Peringatan Keamanan

Side effects include peripheral neuropathy tingling, burning, numbness, or pain in the hands or feet), fatal lactic acidosis has been reported in patients treated with stavudine (ZERIT) in combination with other antiretroviral agents, severe liver enlargement, inflammation (pain and swelling) of the liver, and liver failure.

Stavudine

DB00649

small molecule approved investigational

Deskripsi

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

Struktur Molekul 2D

Berat 224.2133
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 0.8-1.5 hours (in adults)
Volume Distribusi * 46 ± 21 L
Klirens (Clearance) * Renal cl=272 mL/min [Healthy subjects receiving 80 mg PO] * 594 +/- 164 mL/min [HIV-infected adult and pediatric patients following 1-hour IV infusion] * 9.75 +/- 3.76 mL/min/kg [HIV- Exposed or -Infected Pediatric Patients(Age 5 weeks – 15 years) following 1-hour IV infusion]

Absorpsi

Following oral administration, stavudine is rapidly absorbed (bioavailability is 68-104%).

Metabolisme

Phosphorylated intracellularly to stavudine triphosphate, the active substrate for HIV-reverse transcriptase.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Ingesting alcohol while taking stavudine may increase the risk of liver damage and pancreatitis.
  • 2. Take with or without food.

Interaksi Obat

342 Data
Ribavirin Ribavirin may increase the hepatotoxic activities of Stavudine.
Zidovudine The therapeutic efficacy of Stavudine can be decreased when used in combination with Zidovudine.
Didanosine The risk or severity of adverse effects can be increased when Stavudine is combined with Didanosine.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Stavudine.
Doxorubicin The therapeutic efficacy of Stavudine can be decreased when used in combination with Doxorubicin.
Ganciclovir The risk or severity of cytopenia can be increased when Ganciclovir is combined with Stavudine.
Valganciclovir The risk or severity of cytopenia can be increased when Valganciclovir is combined with Stavudine.
Riboflavin The excretion of Stavudine can be decreased when combined with Riboflavin.
Folic acid The excretion of Stavudine can be decreased when combined with Folic acid.
Aspartame The excretion of Stavudine can be decreased when combined with Aspartame.
Cefotiam The excretion of Stavudine can be decreased when combined with Cefotiam.
Ethoxzolamide The excretion of Stavudine can be decreased when combined with Ethoxzolamide.
Valproic acid The excretion of Stavudine can be decreased when combined with Valproic acid.
Codeine The excretion of Stavudine can be decreased when combined with Codeine.
Piperacillin The excretion of Stavudine can be decreased when combined with Piperacillin.
Indomethacin The excretion of Stavudine can be decreased when combined with Indomethacin.
Aminohippuric acid The excretion of Stavudine can be decreased when combined with Aminohippuric acid.
Cidofovir The excretion of Stavudine can be decreased when combined with Cidofovir.
Trifluridine The excretion of Stavudine can be decreased when combined with Trifluridine.
Chloramphenicol The excretion of Stavudine can be decreased when combined with Chloramphenicol.
Cefalotin The excretion of Stavudine can be decreased when combined with Cefalotin.
Cefotaxime The excretion of Stavudine can be decreased when combined with Cefotaxime.
Tolmetin The excretion of Stavudine can be decreased when combined with Tolmetin.
Caspofungin The excretion of Stavudine can be decreased when combined with Caspofungin.
Foscarnet The excretion of Stavudine can be decreased when combined with Foscarnet.
Piroxicam The excretion of Stavudine can be decreased when combined with Piroxicam.
Cephalexin The excretion of Stavudine can be decreased when combined with Cephalexin.
Carbenicillin The excretion of Stavudine can be decreased when combined with Carbenicillin.
Diclofenac The excretion of Stavudine can be decreased when combined with Diclofenac.
Oxytetracycline The excretion of Stavudine can be decreased when combined with Oxytetracycline.
Sulindac The excretion of Stavudine can be decreased when combined with Sulindac.
Cyclothiazide The excretion of Stavudine can be decreased when combined with Cyclothiazide.
Nafcillin The excretion of Stavudine can be decreased when combined with Nafcillin.
Chlorpropamide The excretion of Stavudine can be decreased when combined with Chlorpropamide.
Fluorescein The excretion of Stavudine can be decreased when combined with Fluorescein.
Furosemide The excretion of Stavudine can be decreased when combined with Furosemide.
Methazolamide The excretion of Stavudine can be decreased when combined with Methazolamide.
Flurbiprofen The excretion of Stavudine can be decreased when combined with Flurbiprofen.
Adefovir dipivoxil The excretion of Stavudine can be decreased when combined with Adefovir dipivoxil.
Nateglinide The excretion of Stavudine can be decreased when combined with Nateglinide.
Etodolac The excretion of Stavudine can be decreased when combined with Etodolac.
Tetracycline The excretion of Stavudine can be decreased when combined with Tetracycline.
Nalidixic acid The excretion of Stavudine can be decreased when combined with Nalidixic acid.
Acyclovir The excretion of Stavudine can be decreased when combined with Acyclovir.
Naproxen The excretion of Stavudine can be decreased when combined with Naproxen.
Phenylbutazone The excretion of Stavudine can be decreased when combined with Phenylbutazone.
Acetazolamide The excretion of Stavudine can be decreased when combined with Acetazolamide.
Carprofen The excretion of Stavudine can be decreased when combined with Carprofen.
Cinoxacin The excretion of Stavudine can be decreased when combined with Cinoxacin.
Diflunisal The excretion of Stavudine can be decreased when combined with Diflunisal.
Chlorothiazide The excretion of Stavudine can be decreased when combined with Chlorothiazide.
Etacrynic acid The excretion of Stavudine can be decreased when combined with Etacrynic acid.
Dinoprostone The excretion of Stavudine can be decreased when combined with Dinoprostone.
Salicylic acid The excretion of Stavudine can be decreased when combined with Salicylic acid.
Meclofenamic acid The excretion of Stavudine can be decreased when combined with Meclofenamic acid.
Acetylsalicylic acid The excretion of Stavudine can be decreased when combined with Acetylsalicylic acid.
Hydrochlorothiazide The excretion of Stavudine can be decreased when combined with Hydrochlorothiazide.
Ketoprofen The excretion of Stavudine can be decreased when combined with Ketoprofen.
Glyburide The excretion of Stavudine can be decreased when combined with Glyburide.
Probenecid The excretion of Stavudine can be decreased when combined with Probenecid.
Ibuprofen The excretion of Stavudine can be decreased when combined with Ibuprofen.
Novobiocin The excretion of Stavudine can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Stavudine can be decreased when combined with Benzylpenicillin.
Amoxicillin The excretion of Stavudine can be decreased when combined with Amoxicillin.
Tolbutamide The excretion of Stavudine can be decreased when combined with Tolbutamide.
Cefadroxil The excretion of Stavudine can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Stavudine can be decreased when combined with Ceftriaxone.
Cefamandole The excretion of Stavudine can be decreased when combined with Cefamandole.
Cefazolin The excretion of Stavudine can be decreased when combined with Cefazolin.
Cefoperazone The excretion of Stavudine can be decreased when combined with Cefoperazone.
Cefradine The excretion of Stavudine can be decreased when combined with Cefradine.
Cefacetrile The excretion of Stavudine can be decreased when combined with Cefacetrile.
Aminophenazone The excretion of Stavudine can be decreased when combined with Aminophenazone.
Antipyrine The excretion of Stavudine can be decreased when combined with Antipyrine.
Cilastatin The excretion of Stavudine can be decreased when combined with Cilastatin.
Tazobactam The excretion of Stavudine can be decreased when combined with Tazobactam.
Topiroxostat The excretion of Stavudine can be decreased when combined with Topiroxostat.
Glutaric Acid The excretion of Stavudine can be decreased when combined with Glutaric Acid.
Oxyphenbutazone The excretion of Stavudine can be decreased when combined with Oxyphenbutazone.
Phenacetin The excretion of Stavudine can be decreased when combined with Phenacetin.
Taurocholic acid The excretion of Stavudine can be decreased when combined with Taurocholic acid.
Caprylic acid The excretion of Stavudine can be decreased when combined with Caprylic acid.
Ataluren The excretion of Stavudine can be decreased when combined with Ataluren.
Ellagic acid The excretion of Stavudine can be decreased when combined with Ellagic acid.
Dabrafenib The excretion of Stavudine can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Stavudine can be decreased when combined with Dolutegravir.
Lenvatinib The excretion of Stavudine can be decreased when combined with Lenvatinib.
Silibinin The excretion of Stavudine can be decreased when combined with Silibinin.
Cabotegravir The excretion of Stavudine can be decreased when combined with Cabotegravir.
Enasidenib The excretion of Stavudine can be decreased when combined with Enasidenib.
Istradefylline The excretion of Stavudine can be decreased when combined with Istradefylline.
Favipiravir The excretion of Stavudine can be decreased when combined with Favipiravir.
Ceftizoxime The excretion of Stavudine can be decreased when combined with Ceftizoxime.
Pralsetinib The excretion of Stavudine can be decreased when combined with Pralsetinib.
Tafamidis The excretion of Stavudine can be decreased when combined with Tafamidis.
Linezolid The excretion of Stavudine can be decreased when combined with Linezolid.
Leuprolide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Stavudine.
Somatotropin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Somatotropin is combined with Stavudine.
Infliximab The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Infliximab is combined with Stavudine.
Daptomycin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Stavudine.

