Pentosan polysulfate

DB00686

small molecule approved

Deskripsi

Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties.

Struktur Molekul 2D

Berat 602.497
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 4.8 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Slow

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid herbs and supplements with anticoagulant/antiplatelet activity. Taking pentosan polysulfate with anticoagulant herbs may increase bleeding risk, which is an adverse effect of pentosan polysulfate.
  • 2. Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.

Interaksi Obat

640 Data
Apixaban Apixaban may increase the anticoagulant activities of Pentosan polysulfate.
Dabigatran etexilate Dabigatran etexilate may increase the anticoagulant activities of Pentosan polysulfate.
Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Pentosan polysulfate.
Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Pentosan polysulfate is combined with Deferasirox.
Ursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Ursodeoxycholic acid.
Glycochenodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Glycochenodeoxycholic Acid.
Cholic Acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Cholic Acid.
Glycocholic acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Glycocholic acid.
Deoxycholic acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Deoxycholic acid.
Taurocholic acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Taurocholic acid.
Obeticholic acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Obeticholic acid.
Chenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Chenodeoxycholic acid.
Taurochenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Taurochenodeoxycholic acid.
Tauroursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Tauroursodeoxycholic acid.
Bamet-UD2 The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Bamet-UD2.
Dehydrocholic acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Dehydrocholic acid.
Hyodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Pentosan polysulfate is combined with Hyodeoxycholic Acid.
Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Pentosan polysulfate.
Ibrutinib The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Pentosan polysulfate.
Obinutuzumab The risk or severity of bleeding and hemorrhage can be increased when Pentosan polysulfate is combined with Obinutuzumab.
Rivaroxaban Pentosan polysulfate may increase the anticoagulant activities of Rivaroxaban.
Sugammadex The risk or severity of bleeding and hemorrhage can be increased when Pentosan polysulfate is combined with Sugammadex.
Tibolone Tibolone may increase the anticoagulant activities of Pentosan polysulfate.
Tipranavir The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Pentosan polysulfate.
Urokinase Urokinase may increase the anticoagulant activities of Pentosan polysulfate.
Vitamin E Vitamin E may increase the anticoagulant activities of Pentosan polysulfate.
Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Pentosan polysulfate.
Ginkgo biloba Ginkgo biloba may increase the anticoagulant activities of Pentosan polysulfate.
Ifosfamide The risk or severity of bleeding can be increased when Ifosfamide is combined with Pentosan polysulfate.
Quinine The therapeutic efficacy of Pentosan polysulfate can be increased when used in combination with Quinine.
Quinidine The therapeutic efficacy of Pentosan polysulfate can be increased when used in combination with Quinidine.
Tamoxifen The risk or severity of bleeding can be increased when Tamoxifen is combined with Pentosan polysulfate.
Toremifene The risk or severity of bleeding can be increased when Toremifene is combined with Pentosan polysulfate.
Lepirudin Pentosan polysulfate may increase the anticoagulant activities of Lepirudin.
Bivalirudin Pentosan polysulfate may increase the anticoagulant activities of Bivalirudin.
Alteplase Pentosan polysulfate may increase the anticoagulant activities of Alteplase.
Reteplase Pentosan polysulfate may increase the anticoagulant activities of Reteplase.
Anistreplase Pentosan polysulfate may increase the anticoagulant activities of Anistreplase.
Tenecteplase Pentosan polysulfate may increase the anticoagulant activities of Tenecteplase.
Drotrecogin alfa Pentosan polysulfate may increase the anticoagulant activities of Drotrecogin alfa.
Streptokinase Pentosan polysulfate may increase the anticoagulant activities of Streptokinase.
Dicoumarol Pentosan polysulfate may increase the anticoagulant activities of Dicoumarol.
Argatroban Pentosan polysulfate may increase the anticoagulant activities of Argatroban.
Ardeparin Pentosan polysulfate may increase the anticoagulant activities of Ardeparin.
Phenindione Pentosan polysulfate may increase the anticoagulant activities of Phenindione.
Fondaparinux Pentosan polysulfate may increase the anticoagulant activities of Fondaparinux.
Warfarin Pentosan polysulfate may increase the anticoagulant activities of Warfarin.
Phenprocoumon Pentosan polysulfate may increase the anticoagulant activities of Phenprocoumon.
Heparin Pentosan polysulfate may increase the anticoagulant activities of Heparin.
Enoxaparin Pentosan polysulfate may increase the anticoagulant activities of Enoxaparin.
