Porfimer sodium

DB00707

small molecule approved investigational

Deskripsi

The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10-452 hours
Volume Distribusi * 0.49 ± 0.28 L/kg [2 mg/kg dose of porfimer sodium to 4 male cancer patients]
Klirens (Clearance) * Renal cl=199.7 +/-  56.9 mL/min [Healthy subjects receiving a single 300-mg oral dose]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

77 Data
Riboflavin Riboflavin may increase the photosensitizing activities of Porfimer sodium.
Verteporfin Verteporfin may increase the photosensitizing activities of Porfimer sodium.
Methoxsalen Methoxsalen may increase the photosensitizing activities of Porfimer sodium.
Carprofen Carprofen may increase the photosensitizing activities of Porfimer sodium.
Aminolevulinic acid Aminolevulinic acid may increase the photosensitizing activities of Porfimer sodium.
Tiaprofenic acid Tiaprofenic acid may increase the photosensitizing activities of Porfimer sodium.
Protoporphyrin Protoporphyrin may increase the photosensitizing activities of Porfimer sodium.
Trioxsalen Trioxsalen may increase the photosensitizing activities of Porfimer sodium.
Acetophenone Acetophenone may increase the photosensitizing activities of Porfimer sodium.
Motexafin lutetium Motexafin lutetium may increase the photosensitizing activities of Porfimer sodium.
Motexafin gadolinium Motexafin gadolinium may increase the photosensitizing activities of Porfimer sodium.
Hexaminolevulinate Hexaminolevulinate may increase the photosensitizing activities of Porfimer sodium.
Rostaporfin Rostaporfin may increase the photosensitizing activities of Porfimer sodium.
Cyamemazine Cyamemazine may increase the photosensitizing activities of Porfimer sodium.
Temoporfin Temoporfin may increase the photosensitizing activities of Porfimer sodium.
Talaporfin Talaporfin may increase the photosensitizing activities of Porfimer sodium.
Bergapten Bergapten may increase the photosensitizing activities of Porfimer sodium.
Dihematoporphyrin ether Dihematoporphyrin ether may increase the photosensitizing activities of Porfimer sodium.
Titanium dioxide Titanium dioxide may increase the photosensitizing activities of Porfimer sodium.
Clofazimine Clofazimine may increase the photosensitizing activities of Porfimer sodium.
Vemurafenib Vemurafenib may increase the photosensitizing activities of Porfimer sodium.
Metoprolol Metoprolol may increase the photosensitizing activities of Porfimer sodium.
Methotrimeprazine Methotrimeprazine may increase the photosensitizing activities of Porfimer sodium.
Nilotinib Nilotinib may increase the photosensitizing activities of Porfimer sodium.
Methylene blue Methylene blue may increase the photosensitizing activities of Porfimer sodium.
Dabrafenib Dabrafenib may increase the photosensitizing activities of Porfimer sodium.
Febuxostat Febuxostat may increase the photosensitizing activities of Porfimer sodium.
Fosdenopterin Fosdenopterin may increase the photosensitizing activities of Porfimer sodium.
Cyproheptadine Cyproheptadine may increase the photosensitizing activities of Porfimer sodium.
Hemoporfin Hemoporfin may increase the photosensitizing activities of Porfimer sodium.
Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Porfimer sodium.
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Porfimer sodium.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Porfimer sodium.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Porfimer sodium.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Porfimer sodium.
Levofloxacin Levofloxacin may increase the photosensitizing activities of Porfimer sodium.
Padeliporfin Porfimer sodium may increase the photosensitizing activities of Padeliporfin.
Lidocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Quinisocaine.
Lamotrigine Lamotrigine may increase the photosensitizing activities of Porfimer sodium.
Oxcarbazepine Oxcarbazepine may increase the photosensitizing activities of Porfimer sodium.
Dasatinib Dasatinib may increase the photosensitizing activities of Porfimer sodium.
Ambroxol The risk or severity of methemoglobinemia can be increased when Porfimer sodium is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Porfimer sodium is combined with Etrasimod.
Celecoxib Celecoxib may increase the photosensitizing activities of Porfimer sodium.
Itraconazole Itraconazole may increase the photosensitizing activities of Porfimer sodium.
Losartan Losartan may increase the photosensitizing activities of Porfimer sodium.

Target Protein

Low-density lipoprotein receptor LDLR
High affinity immunoglobulin gamma Fc receptor I FCGR1A

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 4 • International brands: 2
Produk
  • Photofrin
    Injection, powder, for solution • 2.5 mg/1mL • Intravenous • US • Approved
  • Photofrin
    Injection, powder, for solution • 75 mg/31.8mL • Intravenous • US • Approved
  • Photofrin
    Powder, for solution • 15 mg / vial • Intravenous • Canada • Approved
  • Photofrin
    Powder, for solution • 75 mg / vial • Intravenous • Canada • Approved
International Brands
  • PhotoBarr — Axcan
  • Photofrin II

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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