Peringatan Keamanan

Symptoms of overdose include convulsions, decreased activity, diarrhea, sleepiness, tremors, and/or vomiting.

Trovafloxacin

DB00685

small molecule approved investigational withdrawn

Deskripsi

Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective against Gram-positive bacteria than Gram-negative bacteria when compared to previous fluoroquinolones. Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.

Struktur Molekul 2D

Berat 416.36
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Following oral administration, half-life ranged from 9.1 hours to 12.2 hours over the dosage range of 100 to 200 mg tablets. Following intravenous infusion, half-life ranged from 9.4 to 12.7 hours over a dosage range of 100 to 300 mg.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well-absorbed from the gastrointestinal tract after oral administration and does not depend on concomitant food intake. The absolute bioavailability is approximately 88%.

Metabolisme

Metabolism Trovafloxacin is metabolized by conjugation (the role of cytochrome P450 oxidative metabolism of trovafloxacin is minimal). The major metabolites include the ester glucuronide, which appears in the urine (13% of the administered dose); and the N -acetyl metabolite, which appears in the feces and serum (9% and 2.5% of the administered dose, respectively). Other minor metabolites include diacid, hydroxycarboxylic acid, and sulfamate, which have been identified in both the feces and the urine in small amounts (< 4% of the administered dose).

Rute Eliminasi

Approximately 50% of an oral dose is excreted unchanged (43% in the feces and 6% in the urine).

Interaksi Makanan

3 Data
  • 1. Avoid multivalent ions.
  • 2. Take separate from antacids. Take at least 2 hours before or after antacids.
  • 3. Take with or without food. Taking trovafloxacin with food may reduce the risk of dizziness.

