The oral LD50 of phentolamine mesylate, a salt of phentolamine, was 1250 mg/kg in rats and 1000-1100 mg/kg in mice.L48410, L48420
No deaths due to acute poisoning with phentolamine have been reported. Overdosage with phentolamine is characterized chiefly by cardiovascular disturbances, such as arrhythmias, tachycardia, hypotension, and possibly shock. Other possible signs and symptoms include excitation, headache, sweating, pupillary contraction, visual disturbances, nausea, vomiting, diarrhea, and hypoglycemia. There is no specific antidote: Treatment consists of appropriate monitoring and supportive care. A plasma expander and norepinephrine may be administered to manage decreased blood pressure.L48415, L48420
Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.A261781, A261786 It has several therapeutic uses, including the treatment of hypertensive episodes, prevention of norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and treatment of pharmacologically-induced mydriasis.L48420, L48415, L48390 Phentolamine is administered intravenously, intramuscularly, submucosally, and topically.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Phentolamine is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Phentolamine is combined with Levodopa. |
| Risperidone | Phentolamine may increase the hypotensive activities of Risperidone. |
| Amifostine | Phentolamine may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Phentolamine. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Phentolamine. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Phentolamine. |
| Obinutuzumab | Phentolamine may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Phentolamine. |
| Rituximab | Phentolamine may increase the hypotensive activities of Rituximab. |
| Yohimbine | Yohimbine may decrease the antihypertensive activities of Phentolamine. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Phentolamine. |
| Siponimod | Siponimod may decrease the antihypertensive activities of Phentolamine. |
| Valsartan | Phentolamine may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Phentolamine may decrease the antihypertensive activities of Ramipril. |
| Olmesartan | Phentolamine may decrease the antihypertensive activities of Olmesartan. |
| Minoxidil | Phentolamine may decrease the antihypertensive activities of Minoxidil. |
| Trandolapril | Phentolamine may decrease the antihypertensive activities of Trandolapril. |
| Benazepril | Phentolamine may decrease the antihypertensive activities of Benazepril. |
| Enalapril | Phentolamine may decrease the antihypertensive activities of Enalapril. |
| Losartan | Phentolamine may decrease the antihypertensive activities of Losartan. |
| Moexipril | Phentolamine may decrease the antihypertensive activities of Moexipril. |
| Remikiren | Phentolamine may decrease the antihypertensive activities of Remikiren. |
| Guanadrel | Phentolamine may decrease the antihypertensive activities of Guanadrel. |
| Bosentan | Phentolamine may decrease the antihypertensive activities of Bosentan. |
| Candoxatril | Phentolamine may decrease the antihypertensive activities of Candoxatril. |
| Nitroglycerin | Phentolamine may decrease the antihypertensive activities of Nitroglycerin. |
| Metyrosine | Phentolamine may decrease the antihypertensive activities of Metyrosine. |
| Cryptenamine | Phentolamine may decrease the antihypertensive activities of Cryptenamine. |
| Candesartan cilexetil | Phentolamine may decrease the antihypertensive activities of Candesartan cilexetil. |
| Eprosartan | Phentolamine may decrease the antihypertensive activities of Eprosartan. |
| Quinapril | Phentolamine may decrease the antihypertensive activities of Quinapril. |
| Omapatrilat | Phentolamine may decrease the antihypertensive activities of Omapatrilat. |
| Telmisartan | Phentolamine may decrease the antihypertensive activities of Telmisartan. |
| Irbesartan | Phentolamine may decrease the antihypertensive activities of Irbesartan. |
| Deserpidine | Phentolamine may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Phentolamine may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Phentolamine may decrease the antihypertensive activities of Trimethaphan. |
| Bretylium | Phentolamine may decrease the antihypertensive activities of Bretylium. |
| Rescinnamine | Phentolamine may decrease the antihypertensive activities of Rescinnamine. |
| Captopril | Phentolamine may decrease the antihypertensive activities of Captopril. |
| Cilazapril | Phentolamine may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Phentolamine may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Phentolamine may decrease the antihypertensive activities of Spirapril. |
