Peringatan Keamanan

The most common reported adverse reactions (incidence ?15%) in adults were headache, nausea, malaise and fatigue, nasal signs and symptoms, diarrhea, and cough.

Lamivudine

DB00709

small molecule approved investigational

Deskripsi

A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).

Struktur Molekul 2D

Berat 229.256
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 5 to 7 hours (healthy or HBV-infected patients)
Volume Distribusi Apparent volume of distribution, IV administration = 1.3 ± 0.4 L/kg. Volume of distribution was independent of dose and did not correlate with body weight.
Klirens (Clearance) * Renal clearance = 199.7 ± 56.9 mL/min [300 mg oral dose, healthy subjects] * Renal clearance = 280.4 ± 75.2 mL/min [single IV dose, HIV-1-infected patients] * Total clearance = 398.5 ± 69.1 mL/min [HIV-1-infected patients]

Absorpsi

Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in 12 adult patients was 86% ± 16% (mean ± SD) for the 150-mg tablet and 87% ± 13% for the oral solution. The peak serum lamivudine concentration (Cmax) was 1.5 ± 0.5 mcg/mL when an oral dose of 2 mg/kg twice a day was given to HIV-1 patients. When given with food, absorption is slower, compared to the fasted state.

Metabolisme

Metabolism of lamivudine is a minor route of elimination. In man, the only known metabolite of lamivudine is the trans-sulfoxide metabolite. This biotransformation is catalyzed by sulfotransferases.

Rute Eliminasi

The majority of lamivudine is eliminated unchanged in urine by active organic cationic secretion. 5.2% ± 1.4% (mean ± SD) of the dose was excreted as the trans-sulfoxide metabolite in the urine. Lamivudine is excreted in human breast milk and into the milk of lactating rats.

