutic efficacy of Orphenadrine can be decreased when used in combination with Diethylcarbamazine.
Phenobarbital The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Diethylcarbamazine.
Escitalopram The therapeutic efficacy of Escitalopram can be decreased when used in combination with Diethylcarbamazine.
Quetiapine The therapeutic efficacy of Quetiapine can be decreased when used in combination with Diethylcarbamazine.
Levacetylmethadol The therapeutic efficacy of Levacetylmethadol can be decreased when used in combination with Diethylcarbamazine.
Diphenidol The therapeutic efficacy of Diphenidol can be decreased when used in combination with Diethylcarbamazine.
Aripiprazole The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Diethylcarbamazine.
Chlorprothixene The therapeutic efficacy of Chlorprothixene can be decreased when used in combination with Diethylcarbamazine.

Target Protein

Polyunsaturated fatty acid 5-lipoxygenase ALOX5
Prostaglandin G/H synthase 1 PTGS1

Referensi & Sumber

Synthesis reference: Kushner, S. and Brancone, L.; US. Patent 2,467,893; April 19,1949; assigned to American Cyanamid Company. Kushner, S. and Brancone, L.; US. Patent 2,467,895; April 19, 1949; assigned to American Cyanamid Company.

Contoh Produk & Brand

Produk: 1 • International brands: 15
Produk
  • Hetrazan Tab 50mg
    Tablet • 50 mg / tab • Oral • Canada • Approved
International Brands
  • Banocide — GlaxoSmithKline
  • Banocide Forte — GlaxoSmithKline
  • Camin
  • Carbilazine
  • Caricide
  • Cypip
  • Decet — RND Labs
  • Dicarb — Inga
  • Diethizine — Pond's Chemical
  • Eofil

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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