Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Aprepitant. |
| Brexpiprazole | The metabolism of Brexpiprazole can be decreased when combined with Aprepitant. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Aprepitant. |
| Everolimus | The metabolism of Everolimus can be decreased when combined with Aprepitant. |
| Flibanserin | The metabolism of Flibanserin can be decreased when combined with Aprepitant. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Aprepitant. |
| Ivabradine | The metabolism of Ivabradine can be decreased when combined with Aprepitant. |
| Ivacaftor | The metabolism of Ivacaftor can be decreased when combined with Aprepitant. |
| Lurasidone | The metabolism of Lurasidone can be decreased when combined with Aprepitant. |
| Naloxegol | The metabolism of Naloxegol can be decreased when combined with Aprepitant. |
| Olaparib | The metabolism of Olaparib can be decreased when combined with Aprepitant. |
| Ranolazine | The metabolism of Ranolazine can be decreased when combined with Aprepitant. |
| Sonidegib | The metabolism of Sonidegib can be decreased when combined with Aprepitant. |
| Avanafil | The metabolism of Avanafil can be decreased when combined with Aprepitant. |
| Eplerenone | The metabolism of Eplerenone can be decreased when combined with Aprepitant. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Aprepitant. |
| Fentanyl | The metabolism of Fentanyl can be decreased when combined with Aprepitant. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Aprepitant. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Aprepitant. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Aprepitant. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Aprepitant. |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with Aprepitant. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Aprepitant. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with Aprepitant. |
| Octylphenoxy polyethoxyethanol | The serum concentration of Octylphenoxy polyethoxyethanol can be decreased when it is combined with Aprepitant. |
| Trestolone | The serum concentration of Trestolone can be decreased when it is combined with Aprepitant. |
| Nonoxynol-9 | The serum concentration of Nonoxynol-9 can be decreased when it is combined with Aprepitant. |
| Cloprostenol | The serum concentration of Cloprostenol can be decreased when it is combined with Aprepitant. |
| Gossypol | The serum concentration of Gossypol can be decreased when it is combined with Aprepitant. |
| Ormeloxifene | The serum concentration of Ormeloxifene can be decreased when it is combined with Aprepitant. |
| Norgestrienone | The serum concentration of Norgestrienone can be decreased when it is combined with Aprepitant. |
| Norethindrone enanthate | The serum concentration of Norethindrone enanthate can be decreased when it is combined with Aprepitant. |
| Segesterone acetate | The serum concentration of Segesterone acetate can be decreased when it is combined with Aprepitant. |
| Etonogestrel | The serum concentration of Etonogestrel can be decreased when it is combined with Aprepitant. |
| Megestrol acetate | The serum concentration of Megestrol acetate can be decreased when it is combined with Aprepitant. |
| Ethynodiol diacetate | The serum concentration of Ethynodiol diacetate can be decreased when it is combined with Aprepitant. |
| Ethinylestradiol | The serum concentration of Ethinylestradiol can be decreased when it is combined with Aprepitant. |
| Norelgestromin | The serum concentration of Norelgestromin can be decreased when it is combined with Aprepitant. |
| Ulipristal | The serum concentration of Ulipristal can be decreased when it is combined with Aprepitant. |
| Dienogest | The serum concentration of Dienogest can be decreased when it is combined with Aprepitant. |
| Norethynodrel | The serum concentration of Norethynodrel can be decreased when it is combined with Aprepitant. |
| Norgestrel | The serum concentration of Norgestrel can be decreased when it is combined with Aprepitant. |
| Gestrinone | The serum concentration of Gestrinone can be decreased when it is combined with Aprepitant. |
| Nomegestrol | The serum concentration of Nomegestrol can be decreased when it is combined with Aprepitant. |
| Chlormadinone | The serum concentration of Chlormadinone can be decreased when it is combined with Aprepitant. |
| Quingestanol | The serum concentration of Quingestanol can be decreased when it is combined with Aprepitant. |
| Demegestone | The serum concentration of Demegestone can be decreased when it is combined with Aprepitant. |
| Etynodiol | The serum concentration of Etynodiol can be decreased when it is combined with Aprepitant. |
| Nomegestrol acetate | The serum concentration of Nomegestrol acetate can be decreased when it is combined with Aprepitant. |
