The most likely symptoms of human overdosage would be anticipated to be hypotension or hyperkalemia. However, no cases of human overdosage with eplerenone have been reported.
Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Eplerenone is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Eplerenone is combined with Levodopa. |
| Risperidone | Eplerenone may increase the hypotensive activities of Risperidone. |
| Alfuzosin | Alfuzosin may increase the hypotensive activities of Eplerenone. |
| Amifostine | Eplerenone may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Eplerenone. |
| Valsartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Valsartan. |
| Olmesartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Olmesartan. |
| Losartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Losartan. |
| Eprosartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Eprosartan. |
| Telmisartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Telmisartan. |
| Irbesartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Irbesartan. |
| Forasartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Forasartan. |
| Saprisartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Saprisartan. |
| Tasosartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Tasosartan. |
| Saralasin | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Saralasin. |
| Azilsartan medoxomil | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Azilsartan medoxomil. |
| Fimasartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Fimasartan. |
| Candesartan | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Candesartan. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Eplerenone. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Eplerenone. |
| Obinutuzumab | Eplerenone may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Eplerenone. |
| Rituximab | Eplerenone may increase the hypotensive activities of Rituximab. |
| Midodrine | Midodrine may decrease the antihypertensive activities of Eplerenone. |
| Isoetharine | Isoetharine may decrease the antihypertensive activities of Eplerenone. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Eplerenone. |
| Protriptyline | Protriptyline may decrease the antihypertensive activities of Eplerenone. |
| Phenylephrine | Phenylephrine may decrease the antihypertensive activities of Eplerenone. |
| Phenylpropanolamine | Phenylpropanolamine may decrease the antihypertensive activities of Eplerenone. |
| Droperidol | Droperidol may decrease the antihypertensive activities of Eplerenone. |
| Amoxapine | Amoxapine may decrease the antihypertensive activities of Eplerenone. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Eplerenone. |
| Atropine | Atropine may decrease the antihypertensive activities of Eplerenone. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Eplerenone. |
| Nicergoline | Nicergoline may decrease the antihypertensive activities of Eplerenone. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Eplerenone. |
| Propiomazine | Propiomazine may decrease the antihypertensive activities of Eplerenone. |
| Orciprenaline | Orciprenaline may decrease the antihypertensive activities of Eplerenone. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Eplerenone. |
| Trifluoperazine | Trifluoperazine may decrease the antihypertensive activities of Eplerenone. |
| Pseudoephedrine | Pseudoephedrine may decrease the antihypertensive activities of Eplerenone. |
| Ritodrine | Ritodrine may decrease the antihypertensive activities of Eplerenone. |
| Flupentixol | Flupentixol may decrease the antihypertensive activities of Eplerenone. |
| Bitolterol | Bitolterol may decrease the antihypertensive activities of Eplerenone. |
| Diethylpropion | Diethylpropion may decrease the antihypertensive activities of Eplerenone. |
| Naratriptan | Naratriptan may decrease the antihypertensive activities of Eplerenone. |
| Formoterol | Formoterol may decrease the antihypertensive activities of Eplerenone. |
| Frovatriptan | Frovatriptan may decrease the antihypertensive activities of Eplerenone. |
| Isoprenaline | Isoprenaline may decrease the antihypertensive activities of Eplerenone. |
| Arbutamine | Arbutamine may decrease the antihypertensive activities of Eplerenone. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the antihypertensive activities of Eplerenone. |
