Peringatan Keamanan

Human overdoses of moexipril have not been reported. In case reports of overdoses with other ACE inhibitors, hypotension has been the principal adverse effect noted. Single oral doses of 2 g/kg moexipril were associated with significant lethality in mice. Rats, however, tolerated single oral doses of up to 3 g/kg. Common adverse effects include cough, dizziness, diarrhea, flu syndrome, fatigue, pharyngitis, flushing, rash, and myalgia

Moexipril

DB00691

small molecule approved

Deskripsi

Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.

Struktur Molekul 2D

Berat 498.5681

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Moexipril elimination half-life is approximately 1 hour. Moexiprilat elimination half-life is 2 to 9 hours.

Volume Distribusi * 183 L

Klirens (Clearance) * 441 mL/min

Absorpsi

Moexipril is incompletely absorbed, with bioavailability as moexiprilat of about 13% compared to intravenous (I.V.) moexipril (both measuring the metabolite moexiprilat), and is markedly affected by food, which reduces C_max and AUC by about 70% and 40%, respectively, after the ingestion of a low-fat breakfast or by 80% and 50%, respectively, after the ingestion of a high-fat breakfast.

Metabolisme

Rapidly converted to moexiprilat, the active metabolite. Conversion to the active metabolite is thought to require carboxyesterases and is likely to occur in organs or tissues, other than the gastrointestinal tract, in which carboxyesterases occur. The liver is thought to be one site of conversion, but not the primary site.

Rute Eliminasi

Moexiprilat undergoes renal elimination.

Interaksi Makanan

4 Data

1. Avoid hypertensive herbs (e.g. bayberry, blue cohosh, cayenne, ephedra, and licorice).
2. Avoid potassium-containing products. Potassium products increase the risk of hyperkalemia.
3. Limit salt intake. Salt may attenuate the antihypertensive effect.
4. Take separate from meals. Take 1 hour before meals.

Interaksi Obat

1096 Data

Duloxetine	The risk or severity of orthostatic hypotension and syncope can be increased when Moexipril is combined with Duloxetine.
Levodopa	The risk or severity of hypotension and orthostatic hypotension can be increased when Moexipril is combined with Levodopa.
Risperidone	Moexipril may increase the hypotensive activities of Risperidone.
Alfuzosin	Alfuzosin may increase the hypotensive activities of Moexipril.
Amifostine	Moexipril may increase the hypotensive activities of Amifostine.
Diazoxide	Diazoxide may increase the hypotensive activities of Moexipril.
Methylphenidate	Methylphenidate may decrease the antihypertensive activities of Moexipril.
Dexmethylphenidate	Dexmethylphenidate may decrease the antihypertensive activities of Moexipril.
Obinutuzumab	Moexipril may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline	Pentoxifylline may increase the hypotensive activities of Moexipril.
Rituximab	Moexipril may increase the hypotensive activities of Rituximab.
Desmopressin	Desmopressin may decrease the antihypertensive activities of Moexipril.
Phentermine	Phentermine may decrease the antihypertensive activities of Moexipril.
Midodrine	Midodrine may decrease the antihypertensive activities of Moexipril.
Eletriptan	Eletriptan may decrease the antihypertensive activities of Moexipril.
Isoetharine	Isoetharine may decrease the antihypertensive activities of Moexipril.
Methysergide	Methysergide may decrease the antihypertensive activities of Moexipril.
Cabergoline	Cabergoline may decrease the antihypertensive activities of Moexipril.
Etomidate	Etomidate may decrease the antihypertensive activities of Moexipril.
Zolmitriptan	Zolmitriptan may decrease the antihypertensive activities of Moexipril.
Dihydroergotamine	Dihydroergotamine may decrease the antihypertensive activities of Moexipril.
Methylergometrine	Methylergometrine may decrease the antihypertensive activities of Moexipril.
Norepinephrine	Norepinephrine may decrease the antihypertensive activities of Moexipril.
Phenylephrine	Phenylephrine may decrease the antihypertensive activities of Moexipril.
Phenylpropanolamine	Phenylpropanolamine may decrease the antihypertensive activities of Moexipril.
Buspirone	Buspirone may decrease the antihypertensive activities of Moexipril.
Doxapram	Doxapram may decrease the antihypertensive activities of Moexipril.
Lisuride	Lisuride may decrease the antihypertensive activities of Moexipril.
Metaraminol	Metaraminol may decrease the antihypertensive activities of Moexipril.
Epinephrine	Epinephrine may decrease the antihypertensive activities of Moexipril.
Sumatriptan	Sumatriptan may decrease the antihypertensive activities of Moexipril.
Ergotamine	Ergotamine may decrease the antihypertensive activities of Moexipril.
Nicergoline	Nicergoline may decrease the antihypertensive activities of Moexipril.
Methoxamine	Methoxamine may decrease the antihypertensive activities of Moexipril.
Propiomazine	Propiomazine may decrease the antihypertensive activities of Moexipril.
Alfentanil	Alfentanil may decrease the antihypertensive activities of Moexipril.
Fentanyl	Fentanyl may decrease the antihypertensive activities of Moexipril.
Orciprenaline	Orciprenaline may decrease the antihypertensive activities of Moexipril.
Phenmetrazine	Phenmetrazine may decrease the antihypertensive activities of Moexipril.
Trifluoperazine	Trifluoperazine may decrease the antihypertensive activities of Moexipril.
Dobutamine	Dobutamine may decrease the antihypertensive activities of Moexipril.
Pseudoephedrine	Pseudoephedrine may decrease the antihypertensive activities of Moexipril.
Benzphetamine	Benzphetamine may decrease the antihypertensive activities of Moexipril.
Ritodrine	Ritodrine may decrease the antihypertensive activities of Moexipril.
Bitolterol	Bitolterol may decrease the antihypertensive activities of Moexipril.
Almotriptan	Almotriptan may decrease the antihypertensive activities of Moexipril.
Diethylpropion	Diethylpropion may decrease the antihypertensive activities of Moexipril.
Naratriptan	Naratriptan may decrease the antihypertensive activities of Moexipril.
Rizatriptan	Rizatriptan may decrease the antihypertensive activities of Moexipril.
Dopamine	Dopamine may decrease the antihypertensive activities of Moexipril.
Frovatriptan	Frovatriptan may decrease the antihypertensive activities of Moexipril.
Methoxyflurane	Methoxyflurane may decrease the antihypertensive activities of Moexipril.
Ergoloid mesylate	Ergoloid mesylate may decrease the antihypertensive activities of Moexipril.
Isoprenaline	Isoprenaline may decrease the antihypertensive activities of Moexipril.
Arbutamine	Arbutamine may decrease the antihypertensive activities of Moexipril.
Dutasteride	Dutasteride may decrease the antihypertensive activities of Moexipril.
Nefazodone	Nefazodone may decrease the antihypertensive activities of Moexipril.
Pergolide	Pergolide may decrease the antihypertensive activities of Moexipril.
Finasteride	Finasteride may decrease the antihypertensive activities of Moexipril.
Ergometrine	Ergometrine may decrease the antihypertensive activities of Moexipril.
Lisdexamfetamine	Lisdexamfetamine may decrease the antihypertensive activities of Moexipril.
Fenoterol	Fenoterol may decrease the antihypertensive activities of Moexipril.
Pirbuterol	Pirbuterol may decrease the antihypertensive activities of Moexipril.
Ephedra sinica root	Ephedra sinica root may decrease the antihypertensive activities of Moexipril.
Ephedrine	Ephedrine may decrease the antihypertensive activities of Moexipril.
Mephentermine	Mephentermine may decrease the antihypertensive activities of Moexipril.
Procaterol	Procaterol may decrease the antihypertensive activities of Moexipril.
Yohimbine	Yohimbine may decrease the antihypertensive activities of Moexipril.
Clenbuterol	Clenbuterol may decrease the antihypertensive activities of Moexipril.
Bambuterol	Bambuterol may decrease the antihypertensive activities of Moexipril.
MMDA	MMDA may decrease the antihypertensive activities of Moexipril.
Midomafetamine	Midomafetamine may decrease the antihypertensive activities of Moexipril.
2,5-Dimethoxy-4-ethylamphetamine	2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Moexipril.
4-Methoxyamphetamine	4-Methoxyamphetamine may decrease the antihypertensive activities of Moexipril.
4-Bromo-2,5-dimethoxyamphetamine	4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Moexipril.
Tenamfetamine	Tenamfetamine may decrease the antihypertensive activities of Moexipril.
Chlorphentermine	Chlorphentermine may decrease the antihypertensive activities of Moexipril.
Dextroamphetamine	Dextroamphetamine may decrease the antihypertensive activities of Moexipril.
Metamfetamine	Metamfetamine may decrease the antihypertensive activities of Moexipril.
Phendimetrazine	Phendimetrazine may decrease the antihypertensive activities of Moexipril.
Periciazine	Periciazine may decrease the antihypertensive activities of Moexipril.
Acepromazine	Acepromazine may decrease the antihypertensive activities of Moexipril.
Thioproperazine	Thioproperazine may decrease the antihypertensive activities of Moexipril.
Epicaptopril	Epicaptopril may decrease the antihypertensive activities of Moexipril.
1-benzylimidazole	1-benzylimidazole may decrease the antihypertensive activities of Moexipril.
Lysergic acid diethylamide	Lysergic acid diethylamide may decrease the antihypertensive activities of Moexipril.
Amineptine	Amineptine may decrease the antihypertensive activities of Moexipril.
Flibanserin	Flibanserin may decrease the antihypertensive activities of Moexipril.
Amibegron	Amibegron may decrease the antihypertensive activities of Moexipril.
Naluzotan	Naluzotan may decrease the antihypertensive activities of Moexipril.
Cariprazine	Cariprazine may decrease the antihypertensive activities of Moexipril.
Mianserin	Mianserin may decrease the antihypertensive activities of Moexipril.
Pizotifen	Pizotifen may decrease the antihypertensive activities of Moexipril.
Solabegron	Solabegron may decrease the antihypertensive activities of Moexipril.
Droxidopa	Droxidopa may decrease the antihypertensive activities of Moexipril.
Esmirtazapine	Esmirtazapine may decrease the antihypertensive activities of Moexipril.
Vilazodone	Vilazodone may decrease the antihypertensive activities of Moexipril.
Nitrous oxide	Nitrous oxide may decrease the antihypertensive activities of Moexipril.
Xylometazoline	Xylometazoline may decrease the antihypertensive activities of Moexipril.
Isometheptene	Isometheptene may decrease the antihypertensive activities of Moexipril.

