Peringatan Keamanan

Symptoms of overdose include dizziness, general discomfort, headache, nausea, and vomiting.

Nilutamide

DB00665

small molecule approved investigational

Deskripsi

Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.

Struktur Molekul 2D

Berat 317.2207
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 38.0-59.1 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly and completely absorbed, yielding high and persistent plasma concentrations.

Metabolisme

The results of a human metabolism study using 14C-radiolabelled tablets show that nilutamide is extensively metabolized and less than 2% of the drug is excreted unchanged in urine after 5 days.

Rute Eliminasi

Nilutamide is extensively metabolized andless than 2% of the drug is excreted unchanged in urine after 5 days. Fecal elimination is negligible, ranging from 1.4% to 7% of the dose after 4 to 5 days.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take separate from meals. Take before breakfast.

Interaksi Obat

1049 Data
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Nilutamide.
Dabrafenib The serum concentration of Nilutamide can be decreased when it is combined with Dabrafenib.
Luliconazole The serum concentration of Nilutamide can be increased when it is combined with Luliconazole.
Lumacaftor The serum concentration of Nilutamide can be decreased when it is combined with Lumacaftor.
Choline C 11 Nilutamide may decrease effectiveness of Choline C 11 as a diagnostic agent.
Capromab pendetide Nilutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Fluoxetine The metabolism of Nilutamide can be decreased when combined with Fluoxetine.
Fluvoxamine The metabolism of Nilutamide can be decreased when combined with Fluvoxamine.
Ticlopidine The metabolism of Nilutamide can be decreased when combined with Ticlopidine.
Isoniazid The metabolism of Nilutamide can be decreased when combined with Isoniazid.
Gemfibrozil The metabolism of Nilutamide can be decreased when combined with Gemfibrozil.
Stiripentol The metabolism of Nilutamide can be decreased when combined with Stiripentol.
Lansoprazole The metabolism of Nilutamide can be decreased when combined with Lansoprazole.
Zafirlukast The metabolism of Nilutamide can be decreased when combined with Zafirlukast.
Chloramphenicol The metabolism of Nilutamide can be decreased when combined with Chloramphenicol.
Delavirdine The metabolism of Nilutamide can be decreased when combined with Delavirdine.
Miconazole The metabolism of Nilutamide can be decreased when combined with Miconazole.
Efavirenz The metabolism of Nilutamide can be decreased when combined with Efavirenz.
Eslicarbazepine acetate The metabolism of Nilutamide can be decreased when combined with Eslicarbazepine acetate.
Apalutamide The serum concentration of Nilutamide can be increased when it is combined with Apalutamide.
Cyclosporine Cyclosporine may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Azapropazone Azapropazone may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Salicylamide Salicylamide may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Kebuzone Kebuzone may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Isoxicam Isoxicam may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Indoprofen Indoprofen may decrease the excretion rate of Nilutamide which could result in a higher serum level.

Target Protein

Androgen receptor AR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 12686822
    Kassouf W, Tanguay S, Aprikian AG: Nilutamide as second line hormone therapy for prostate cancer after androgen ablation fails. J Urol. 2003 May;169(5):1742-4.
  • PMID: 17576447
    Lukka H, Waldron T, Klotz L, Winquist E, Trachtenberg J: Maximal androgen blockade for the treatment of metastatic prostate cancer--a systematic review. Curr Oncol. 2006 Jun;13(3):81-93.

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