| Debrisoquine | Phentolamine may decrease the antihypertensive activities of Debrisoquine. |
| Sitaxentan | Phentolamine may decrease the antihypertensive activities of Sitaxentan. |
| Ambrisentan | Phentolamine may decrease the antihypertensive activities of Ambrisentan. |
| Diethylnorspermine | Phentolamine may decrease the antihypertensive activities of Diethylnorspermine. |
| Pinacidil | Phentolamine may decrease the antihypertensive activities of Pinacidil. |
| Temocapril | Phentolamine may decrease the antihypertensive activities of Temocapril. |
| Riociguat | Phentolamine may decrease the antihypertensive activities of Riociguat. |
| Hexamethonium | Phentolamine may decrease the antihypertensive activities of Hexamethonium. |
| Aliskiren | Phentolamine may decrease the antihypertensive activities of Aliskiren. |
| Rauwolfia serpentina root | Phentolamine may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Selexipag | Phentolamine may decrease the antihypertensive activities of Selexipag. |
| Angiotensin 1-7 | Phentolamine may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Phentolamine may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Phentolamine may decrease the antihypertensive activities of BQ-123. |
| Dihydralazine | Phentolamine may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Phentolamine may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Phentolamine may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Phentolamine may decrease the antihypertensive activities of Delapril. |
| Vincamine | Phentolamine may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Phentolamine may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Phentolamine may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Phentolamine may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Phentolamine may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Phentolamine may decrease the antihypertensive activities of Cadralazine. |
| Bietaserpine | Phentolamine may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Phentolamine may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Phentolamine may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Phentolamine may decrease the antihypertensive activities of Guanoclor. |
| Candesartan | Phentolamine may decrease the antihypertensive activities of Candesartan. |
| Tocopherylquinone | Phentolamine may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Phentolamine may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Phentolamine may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Phentolamine may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Phentolamine may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Phentolamine may decrease the antihypertensive activities of Quinaprilat. |
| Sufentanil | Sufentanil may decrease the antihypertensive activities of Phentolamine. |
| Isoflurane | Isoflurane may decrease the antihypertensive activities of Phentolamine. |
| Propofol | Propofol may decrease the antihypertensive activities of Phentolamine. |
| Remifentanil | Remifentanil may decrease the antihypertensive activities of Phentolamine. |
| Halothane | Halothane may decrease the antihypertensive activities of Phentolamine. |
| Desflurane | Desflurane may decrease the antihypertensive activities of Phentolamine. |
| Sevoflurane | Sevoflurane may decrease the antihypertensive activities of Phentolamine. |
| Rotigotine | Rotigotine may decrease the antihypertensive activities of Phentolamine. |
| Fentanyl | Fentanyl may decrease the antihypertensive activities of Phentolamine. |
| Desipramine | Desipramine may decrease the antihypertensive activities of Phentolamine. |
| Clomipramine | Clomipramine may decrease the antihypertensive activities of Phentolamine. |
| Dimetacrine | Dimetacrine may decrease the antihypertensive activities of Phentolamine. |
| Selpercatinib | Selpercatinib may decrease the antihypertensive activities of Phentolamine. |
| Naxitamab | Naxitamab may decrease the antihypertensive activities of Phentolamine. |
| Levamlodipine | Phentolamine may decrease the antihypertensive activities of Levamlodipine. |
| Eletriptan | Eletriptan may decrease the antihypertensive activities of Phentolamine. |
| Methysergide | Methysergide may decrease the antihypertensive activities of Phentolamine. |
| Cabergoline | Cabergoline may decrease the antihypertensive activities of Phentolamine. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Phentolamine. |
| Protriptyline | Protriptyline may decrease the antihypertensive activities of Phentolamine. |
| Methylergometrine | Methylergometrine may decrease the antihypertensive activities of Phentolamine. |