Peringatan Keamanan

The oral LD₅₀ in rats is 10 g/kg.^L10743 There have been no reports of serious toxic effects following overdosage of nystatin - doses in excess of five million units daily have resulted in nausea and gastrointestinal upset with no other associated effects.^L10686

Nystatin

DB00646

small molecule approved vet_approved

Deskripsi

Nystatin is a polyene antifungal drug that has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably Candida species.^L10686 It is one of the most effective antifungal agents synthesized by bacteria, in this case a strain of Streptomyces noursei,^L10776 and is closely related to amphotericin B, differing only slightly in structure.^A188562 Nystatin has a greater antifungal activity than amphotericin B - parenterally administered nystatin, however, is associated with significant toxicity and is not available in a formulation appropriate for systemic use.^A188562 As it undergoes very little absorption following oral or topical administration, nystatin's efficacy is limited to the treatment/prevention of cutaneous, mucocutaneous, and gastrointestinal fungal infections.L10686,L10728

Struktur Molekul 2D

Berat 926.107

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi Nystatin is not absorbed into the systemic circulation[L10686] and thus does not undergo distribution.

Klirens (Clearance) -

Absorpsi

Systemic absorption of nystatin is minimal following oral administration,^L10686 and no detectable plasma concentrations are attained following topical or vaginal administration.^L10749

Metabolisme

Because nystatin undergoes little-to-no systemic absorption it is not metabolized to any appreciable extent.^L10686

Rute Eliminasi

The majority of orally administered nystatin is eliminated unchanged in the feces.^L10686

Interaksi Obat

65 Data

Eluxadoline	The serum concentration of Eluxadoline can be increased when it is combined with Nystatin.
Pravastatin	The excretion of Pravastatin can be decreased when combined with Nystatin.
Valsartan	The excretion of Valsartan can be decreased when combined with Nystatin.
Torasemide	The excretion of Torasemide can be decreased when combined with Nystatin.
Liothyronine	The excretion of Liothyronine can be decreased when combined with Nystatin.
Digoxin	The excretion of Digoxin can be decreased when combined with Nystatin.
Raloxifene	The excretion of Raloxifene can be decreased when combined with Nystatin.
Sumatriptan	The excretion of Sumatriptan can be decreased when combined with Nystatin.
Penicillamine	The excretion of Penicillamine can be decreased when combined with Nystatin.
Dinoprostone	The excretion of Dinoprostone can be decreased when combined with Nystatin.
Fexofenadine	The excretion of Fexofenadine can be decreased when combined with Nystatin.
Ezetimibe	The excretion of Ezetimibe can be decreased when combined with Nystatin.
Benzylpenicillin	The excretion of Benzylpenicillin can be decreased when combined with Nystatin.
Ouabain	The excretion of Ouabain can be decreased when combined with Nystatin.
Cholic Acid	The excretion of Cholic Acid can be decreased when combined with Nystatin.
Taurocholic acid	The excretion of Taurocholic acid can be decreased when combined with Nystatin.
Atrasentan	The excretion of Atrasentan can be decreased when combined with Nystatin.
Gimatecan	The excretion of Gimatecan can be decreased when combined with Nystatin.
Temocapril	The excretion of Temocapril can be decreased when combined with Nystatin.
Cholecystokinin	The excretion of Cholecystokinin can be decreased when combined with Nystatin.
Gadoxetic acid	The excretion of Gadoxetic acid can be decreased when combined with Nystatin.
Technetium Tc-99m mebrofenin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Nystatin.
Fimasartan	The excretion of Fimasartan can be decreased when combined with Nystatin.
Elagolix	The excretion of Elagolix can be decreased when combined with Nystatin.
Letermovir	The excretion of Letermovir can be decreased when combined with Nystatin.
Levosalbutamol	The excretion of Levosalbutamol can be decreased when combined with Nystatin.
Glecaprevir	The excretion of Glecaprevir can be decreased when combined with Nystatin.
Cerivastatin	The excretion of Cerivastatin can be decreased when combined with Nystatin.
Bosentan	The excretion of Bosentan can be decreased when combined with Nystatin.
Repaglinide	The excretion of Repaglinide can be decreased when combined with Nystatin.
Axitinib	The excretion of Axitinib can be decreased when combined with Nystatin.
Asunaprevir	The excretion of Asunaprevir can be decreased when combined with Nystatin.
Enalapril	The excretion of Enalapril can be decreased when combined with Nystatin.
Caspofungin	The excretion of Caspofungin can be decreased when combined with Nystatin.
Methotrexate	The excretion of Methotrexate can be decreased when combined with Nystatin.
Simvastatin	The excretion of Simvastatin can be decreased when combined with Nystatin.
Atorvastatin	The excretion of Atorvastatin can be decreased when combined with Nystatin.
Rosuvastatin	The excretion of Rosuvastatin can be decreased when combined with Nystatin.
Tenofovir alafenamide	The excretion of Tenofovir alafenamide can be decreased when combined with Nystatin.
Belantamab mafodotin	The excretion of Belantamab mafodotin can be decreased when combined with Nystatin.
Sincalide	The excretion of Sincalide can be decreased when combined with Nystatin.
Erythromycin	The excretion of Erythromycin can be decreased when combined with Nystatin.
Conjugated estrogens	The excretion of Conjugated estrogens can be decreased when combined with Nystatin.
Mycophenolate mofetil	The excretion of Mycophenolate mofetil can be decreased when combined with Nystatin.
Fluvastatin	The excretion of Fluvastatin can be decreased when combined with Nystatin.
Liotrix	The excretion of Liotrix can be decreased when combined with Nystatin.
Simeprevir	The excretion of Simeprevir can be decreased when combined with Nystatin.
Ambrisentan	The excretion of Ambrisentan can be decreased when combined with Nystatin.
Paritaprevir	The excretion of Paritaprevir can be decreased when combined with Nystatin.
Selexipag	The excretion of Selexipag can be decreased when combined with Nystatin.
Grazoprevir	The excretion of Grazoprevir can be decreased when combined with Nystatin.
Voxilaprevir	The excretion of Voxilaprevir can be decreased when combined with Nystatin.
Testosterone	The excretion of Testosterone can be decreased when combined with Nystatin.
Docetaxel	The excretion of Docetaxel can be decreased when combined with Nystatin.
Paclitaxel	The excretion of Paclitaxel can be decreased when combined with Nystatin.
Bempedoic acid	The excretion of Bempedoic acid can be decreased when combined with Nystatin.
Revefenacin	Nystatin may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Cyclosporine	The serum concentration of Cyclosporine can be increased when it is combined with Nystatin.
Brincidofovir	The serum concentration of Brincidofovir can be increased when it is combined with Nystatin.
Atogepant	The serum concentration of Atogepant can be increased when it is combined with Nystatin.
Mesalazine	The excretion of Mesalazine can be decreased when combined with Nystatin.
Zavegepant	The serum concentration of Zavegepant can be increased when it is combined with Nystatin.
Tezacaftor	The excretion of Tezacaftor can be decreased when combined with Nystatin.
Momelotinib	The serum concentration of Momelotinib can be increased when it is combined with Nystatin.
Resmetirom	The serum concentration of Resmetirom can be increased when it is combined with Nystatin.

