Peringatan Keamanan

LD50=1954 mg/kg (orally in mice)

Dyphylline

DB00651

small molecule approved

Deskripsi

Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.

Struktur Molekul 2D

Berat 254.2426
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2 hours (range 1.8 - 2.1 hours)
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic

Rute Eliminasi

Dyphylline exerts its bronchodilatory effects directly and, unlike the­ophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Approximately 88% of a single oral dose can be recovered from the urine unchanged.

Interaksi Obat

992 Data
Regadenoson Dyphylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Adalimumab The serum concentration of Dyphylline can be decreased when it is combined with Adalimumab.
Adenosine The therapeutic efficacy of Adenosine can be decreased when used in combination with Dyphylline.
Allopurinol The serum concentration of Dyphylline can be increased when it is combined with Allopurinol.
Carbamazepine The serum concentration of Dyphylline can be decreased when it is combined with Carbamazepine.
Cimetidine The metabolism of Dyphylline can be decreased when combined with Cimetidine.
Disulfiram The serum concentration of Dyphylline can be increased when it is combined with Disulfiram.
Febuxostat The serum concentration of the active metabolites of Dyphylline can be increased when Dyphylline is used in combination with Febuxostat.
Fluvoxamine The metabolism of Dyphylline can be decreased when combined with Fluvoxamine.
Formoterol The risk or severity of hypokalemia can be increased when Dyphylline is combined with Formoterol.
Indacaterol The risk or severity of adverse effects can be increased when Dyphylline is combined with Indacaterol.
Isoniazid The serum concentration of Dyphylline can be increased when it is combined with Isoniazid.
Lithium hydroxide The serum concentration of Lithium hydroxide can be decreased when it is combined with Dyphylline.
Lithium citrate The serum concentration of Lithium citrate can be decreased when it is combined with Dyphylline.
Mexiletine The metabolism of Dyphylline can be decreased when combined with Mexiletine.
Olodaterol Dyphylline may increase the hyperkalemic activities of Olodaterol.
Pancuronium The therapeutic efficacy of Pancuronium can be decreased when used in combination with Dyphylline.
Pentoxifylline The serum concentration of Dyphylline can be increased when it is combined with Pentoxifylline.
Phenytoin The serum concentration of Dyphylline can be decreased when it is combined with Phenytoin.
Fosphenytoin The serum concentration of Dyphylline can be decreased when it is combined with Fosphenytoin.
Propafenone The serum concentration of Dyphylline can be increased when it is combined with Propafenone.
Quinine The serum concentration of Dyphylline can be increased when it is combined with Quinine.
Quinidine The serum concentration of Dyphylline can be increased when it is combined with Quinidine.
Riociguat Dyphylline may increase the hypotensive activities of Riociguat.
Thiabendazole The metabolism of Dyphylline can be decreased when combined with Thiabendazole.
Ticlopidine The metabolism of Dyphylline can be decreased when combined with Ticlopidine.
Zafirlukast The serum concentration of Zafirlukast can be decreased when it is combined with Dyphylline.
Probenecid The serum concentration of Dyphylline can be increased when it is combined with Probenecid.
Isoprenaline The serum concentration of Dyphylline can be decreased when it is combined with Isoprenaline.
Amphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Dyphylline.
Phentermine The risk or severity of adverse effects can be increased when Phentermine is combined with Dyphylline.
Midodrine The risk or severity of adverse effects can be increased when Midodrine is combined with Dyphylline.
Norepinephrine The risk or severity of adverse effects can be increased when Norepinephrine is combined with Dyphylline.
Phenylephrine The risk or severity of adverse effects can be increased when Phenylephrine is combined with Dyphylline.
Phenylpropanolamine The risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Dyphylline.
Labetalol The risk or severity of adverse effects can be increased when Labetalol is combined with Dyphylline.
Metaraminol The risk or severity of adverse effects can be increased when Metaraminol is combined with Dyphylline.
Epinephrine The risk or severity of adverse effects can be increased when Epinephrine is combined with Dyphylline.
Methoxamine The risk or severity of adverse effects can be increased when Methoxamine is combined with Dyphylline.
Orciprenaline The risk or severity of adverse effects can be increased when Orciprenaline is combined with Dyphylline.
Phenmetrazine The risk or severity of adverse effects can be increased when Phenmetrazine is combined with Dyphylline.
Dobutamine The risk or severity of adverse effects can be increased when Dobutamine is combined with Dyphylline.
Pseudoephedrine The risk or severity of adverse effects can be increased when Pseudoephedrine is combined with Dyphylline.
Benzphetamine The risk or severity of adverse effects can be increased when Benzphetamine is combined with Dyphylline.
Ritodrine The risk or severity of adverse effects can be increased when Ritodrine is combined with Dyphylline.
Terbutaline The risk or severity of adverse effects can be increased when Terbutaline is combined with Dyphylline.
Oxymetazoline The risk or severity of adverse effects can be increased when Oxymetazoline is combined with Dyphylline.
Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Dyphylline.
Dopamine The risk or severity of adverse effects can be increased when Dopamine is combined with Dyphylline.
Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with Dyphylline.
Lisdexamfetamine The risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with Dyphylline.
Fenoterol The risk or severity of adverse effects can be increased when Fenoterol is combined with Dyphylline.
Ephedrine The risk or severity of adverse effects can be increased when Ephedrine is combined with Dyphylline.
Mephentermine The risk or severity of adverse effects can be increased when Mephentermine is combined with Dyphylline.
Procaterol The risk or severity of adverse effects can be increased when Procaterol is combined with Dyphylline.
Clenbuterol The risk or severity of adverse effects can be increased when Clenbuterol is combined with Dyphylline.
MMDA The risk or severity of adverse effects can be increased when MMDA is combined with Dyphylline.
Midomafetamine The risk or severity of adverse effects can be increased when Midomafetamine is combined with Dyphylline.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Dyphylline.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Dyphylline.
Tenamfetamine The risk or severity of adverse effects can be increased when Tenamfetamine is combined with Dyphylline.
Chlorphentermine The risk or severity of adverse effects can be increased when Chlorphentermine is combined with Dyphylline.
Methylenedioxyethamphetamine The risk or severity of adverse effects can be increased when Methylenedioxyethamphetamine is combined with Dyphylline.
Dextroamphetamine The risk or severity of adverse effects can be increased when Dextroamphetamine is combined with Dyphylline.
Metamfetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Dyphylline.
Celiprolol The risk or severity of adverse effects can be increased when Celiprolol is combined with Dyphylline.
Nylidrin The risk or severity of adverse effects can be increased when Nylidrin is combined with Dyphylline.
Tetryzoline The risk or severity of adverse effects can be increased when Tetryzoline is combined with Dyphylline.
Tyramine The risk or severity of adverse effects can be increased when Tyramine is combined with Dyphylline.
Isoxsuprine The risk or severity of adverse effects can be increased when Isoxsuprine is combined with Dyphylline.
Etilefrine The risk or severity of adverse effects can be increased when Etilefrine is combined with Dyphylline.
Synephrine The risk or severity of adverse effects can be increased when Synephrine is combined with Dyphylline.
Hydroxyamphetamine The risk or severity of adverse effects can be increased when Hydroxyamphetamine is combined with Dyphylline.
Iofetamine I-123 The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with Dyphylline.
Racepinephrine The risk or severity of adverse effects can be increased when Racepinephrine is combined with Dyphylline.
Ritobegron The risk or severity of adverse effects can be increased when Ritobegron is combined with Dyphylline.
Bucindolol The risk or severity of adverse effects can be increased when Bucindolol is combined with Dyphylline.
Tramazoline The risk or severity of adverse effects can be increased when Tramazoline is combined with Dyphylline.
Mephedrone The risk or severity of adverse effects can be increased when Mephedrone is combined with Dyphylline.
Fenozolone The risk or severity of adverse effects can be increased when Fenozolone is combined with Dyphylline.
Methoxyphenamine The risk or severity of adverse effects can be increased when Methoxyphenamine is combined with Dyphylline.
Tretoquinol The risk or severity of adverse effects can be increased when Tretoquinol is combined with Dyphylline.
Gepefrine The risk or severity of adverse effects can be increased when Gepefrine is combined with Dyphylline.
Epanolol The risk or severity of adverse effects can be increased when Epanolol is combined with Dyphylline.
Prenalterol The risk or severity of adverse effects can be increased when Prenalterol is combined with Dyphylline.
Mefenorex The risk or severity of adverse effects can be increased when Mefenorex is combined with Dyphylline.
2,5-Dimethoxy-4-ethylthioamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylthioamphetamine is combined with Dyphylline.
Esmolol The risk or severity of adverse effects can be increased when Esmolol is combined with Dyphylline.
Betaxolol The risk or severity of adverse effects can be increased when Betaxolol is combined with Dyphylline.
Metoprolol The risk or severity of adverse effects can be increased when Metoprolol is combined with Dyphylline.
Atenolol The risk or severity of adverse effects can be increased when Atenolol is combined with Dyphylline.
Timolol The risk or severity of adverse effects can be increased when Timolol is combined with Dyphylline.
Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Dyphylline.
Propranolol The risk or severity of adverse effects can be increased when Propranolol is combined with Dyphylline.
Bisoprolol The risk or severity of adverse effects can be increased when Bisoprolol is combined with Dyphylline.
Alprenolol The risk or severity of adverse effects can be increased when Alprenolol is combined with Dyphylline.
Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Dyphylline.
Carvedilol The risk or severity of adverse effects can be increased when Carvedilol is combined with Dyphylline.
Bevantolol The risk or severity of adverse effects can be increased when Bevantolol is combined with Dyphylline.
Practolol The risk or severity of adverse effects can be increased when Practolol is combined with Dyphylline.