| Fenoterol | Fenoterol may decrease the antihypertensive activities of Eplerenone. |
| Pirbuterol | Pirbuterol may decrease the antihypertensive activities of Eplerenone. |
| Ephedra sinica root | Ephedra sinica root may decrease the antihypertensive activities of Eplerenone. |
| Mephentermine | Mephentermine may decrease the antihypertensive activities of Eplerenone. |
| Procaterol | Procaterol may decrease the antihypertensive activities of Eplerenone. |
| Methotrimeprazine | Methotrimeprazine may decrease the antihypertensive activities of Eplerenone. |
| Clenbuterol | Clenbuterol may decrease the antihypertensive activities of Eplerenone. |
| Bambuterol | Bambuterol may decrease the antihypertensive activities of Eplerenone. |
| MMDA | MMDA may decrease the antihypertensive activities of Eplerenone. |
| Midomafetamine | Midomafetamine may decrease the antihypertensive activities of Eplerenone. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Eplerenone. |
| 4-Methoxyamphetamine | 4-Methoxyamphetamine may decrease the antihypertensive activities of Eplerenone. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Eplerenone. |
| Tenamfetamine | Tenamfetamine may decrease the antihypertensive activities of Eplerenone. |
| Chlorphentermine | Chlorphentermine may decrease the antihypertensive activities of Eplerenone. |
| Dextroamphetamine | Dextroamphetamine may decrease the antihypertensive activities of Eplerenone. |
| Phendimetrazine | Phendimetrazine may decrease the antihypertensive activities of Eplerenone. |
| Periciazine | Periciazine may decrease the antihypertensive activities of Eplerenone. |
| Acepromazine | Acepromazine may decrease the antihypertensive activities of Eplerenone. |
| Thioproperazine | Thioproperazine may decrease the antihypertensive activities of Eplerenone. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Eplerenone. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Eplerenone. |
| Amineptine | Amineptine may decrease the antihypertensive activities of Eplerenone. |
| Amibegron | Amibegron may decrease the antihypertensive activities of Eplerenone. |
| Naluzotan | Naluzotan may decrease the antihypertensive activities of Eplerenone. |
| Pizotifen | Pizotifen may decrease the antihypertensive activities of Eplerenone. |
| Solabegron | Solabegron may decrease the antihypertensive activities of Eplerenone. |
| Esmirtazapine | Esmirtazapine may decrease the antihypertensive activities of Eplerenone. |
| Nitrous oxide | Nitrous oxide may decrease the antihypertensive activities of Eplerenone. |
| Xylometazoline | Xylometazoline may decrease the antihypertensive activities of Eplerenone. |
| Isometheptene | Isometheptene may decrease the antihypertensive activities of Eplerenone. |
| Naphazoline | Naphazoline may decrease the antihypertensive activities of Eplerenone. |
| Tetryzoline | Tetryzoline may decrease the antihypertensive activities of Eplerenone. |
| Cinitapride | Cinitapride may decrease the antihypertensive activities of Eplerenone. |
| Tyramine | Tyramine may decrease the antihypertensive activities of Eplerenone. |
| Adrafinil | Adrafinil may decrease the antihypertensive activities of Eplerenone. |
| Ifenprodil | Ifenprodil may decrease the antihypertensive activities of Eplerenone. |
| Hexoprenaline | Hexoprenaline may decrease the antihypertensive activities of Eplerenone. |
| Etilefrine | Etilefrine may decrease the antihypertensive activities of Eplerenone. |
| Butriptyline | Butriptyline may decrease the antihypertensive activities of Eplerenone. |
| Olodaterol | Olodaterol may decrease the antihypertensive activities of Eplerenone. |
| Dosulepin | Dosulepin may decrease the antihypertensive activities of Eplerenone. |
| Cirazoline | Cirazoline may decrease the antihypertensive activities of Eplerenone. |
| Synephrine | Synephrine may decrease the antihypertensive activities of Eplerenone. |
| Oxaprotiline | Oxaprotiline may decrease the antihypertensive activities of Eplerenone. |
| Iofetamine I-123 | Iofetamine I-123 may decrease the antihypertensive activities of Eplerenone. |
| Amitraz | Amitraz may decrease the antihypertensive activities of Eplerenone. |
| Medetomidine | Medetomidine may decrease the antihypertensive activities of Eplerenone. |