Mecamylamine

DB00657

small molecule approved investigational

Deskripsi

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Struktur Molekul 2D

Berat 167.2911
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Mecamylamine is almost completely absorbed from the gastrointestinal tract

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Mecamylamine is excreted slowly in the urine in the unchanged form. The rate of its renal elimination is influenced markedly by urinary pH. Alkalinization of the urine reduces, and acidification promotes, renal excretion of mecamylamine. Mecamylamine crosses the blood-brain and placental barriers.

Interaksi Makanan

2 Data
  • 1. Avoid excessive or chronic alcohol consumption. The ingestion of alcohol may potentiate the actions of mecamylamine.
  • 2. Take after a meal. This slows mecamylamine absorption allowing for a gradual reduction in blood pressure. Take consistently at the same time in regard to meals.

Interaksi Obat

1490 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Mecamylamine is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Mecamylamine is combined with Levodopa.
Risperidone Mecamylamine may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Mecamylamine.
Amifostine Mecamylamine may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Mecamylamine.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Mecamylamine.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Mecamylamine.
Obinutuzumab Mecamylamine may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Mecamylamine.
Rituximab Mecamylamine may increase the hypotensive activities of Rituximab.
Phentermine Phentermine may decrease the antihypertensive activities of Mecamylamine.
Midodrine Midodrine may decrease the antihypertensive activities of Mecamylamine.
Eletriptan Eletriptan may decrease the antihypertensive activities of Mecamylamine.
Isoetharine Isoetharine may decrease the antihypertensive activities of Mecamylamine.
Methysergide Methysergide may decrease the antihypertensive activities of Mecamylamine.
Cabergoline Cabergoline may decrease the antihypertensive activities of Mecamylamine.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Mecamylamine.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Mecamylamine.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Mecamylamine.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Mecamylamine.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Mecamylamine.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Mecamylamine.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Mecamylamine.
Promazine Promazine may decrease the antihypertensive activities of Mecamylamine.
Droperidol Droperidol may decrease the antihypertensive activities of Mecamylamine.
Doxapram Doxapram may decrease the antihypertensive activities of Mecamylamine.
Atropine Atropine may decrease the antihypertensive activities of Mecamylamine.
Lisuride Lisuride may decrease the antihypertensive activities of Mecamylamine.
Metaraminol Metaraminol may decrease the antihypertensive activities of Mecamylamine.
Trazodone Trazodone may decrease the antihypertensive activities of Mecamylamine.
Epinephrine Epinephrine may decrease the antihypertensive activities of Mecamylamine.
Ergotamine Ergotamine may decrease the antihypertensive activities of Mecamylamine.
Nicergoline Nicergoline may decrease the antihypertensive activities of Mecamylamine.
Methoxamine Methoxamine may decrease the antihypertensive activities of Mecamylamine.
Propiomazine Propiomazine may decrease the antihypertensive activities of Mecamylamine.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Mecamylamine.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Mecamylamine.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Mecamylamine.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Mecamylamine.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Mecamylamine.
Ritodrine Ritodrine may decrease the antihypertensive activities of Mecamylamine.
Flupentixol Flupentixol may decrease the antihypertensive activities of Mecamylamine.
Bitolterol Bitolterol may decrease the antihypertensive activities of Mecamylamine.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Mecamylamine.
Salmeterol Salmeterol may decrease the antihypertensive activities of Mecamylamine.
Naratriptan Naratriptan may decrease the antihypertensive activities of Mecamylamine.
Formoterol Formoterol may decrease the antihypertensive activities of Mecamylamine.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Mecamylamine.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Mecamylamine.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Mecamylamine.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Mecamylamine.
