Peringatan Keamanan

Oral LD50 in mice is 1600 mg/kg.

Trimethobenzamide

DB00662

small molecule approved investigational

Deskripsi

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Struktur Molekul 2D

Berat 388.4574
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The mean elimination half-life of trimethobenzamide is 7 to 9 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Metabolisme

Hepatic.

Rute Eliminasi

Between 30 – 50% of a single dose in humans is excreted unchanged in the urine within 48–72 hours.

Interaksi Makanan

1 Data
  • 1. Avoid alcohol. Ingestion of alcohol may increase the CNS depressant effects of trimethobenzamide causing drowsiness.

Interaksi Obat

670 Data
Buprenorphine Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Hydrocodone Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Magnesium sulfate The therapeutic efficacy of Trimethobenzamide can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Trimethobenzamide may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Mirtazapine Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Orphenadrine Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Pramipexole Trimethobenzamide may increase the sedative activities of Pramipexole.
Ropinirole Trimethobenzamide may increase the sedative activities of Ropinirole.
Rotigotine Trimethobenzamide may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Trimethobenzamide.
Sodium oxybate Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Thalidomide Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Trimethobenzamide.
Ethanol Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Fluvoxamine The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Trazodone.
Sertraline The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Alaproclate.
Paroxetine The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Paroxetine.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Trimethobenzamide.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Trimethobenzamide.
Clozapine The risk or severity of CNS depression can be increased when Clozapine is combined with Trimethobenzamide.
Promazine The risk or severity of CNS depression can be increased when Promazine is combined with Trimethobenzamide.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Trimethobenzamide.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Trimethobenzamide.
Chlorpromazine The risk or severity of CNS depression can be increased when Chlorpromazine is combined with Trimethobenzamide.
Gallamine triethiodide The risk or severity of CNS depression can be increased when Gallamine triethiodide is combined with Trimethobenzamide.
Triflupromazine The risk or severity of CNS depression can be increased when Triflupromazine is combined with Trimethobenzamide.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Trimethobenzamide.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Trimethobenzamide.
Lamotrigine The risk or severity of CNS depression can be increased when Lamotrigine is combined with Trimethobenzamide.
Rocuronium The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Rocuronium.
Scopolamine The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Scopolamine.
Clidinium The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Clidinium.
Propiomazine The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Propiomazine.
Brompheniramine The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Brompheniramine.
Flupentixol The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Flupentixol.
Maprotiline The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Maprotiline.
Promethazine The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Promethazine.
Diphenhydramine The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Diphenhydramine.
Doxepin The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Doxepin.
Desipramine The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Desipramine.
Quetiapine The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Quetiapine.
Mivacurium The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Mivacurium.
Aripiprazole The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Aripiprazole.
Chlorprothixene The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Chlorprothixene.
Metocurine The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Metocurine.
Pancuronium The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Pancuronium.
Pipecuronium The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Pipecuronium.
Rapacuronium The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Rapacuronium.
Pizotifen The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Pizotifen.
Benactyzine The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Benactyzine.
Dosulepin The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Dosulepin.
Emepronium The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Emepronium.
Zopiclone The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Trimethobenzamide.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Trimethobenzamide.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Trimethobenzamide.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Trimethobenzamide.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Trimethobenzamide.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Trimethobenzamide.
Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Trimethobenzamide.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Trimethobenzamide.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Trimethobenzamide.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Trimethobenzamide.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Trimethobenzamide.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Trimethobenzamide.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Trimethobenzamide.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Trimethobenzamide.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Trimethobenzamide.
Phenytoin The risk or severity of CNS depression can be increased when Phenytoin is combined with Trimethobenzamide.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Trimethobenzamide.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Trimethobenzamide.

Target Protein

D(2) dopamine receptor DRD2

Referensi & Sumber

Synthesis reference: Vittorio Rossetti, Alessandro Dondoni, Giancarlo Fantin, "N-(4-Hydroxybenzyl)-3,4,5-trimethoxybenzamide and method for producing trimethobenzamide chlorohydrate." U.S. Patent US4507499, issued December, 1969.
Artikel (PubMed)
  • PMID: 7400373
    Hurley JD, Eshelman FN: Trimethobenzamide HCl in the treatment of nausea and vomiting associated with antineoplastic chemotherapy. J Clin Pharmacol. 1980 May-Jun;20(5-6 Pt 1):352-6.
  • PMID: 5908416
    Dundee JW, Halliday F, Nicholl RM, Moore J: Studies of drugs given before anaesthesia. X. Two non-phenothiazine anti-emetics--cyclizine and trimethobenzamide. Br J Anaesth. 1966 Jan;38(1):50-7.

Contoh Produk & Brand

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Menampilkan 8 dari 42 produk.
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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