Target Protein

Angiotensin-converting enzyme ACE

Referensi & Sumber

Artikel (PubMed)

PMID: 11918132
Asmar R, Sayegh F, Tracz W, Hlawaty M, Olszowska M, Jourde M, Vincent M, Goujoun B, Maldonado J: Reversal of left ventricular hypertrophy with the ACE inhibitor moexipril in patients with essential hypertension. Acta Cardiol. 2002 Feb;57(1):31-2.
PMID: 9825188
Blacher J, Raison J, Amah G, Schiemann AL, Stimpel M, Safar ME: Increased arterial distensibility in postmenopausal hypertensive women with and without hormone replacement therapy after acute administration of the ACE inhibitor moexipril. Cardiovasc Drugs Ther. 1998 Sep;12(4):409-14.
PMID: 9617599
Brogden RN, Wiseman LR: Moexipril. A review of its use in the management of essential hypertension. Drugs. 1998 Jun;55(6):845-60.
PMID: 11837383
Cawello W, Boekens H, Waitzinger J, Miller U: Moexipril shows a long duration of action related to an extended pharmacokinetic half-life and prolonged ACE inhibition. Int J Clin Pharmacol Ther. 2002 Jan;40(1):9-17.
PMID: 15286086
Chrysant SG, Chrysant GS: Pharmacological and clinical profile of moexipril: a concise review. J Clin Pharmacol. 2004 Aug;44(8):827-36.
PMID: 15030263
Chrysant SG, Chrysant GS: Pharmacological profile and clinical use of moexipril. Expert Rev Cardiovasc Ther. 2003 Sep;1(3):345-52.
PMID: 17583172
Chrysant GS, Nguyen PK: Moexipril and left ventricular hypertrophy. Vasc Health Risk Manag. 2007;3(1):23-30.
PMID: 2554270
Grass GM, Morehead WT: Evidence for site-specific absorption of a novel ACE inhibitor. Pharm Res. 1989 Sep;6(9):759-65.

Menampilkan 8 dari 14 artikel.

Contoh Produk & Brand

Produk: 42 • International brands: 0

Produk

Moexipril Hydrochloride

Tablet • 7.5 mg/1 • Oral • US • Generic • Approved
Moexipril Hydrochloride

Tablet • 15 mg/1 • Oral • US • Generic • Approved
Moexipril hydrochloride

Tablet, film coated • 7.5 mg/1 • Oral • US • Approved
Moexipril hydrochloride

Tablet, film coated • 15 mg/1 • Oral • US • Approved
Moexipril Hydrochloride

Tablet, coated • 7.5 mg/1 • Oral • US • Generic • Approved
Moexipril Hydrochloride

Tablet, coated • 15 mg/1 • Oral • US • Generic • Approved
Moexipril Hydrochloride

Tablet, film coated • 7.5 mg/1 • Oral • US • Generic • Approved
Moexipril Hydrochloride

Tablet, film coated • 15 mg/1 • Oral • US • Generic • Approved

Menampilkan 8 dari 42 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.