Target Protein

3',5'-cyclic-AMP phosphodiesterase 4B PDE4B
5'-nucleotidase NT5E
3',5'-cyclic-AMP phosphodiesterase 4A PDE4A
3',5'-cyclic-AMP phosphodiesterase 4C PDE4C
3',5'-cyclic-AMP phosphodiesterase 4D PDE4D
Adenosine receptor A1 ADORA1
Adenosine receptor A2a ADORA2A

Referensi & Sumber

Synthesis reference: Jones, J.W. and Maney, P.V.; U.S. Patent 2,575,344; November 20,1951; assigned to the State of Iowa.

Contoh Produk & Brand

Produk: 16 • International brands: 2
Produk
  • Dilex-G 400
    Tablet • - • Oral • US
  • Dy G
    Liquid • - • Oral • US
  • Dyphylline and Guaifenesin
    Tablet • - • Oral • US
  • Dyphylline GG
    Tablet • - • Oral • US
  • Dyphylline Gg
    Elixir • - • Oral • US
  • Dyphylline GG ES
    Tablet • - • Oral • US
  • Jay-Phyl
    Syrup • - • Oral • US
  • Lufyllin
    Tablet • 200 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 16 produk.
International Brands
  • Corphyllin — Nippon Shinyaku
  • Dilor — Savage

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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