Acenocoumarol Pentosan polysulfate may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Pentosan polysulfate may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Pentosan polysulfate may increase the anticoagulant activities of Coumarin.
Ximelagatran Pentosan polysulfate may increase the anticoagulant activities of Ximelagatran.
Desmoteplase Pentosan polysulfate may increase the anticoagulant activities of Desmoteplase.
Ancrod Pentosan polysulfate may increase the anticoagulant activities of Ancrod.
Sulodexide Pentosan polysulfate may increase the anticoagulant activities of Sulodexide.
Semuloparin Pentosan polysulfate may increase the anticoagulant activities of Semuloparin.
Idraparinux Pentosan polysulfate may increase the anticoagulant activities of Idraparinux.
Astaxanthin Pentosan polysulfate may increase the anticoagulant activities of Astaxanthin.
Otamixaban Pentosan polysulfate may increase the anticoagulant activities of Otamixaban.
Amediplase Pentosan polysulfate may increase the anticoagulant activities of Amediplase.
Danaparoid Pentosan polysulfate may increase the anticoagulant activities of Danaparoid.
Dalteparin Pentosan polysulfate may increase the anticoagulant activities of Dalteparin.
Tinzaparin Pentosan polysulfate may increase the anticoagulant activities of Tinzaparin.
(R)-warfarin Pentosan polysulfate may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Pentosan polysulfate may increase the anticoagulant activities of Ethyl biscoumacetate.
Nadroparin Pentosan polysulfate may increase the anticoagulant activities of Nadroparin.
Ditazole Pentosan polysulfate may increase the anticoagulant activities of Ditazole.
Sodium citrate Pentosan polysulfate may increase the anticoagulant activities of Sodium citrate.
Dextran Pentosan polysulfate may increase the anticoagulant activities of Dextran.
Bemiparin Pentosan polysulfate may increase the anticoagulant activities of Bemiparin.
Parnaparin Pentosan polysulfate may increase the anticoagulant activities of Parnaparin.
Desirudin Pentosan polysulfate may increase the anticoagulant activities of Desirudin.
Antithrombin Alfa Pentosan polysulfate may increase the anticoagulant activities of Antithrombin Alfa.
Protein C Pentosan polysulfate may increase the anticoagulant activities of Protein C.
Antithrombin III human Pentosan polysulfate may increase the anticoagulant activities of Antithrombin III human.
Letaxaban Pentosan polysulfate may increase the anticoagulant activities of Letaxaban.
Darexaban Pentosan polysulfate may increase the anticoagulant activities of Darexaban.
Betrixaban Pentosan polysulfate may increase the anticoagulant activities of Betrixaban.
Nafamostat Pentosan polysulfate may increase the anticoagulant activities of Nafamostat.
Monteplase Pentosan polysulfate may increase the anticoagulant activities of Monteplase.
Gabexate Pentosan polysulfate may increase the anticoagulant activities of Gabexate.
Fluindione Pentosan polysulfate may increase the anticoagulant activities of Fluindione.
Protein S human Pentosan polysulfate may increase the anticoagulant activities of Protein S human.
Brinase Pentosan polysulfate may increase the anticoagulant activities of Brinase.
Clorindione Pentosan polysulfate may increase the anticoagulant activities of Clorindione.
Diphenadione Pentosan polysulfate may increase the anticoagulant activities of Diphenadione.
Tioclomarol Pentosan polysulfate may increase the anticoagulant activities of Tioclomarol.
Melagatran Pentosan polysulfate may increase the anticoagulant activities of Melagatran.
Saruplase Pentosan polysulfate may increase the anticoagulant activities of Saruplase.
(S)-Warfarin Pentosan polysulfate may increase the anticoagulant activities of (S)-Warfarin.
Tocopherylquinone Pentosan polysulfate may increase the anticoagulant activities of Tocopherylquinone.
Dabigatran Pentosan polysulfate may increase the anticoagulant activities of Dabigatran.
Edetic acid Pentosan polysulfate may increase the anticoagulant activities of Edetic acid.
Troxerutin Pentosan polysulfate may increase the anticoagulant activities of Troxerutin.
Reviparin Pentosan polysulfate may increase the anticoagulant activities of Reviparin.
Dermatan sulfate Pentosan polysulfate may increase the anticoagulant activities of Dermatan sulfate.
SR-123781A Pentosan polysulfate may increase the anticoagulant activities of SR-123781A.
Abciximab The risk or severity of adverse effects can be increased when Pentosan polysulfate is combined with Abciximab.

Target Protein

Fibroblast growth factor 2 FGF2
Fibroblast growth factor 1 FGF1
Fibroblast growth factor 4 FGF4

Referensi & Sumber

Synthesis reference: Pandurang Balwant Deshpande, Parvenkumar Luthra, Anand Kumar Pandey, Dinesh Jayntibhai Paghdar, Phani,Sharma,Gowthamaiah Vemavarapu Govardhana, "PROCESS FOR THE PREPARATION OF PENTOSAN POLYSULFATE OR SALTS THEREOF." U.S. Patent US20100105889, issued April 29, 2010.
Artikel (PubMed)
  • PMID: 12014849
    Ghosh P, Smith M: Osteoarthritis, genetic and molecular mechanisms. Biogerontology. 2002;3(1-2):85-8.

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International Brands
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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