Target Protein

Ergosterol

Referensi & Sumber

Artikel (PubMed)

PMID: 7534361
Akaike N, Harata N: Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Jpn J Physiol. 1994;44(5):433-73.
PMID: 29098221
Dos Santos AG, Marques JT, Carreira AC, Castro IR, Viana AS, Mingeot-Leclercq MP, de Almeida RFM, Silva LC: The molecular mechanism of Nystatin action is dependent on the membrane biophysical properties and lipid composition. Phys Chem Chem Phys. 2017 Nov 15;19(44):30078-30088. doi: 10.1039/c7cp05353c.
PMID: 22541068
Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem. 2012 May 24;55(10):4740-63. doi: 10.1021/jm300212s. Epub 2012 May 15.
PMID: 26679628
Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Feb 15;62(4):e1-50. doi: 10.1093/cid/civ933. Epub 2015 Dec 16.
PMID: 21756054
Yamasaki M, Tamura N, Nakamura K, Sasaki N, Murakami M, Rajapakshage W, Kumara B, Tamura Y, Lim SY, Ohta H, Takiguchi M: Effects and mechanisms of action of polyene macrolide antibiotic nystatin on Babesia gibsoni in vitro. J Parasitol. 2011 Dec;97(6):1190-2. doi: 10.1645/GE-2799.1. Epub 2011 Jul 14.
PMID: 16500971
Silva L, Coutinho A, Fedorov A, Prieto M: Competitive binding of cholesterol and ergosterol to the polyene antibiotic nystatin. A fluorescence study. Biophys J. 2006 May 15;90(10):3625-31. Epub 2006 Feb 24.
PMID: 29551534
Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S: A Drug-drug Interaction Between Cyclosporine and Nystatin. Clin Ther. 2018 Apr;40(4):660-662. doi: 10.1016/j.clinthera.2018.02.008. Epub 2018 Mar 16.

Link

Contoh Produk & Brand

Produk: 343 • International brands: 29

Produk

Candistatin Topical Powder - 100000 Unit/g

Powder • 100000 unit / g • Topical • Canada • OTC • Approved
Dom-nystatin Suspension

Suspension • 100000 unit / mL • Oral • Canada • Generic • Approved
FIRST BXN Mouthwash

Kit • - • Oral • US
FIRST Dukes Mouthwash Compounding

Kit • - • Oral • US
FIRST Marys Mouthwash Compounding

Kit • - • Oral • US
Flagystatin

Insert • - • Vaginal • Canada • Approved
Flagystatin

Suppository • - • Vaginal • Canada • Approved
Flagystatin

Cream • - • Vaginal • Canada • Approved

Menampilkan 8 dari 343 produk.

International Brands

Adiclair — Ardeypharm
Afunginal — Euro Generics
Biofanal — Pfleger
Candacide — Be-Tabs Pharmaceuticals
Candermil — LKM
Candex — Square
Candidias — Fabra
Candistat — Ambalal Sarabhai Enterprises
Candistin — Pharos
Canstat — Aspen Pharmacare

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.