Symptoms of overdose include nausea and vomiting. Estrogen related side effects include nausea, breast tenderness, fluid retention and edema, headaches and/or migraines, chloasma and poor contact lens fit. Estrogen hormone deficiency is associated with breakthrough bleeding, hypomenorrhea, irritability, depression and menopausal symptoms. Withdrawal bleeds may occur in females.
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Prasterone | The risk or severity of adverse effects can be increased when Prasterone is combined with Estrone. |
| Exemestane | The therapeutic efficacy of Exemestane can be decreased when used in combination with Estrone. |
| Lenalidomide | Estrone may increase the thrombogenic activities of Lenalidomide. |
| Ospemifene | The risk or severity of adverse effects can be increased when Estrone is combined with Ospemifene. |
| Ropinirole | Estrone may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy. |
| Thalidomide | Estrone may increase the thrombogenic activities of Thalidomide. |
| Cetuximab | Estrone may increase the thrombogenic activities of Cetuximab. |
| Human immunoglobulin G | Estrone may increase the thrombogenic activities of Human immunoglobulin G. |
| Omalizumab | Estrone may increase the thrombogenic activities of Omalizumab. |
| Gemtuzumab ozogamicin | Estrone may increase the thrombogenic activities of Gemtuzumab ozogamicin. |
| Indium In-111 satumomab pendetide | Estrone may increase the thrombogenic activities of Indium In-111 satumomab pendetide. |
| Trastuzumab | Estrone may increase the thrombogenic activities of Trastuzumab. |
| Rituximab | Estrone may increase the thrombogenic activities of Rituximab. |
| Basiliximab | Estrone may increase the thrombogenic activities of Basiliximab. |
| Muromonab | Estrone may increase the thrombogenic activities of Muromonab. |
| Digoxin Immune Fab (Ovine) | Estrone may increase the thrombogenic activities of Digoxin Immune Fab (Ovine). |
| Ibritumomab tiuxetan | Estrone may increase the thrombogenic activities of Ibritumomab tiuxetan. |
| Tositumomab | Estrone may increase the thrombogenic activities of Tositumomab. |
| Alemtuzumab | Estrone may increase the thrombogenic activities of Alemtuzumab. |
| Capromab pendetide | Estrone may increase the thrombogenic activities of Capromab pendetide. |
| Efalizumab | Estrone may increase the thrombogenic activities of Efalizumab. |
| Antithymocyte immunoglobulin (rabbit) | Estrone may increase the thrombogenic activities of Antithymocyte immunoglobulin (rabbit). |
| Natalizumab | Estrone may increase the thrombogenic activities of Natalizumab. |
| Palivizumab | Estrone may increase the thrombogenic activities of Palivizumab. |
| Daclizumab | Estrone may increase the thrombogenic activities of Daclizumab. |
| Bevacizumab | Estrone may increase the thrombogenic activities of Bevacizumab. |
| Technetium Tc-99m arcitumomab | Estrone may increase the thrombogenic activities of Technetium Tc-99m arcitumomab. |
| Eculizumab | Estrone may increase the thrombogenic activities of Eculizumab. |
| Panitumumab | Estrone may increase the thrombogenic activities of Panitumumab. |
| Ranibizumab | Estrone may increase the thrombogenic activities of Ranibizumab. |
| Galiximab | Estrone may increase the thrombogenic activities of Galiximab. |
| Pexelizumab | Estrone may increase the thrombogenic activities of Pexelizumab. |
| Epratuzumab | Estrone may increase the thrombogenic activities of Epratuzumab. |
| Bectumomab | Estrone may increase the thrombogenic activities of Bectumomab. |
| Oregovomab | Estrone may increase the thrombogenic activities of Oregovomab. |
| IGN311 | Estrone may increase the thrombogenic activities of IGN311. |
| Adecatumumab | Estrone may increase the thrombogenic activities of Adecatumumab. |
| Labetuzumab | Estrone may increase the thrombogenic activities of Labetuzumab. |
| Matuzumab | Estrone may increase the thrombogenic activities of Matuzumab. |
| Fontolizumab | Estrone may increase the thrombogenic activities of Fontolizumab. |
| Bavituximab | Estrone may increase the thrombogenic activities of Bavituximab. |
| CR002 | Estrone may increase the thrombogenic activities of CR002. |
| Rozrolimupab | Estrone may increase the thrombogenic activities of Rozrolimupab. |
| Girentuximab | Estrone may increase the thrombogenic activities of Girentuximab. |
| Obiltoxaximab | Estrone may increase the thrombogenic activities of Obiltoxaximab. |
| XTL-001 | Estrone may increase the thrombogenic activities of XTL-001. |
| NAV 1800 | Estrone may increase the thrombogenic activities of NAV 1800. |
| Briakinumab | Estrone may increase the thrombogenic activities of Briakinumab. |
| Otelixizumab | Estrone may increase the thrombogenic activities of Otelixizumab. |
| AMG 108 | Estrone may increase the thrombogenic activities of AMG 108. |
| Iratumumab | Estrone may increase the thrombogenic activities of Iratumumab. |
| Enokizumab | Estrone may increase the thrombogenic activities of Enokizumab. |
| Ramucirumab | Estrone may increase the thrombogenic activities of Ramucirumab. |
| Farletuzumab | Estrone may increase the thrombogenic activities of Farletuzumab. |
| Veltuzumab | Estrone may increase the thrombogenic activities of Veltuzumab. |
| Ustekinumab | Estrone may increase the thrombogenic activities of Ustekinumab. |
| PRO-542 | Estrone may increase the thrombogenic activities of PRO-542. |
| TNX-901 | Estrone may increase the thrombogenic activities of TNX-901. |
| Inotuzumab ozogamicin | Estrone may increase the thrombogenic activities of Inotuzumab ozogamicin. |
| RI 624 | Estrone may increase the thrombogenic activities of RI 624. |
| Stamulumab | Estrone may increase the thrombogenic activities of MYO-029. |
| CT-011 | Estrone may increase the thrombogenic activities of CT-011. |
| Leronlimab | Estrone may increase the thrombogenic activities of Leronlimab. |
| Glembatumumab vedotin | Estrone may increase the thrombogenic activities of Glembatumumab vedotin. |
| Olaratumab | Estrone may increase the thrombogenic activities of Olaratumab. |
| IPH 2101 | Estrone may increase the thrombogenic activities of IPH 2101. |
| TB-402 | Estrone may increase the thrombogenic activities of TB-402. |
| Caplacizumab | Estrone may increase the thrombogenic activities of Caplacizumab. |
| IMC-1C11 | Estrone may increase the thrombogenic activities of IMC-1C11. |
| Eldelumab | Estrone may increase the thrombogenic activities of Eldelumab. |
| Lumiliximab | Estrone may increase the thrombogenic activities of Lumiliximab. |
| Ipilimumab | Estrone may increase the thrombogenic activities of Ipilimumab. |
| Nimotuzumab | Estrone may increase the thrombogenic activities of Nimotuzumab. |
| Clenoliximab | Estrone may increase the thrombogenic activities of Clenoliximab. |
| BIIB015 | Estrone may increase the thrombogenic activities of BIIB015. |
| Sonepcizumab | Estrone may increase the thrombogenic activities of Sonepcizumab. |
| Motavizumab | Estrone may increase the thrombogenic activities of Motavizumab. |
| Elotuzumab | Estrone may increase the thrombogenic activities of Elotuzumab. |
| AVE9633 | Estrone may increase the thrombogenic activities of AVE9633. |
| Carotuximab | Estrone may increase the thrombogenic activities of Carotuximab. |
| XmAb 2513 | Estrone may increase the thrombogenic activities of XmAb 2513. |
| Coltuximab ravtansine | Estrone may increase the thrombogenic activities of Coltuximab ravtansine. |
| Lucatumumab | Estrone may increase the thrombogenic activities of Lucatumumab. |
| Pertuzumab | Estrone may increase the thrombogenic activities of Pertuzumab. |
| Siplizumab | Estrone may increase the thrombogenic activities of Siplizumab. |
| Apolizumab | Estrone may increase the thrombogenic activities of Apolizumab. |
| Sibrotuzumab | Estrone may increase the thrombogenic activities of Sibrotuzumab. |
| Bivatuzumab | Estrone may increase the thrombogenic activities of Bivatuzumab. |
| Lerdelimumab | Estrone may increase the thrombogenic activities of Lerdelimumab. |
| Lexatumumab | Estrone may increase the thrombogenic activities of Lexatumumab. |
| Reslizumab | Estrone may increase the thrombogenic activities of Reslizumab. |
| Teplizumab | Estrone may increase the thrombogenic activities of Teplizumab. |
| Catumaxomab | Estrone may increase the thrombogenic activities of Catumaxomab. |
| Mepolizumab | Estrone may increase the thrombogenic activities of Mepolizumab. |
| Denosumab | Estrone may increase the thrombogenic activities of Denosumab. |
| Volociximab | Estrone may increase the thrombogenic activities of Volociximab. |
| Ofatumumab | Estrone may increase the thrombogenic activities of Ofatumumab. |
| Brentuximab vedotin | Estrone may increase the thrombogenic activities of Brentuximab vedotin. |
| Belimumab | Estrone may increase the thrombogenic activities of Belimumab. |
| Raxibacumab | Estrone may increase the thrombogenic activities of Raxibacumab. |