Arbutamine Arbutamine may decrease the antihypertensive activities of Mecamylamine.
Dutasteride Dutasteride may decrease the antihypertensive activities of Mecamylamine.
Propafenone Propafenone may decrease the antihypertensive activities of Mecamylamine.
Pergolide Pergolide may decrease the antihypertensive activities of Mecamylamine.
Finasteride Finasteride may decrease the antihypertensive activities of Mecamylamine.
Ergometrine Ergometrine may decrease the antihypertensive activities of Mecamylamine.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Mecamylamine.
Fenoterol Fenoterol may decrease the antihypertensive activities of Mecamylamine.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Mecamylamine.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Mecamylamine.
Ephedrine Ephedrine may decrease the antihypertensive activities of Mecamylamine.
Mephentermine Mephentermine may decrease the antihypertensive activities of Mecamylamine.
Procaterol Procaterol may decrease the antihypertensive activities of Mecamylamine.
Yohimbine Yohimbine may decrease the antihypertensive activities of Mecamylamine.
Methotrimeprazine Methotrimeprazine may decrease the antihypertensive activities of Mecamylamine.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Mecamylamine.
MMDA MMDA may decrease the antihypertensive activities of Mecamylamine.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Mecamylamine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Mecamylamine.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Mecamylamine.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Mecamylamine.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Mecamylamine.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Mecamylamine.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Mecamylamine.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Mecamylamine.
Solifenacin Solifenacin may decrease the antihypertensive activities of Mecamylamine.
Periciazine Periciazine may decrease the antihypertensive activities of Mecamylamine.
Acepromazine Acepromazine may decrease the antihypertensive activities of Mecamylamine.
Thioproperazine Thioproperazine may decrease the antihypertensive activities of Mecamylamine.
Zuclopenthixol Zuclopenthixol may decrease the antihypertensive activities of Mecamylamine.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Mecamylamine.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Mecamylamine.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Mecamylamine.
Dronedarone Dronedarone may decrease the antihypertensive activities of Mecamylamine.
Flibanserin Flibanserin may decrease the antihypertensive activities of Mecamylamine.
Iloperidone Iloperidone may decrease the antihypertensive activities of Mecamylamine.
Indacaterol Indacaterol may decrease the antihypertensive activities of Mecamylamine.
Amibegron Amibegron may decrease the antihypertensive activities of Mecamylamine.
Naluzotan Naluzotan may decrease the antihypertensive activities of Mecamylamine.
Cariprazine Cariprazine may decrease the antihypertensive activities of Mecamylamine.
Mianserin Mianserin may decrease the antihypertensive activities of Mecamylamine.
Nylidrin Nylidrin may decrease the antihypertensive activities of Mecamylamine.
Pizotifen Pizotifen may decrease the antihypertensive activities of Mecamylamine.
Solabegron Solabegron may decrease the antihypertensive activities of Mecamylamine.
Asenapine Asenapine may decrease the antihypertensive activities of Mecamylamine.
Esmirtazapine Esmirtazapine may decrease the antihypertensive activities of Mecamylamine.
Vilazodone Vilazodone may decrease the antihypertensive activities of Mecamylamine.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Mecamylamine.

Target Protein

Neuronal acetylcholine receptor subunit alpha-2 CHRNA2
Neuronal acetylcholine receptor subunit alpha-7 CHRNA7
Neuronal acetylcholine receptor subunit alpha-4 CHRNA4
Neuronal acetylcholine receptor subunit beta-2 CHRNB2

Referensi & Sumber

Synthesis reference: U.S. Patent 2,831,027.

Contoh Produk & Brand

Produk: 5 • International brands: 0
Produk
  • Inversine
    Tablet • 2.5 mg/1 • Oral • US • Approved
  • Mecamylamine Hydrochloride
    Tablet • 2.5 mg/1 • Oral • US • Generic • Approved
  • Mecamylamine Hydrochloride
    Tablet • 2.5 mg/1 • Oral • US • Generic • Approved
  • Vecamyl
    Tablet • 2.5 mg/1 • Oral • US • Generic • Approved
  • Vecamyl
    Tablet • 2.5 mg/1 • Oral • US • Generic • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul