Peringatan Keamanan

Coma, confusion, low blood pressure, sleepiness

Flurazepam

DB00690

small molecule approved illicit investigational

Deskripsi

A benzodiazepine derivative used mainly as a hypnotic.

Struktur Molekul 2D

Berat 387.878
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The mean apparent half-life of flurazepam is 2.3 hours. The half life of elimination of N1-des-alkyl- flurazepam ranged from 47 to 100 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Flurazepam hydrochloride is rapidly (30 minutes) absorbed from the gastrointestinal tract

Metabolisme

Flurazepam is rapidly metabolized and is excreted primarily in the urine. Both hydroxyethyl flurazepam (the major metabolite) and N-desalkyl flurazepam are active. The N-desalkyl metabolite is slowly excreted in the urine as the conjugated form

Rute Eliminasi

Flurazepam is rapidly metabolized and is excreted primarily in the urine. Less than 1% of the dose is excreted in the urine as N1-desalkyl-flurazepam.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1454 Data
Buprenorphine Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Hydrocodone Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Magnesium sulfate The therapeutic efficacy of Flurazepam can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Flurazepam may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Mirtazapine Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Orphenadrine Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Pramipexole Flurazepam may increase the sedative activities of Pramipexole.
Ropinirole Flurazepam may increase the sedative activities of Ropinirole.
Rotigotine Flurazepam may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Flurazepam.
Suvorexant Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Thalidomide Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Clozapine The risk or severity of adverse effects can be increased when Flurazepam is combined with Clozapine.
Methadone Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Sodium oxybate Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Teduglutide The serum concentration of Flurazepam can be increased when it is combined with Teduglutide.
Yohimbine The therapeutic efficacy of Flurazepam can be increased when used in combination with Yohimbine.
Saquinavir The serum concentration of Flurazepam can be increased when it is combined with Saquinavir.
Ethanol Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Zimelidine The risk or severity of adverse effects can be increased when Flurazepam is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Flurazepam is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Flurazepam is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Flurazepam is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Flurazepam is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Flurazepam is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Flurazepam is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Flurazepam is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Flurazepam is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Flurazepam is combined with Sibutramine.
Escitalopram The risk or severity of adverse effects can be increased when Flurazepam is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Flurazepam is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Flurazepam is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Flurazepam is combined with Levomilnacipran.
Indalpine The risk or severity of adverse effects can be increased when Flurazepam is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Flurazepam is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Flurazepam is combined with Alaproclate.
Benzatropine Benzatropine may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Disopyramide Disopyramide may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Flurazepam.
Propiomazine The risk or severity of CNS depression can be increased when Flurazepam is combined with Propiomazine.
Propantheline Flurazepam may decrease the excretion rate of Propantheline which could result in a higher serum level.
Dicyclomine Flurazepam may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Tolterodine Flurazepam may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Flavoxate Flurazepam may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Tiotropium Flurazepam may decrease the excretion rate of Tiotropium which could result in a higher serum level.
Aclidinium Flurazepam may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Trimebutine Flurazepam may decrease the excretion rate of Trimebutine which could result in a higher serum level.
Imidafenacin Flurazepam may decrease the excretion rate of Imidafenacin which could result in a higher serum level.
Propiverine Flurazepam may decrease the excretion rate of Propiverine which could result in a higher serum level.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Flurazepam.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Flurazepam.
Nicardipine The metabolism of Flurazepam can be decreased when combined with Nicardipine.
Doxepin The risk or severity of CNS depression can be increased when Flurazepam is combined with Doxepin.
Fesoterodine Flurazepam may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Desipramine The risk or severity of CNS depression can be increased when Flurazepam is combined with Desipramine.
Zopiclone The risk or severity of adverse effects can be increased when Flurazepam is combined with Zopiclone.
Caffeine The therapeutic efficacy of Flurazepam can be decreased when used in combination with Caffeine.
Dyphylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Dyphylline.
Pentoxifylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Pentoxifylline.
Mercaptopurine The therapeutic efficacy of Flurazepam can be decreased when used in combination with Mercaptopurine.
Oxtriphylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Oxtriphylline.
Theobromine The therapeutic efficacy of Flurazepam can be decreased when used in combination with Theobromine.
Fenethylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Fenethylline.
8-azaguanine The therapeutic efficacy of Flurazepam can be decreased when used in combination with 8-azaguanine.
7,9-Dimethylguanine The therapeutic efficacy of Flurazepam can be decreased when used in combination with 7,9-Dimethylguanine.
Xanthine The therapeutic efficacy of Flurazepam can be decreased when used in combination with Xanthine.
7-Deazaguanine The therapeutic efficacy of Flurazepam can be decreased when used in combination with 7-Deazaguanine.
Guanine The therapeutic efficacy of Flurazepam can be decreased when used in combination with Guanine.
9-Methylguanine The therapeutic efficacy of Flurazepam can be decreased when used in combination with 9-Methylguanine.
Peldesine The therapeutic efficacy of Flurazepam can be decreased when used in combination with Peldesine.
Hypoxanthine The therapeutic efficacy of Flurazepam can be decreased when used in combination with Hypoxanthine.
9-Deazaguanine The therapeutic efficacy of Flurazepam can be decreased when used in combination with 9-Deazaguanine.
Propentofylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Propentofylline.
Valomaciclovir The therapeutic efficacy of Flurazepam can be decreased when used in combination with Valomaciclovir.
3-isobutyl-1-methyl-7H-xanthine The therapeutic efficacy of Flurazepam can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine.
Uric acid The therapeutic efficacy of Flurazepam can be decreased when used in combination with Uric acid.
Doxofylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Doxofylline.
6-O-benzylguanine The therapeutic efficacy of Flurazepam can be decreased when used in combination with 6-O-benzylguanine.
Lisofylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Lisofylline.
Lobucavir The therapeutic efficacy of Flurazepam can be decreased when used in combination with Lobucavir.
Cafedrine The therapeutic efficacy of Flurazepam can be decreased when used in combination with Cafedrine.
Theodrenaline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Theodrenaline.
Bamifylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Bamifylline.
Proxyphylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Proxyphylline.
Acefylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Acefylline.
Etamiphylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Etamiphylline.
Pentifylline The therapeutic efficacy of Flurazepam can be decreased when used in combination with Pentifylline.

Target Protein

Translocator protein TSPO
GABA(A) Receptor GABRA1
GABA(A) Receptor Benzodiazepine Binding Site GABRA1

Referensi & Sumber

Synthesis reference: Fryer, R. and Sternbach, L.H.; U.S. Patent 3,567,710; March 2, 1971; assigned to Hoffman-La Roche, Inc.
Artikel (PubMed)
Link

Contoh Produk & Brand

Produk: 38 • International brands: 7
Produk
  • Bio-flurazepam
    Capsule • 15 mg • Oral • Canada • Generic • Approved
  • Bio-flurazepam
    Capsule • 30 mg • Oral • Canada • Generic • Approved
  • Dalmane
    Capsule • 30 mg • Oral • Canada • Approved
  • Dalmane
    Capsule • 15 mg • Oral • Canada • Approved
  • Flurazepam
    Capsule • 30 mg/1 • Oral • US • Generic • Approved
  • Flurazepam
    Capsule • 30 mg/1 • Oral • US • Generic • Approved
  • Flurazepam
    Capsule • 15 mg/1 • Oral • US • Generic • Approved
  • Flurazepam
    Capsule • 30 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 38 produk.
International Brands
  • Dalmadorm — Meda
  • Dalmadorm medium — Meda
  • Felison — SIT
  • Flunox — Teofarma
  • Insumin
  • Sompan — I.C.N.
  • Valdorm — Valeas

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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