Interaksi Obat

935 Data
Tizanidine The serum concentration of Tizanidine can be increased when it is combined with Trovafloxacin.
Didanosine Didanosine can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Probenecid Probenecid may decrease the excretion rate of Trovafloxacin which could result in a higher serum level.
Quinapril Quinapril can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium acetate Calcium acetate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron Dextran Iron Dextran can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium Calcium can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum carbonate Lanthanum carbonate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric carboxymaltose Ferric carboxymaltose can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose Iron sucrose can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric pyrophosphate Ferric pyrophosphate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium citrate Calcium citrate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium gluconate Calcium gluconate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric sulfate Ferric sulfate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric cation Ferric cation can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetraferric tricitrate decahydrate Tetraferric tricitrate decahydrate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum III cation Lanthanum III cation can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium polycarbophil Calcium polycarbophil can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric oxyhydroxide Ferric oxyhydroxide can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sucralfate Sucralfate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Trovafloxacin.
Nitrofurantoin The therapeutic efficacy of Trovafloxacin can be decreased when used in combination with Nitrofurantoin.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Trovafloxacin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Trovafloxacin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Trovafloxacin.
Insulin human The therapeutic efficacy of Insulin human can be increased when used in combination with Trovafloxacin.
Insulin lispro The therapeutic efficacy of Insulin lispro can be increased when used in combination with Trovafloxacin.
Insulin pork The therapeutic efficacy of Insulin pork can be increased when used in combination with Trovafloxacin.
Troglitazone The therapeutic efficacy of Troglitazone can be increased when used in combination with Trovafloxacin.
Glimepiride The therapeutic efficacy of Glimepiride can be increased when used in combination with Trovafloxacin.
Acarbose The therapeutic efficacy of Acarbose can be increased when used in combination with Trovafloxacin.
Metformin The therapeutic efficacy of Metformin can be increased when used in combination with Trovafloxacin.
Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Trovafloxacin.
Rosiglitazone The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Trovafloxacin.
Acetohexamide The therapeutic efficacy of Acetohexamide can be increased when used in combination with Trovafloxacin.
Miglitol The therapeutic efficacy of Miglitol can be increased when used in combination with Trovafloxacin.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Trovafloxacin.
Nateglinide The therapeutic efficacy of Nateglinide can be increased when used in combination with Trovafloxacin.
Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Trovafloxacin.
Repaglinide The therapeutic efficacy of Repaglinide can be increased when used in combination with Trovafloxacin.
Phenformin The therapeutic efficacy of Phenformin can be increased when used in combination with Trovafloxacin.
Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Trovafloxacin.
Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Trovafloxacin.
Gliclazide The therapeutic efficacy of Gliclazide can be increased when used in combination with Trovafloxacin.
Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Trovafloxacin.
Pioglitazone The therapeutic efficacy of Pioglitazone can be increased when used in combination with Trovafloxacin.
Bromocriptine The therapeutic efficacy of Bromocriptine can be increased when used in combination with Trovafloxacin.
Gliquidone The therapeutic efficacy of Gliquidone can be increased when used in combination with Trovafloxacin.
Mitiglinide The therapeutic efficacy of Mitiglinide can be increased when used in combination with Trovafloxacin.
Sitagliptin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Trovafloxacin.
Exenatide The therapeutic efficacy of Exenatide can be increased when used in combination with Trovafloxacin.
Mecasermin The therapeutic efficacy of Mecasermin can be increased when used in combination with Trovafloxacin.
Pramlintide The therapeutic efficacy of Pramlintide can be increased when used in combination with Trovafloxacin.
Glisoxepide The therapeutic efficacy of Glisoxepide can be increased when used in combination with Trovafloxacin.
Insulin aspart The therapeutic efficacy of Insulin aspart can be increased when used in combination with Trovafloxacin.
Insulin glulisine The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Trovafloxacin.
Glymidine The therapeutic efficacy of Glymidine can be increased when used in combination with Trovafloxacin.
AICA ribonucleotide The therapeutic efficacy of AICA ribonucleotide can be increased when used in combination with Trovafloxacin.
Buformin The therapeutic efficacy of Buformin can be increased when used in combination with Trovafloxacin.
Vildagliptin The therapeutic efficacy of Vildagliptin can be increased when used in combination with Trovafloxacin.
Voglibose The therapeutic efficacy of Voglibose can be increased when used in combination with Trovafloxacin.
NN344 The therapeutic efficacy of NN344 can be increased when used in combination with Trovafloxacin.
AMG-222 The therapeutic efficacy of AMG-222 can be increased when used in combination with Trovafloxacin.
Bisegliptin The therapeutic efficacy of Bisegliptin can be increased when used in combination with Trovafloxacin.
Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Trovafloxacin.
Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Trovafloxacin.
Saxagliptin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Trovafloxacin.
Liraglutide The therapeutic efficacy of Liraglutide can be increased when used in combination with Trovafloxacin.
Gosogliptin The therapeutic efficacy of Gosogliptin can be increased when used in combination with Trovafloxacin.
Linagliptin The therapeutic efficacy of Linagliptin can be increased when used in combination with Trovafloxacin.
Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Trovafloxacin.
Glibornuride The therapeutic efficacy of Glibornuride can be increased when used in combination with Trovafloxacin.
Benfluorex The therapeutic efficacy of Benfluorex can be increased when used in combination with Trovafloxacin.
Empagliflozin The therapeutic efficacy of Empagliflozin can be increased when used in combination with Trovafloxacin.
Albiglutide The therapeutic efficacy of Albiglutide can be increased when used in combination with Trovafloxacin.
Dulaglutide The therapeutic efficacy of Dulaglutide can be increased when used in combination with Trovafloxacin.
Lobeglitazone The therapeutic efficacy of Lobeglitazone can be increased when used in combination with Trovafloxacin.
Netoglitazone The therapeutic efficacy of Netoglitazone can be increased when used in combination with Trovafloxacin.
Rivoglitazone The therapeutic efficacy of Rivoglitazone can be increased when used in combination with Trovafloxacin.
Ciglitazone The therapeutic efficacy of Ciglitazone can be increased when used in combination with Trovafloxacin.
Lixisenatide The therapeutic efficacy of Lixisenatide can be increased when used in combination with Trovafloxacin.
Insulin beef The therapeutic efficacy of Insulin beef can be increased when used in combination with Trovafloxacin.
Insulin degludec The therapeutic efficacy of Insulin degludec can be increased when used in combination with Trovafloxacin.
Insulin peglispro The therapeutic efficacy of Insulin peglispro can be increased when used in combination with Trovafloxacin.
Insulin tregopil The therapeutic efficacy of Insulin tregopil can be increased when used in combination with Trovafloxacin.
Ipragliflozin The therapeutic efficacy of Ipragliflozin can be increased when used in combination with Trovafloxacin.
Dutogliptin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Trovafloxacin.
Allicin The therapeutic efficacy of Allicin can be increased when used in combination with Trovafloxacin.
Tofogliflozin The therapeutic efficacy of Tofogliflozin can be increased when used in combination with Trovafloxacin.
Ertugliflozin The therapeutic efficacy of Ertugliflozin can be increased when used in combination with Trovafloxacin.
2,4-thiazolidinedione The therapeutic efficacy of 2,4-thiazolidinedione can be increased when used in combination with Trovafloxacin.
Teneligliptin The therapeutic efficacy of Teneligliptin can be increased when used in combination with Trovafloxacin.
Omarigliptin The therapeutic efficacy of Omarigliptin can be increased when used in combination with Trovafloxacin.
Carmegliptin The therapeutic efficacy of Carmegliptin can be increased when used in combination with Trovafloxacin.
Gemigliptin The therapeutic efficacy of Gemigliptin can be increased when used in combination with Trovafloxacin.
Anagliptin The therapeutic efficacy of Anagliptin can be increased when used in combination with Trovafloxacin.
Evogliptin The therapeutic efficacy of Evogliptin can be increased when used in combination with Trovafloxacin.
Sotagliflozin The therapeutic efficacy of Sotagliflozin can be increased when used in combination with Trovafloxacin.

Target Protein

DNA gyrase subunit A gyrA
DNA gyrase subunit B gyrB
DNA gyrase subunit A gyrA
DNA topoisomerase 4 subunit A parC
DNA topoisomerase 2-alpha TOP2A

Referensi & Sumber

Contoh Produk & Brand

Produk: 6 • International brands: 1
Produk
  • Trovan
    Tablet, film coated • 100 mg/1 • Oral • US • Approved
  • Trovan
    Tablet, film coated • 200 mg/1 • Oral • US • Approved
  • Trovan
    Injection, solution, concentrate • 5 mg/1mL • Intravenous • US • Approved
  • Trovan
    Injection, solution, concentrate • 5 mg/1mL • Intravenous • US • Approved
  • Trovan Tablets 100mg
    Tablet • 100 mg / tab • Oral • Canada • Approved
  • Trovan Tablets 200mg
    Tablet • 200 mg / tab • Oral • Canada • Approved
International Brands
  • Trovan — Pfizer

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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