Peringatan Keamanan

Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur in the case of an overdose.

Methazolamide

DB00703

small molecule approved

Deskripsi

A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Struktur Molekul 2D

Berat 236.26
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 14 hours
Volume Distribusi * 17 to 23 L
Klirens (Clearance) -

Absorpsi

Methazolamide is well absorbed from the gastrointestinal tract.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Drink plenty of fluids.
  • 2. Take with food.

Interaksi Obat

1018 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Methazolamide is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Methazolamide is combined with Levodopa.
Risperidone Methazolamide may increase the hypotensive activities of Risperidone.
Mecamylamine The risk or severity of adverse effects can be increased when Methazolamide is combined with Mecamylamine.
Pentolinium The risk or severity of adverse effects can be increased when Methazolamide is combined with Pentolinium.
Trimethaphan The risk or severity of adverse effects can be increased when Methazolamide is combined with Trimethaphan.
Hexamethonium The risk or severity of adverse effects can be increased when Methazolamide is combined with Hexamethonium.
Nicotine The risk or severity of adverse effects can be increased when Methazolamide is combined with Nicotine.
Cyclopentamine The risk or severity of adverse effects can be increased when Methazolamide is combined with Cyclopentamine.
Flecainide The excretion of Flecainide can be decreased when combined with Methazolamide.
Memantine The excretion of Memantine can be decreased when combined with Methazolamide.
Quinine The excretion of Quinine can be decreased when combined with Methazolamide.
Quinidine The excretion of Quinidine can be decreased when combined with Methazolamide.
Methotrexate The protein binding of Methotrexate can be increased when combined with Methazolamide.
Lithium hydroxide The excretion of Lithium hydroxide can be increased when combined with Methazolamide.
Lithium citrate The excretion of Lithium citrate can be increased when combined with Methazolamide.
Metformin The risk or severity of lactic acidosis can be increased when Methazolamide is combined with Metformin.
Aripiprazole Aripiprazole may increase the hypotensive activities of Methazolamide.
Aripiprazole lauroxil Aripiprazole lauroxil may increase the hypotensive activities of Methazolamide.
Nicorandil Nicorandil may increase the hypotensive activities of Methazolamide.
Dexketoprofen The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Methazolamide.
Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Methazolamide.
Methenamine The serum concentration of the active metabolites of Methenamine can be reduced when Methenamine is used in combination with Methazolamide resulting in a loss in efficacy.
Cyclosporine The risk or severity of renal failure can be increased when Methazolamide is combined with Cyclosporine.
Triethylenetetramine The excretion of Triethylenetetramine can be increased when combined with Methazolamide.
Linezolid Linezolid may increase the orthostatic hypotensive activities of Methazolamide.
Furazolidone Furazolidone may increase the orthostatic hypotensive activities of Methazolamide.
Procaine Procaine may increase the orthostatic hypotensive activities of Methazolamide.
Tranylcypromine Tranylcypromine may increase the orthostatic hypotensive activities of Methazolamide.
Phenelzine Phenelzine may increase the orthostatic hypotensive activities of Methazolamide.
Minaprine Minaprine may increase the orthostatic hypotensive activities of Methazolamide.
Selegiline Selegiline may increase the orthostatic hypotensive activities of Methazolamide.
Procarbazine Procarbazine may increase the orthostatic hypotensive activities of Methazolamide.
Moclobemide Moclobemide may increase the orthostatic hypotensive activities of Methazolamide.
Isocarboxazid Isocarboxazid may increase the orthostatic hypotensive activities of Methazolamide.
Rasagiline Rasagiline may increase the orthostatic hypotensive activities of Methazolamide.
Pargyline Pargyline may increase the orthostatic hypotensive activities of Methazolamide.
Clorgiline Clorgiline may increase the orthostatic hypotensive activities of Methazolamide.
Iproniazid Iproniazid may increase the orthostatic hypotensive activities of Methazolamide.
Nialamide Nialamide may increase the orthostatic hypotensive activities of Methazolamide.
Safinamide Safinamide may increase the orthostatic hypotensive activities of Methazolamide.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the orthostatic hypotensive activities of Methazolamide.
Methylene blue Methylene blue may increase the orthostatic hypotensive activities of Methazolamide.
Hydracarbazine Hydracarbazine may increase the orthostatic hypotensive activities of Methazolamide.
Pirlindole Pirlindole may increase the orthostatic hypotensive activities of Methazolamide.
Toloxatone Toloxatone may increase the orthostatic hypotensive activities of Methazolamide.
Benmoxin Benmoxin may increase the orthostatic hypotensive activities of Methazolamide.
Mebanazine Mebanazine may increase the orthostatic hypotensive activities of Methazolamide.
Octamoxin Octamoxin may increase the orthostatic hypotensive activities of Methazolamide.
Pheniprazine Pheniprazine may increase the orthostatic hypotensive activities of Methazolamide.
Phenoxypropazine Phenoxypropazine may increase the orthostatic hypotensive activities of Methazolamide.
Pivhydrazine Pivhydrazine may increase the orthostatic hypotensive activities of Methazolamide.
Safrazine Safrazine may increase the orthostatic hypotensive activities of Methazolamide.
Caroxazone Caroxazone may increase the orthostatic hypotensive activities of Methazolamide.
Harmaline Harmaline may increase the orthostatic hypotensive activities of Methazolamide.
Brofaromine Brofaromine may increase the orthostatic hypotensive activities of Methazolamide.
Butalbital Butalbital may increase the hypotensive activities of Methazolamide.
Pentobarbital Pentobarbital may increase the hypotensive activities of Methazolamide.
Secobarbital Secobarbital may increase the hypotensive activities of Methazolamide.
Methohexital Methohexital may increase the hypotensive activities of Methazolamide.
Primidone Primidone may increase the hypotensive activities of Methazolamide.
Methylphenobarbital Methylphenobarbital may increase the hypotensive activities of Methazolamide.
Thiamylal Thiamylal may increase the hypotensive activities of Methazolamide.
Amobarbital Amobarbital may increase the hypotensive activities of Methazolamide.
Hexobarbital Hexobarbital may increase the hypotensive activities of Methazolamide.
Barbital Barbital may increase the hypotensive activities of Methazolamide.
Barbexaclone Barbexaclone may increase the hypotensive activities of Methazolamide.
Thiopental Thiopental may increase the hypotensive activities of Methazolamide.
Phenobarbital Phenobarbital may increase the hypotensive activities of Methazolamide.
Aminosalicylic acid The risk or severity of adverse effects can be increased when Aminosalicylic acid is combined with Methazolamide.
Mesalazine The risk or severity of adverse effects can be increased when Mesalazine is combined with Methazolamide.
Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Methazolamide.
Diflunisal The risk or severity of adverse effects can be increased when Diflunisal is combined with Methazolamide.
Salicylic acid The risk or severity of adverse effects can be increased when Salicylic acid is combined with Methazolamide.
Balsalazide The risk or severity of adverse effects can be increased when Balsalazide is combined with Methazolamide.
Olsalazine The risk or severity of adverse effects can be increased when Olsalazine is combined with Methazolamide.
Bismuth subsalicylate The risk or severity of adverse effects can be increased when Bismuth subsalicylate is combined with Methazolamide.
Dersalazine The risk or severity of adverse effects can be increased when Dersalazine is combined with Methazolamide.
Phenyl aminosalicylate The risk or severity of adverse effects can be increased when Phenyl aminosalicylate is combined with Methazolamide.
Methyl salicylate The risk or severity of adverse effects can be increased when Methyl salicylate is combined with Methazolamide.
Nitroaspirin The risk or severity of adverse effects can be increased when Nitroaspirin is combined with Methazolamide.
Aloxiprin The risk or severity of adverse effects can be increased when Aloxiprin is combined with Methazolamide.
Guacetisal The risk or severity of adverse effects can be increased when Guacetisal is combined with Methazolamide.
Carbaspirin calcium The risk or severity of adverse effects can be increased when Carbaspirin calcium is combined with Methazolamide.
Choline salicylate The risk or severity of adverse effects can be increased when Choline salicylate is combined with Methazolamide.
Thiosalicylic acid The risk or severity of adverse effects can be increased when Thiosalicylic acid is combined with Methazolamide.
Phenytoin The risk or severity of osteomalacia can be increased when Methazolamide is combined with Phenytoin.
Fosphenytoin The risk or severity of osteomalacia can be increased when Methazolamide is combined with Fosphenytoin.
Ethoxzolamide The risk or severity of adverse effects can be increased when Ethoxzolamide is combined with Methazolamide.
Acetazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Acetazolamide.
Zonisamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Zonisamide.
Diclofenamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Diclofenamide.
Phentermine Methazolamide may decrease the excretion rate of Phentermine which could result in a higher serum level.
Pseudoephedrine Methazolamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.
Benzphetamine Methazolamide may decrease the excretion rate of Benzphetamine which could result in a higher serum level.
Diethylpropion Methazolamide may decrease the excretion rate of Diethylpropion which could result in a higher serum level.
Lisdexamfetamine Methazolamide may decrease the excretion rate of Lisdexamfetamine which could result in a higher serum level.
Mephentermine Methazolamide may decrease the excretion rate of Mephentermine which could result in a higher serum level.
MMDA Methazolamide may decrease the excretion rate of MMDA which could result in a higher serum level.
Midomafetamine Methazolamide may decrease the excretion rate of Midomafetamine which could result in a higher serum level.

