Peringatan Keamanan

Can lead to signs of irritation such as burning sensation, itching or skin rash at the site of application; hypersensitivity reactions.

Flumethasone

DB00663

small molecule approved vet_approved

Deskripsi

Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Struktur Molekul 2D

Berat 410.458
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Minimal if applied topically

Metabolisme

Primarily hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

715 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Flumethasone.
Natalizumab The risk or severity of immunosuppression can be increased when Flumethasone is combined with Natalizumab.
Pimecrolimus The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Flumethasone.
Roflumilast Roflumilast may increase the immunosuppressive activities of Flumethasone.
Sipuleucel-T The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Flumethasone.
Ceritinib The risk or severity of hyperglycemia can be increased when Flumethasone is combined with Ceritinib.
Corticorelin ovine triflutate The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Flumethasone.
Deferasirox The risk or severity of gastrointestinal ulceration and gastrointestinal irritation can be increased when Flumethasone is combined with Deferasirox.
Amphotericin B The risk or severity of hypokalemia can be increased when Flumethasone is combined with Amphotericin B.
Isoetharine The risk or severity of hypokalemia can be increased when Flumethasone is combined with Isoetharine.
Norepinephrine The risk or severity of hypokalemia can be increased when Flumethasone is combined with Norepinephrine.
Phenylpropanolamine The risk or severity of hypokalemia can be increased when Flumethasone is combined with Phenylpropanolamine.
Epinephrine The risk or severity of hypokalemia can be increased when Flumethasone is combined with Epinephrine.
Orciprenaline The risk or severity of hypokalemia can be increased when Flumethasone is combined with Orciprenaline.
Dobutamine The risk or severity of hypokalemia can be increased when Flumethasone is combined with Dobutamine.
Ritodrine The risk or severity of hypokalemia can be increased when Flumethasone is combined with Ritodrine.
Bitolterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Bitolterol.
Salmeterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Salmeterol.
Formoterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Formoterol.
Albuterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Salbutamol.
Isoprenaline The therapeutic efficacy of Isoprenaline can be decreased when used in combination with Flumethasone.
Arbutamine The risk or severity of hypokalemia can be increased when Flumethasone is combined with Arbutamine.
Arformoterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Arformoterol.
Fenoterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Fenoterol.
Pirbuterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypokalemia can be increased when Flumethasone is combined with Ephedra sinica root.
Procaterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Procaterol.
Clenbuterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Clenbuterol.
Celiprolol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Celiprolol.
Indacaterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Indacaterol.
Droxidopa The risk or severity of hypokalemia can be increased when Flumethasone is combined with Droxidopa.
Protokylol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Protokylol.
Hexoprenaline The risk or severity of hypokalemia can be increased when Flumethasone is combined with Hexoprenaline.
Olodaterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Olodaterol.
Vilanterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Vilanterol.
Doxofylline The risk or severity of hypokalemia can be increased when Flumethasone is combined with Doxofylline.
Racepinephrine The risk or severity of hypokalemia can be increased when Flumethasone is combined with Racepinephrine.
Etafedrine The risk or severity of hypokalemia can be increased when Flumethasone is combined with Etafedrine.
PF-00610355 The risk or severity of hypokalemia can be increased when Flumethasone is combined with PF-00610355.
Abediterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Abediterol.
Batefenterol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Batefenterol.
Levosalbutamol The risk or severity of hypokalemia can be increased when Flumethasone is combined with Levosalbutamol.
Mitotane The serum concentration of Flumethasone can be decreased when it is combined with Mitotane.
Dicoumarol Flumethasone may increase the anticoagulant activities of Dicoumarol.
Phenindione Flumethasone may increase the anticoagulant activities of Phenindione.
Warfarin Flumethasone may increase the anticoagulant activities of Warfarin.
Phenprocoumon Flumethasone may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Flumethasone may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Flumethasone may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Flumethasone may increase the anticoagulant activities of Coumarin.
(R)-warfarin Flumethasone may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Flumethasone may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Flumethasone may increase the anticoagulant activities of Fluindione.
Clorindione Flumethasone may increase the anticoagulant activities of Clorindione.
Diphenadione Flumethasone may increase the anticoagulant activities of Diphenadione.
Tioclomarol Flumethasone may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Flumethasone may increase the anticoagulant activities of (S)-Warfarin.
Sulfamethoxazole The risk or severity of myelosuppression can be increased when Sulfamethoxazole is combined with Flumethasone.
