Peringatan Keamanan

Signs of overexposure include irritation, nausea, vomiting, headache, diarrhea, thirst, coldness of skin, pruritus, weak pulse, numbness, tingling of extremities, and confusion.

Ergotamine

DB00696

small molecule approved

Deskripsi

A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.

Struktur Molekul 2D

Berat 581.6615
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

The bioavailability of sublingually administered ergotamine has not been determined.

Metabolisme

Hepatic. Ergotamine is metabolized by the liver by largely undefined pathways, and 90% of the metabolites are excreted in the bile.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1746 Data
Armodafinil The metabolism of Ergotamine can be increased when combined with Armodafinil.
Carboprost tromethamine Carboprost tromethamine may increase the uterotonic activities of Ergotamine.
Valsartan Ergotamine may decrease the antihypertensive activities of Valsartan.
Ramipril Ergotamine may decrease the antihypertensive activities of Ramipril.
Remikiren Ergotamine may decrease the antihypertensive activities of Remikiren.
Torasemide Ergotamine may decrease the antihypertensive activities of Torasemide.
Guanadrel Ergotamine may decrease the antihypertensive activities of Guanadrel.
Olmesartan Ergotamine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Ergotamine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Ergotamine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Ergotamine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Ergotamine may decrease the antihypertensive activities of Treprostinil.
Bendroflumethiazide Ergotamine may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Ergotamine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Ergotamine may decrease the antihypertensive activities of Trandolapril.
Metolazone Ergotamine may decrease the antihypertensive activities of Metolazone.
Benazepril Ergotamine may decrease the antihypertensive activities of Benazepril.
Cyclothiazide Ergotamine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Ergotamine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Ergotamine may decrease the antihypertensive activities of Mecamylamine.
Moexipril Ergotamine may decrease the antihypertensive activities of Moexipril.
Lisinopril Ergotamine may decrease the antihypertensive activities of Lisinopril.
Hydroflumethiazide Ergotamine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Ergotamine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Ergotamine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Ergotamine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Ergotamine may decrease the antihypertensive activities of Fenoldopam.
Eprosartan Ergotamine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Ergotamine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Ergotamine may decrease the antihypertensive activities of Quinapril.
Telmisartan Ergotamine may decrease the antihypertensive activities of Telmisartan.
Hydrochlorothiazide Ergotamine may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Ergotamine may decrease the antihypertensive activities of Trichlormethiazide.
Deserpidine Ergotamine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Ergotamine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Ergotamine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Ergotamine may decrease the antihypertensive activities of Diazoxide.
Bretylium Ergotamine may decrease the antihypertensive activities of Bretylium.
Captopril Ergotamine may decrease the antihypertensive activities of Captopril.
Epoprostenol Ergotamine may decrease the antihypertensive activities of Epoprostenol.
Polythiazide Ergotamine may decrease the antihypertensive activities of Polythiazide.
Cilazapril Ergotamine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Ergotamine may decrease the antihypertensive activities of Saprisartan.
Spirapril Ergotamine may decrease the antihypertensive activities of Spirapril.
Tienilic acid Ergotamine may decrease the antihypertensive activities of Tienilic acid.
Diethylnorspermine Ergotamine may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Ergotamine may decrease the antihypertensive activities of Temocapril.
Nicorandil Ergotamine may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Ergotamine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Ergotamine may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Ergotamine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Ergotamine may decrease the antihypertensive activities of Imidapril.
BQ-123 Ergotamine may decrease the antihypertensive activities of BQ-123.
Cicletanine Ergotamine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Ergotamine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Ergotamine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Ergotamine may decrease the antihypertensive activities of Guanoxan.
Delapril Ergotamine may decrease the antihypertensive activities of Delapril.
Vincamine Ergotamine may decrease the antihypertensive activities of Vincamine.
Linsidomine Ergotamine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Ergotamine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Ergotamine may decrease the antihypertensive activities of Tolonidine.
Endralazine Ergotamine may decrease the antihypertensive activities of Endralazine.
Cadralazine Ergotamine may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Ergotamine may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Ergotamine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Ergotamine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Ergotamine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Ergotamine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Ergotamine may decrease the antihypertensive activities of Muzolimine.
Xipamide Ergotamine may decrease the antihypertensive activities of Xipamide.
Candesartan Ergotamine may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Ergotamine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Ergotamine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Ergotamine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Ergotamine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Ergotamine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Ergotamine may decrease the antihypertensive activities of Quinaprilat.
Furosemide Ergotamine may decrease the antihypertensive activities of Furosemide.
Enalapril Ergotamine may decrease the antihypertensive activities of Enalapril.
Guanethidine Ergotamine may decrease the antihypertensive activities of Guanethidine.
Debrisoquine Ergotamine may decrease the antihypertensive activities of Debrisoquine.
Buthiazide Ergotamine may decrease the antihypertensive activities of Buthiazide.
Azilsartan medoxomil Ergotamine may decrease the antihypertensive activities of Azilsartan medoxomil.
Buprenorphine Ergotamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ergotamine.
Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Ergotamine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Ergotamine.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ergotamine.
Magnesium sulfate The therapeutic efficacy of Ergotamine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Ergotamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Ergotamine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Ergotamine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Ergotamine.
Orphenadrine Ergotamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Ergotamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Ergotamine.
Pramipexole Ergotamine may increase the sedative activities of Pramipexole.
Ropinirole Ergotamine may increase the sedative activities of Ropinirole.
Rotigotine Ergotamine may increase the sedative activities of Rotigotine.

Target Protein

5-hydroxytryptamine receptor 1D HTR1D
5-hydroxytryptamine receptor 1B HTR1B
5-hydroxytryptamine receptor 2A HTR2A
Alpha-1A adrenergic receptor ADRA1A
Alpha-1B adrenergic receptor ADRA1B
Alpha-1D adrenergic receptor ADRA1D
D(2) dopamine receptor DRD2
Alpha-2A adrenergic receptor ADRA2A
D(1) dopamine receptor DRD1
5-hydroxytryptamine receptor 1A HTR1A
5-hydroxytryptamine receptor 1F HTR1F
5-hydroxytryptamine receptor 2C HTR2C
5-hydroxytryptamine receptor 2B HTR2B
Alpha-2C adrenergic receptor ADRA2C

Referensi & Sumber

Artikel (PubMed)
  • PMID: 10611116
    Tfelt-Hansen P, Saxena PR, Dahlof C, Pascual J, Lainez M, Henry P, Diener H, Schoenen J, Ferrari MD, Goadsby PJ: Ergotamine in the acute treatment of migraine: a review and European consensus. Brain. 2000 Jan;123 ( Pt 1):9-18.
  • PMID: 17133714
    Schardl CL, Panaccione DG, Tudzynski P: Ergot alkaloids--biology and molecular biology. Alkaloids Chem Biol. 2006;63:45-86.

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Menampilkan 8 dari 28 produk.
International Brands
  • Anervan — Recip
  • Antimigraine — Ta Fong
  • Enxak — Cazi
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  • Ergo-Kranit — Krewel Meuselbach
  • Gynaemine — Sriprasit Dispensary
  • Gynergen
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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