Amprenavir

DB00701

small molecule approved investigational

Deskripsi

Amprenavir is a protease inhibitor used to treat HIV infection.

Struktur Molekul 2D

Berat 505.627
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 7.1-10.6 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed after oral administration in HIV-1-infected patients with a time to peak concentration (Tmax) typically between 1 and 2 hours after a single oral dose. The absolute oral bioavailability of amprenavir in humans has not been established.

Metabolisme

Hepatic. Amprenavir is metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system. The 2 major metabolites result from oxidation of the tetrahydrofuran and aniline moieties. Glucuronide conjugates of oxidized metabolites have been identified as minor metabolites in urine and feces.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

3 Data
  • 1. Avoid alcohol. Drug impairs alcohol metabolism.
  • 2. Avoid fatty foods.
  • 3. Take with or without food.

Interaksi Obat

1151 Data
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Amprenavir.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Amprenavir.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Amprenavir.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Amprenavir.
Clarithromycin The serum concentration of Clarithromycin can be increased when it is combined with Amprenavir.
Colchicine The metabolism of Colchicine can be decreased when combined with Amprenavir.
Cyclophosphamide The serum concentration of the active metabolites of Cyclophosphamide can be increased when Cyclophosphamide is used in combination with Amprenavir.
Fentanyl The metabolism of Fentanyl can be decreased when combined with Amprenavir.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Amprenavir.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Amprenavir.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Amprenavir.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Amprenavir.
Methadone The serum concentration of the active metabolites of Amprenavir can be reduced when Amprenavir is used in combination with Methadone resulting in a loss in efficacy.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Amprenavir.
Olanzapine Olanzapine can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nizatidine Nizatidine can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ranitidine Ranitidine can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Famotidine Famotidine can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methantheline Methantheline can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Metiamide Metiamide can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Roxatidine acetate Roxatidine acetate can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lafutidine Lafutidine can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lavoltidine Lavoltidine can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Niperotidine Niperotidine can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Voriconazole The serum concentration of Voriconazole can be increased when it is combined with Amprenavir.
Rifabutin The serum concentration of 25-O-Desacetylrifabutin, an active metabolite of Rifabutin, can be increased when used in combination with Amprenavir.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Amprenavir.
Perampanel The metabolism of Perampanel can be increased when combined with Amprenavir.
Efavirenz The serum concentration of the active metabolites of Amprenavir can be reduced when Amprenavir is used in combination with Efavirenz resulting in a loss in efficacy.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Amprenavir.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Amprenavir.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Amprenavir.
Delavirdine The serum concentration of Delavirdine can be decreased when it is combined with Amprenavir.
Paroxetine The serum concentration of Paroxetine can be decreased when it is combined with Amprenavir.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Amprenavir.
Ketoconazole The serum concentration of Ketoconazole can be increased when it is combined with Amprenavir.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Amprenavir.
Itraconazole The serum concentration of Itraconazole can be increased when it is combined with Amprenavir.
Propafenone The serum concentration of Propafenone can be increased when it is combined with Amprenavir.
Flecainide The serum concentration of Flecainide can be increased when it is combined with Amprenavir.
Mirabegron The serum concentration of Amprenavir can be increased when it is combined with Mirabegron.
Etravirine The serum concentration of the active metabolites of Amprenavir can be increased when Amprenavir is used in combination with Etravirine.
Lopinavir The serum concentration of Lopinavir can be decreased when it is combined with Amprenavir.
Raltegravir The serum concentration of Raltegravir can be decreased when it is combined with Amprenavir.
Telaprevir The serum concentration of Telaprevir can be decreased when it is combined with Amprenavir.
Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Amprenavir.
Garlic Garlic can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Erlotinib The metabolism of Erlotinib can be decreased when combined with Amprenavir.
Cimetidine Cimetidine can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Desipramine The metabolism of Amprenavir can be decreased when combined with Desipramine.
Dosulepin The metabolism of Amprenavir can be decreased when combined with Dosulepin.
Sulfaphenazole The metabolism of Amprenavir can be decreased when combined with Sulfaphenazole.
Tranylcypromine The metabolism of Amprenavir can be decreased when combined with Tranylcypromine.
Metoprolol The metabolism of Amprenavir can be decreased when combined with Metoprolol.
Duloxetine The metabolism of Amprenavir can be decreased when combined with Duloxetine.
Tegaserod The metabolism of Amprenavir can be decreased when combined with Tegaserod.
Phenylbutyric acid The metabolism of Amprenavir can be decreased when combined with Phenylbutyric acid.
Ritanserin The metabolism of Amprenavir can be decreased when combined with Ritanserin.
Rhein The metabolism of Amprenavir can be decreased when combined with Rhein.
Berotralstat The metabolism of Amprenavir can be decreased when combined with Berotralstat.
Thioridazine The metabolism of Amprenavir can be decreased when combined with Thioridazine.
Methotrimeprazine The metabolism of Amprenavir can be decreased when combined with Methotrimeprazine.
Glycerol phenylbutyrate The metabolism of Amprenavir can be decreased when combined with Glycerol phenylbutyrate.
Nabilone The metabolism of Nabilone can be decreased when combined with Amprenavir.
Iproniazid The metabolism of Amprenavir can be decreased when combined with Iproniazid.
Troglitazone The metabolism of Amprenavir can be decreased when combined with Troglitazone.
Valproic acid The metabolism of Amprenavir can be decreased when combined with Valproic acid.
Fluconazole The metabolism of Amprenavir can be decreased when combined with Fluconazole.
Floxuridine The metabolism of Amprenavir can be decreased when combined with Floxuridine.
Miconazole The metabolism of Amprenavir can be decreased when combined with Miconazole.
Pitolisant The serum concentration of Amprenavir can be decreased when it is combined with Pitolisant.
Bupropion The serum concentration of Bupropion can be increased when it is combined with Amprenavir.
Liothyronine The excretion of Liothyronine can be decreased when combined with Amprenavir.
Penicillamine The excretion of Penicillamine can be decreased when combined with Amprenavir.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Amprenavir.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Amprenavir.
Ouabain The excretion of Ouabain can be decreased when combined with Amprenavir.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Amprenavir.
Atrasentan The excretion of Atrasentan can be decreased when combined with Amprenavir.
Gimatecan The excretion of Gimatecan can be decreased when combined with Amprenavir.
Temocapril The excretion of Temocapril can be decreased when combined with Amprenavir.
Cholecystokinin The excretion of Cholecystokinin can be decreased when combined with Amprenavir.
Gadoxetic acid The excretion of Gadoxetic acid can be decreased when combined with Amprenavir.
Technetium Tc-99m mebrofenin The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Amprenavir.
Fimasartan The excretion of Fimasartan can be decreased when combined with Amprenavir.
Caspofungin The excretion of Caspofungin can be decreased when combined with Amprenavir.
Enalapril The excretion of Enalapril can be decreased when combined with Amprenavir.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Amprenavir.
Glecaprevir The excretion of Glecaprevir can be decreased when combined with Amprenavir.
Pravastatin The excretion of Pravastatin can be decreased when combined with Amprenavir.
Digoxin The excretion of Digoxin can be decreased when combined with Amprenavir.
Raloxifene The excretion of Raloxifene can be decreased when combined with Amprenavir.
Sumatriptan The excretion of Sumatriptan can be decreased when combined with Amprenavir.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Amprenavir.
Ezetimibe The excretion of Ezetimibe can be decreased when combined with Amprenavir.
Elagolix The excretion of Elagolix can be decreased when combined with Amprenavir.
Belantamab mafodotin The excretion of Belantamab mafodotin can be decreased when combined with Amprenavir.
Levosalbutamol The excretion of Levosalbutamol can be decreased when combined with Amprenavir.
Segesterone acetate The metabolism of Segesterone acetate can be increased when combined with Amprenavir.
Metreleptin The metabolism of Amprenavir can be increased when combined with Metreleptin.

Target Protein

Pol polyprotein pol
Gag-Pol polyprotein gag-pol

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 9 • International brands: 2
Produk
  • Agenerase
    Capsule • 50 mg/1 • Oral • US • Approved
  • Agenerase
    Solution • 15 mg/1mL • Oral • US • Approved
  • Agenerase
    Capsule • 50 mg • Oral • Canada • Approved
  • Agenerase
    Capsule • 150 mg • Oral • Canada • Approved
  • Agenerase
    Liquid • 15 mg / mL • Oral • Canada • Approved
  • Agenerase
    Capsule • 50 mg • Oral • EU
  • Agenerase
    Capsule • 150 mg • Oral • EU
  • Agenerase
    Capsule • 150 mg • Oral • EU
Menampilkan 8 dari 9 produk.
International Brands
  • Agemerase — GlaxoSmithKline
  • Prozei — Kissei Pharmaceuticals Co., Ltd.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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