LD50=956-1034 mg/kg (Orally in rats); Agitation, blurred vision, coma, confusion, constipation, difficulty breathing, dilated or constricted pupils, diminished flow of urine, dry mouth, dry skin, excessively high or low body temperature, extremely low blood pressure, fluid in the lungs, heart abnormalities, inability to urinate, intestinal blockage, nasal congestion, restlessness, sedation, seizures, shock
A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618).
Thioridazine was withdrawn worldwide in 2005 due to its association with cardiac arrythmias.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Thioridazine is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Thioridazine is combined with Levodopa. |
| Risperidone | Thioridazine may increase the hypotensive activities of Risperidone. |
| Fluvoxamine | The serum concentration of Thioridazine can be increased when it is combined with Fluvoxamine. |
| Furosemide | Thioridazine may decrease the antihypertensive activities of Furosemide. |
| Valsartan | Thioridazine may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Thioridazine may decrease the antihypertensive activities of Ramipril. |
| Remikiren | Thioridazine may decrease the antihypertensive activities of Remikiren. |
| Guanadrel | Thioridazine may decrease the antihypertensive activities of Guanadrel. |
| Olmesartan | Thioridazine may decrease the antihypertensive activities of Olmesartan. |
| Chlorthalidone | Thioridazine may decrease the antihypertensive activities of Chlorthalidone. |
| Nitroprusside | Thioridazine may decrease the antihypertensive activities of Nitroprusside. |
| Minoxidil | Thioridazine may decrease the antihypertensive activities of Minoxidil. |
| Bendroflumethiazide | Thioridazine may decrease the antihypertensive activities of Bendroflumethiazide. |
| Fosinopril | Thioridazine may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Thioridazine may decrease the antihypertensive activities of Trandolapril. |
| Metolazone | Thioridazine may decrease the antihypertensive activities of Metolazone. |
| Benazepril | Thioridazine may decrease the antihypertensive activities of Benazepril. |
| Bosentan | Thioridazine may decrease the antihypertensive activities of Bosentan. |
| Enalapril | Thioridazine may decrease the antihypertensive activities of Enalapril. |
| Cyclothiazide | Thioridazine may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Thioridazine may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Thioridazine may decrease the antihypertensive activities of Mecamylamine. |
| Eplerenone | Thioridazine may decrease the antihypertensive activities of Eplerenone. |
| Lisinopril | Thioridazine may decrease the antihypertensive activities of Lisinopril. |
| Nitroglycerin | Thioridazine may decrease the antihypertensive activities of Nitroglycerin. |
| Hydroflumethiazide | Thioridazine may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Thioridazine may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Thioridazine may decrease the antihypertensive activities of Perindopril. |
| Candesartan cilexetil | Thioridazine may decrease the antihypertensive activities of Candesartan cilexetil. |
| Eprosartan | Thioridazine may decrease the antihypertensive activities of Eprosartan. |
| Chlorothiazide | Thioridazine may decrease the antihypertensive activities of Chlorothiazide. |
| Quinapril | Thioridazine may decrease the antihypertensive activities of Quinapril. |
| Omapatrilat | Thioridazine may decrease the antihypertensive activities of Omapatrilat. |
| Trichlormethiazide | Thioridazine may decrease the antihypertensive activities of Trichlormethiazide. |
| Deserpidine | Thioridazine may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Thioridazine may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Thioridazine may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Thioridazine may decrease the antihypertensive activities of Diazoxide. |
| Guanethidine | Thioridazine may decrease the antihypertensive activities of Guanethidine. |
| Rescinnamine | Thioridazine may decrease the antihypertensive activities of Rescinnamine. |
| Epoprostenol | Thioridazine may decrease the antihypertensive activities of Epoprostenol. |
| Hydralazine | Thioridazine may decrease the antihypertensive activities of Hydralazine. |
| Polythiazide | Thioridazine may decrease the antihypertensive activities of Polythiazide. |
| Cilazapril | Thioridazine may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Thioridazine may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Thioridazine may decrease the antihypertensive activities of Spirapril. |
| Tienilic acid | Thioridazine may decrease the antihypertensive activities of Tienilic acid. |
| Ambrisentan | Thioridazine may decrease the antihypertensive activities of Ambrisentan. |
| Diethylnorspermine | Thioridazine may decrease the antihypertensive activities of Diethylnorspermine. |
| Pinacidil | Thioridazine may decrease the antihypertensive activities of Pinacidil. |
| Temocapril | Thioridazine may decrease the antihypertensive activities of Temocapril. |
| Macitentan | Thioridazine may decrease the antihypertensive activities of Macitentan. |
| Aliskiren | Thioridazine may decrease the antihypertensive activities of Aliskiren. |
| Rauwolfia serpentina root | Thioridazine may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Thioridazine may decrease the antihypertensive activities of Enalaprilat. |
| Angiotensin 1-7 | Thioridazine may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Thioridazine may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Thioridazine may decrease the antihypertensive activities of BQ-123. |
| Dihydralazine | Thioridazine may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Thioridazine may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Thioridazine may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Thioridazine may decrease the antihypertensive activities of Delapril. |
| Vincamine | Thioridazine may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Thioridazine may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Thioridazine may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Thioridazine may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Thioridazine may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Thioridazine may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Thioridazine may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Thioridazine may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Thioridazine may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Thioridazine may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Thioridazine may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Thioridazine may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Thioridazine may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Thioridazine may decrease the antihypertensive activities of Candesartan. |
| Tocopherylquinone | Thioridazine may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Thioridazine may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Thioridazine may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Thioridazine may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Thioridazine may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Thioridazine may decrease the antihypertensive activities of Quinaprilat. |
| Torasemide | Thioridazine may decrease the antihypertensive activities of Torasemide. |
| Irbesartan | Thioridazine may decrease the antihypertensive activities of Irbesartan. |
| Captopril | Thioridazine may decrease the antihypertensive activities of Captopril. |
| Riociguat | Thioridazine may decrease the antihypertensive activities of Riociguat. |
| Selexipag | Thioridazine may decrease the antihypertensive activities of Selexipag. |
| Levamlodipine | Thioridazine may decrease the antihypertensive activities of Levamlodipine. |
| Buthiazide | Thioridazine may decrease the antihypertensive activities of Buthiazide. |
| Buprenorphine | Thioridazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Thioridazine. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Thioridazine. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Thioridazine. |
| Hydrocodone | Thioridazine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Magnesium sulfate | The therapeutic efficacy of Thioridazine can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Thioridazine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Thioridazine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Thioridazine. |
| Orphenadrine | Thioridazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |