Peringatan Keamanan

Major toxicity of delavirdine is rash and should be advised to promptly notify their physician should rash occur. The majority of rashes associated with delavirdine occur within 1 to 3 weeks after initiating treatment with delavirdine. The rash normally resolves in 3 to 14 days and may be treated symptomatically while therapy with delavirdine is continued. Any patient experiencing severe rash or rash accompanied by symptoms such as fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician.

Delavirdine

DB00705

small molecule approved

Deskripsi

A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.

Struktur Molekul 2D

Berat 456.561
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 5.8 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed

Metabolisme

Hepatic

Rute Eliminasi

Delavirdine is extensively converted to several inactive metabolites by cytochrome P450 3A (CYP3A). Delavirdine was excreted in the milk of lactating rats at a concentration three to five times that of rat plasma.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1067 Data
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Delavirdine.
Citalopram The serum concentration of Citalopram can be increased when it is combined with Delavirdine.
Clopidogrel The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Delavirdine resulting in a loss in efficacy.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Delavirdine.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Delavirdine.
Magnesium oxide Magnesium oxide can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sodium bicarbonate Sodium bicarbonate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum hydroxide Aluminum hydroxide can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magaldrate Magaldrate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium hydroxide Magnesium hydroxide can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium trisilicate Magnesium trisilicate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium carbonate Magnesium carbonate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bismuth subnitrate Bismuth subnitrate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium silicate Magnesium silicate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium acetoacetate Aluminium acetoacetate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Hydrotalcite Hydrotalcite can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium peroxide Magnesium peroxide can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Almasilate Almasilate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium glycinate Aluminium glycinate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aloglutamol Aloglutamol can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium silicate Calcium silicate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium phosphate Aluminium phosphate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dexrabeprazole Dexrabeprazole can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Omeprazole Omeprazole can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lansoprazole Lansoprazole can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pantoprazole Pantoprazole can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Esomeprazole Esomeprazole can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rabeprazole Rabeprazole can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dexlansoprazole Dexlansoprazole can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sodium zirconium cyclosilicate Sodium zirconium cyclosilicate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Vonoprazan Vonoprazan can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colchicine The metabolism of Colchicine can be decreased when combined with Delavirdine.
Fentanyl The metabolism of Fentanyl can be decreased when combined with Delavirdine.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Delavirdine.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Delavirdine.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Delavirdine.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Delavirdine.
Phenytoin The serum concentration of Delavirdine can be decreased when it is combined with Phenytoin.
Fosphenytoin The serum concentration of Delavirdine can be decreased when it is combined with Fosphenytoin.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Delavirdine.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Delavirdine.
Olanzapine Olanzapine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cimetidine Cimetidine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nizatidine Nizatidine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ranitidine Ranitidine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Famotidine Famotidine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methantheline Methantheline can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Promethazine Promethazine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Doxepin Doxepin can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Asenapine Asenapine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Metiamide Metiamide can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Roxatidine acetate Roxatidine acetate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lafutidine Lafutidine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lavoltidine Lavoltidine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Niperotidine Niperotidine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Epinastine Epinastine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Delavirdine.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Delavirdine.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Delavirdine.
Amprenavir The serum concentration of Delavirdine can be decreased when it is combined with Amprenavir.
Fosamprenavir The serum concentration of Delavirdine can be decreased when it is combined with Fosamprenavir.
Lacosamide The serum concentration of Lacosamide can be increased when it is combined with Delavirdine.
Terfenadine The metabolism of Terfenadine can be decreased when combined with Delavirdine.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Delavirdine.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Delavirdine.
Mirabegron The serum concentration of Delavirdine can be increased when it is combined with Mirabegron.
Pentobarbital The metabolism of Delavirdine can be increased when combined with Pentobarbital.
Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Delavirdine.
Thiopental The metabolism of Thiopental can be decreased when combined with Delavirdine.
Primidone The metabolism of Delavirdine can be increased when combined with Primidone.
Methylphenobarbital The metabolism of Methylphenobarbital can be decreased when combined with Delavirdine.
Hexobarbital The metabolism of Hexobarbital can be decreased when combined with Delavirdine.
Barbital The metabolism of Barbital can be decreased when combined with Delavirdine.
Methsuximide The metabolism of Methsuximide can be decreased when combined with Delavirdine.
Valproic acid The metabolism of Valproic acid can be decreased when combined with Delavirdine.
Nilutamide The metabolism of Nilutamide can be decreased when combined with Delavirdine.
Duloxetine The metabolism of Delavirdine can be decreased when combined with Duloxetine.
Perphenazine The metabolism of Perphenazine can be decreased when combined with Delavirdine.
Formoterol The metabolism of Formoterol can be decreased when combined with Delavirdine.
Methoxyflurane The metabolism of Methoxyflurane can be decreased when combined with Delavirdine.
Diphenhydramine The metabolism of Diphenhydramine can be decreased when combined with Delavirdine.
Moclobemide The metabolism of Moclobemide can be decreased when combined with Delavirdine.
Idarubicin The metabolism of Idarubicin can be decreased when combined with Delavirdine.
Arformoterol The metabolism of Arformoterol can be decreased when combined with Delavirdine.
Pentamidine The metabolism of Pentamidine can be decreased when combined with Delavirdine.
Benzyl alcohol The metabolism of Benzyl alcohol can be decreased when combined with Delavirdine.
Elagolix The metabolism of Elagolix can be decreased when combined with Delavirdine.
Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Delavirdine.
Metoprolol The metabolism of Delavirdine can be decreased when combined with Metoprolol.
Amphetamine The metabolism of Amphetamine can be decreased when combined with Delavirdine.
Esmolol The metabolism of Esmolol can be decreased when combined with Delavirdine.
Betaxolol The metabolism of Betaxolol can be decreased when combined with Delavirdine.
Benzatropine The metabolism of Benzatropine can be decreased when combined with Delavirdine.
Atenolol The metabolism of Atenolol can be decreased when combined with Delavirdine.
Remoxipride The metabolism of Remoxipride can be decreased when combined with Delavirdine.
Piperazine The metabolism of Piperazine can be decreased when combined with Delavirdine.
Meclizine The metabolism of Meclizine can be decreased when combined with Delavirdine.
Minaprine The metabolism of Minaprine can be decreased when combined with Delavirdine.
Alprenolol The metabolism of Alprenolol can be decreased when combined with Delavirdine.

Target Protein

Gag-Pol polyprotein gag-pol
Reverse transcriptase/RNaseH pol

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 7 • International brands: 0
Produk
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    Tablet • 100 mg/1 • Oral • US • Approved
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    Tablet • 200 mg/1 • Oral • US • Approved
  • Rescriptor
    Tablet • 200 mg/1 • Oral • US • Approved
  • Rescriptor
    Tablet • 200 mg/1 • Oral • US • Approved
  • Rescriptor
    Tablet • 100 mg/1 • Oral • US • Approved
  • Rescriptor
    Tablet • 200 mg/1 • Oral • US • Approved
  • Rescriptor
    Tablet • 100 mg • Oral • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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