Interaksi Makanan

1 Data
  • 1. Take with or without food. Food delays drug absorption, but not to a clinically significant extent.

Interaksi Obat

964 Data
Bupropion The excretion of Lamivudine can be decreased when combined with Bupropion.
Ribavirin Ribavirin may increase the hepatotoxic activities of Lamivudine.
Ganciclovir The risk or severity of cytopenia can be increased when Ganciclovir is combined with Lamivudine.
Valganciclovir The risk or severity of cytopenia can be increased when Valganciclovir is combined with Lamivudine.
Pravastatin Pravastatin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Diethylstilbestrol Diethylstilbestrol may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Novobiocin Novobiocin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Hesperetin Hesperetin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Rabeprazole Rabeprazole may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Dexamethasone Dexamethasone may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Dasatinib Dasatinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Topiroxostat Topiroxostat may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Daidzin Daidzin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Fusidic acid Fusidic acid may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Naringenin Naringenin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Eltrombopag Eltrombopag may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Safinamide Safinamide may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Vismodegib Vismodegib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Teriflunomide Teriflunomide may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Dabrafenib Dabrafenib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Cannabidiol Cannabidiol may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Palbociclib Palbociclib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Dasabuvir Dasabuvir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Dacomitinib Dacomitinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Glasdegib Glasdegib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Fostamatinib Fostamatinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Gilteritinib Gilteritinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Brigatinib Brigatinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Nabiximols Nabiximols may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Fedratinib Fedratinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Istradefylline Istradefylline may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Caffeine Caffeine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Vemurafenib Vemurafenib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Cyclosporine Cyclosporine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Pantoprazole Pantoprazole may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Nelfinavir Nelfinavir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Gefitinib Gefitinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Beclomethasone dipropionate Beclomethasone dipropionate may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Sorafenib Sorafenib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Lansoprazole Lansoprazole may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Ritonavir Ritonavir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Erlotinib Erlotinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Buprenorphine Buprenorphine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Telmisartan Telmisartan may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Saquinavir Saquinavir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Sunitinib Sunitinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Genistein Genistein may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Quercetin Quercetin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Taurocholic acid Taurocholic acid may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Nilotinib Nilotinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Elacridar Elacridar may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Dovitinib Dovitinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Simeprevir Simeprevir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Regorafenib Regorafenib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Ponatinib Ponatinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Afatinib Afatinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Cobicistat Cobicistat may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Daclatasvir Daclatasvir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Rolapitant Rolapitant may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Paritaprevir Paritaprevir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Alectinib Alectinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Venetoclax Venetoclax may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Velpatasvir Velpatasvir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Abemaciclib Abemaciclib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Voxilaprevir Voxilaprevir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Rucaparib Rucaparib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Pibrentasvir Pibrentasvir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Glecaprevir Glecaprevir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Progesterone Progesterone may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Imatinib Imatinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Estradiol Estradiol may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Vandetanib Vandetanib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Isavuconazole Isavuconazole may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Baricitinib Lamivudine may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Enasidenib Enasidenib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Estradiol acetate Estradiol acetate may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Estradiol benzoate Estradiol benzoate may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Estradiol cypionate Estradiol cypionate may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Estradiol dienanthate Estradiol dienanthate may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Estradiol valerate Estradiol valerate may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Ripretinib Ripretinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Fostemsavir Fostemsavir may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Pralsetinib Pralsetinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Clofazimine Clofazimine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Dexamethasone acetate Dexamethasone acetate may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Avanafil Avanafil may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Tepotinib Tepotinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Tivozanib Tivozanib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Osimertinib Osimertinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Belumosudil Belumosudil may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Methylene blue The serum concentration of Lamivudine can be increased when it is combined with Methylene blue.
Choline The serum concentration of Lamivudine can be increased when it is combined with Choline.
Thiamine The serum concentration of Lamivudine can be increased when it is combined with Thiamine.
Nicotine The serum concentration of Lamivudine can be increased when it is combined with Nicotine.
Ranolazine The serum concentration of Lamivudine can be increased when it is combined with Ranolazine.
Metoprolol The serum concentration of Lamivudine can be increased when it is combined with Metoprolol.
Disopyramide The serum concentration of Lamivudine can be increased when it is combined with Disopyramide.
Metformin Metformin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Aminohippuric acid The serum concentration of Lamivudine can be increased when it is combined with Aminohippuric acid.

Target Protein

Gag-Pol polyprotein gag-pol
Reverse transcriptase/RNaseH pol
DNA
Protein P P

Referensi & Sumber

Synthesis reference: Jinliang LI, Feng LV, "PROCESS FOR STEREOSELECTIVE SYNTHESIS OF LAMIVUDINE." U.S. Patent US20100249409, issued September 30, 2010.

Contoh Produk & Brand

Produk: 264 • International brands: 18
Produk
  • 3tc
    Tablet • 150 mg • Oral • Canada • Approved
  • 3tc
    Solution • 10 mg / mL • Oral • Canada • Approved
  • 3tc
    Tablet • 300 mg • Oral • Canada • Approved
  • Abacavir and Lamivudine
    Tablet, film coated • - • Oral • US • Generic • Approved
  • Abacavir and Lamivudine
    Tablet, film coated • - • Oral • US • Generic • Approved
  • Abacavir and lamivudine
    Tablet, film coated • - • Oral • US • Generic • Approved
  • Abacavir and lamivudine
    Tablet, film coated • - • Oral • US • Generic • Approved
  • Abacavir and Lamivudine
    Tablet, film coated • - • Oral • US • Generic • Approved
Menampilkan 8 dari 264 produk.
International Brands
  • Amilitrap — Dosa
  • Antiheb — Mebiphar
  • Avilam — Beximco
  • Avolam — Ranbaxy Laboratories
  • Epivir-HBV — GlaxoSmithKline
  • Flamivud — Flamingo Pharmacueticals
  • Ganvirel — Ivax
  • Hepavir — Square
  • Hepitec — GlaxoSmithKline
  • Heptavir — Hetero

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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