Target Protein

Carbonic anhydrase 1 CA1
Carbonic anhydrase 4 CA4
Carbonic anhydrase 2 CA2
Carbonic anhydrase 7 CA7
Carbonic anhydrase 3 CA3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 10533697
    Iyer GR, Bellantone RA, Taft DR: In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics. J Pharmacokinet Biopharm. 1999 Feb;27(1):45-66.
  • PMID: 9109770
    Shirato S, Kagaya F, Suzuki Y, Joukou S: Stevens-Johnson syndrome induced by methazolamide treatment. Arch Ophthalmol. 1997 Apr;115(4):550-3.
  • PMID: 12602587
    Skorobohach BJ, Ward DA, Hendrix DV: Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs. Am J Vet Res. 2003 Feb;64(2):183-7.

Contoh Produk & Brand

Produk: 47 • International brands: 1
Produk
  • Methazolamide
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Methazolamide
    Tablet • 25 mg/1 • Oral • US • Generic • Approved
  • Methazolamide
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Methazolamide
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Methazolamide
    Tablet • 25 mg/1 • Oral • US • Generic • Approved
  • Methazolamide
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Methazolamide
    Tablet • 25 mg/1 • Oral • US • Generic • Approved
  • Methazolamide
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 47 produk.
International Brands
  • Naptazane — Fera Pharmaceuticals

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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