Leflunomide The risk or severity of adverse effects can be increased when Flumethasone is combined with Leflunomide.
Tofacitinib Flumethasone may increase the immunosuppressive activities of Tofacitinib.
Trastuzumab The risk or severity of neutropenia can be increased when Trastuzumab is combined with Flumethasone.
Fingolimod Flumethasone may increase the immunosuppressive activities of Fingolimod.
Nicorandil The risk or severity of ulceration can be increased when Flumethasone is combined with Nicorandil.
Tacrolimus Tacrolimus may increase the immunosuppressive activities of Flumethasone.
Calcitriol The therapeutic efficacy of Calcitriol can be decreased when used in combination with Flumethasone.
Calcifediol The therapeutic efficacy of Calcifediol can be decreased when used in combination with Flumethasone.
Ergocalciferol The therapeutic efficacy of Ergocalciferol can be decreased when used in combination with Flumethasone.
Cholecalciferol The therapeutic efficacy of Cholecalciferol can be decreased when used in combination with Flumethasone.
Paricalcitol The therapeutic efficacy of Paricalcitol can be decreased when used in combination with Flumethasone.
Dihydrotachysterol The therapeutic efficacy of Dihydrotachysterol can be decreased when used in combination with Flumethasone.
Alfacalcidol The therapeutic efficacy of Alfacalcidol can be decreased when used in combination with Flumethasone.
Seocalcitol The therapeutic efficacy of Seocalcitol can be decreased when used in combination with Flumethasone.
Inecalcitol The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Flumethasone.
Becocalcidiol The therapeutic efficacy of Becocalcidiol can be decreased when used in combination with Flumethasone.
Eldecalcitol The therapeutic efficacy of Eldecalcitol can be decreased when used in combination with Flumethasone.
1alpha,24S-Dihydroxyvitamin D2 The therapeutic efficacy of 1alpha,24S-Dihydroxyvitamin D2 can be decreased when used in combination with Flumethasone.
Elocalcitol The therapeutic efficacy of Elocalcitol can be decreased when used in combination with Flumethasone.
Maxacalcitol The therapeutic efficacy of Maxacalcitol can be decreased when used in combination with Flumethasone.
Doxercalciferol The therapeutic efficacy of Doxercalciferol can be decreased when used in combination with Flumethasone.
Vitamin D The therapeutic efficacy of Vitamin D can be decreased when used in combination with Flumethasone.
1alpha-Hydroxyvitamin D5 The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Flumethasone.
Previtamin D(3) The therapeutic efficacy of Previtamin D(3) can be decreased when used in combination with Flumethasone.
Mifepristone The serum concentration of Flumethasone can be increased when it is combined with Mifepristone.
Diethylstilbestrol The serum concentration of Flumethasone can be increased when it is combined with Diethylstilbestrol.
Etonogestrel The serum concentration of Flumethasone can be increased when it is combined with Etonogestrel.
Desogestrel The serum concentration of Flumethasone can be increased when it is combined with Desogestrel.
Megestrol acetate The serum concentration of Flumethasone can be increased when it is combined with Megestrol acetate.
Levonorgestrel The serum concentration of Flumethasone can be increased when it is combined with Levonorgestrel.
Progesterone The serum concentration of Flumethasone can be increased when it is combined with Progesterone.
Medroxyprogesterone acetate The serum concentration of Flumethasone can be increased when it is combined with Medroxyprogesterone acetate.
Norethisterone The serum concentration of Flumethasone can be increased when it is combined with Norethisterone.
Estradiol The serum concentration of Flumethasone can be increased when it is combined with Estradiol.
Ethynodiol diacetate The serum concentration of Flumethasone can be increased when it is combined with Ethynodiol diacetate.
Norgestimate The serum concentration of Flumethasone can be increased when it is combined with Norgestimate.
Ethinylestradiol The serum concentration of Flumethasone can be increased when it is combined with Ethinylestradiol.
Mestranol The serum concentration of Flumethasone can be increased when it is combined with Mestranol.
Drospirenone The serum concentration of Flumethasone can be increased when it is combined with Drospirenone.
Estrone sulfate The serum concentration of Flumethasone can be increased when it is combined with Estrone sulfate.
Octylphenoxy polyethoxyethanol The serum concentration of Flumethasone can be increased when it is combined with Octylphenoxy polyethoxyethanol.
Cyproterone acetate The serum concentration of Flumethasone can be increased when it is combined with Cyproterone acetate.

Target Protein

Glucocorticoid receptor NR3C1
Steroid hormone receptor ERR2 ESRRB
Estrogen-related receptor gamma ESRRG
Steroid hormone receptor ERR1 ESRRA

Referensi & Sumber

Synthesis reference: Lincoln, F.H., Schneider, W.P. and Spero, G.B.; U.S. Patent 3,557,158; January 19, 1971; assigned to The Upjohn Co.

Contoh Produk & Brand

Produk: 6 • International brands: 4
Produk
  • Locacorten .03%
    Cream • .03 % • Topical • Canada • Approved
  • Locacorten Vioform
    Cream • - • Topical • Canada • Approved
  • Locacorten Vioform
    Ointment • - • Topical • Canada • Approved
  • Locacorten Vioform Eardrops
    Solution / drops • - • Auricular (otic) • Canada • Approved
  • Locasalen
    Ointment • - • Topical • Canada • Approved
  • PMS-flumethasone-clioquinol
    Solution / drops • - • Auricular (otic) • Canada • Generic • Approved
International Brands
  • Cerson — Riemser
  • Locacorten — Novartis
  • Locorten — Novartis
  • Testohgen — Maeda Yakuhin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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