Target Protein

Gag-Pol polyprotein gag-pol
Reverse transcriptase/RNaseH pol

Referensi & Sumber

Synthesis reference: Purna Chandra Ray, Jagan Mohana Chary Tummanapalli, Seeta Ramanjaneyulu Gorantla, "Process for the Large Scale Production of Stavudine." U.S. Patent US20080312428, issued December 18, 2008.

Contoh Produk & Brand

Produk: 59 • International brands: 18
Produk
  • Stavudine
    Capsule • 15 mg/1 • Oral • US • Generic • Approved
  • Stavudine
    Capsule • 20 mg/1 • Oral • US • Generic • Approved
  • Stavudine
    Capsule • 30 mg/1 • Oral • US • Generic • Approved
  • Stavudine
    Capsule • 40 mg/1 • Oral • US • Generic • Approved
  • Stavudine
    Capsule • 40 mg/1 • Oral • US • Generic • Approved
  • Stavudine
    Capsule • 40 mg/1 • Oral • US • Generic • Approved
  • Stavudine
    Capsule • 15 mg/1 • Oral • US • Generic • Approved
  • Stavudine
    Capsule • 20 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 59 produk.
International Brands
  • Actastav — Actavis
  • Ai Fu Ding — Wujing Medicine
  • Avostav — Ranbaxy Laboratories
  • Estavudox — Biotoscana
  • Exvihr — Biogen
  • Flamistav — Flamingo Pharmacueticals
  • Landstav — Landsteiner
  • Lion — Filaxis
  • Mai Si Ting — Meijisi Pharmaceutical
  • S.T.V. — Ivax

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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