| Diethylstilbestrol | The serum concentration of Diethylstilbestrol can be decreased when it is combined with Aprepitant. |
| Medroxyprogesterone acetate | The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Aprepitant. |
| Norgestimate | The serum concentration of Norgestimate can be decreased when it is combined with Aprepitant. |
| Cyproterone acetate | The serum concentration of Cyproterone acetate can be decreased when it is combined with Aprepitant. |
| Desogestrel | The serum concentration of Desogestrel can be decreased when it is combined with Aprepitant. |
| Mestranol | The serum concentration of Mestranol can be decreased when it is combined with Aprepitant. |
| Estrone sulfate | The serum concentration of Estrone sulfate can be decreased when it is combined with Aprepitant. |
| Lynestrenol | The serum concentration of Lynestrenol can be decreased when it is combined with Aprepitant. |
| Alfuzosin | The metabolism of Alfuzosin can be decreased when combined with Aprepitant. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Aprepitant. |
| Warfarin | The serum concentration of Warfarin can be increased when it is combined with Aprepitant. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be increased when it is combined with Aprepitant. |
| (R)-warfarin | The serum concentration of (R)-warfarin can be increased when it is combined with Aprepitant. |
| R,S-Warfarin alcohol | The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Aprepitant. |
| S,R-Warfarin alcohol | The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Aprepitant. |
| (S)-Warfarin | The serum concentration of (S)-Warfarin can be increased when it is combined with Aprepitant. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Aprepitant. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Aprepitant. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Aprepitant. |
| Cobimetinib | The metabolism of Cobimetinib can be decreased when combined with Aprepitant. |
| Pitolisant | The serum concentration of Aprepitant can be decreased when it is combined with Pitolisant. |
| Aripiprazole | The metabolism of Aripiprazole can be decreased when combined with Aprepitant. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be decreased when combined with Aprepitant. |
| Metreleptin | The metabolism of Aprepitant can be increased when combined with Metreleptin. |
| Tezacaftor | The metabolism of Tezacaftor can be decreased when combined with Aprepitant. |
| Vincristine | The metabolism of Vincristine can be decreased when combined with Aprepitant. |
| Irinotecan | The metabolism of Irinotecan can be decreased when combined with Aprepitant. |
| Dasatinib | The metabolism of Dasatinib can be decreased when combined with Aprepitant. |
| Romidepsin | The metabolism of Romidepsin can be decreased when combined with Aprepitant. |
| Axitinib | The metabolism of Axitinib can be decreased when combined with Aprepitant. |
| Cabazitaxel | The metabolism of Cabazitaxel can be decreased when combined with Aprepitant. |
| Ponatinib | The metabolism of Ponatinib can be decreased when combined with Aprepitant. |
| Copanlisib | The metabolism of Copanlisib can be decreased when combined with Aprepitant. |
| Bortezomib | The metabolism of Bortezomib can be decreased when combined with Aprepitant. |
| Trabectedin | The metabolism of Trabectedin can be decreased when combined with Aprepitant. |
| Erdafitinib | The metabolism of Erdafitinib can be decreased when combined with Aprepitant. |
| Dofetilide | The metabolism of Dofetilide can be decreased when combined with Aprepitant. |
| Theophylline | The metabolism of Theophylline can be decreased when combined with Aprepitant. |
| Busulfan | The metabolism of Busulfan can be decreased when combined with Aprepitant. |
| Aminophylline | The metabolism of Aminophylline can be decreased when combined with Aprepitant. |
| Digitoxin | The metabolism of Digitoxin can be decreased when combined with Aprepitant. |
| Tianeptine | The metabolism of Tianeptine can be decreased when combined with Aprepitant. |
| Carbamazepine | The metabolism of Carbamazepine can be decreased when combined with Aprepitant. |
| Paclitaxel | The metabolism of Paclitaxel can be decreased when combined with Aprepitant. |
| Sorafenib | The metabolism of Sorafenib can be decreased when combined with Aprepitant. |
| Teniposide | The metabolism of Teniposide can be decreased when combined with Aprepitant. |
| Erlotinib | The metabolism of Erlotinib can be decreased when combined with Aprepitant. |
| Cyclophosphamide | The metabolism of Cyclophosphamide can be decreased when combined with Aprepitant. |
| Tamoxifen | The metabolism of Tamoxifen can be decreased when combined with Aprepitant. |
| Etoposide | The metabolism of Etoposide can be decreased when combined with Aprepitant. |
| Ifosfamide | The metabolism of Ifosfamide can be decreased when combined with Aprepitant. |