Fluorescein

DB00693

small molecule approved

Deskripsi

A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)

Struktur Molekul 2D

Berat 332.3063
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi * 0.5 L/kg
Klirens (Clearance) * renal cl=1.75 mL/min/kg [After IV administration] * hepatic cl=1.50 mL/min/kg [After IV administration]

Absorpsi

Rapidly distributed

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Fluorescein and its metabolites are mainly eliminated via renal excretion.

Interaksi Obat

223 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Troglitazone Troglitazone may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Erythromycin Erythromycin may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Reserpine Reserpine may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Progesterone Progesterone may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Chlorpromazine Chlorpromazine may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Cimetidine Cimetidine may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Bosentan Bosentan may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Tamoxifen Tamoxifen may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Quinidine Quinidine may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Tipranavir Tipranavir may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Ethinylestradiol Ethinylestradiol may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Glyburide Glyburide may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Ketoconazole Ketoconazole may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Ursodeoxycholic acid Ursodeoxycholic acid may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Cholic Acid Cholic Acid may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Fusidic acid Fusidic acid may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Simeprevir Simeprevir may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Lenvatinib Lenvatinib may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Valinomycin Valinomycin may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Olmesartan Olmesartan may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Pralsetinib Pralsetinib may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Aspartame The excretion of Fluorescein can be decreased when combined with Aspartame.
Pravastatin The excretion of Fluorescein can be decreased when combined with Pravastatin.
Pantoprazole The excretion of Fluorescein can be decreased when combined with Pantoprazole.
Cefotiam The excretion of Fluorescein can be decreased when combined with Cefotiam.
Liothyronine The excretion of Fluorescein can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Fluorescein can be decreased when combined with Conjugated estrogens.
Valproic acid The excretion of Fluorescein can be decreased when combined with Valproic acid.
Indomethacin The excretion of Fluorescein can be decreased when combined with Indomethacin.
Aminohippuric acid The excretion of Fluorescein can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Fluorescein can be decreased when combined with Lansoprazole.
Cefalotin The excretion of Fluorescein can be decreased when combined with Cefalotin.
Tenoxicam The excretion of Fluorescein can be decreased when combined with Tenoxicam.
Cefotaxime The excretion of Fluorescein can be decreased when combined with Cefotaxime.
Zidovudine The excretion of Fluorescein can be decreased when combined with Zidovudine.
Guanidine The excretion of Fluorescein can be decreased when combined with Guanidine.
Piroxicam The excretion of Fluorescein can be decreased when combined with Piroxicam.
Methotrexate The excretion of Fluorescein can be decreased when combined with Methotrexate.
Cephalexin The excretion of Fluorescein can be decreased when combined with Cephalexin.
Enalapril The excretion of Fluorescein can be decreased when combined with Enalapril.
Diclofenac The excretion of Fluorescein can be decreased when combined with Diclofenac.
Oxytetracycline The excretion of Fluorescein can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Fluorescein can be decreased when combined with Leucovorin.
Furosemide The excretion of Fluorescein can be decreased when combined with Furosemide.
Esomeprazole The excretion of Fluorescein can be decreased when combined with Esomeprazole.
Tetracycline The excretion of Fluorescein can be decreased when combined with Tetracycline.
Acyclovir The excretion of Fluorescein can be decreased when combined with Acyclovir.
Phenylbutazone The excretion of Fluorescein can be decreased when combined with Phenylbutazone.
Cefaclor The excretion of Fluorescein can be decreased when combined with Cefaclor.
Bumetanide The excretion of Fluorescein can be decreased when combined with Bumetanide.
Dinoprostone The excretion of Fluorescein can be decreased when combined with Dinoprostone.
Famotidine The excretion of Fluorescein can be decreased when combined with Famotidine.
Salicylic acid The excretion of Fluorescein can be decreased when combined with Salicylic acid.
Acetylsalicylic acid The excretion of Fluorescein can be decreased when combined with Acetylsalicylic acid.
Ganciclovir The excretion of Fluorescein can be decreased when combined with Ganciclovir.
Ketoprofen The excretion of Fluorescein can be decreased when combined with Ketoprofen.
Minocycline The excretion of Fluorescein can be decreased when combined with Minocycline.
Probenecid The excretion of Fluorescein can be decreased when combined with Probenecid.
Mercaptopurine The excretion of Fluorescein can be decreased when combined with Mercaptopurine.
Ibuprofen The excretion of Fluorescein can be decreased when combined with Ibuprofen.
Novobiocin The excretion of Fluorescein can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Fluorescein can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Fluorescein can be decreased when combined with Melatonin.
Ouabain The excretion of Fluorescein can be decreased when combined with Ouabain.
Rosuvastatin The excretion of Fluorescein can be decreased when combined with Rosuvastatin.
Cefadroxil The excretion of Fluorescein can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Fluorescein can be decreased when combined with Ceftriaxone.
Cefamandole The excretion of Fluorescein can be decreased when combined with Cefamandole.
Cefazolin The excretion of Fluorescein can be decreased when combined with Cefazolin.
Cefoperazone The excretion of Fluorescein can be decreased when combined with Cefoperazone.
Ceftizoxime The excretion of Fluorescein can be decreased when combined with Ceftizoxime.
Cefacetrile The excretion of Fluorescein can be decreased when combined with Cefacetrile.
Ceftibuten The excretion of Fluorescein can be decreased when combined with Ceftibuten.
Liotrix The excretion of Fluorescein can be decreased when combined with Liotrix.
Cilastatin The excretion of Fluorescein can be decreased when combined with Cilastatin.
Tazobactam The excretion of Fluorescein can be decreased when combined with Tazobactam.
trans-2-hydroxycinnamic acid The excretion of Fluorescein can be decreased when combined with trans-2-hydroxycinnamic acid.
Topiroxostat The excretion of Fluorescein can be decreased when combined with Topiroxostat.
Glutaric Acid The excretion of Fluorescein can be decreased when combined with Glutaric Acid.
Benzoic acid The excretion of Fluorescein can be decreased when combined with Benzoic acid.
Caprylic acid The excretion of Fluorescein can be decreased when combined with Caprylic acid.
Ataluren The excretion of Fluorescein can be decreased when combined with Ataluren.
Teriflunomide The excretion of Fluorescein can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Fluorescein can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Fluorescein can be decreased when combined with Dolutegravir.
Cefaloridine The excretion of Fluorescein can be decreased when combined with Cefaloridine.
Cabotegravir The excretion of Fluorescein can be decreased when combined with Cabotegravir.
Apalutamide The excretion of Fluorescein can be decreased when combined with Apalutamide.
Pradigastat The excretion of Fluorescein can be decreased when combined with Pradigastat.
Enasidenib The excretion of Fluorescein can be decreased when combined with Enasidenib.
Gemfibrozil The excretion of Fluorescein can be decreased when combined with Gemfibrozil.
Dronedarone The excretion of Fluorescein can be decreased when combined with Dronedarone.
Favipiravir The excretion of Fluorescein can be decreased when combined with Favipiravir.
Tafamidis The excretion of Fluorescein can be decreased when combined with Tafamidis.
Linezolid The excretion of Fluorescein can be decreased when combined with Linezolid.
Phenobarbital Phenobarbital may increase the excretion rate of Fluorescein which could result in a lower serum level and potentially a reduction in efficacy.
Dexamethasone Dexamethasone may increase the excretion rate of Fluorescein which could result in a lower serum level and potentially a reduction in efficacy.
Deoxycholic acid Deoxycholic acid may increase the excretion rate of Fluorescein which could result in a lower serum level and potentially a reduction in efficacy.

Target Protein

Organic anion transporter 3 SLC22A8
Immunoglobulin kappa variable 2-30 IGKV2-30
DNA

Referensi & Sumber

Synthesis reference: Richard T. Dean, Conrad P. Dorn, Jr., Tsung-Ying Shen, "Fluorescein esters and ethers and the preparation thereof." U.S. Patent US4304720, issued January, 1972.
Artikel (PubMed)
  • PMID: 12450204
    Noga EJ, Udomkusonsri P: Fluorescein: a rapid, sensitive, nonlethal method for detecting skin ulceration in fish. Vet Pathol. 2002 Nov;39(6):726-31.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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