Peringatan Keamanan

Symptoms of overdose include cardiovascular system depression, CNS toxicity, and methemoglobinemia.

Dyclonine

DB00645

small molecule approved

Deskripsi

Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It may also be found in some Cepacol sore throat spray products.

Struktur Molekul 2D

Berat 289.4125
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 30 to 60 minutes.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Readily absorbed through mucous membranes into the systemic circulation. The rate of absorption is influenced by the vascularity or rate of blood flow at the site of application, the total dosage (concentration and volume) administered, and the duration of exposure. Absorption from mucous membranes of the throat or respiratory tract may be especially rapid.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take separate from meals. Using Dyclonine in the mouth or for relief of ulcers in the stomach may cause numbness of the mouth, which increases the risk of biting injury. Avoid ingesting food for 60 minutes after use, or until the numbness has subsided.

Interaksi Obat

1593 Data
Buprenorphine Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Hydrocodone Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Magnesium sulfate The therapeutic efficacy of Dyclonine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Dyclonine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Mirtazapine Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Orphenadrine Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Pramipexole Dyclonine may increase the sedative activities of Pramipexole.
Ropinirole Dyclonine may increase the sedative activities of Ropinirole.
Rotigotine Dyclonine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Dyclonine.
Sodium oxybate Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Thalidomide Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Hyaluronidase (ovine) Hyaluronidase (ovine) can cause an increase in the absorption of Dyclonine resulting in an increased serum concentration and potentially a worsening of adverse effects.
Hyaluronidase (human recombinant) Hyaluronidase (human recombinant) can cause an increase in the absorption of Dyclonine resulting in an increased serum concentration and potentially a worsening of adverse effects.
Hyaluronidase Hyaluronidase can cause an increase in the absorption of Dyclonine resulting in an increased serum concentration and potentially a worsening of adverse effects.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Dyclonine.
Ethanol Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Fluvoxamine The risk or severity of adverse effects can be increased when Dyclonine is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Dyclonine is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Dyclonine is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Dyclonine is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Dyclonine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Dyclonine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Dyclonine is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Dyclonine is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Dyclonine is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Dyclonine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Dyclonine is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Dyclonine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Dyclonine is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Dyclonine is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Dyclonine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Dyclonine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Dyclonine is combined with Alaproclate.
Technetium Tc-99m tilmanocept Dyclonine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Dyclonine.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Dyclonine.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Dyclonine.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Dyclonine.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Dyclonine.
Propiomazine The risk or severity of CNS depression can be increased when Dyclonine is combined with Propiomazine.
Cocaine The risk or severity of methemoglobinemia can be increased when Dyclonine is combined with Cocaine.
Quinidine The risk or severity of methemoglobinemia can be increased when Quinidine is combined with Dyclonine.
Maprotiline The risk or severity of CNS depression can be increased when Dyclonine is combined with Maprotiline.
Doxepin The risk or severity of CNS depression can be increased when Dyclonine is combined with Doxepin.
Desipramine The risk or severity of CNS depression can be increased when Dyclonine is combined with Desipramine.
Pizotifen The risk or severity of CNS depression can be increased when Dyclonine is combined with Pizotifen.
Dosulepin The risk or severity of CNS depression can be increased when Dyclonine is combined with Dosulepin.
Zopiclone The risk or severity of adverse effects can be increased when Dyclonine is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Dyclonine.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Dyclonine.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Dyclonine.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Lorazepam The risk or severity of methemoglobinemia can be increased when Lorazepam is combined with Dyclonine.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Dyclonine.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Dyclonine.
Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Dyclonine.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Dyclonine.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Dyclonine.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Dyclonine.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Dyclonine.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Dyclonine.
Butalbital The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Dyclonine.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Dyclonine.
Cabergoline The risk or severity of methemoglobinemia can be increased when Cabergoline is combined with Dyclonine.
Phenytoin The risk or severity of methemoglobinemia can be increased when Phenytoin is combined with Dyclonine.
Topiramate The risk or severity of methemoglobinemia can be increased when Topiramate is combined with Dyclonine.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Dyclonine.
Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Dyclonine.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Dyclonine.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Dyclonine.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Dyclonine.
Pentobarbital The risk or severity of methemoglobinemia can be increased when Pentobarbital is combined with Dyclonine.
Valproic acid The risk or severity of methemoglobinemia can be increased when Valproic acid is combined with Dyclonine.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Dyclonine.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Dyclonine.
Dihydroergotamine The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Dyclonine.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Dyclonine.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Dyclonine.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Dyclonine.
Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Dyclonine.
Protriptyline The risk or severity of CNS depression can be increased when Protriptyline is combined with Dyclonine.
Trimethadione The risk or severity of methemoglobinemia can be increased when Trimethadione is combined with Dyclonine.
Clobazam The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Dyclonine.
Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Dyclonine.
Clozapine The risk or severity of CNS depression can be increased when Clozapine is combined with Dyclonine.

Target Protein

Sodium channel protein type 10 subunit alpha SCN10A
Sodium channel protein type 5 subunit alpha SCN5A

Referensi & Sumber

Synthesis reference: Tianjiang Sun, Xiaohong Gu, Hongguo Lu, Min Chen, "Oral Preparation of Dyclonine Hydrochloride." U.S. Patent US20080200506, issued August 21, 2008.

Contoh Produk & Brand

Produk: 57 • International brands: 1
Produk
  • Ambix First Aid
    Cream • - • Topical • US • OTC
  • Ambix First Aid
    Cream • - • Topical • US • OTC
  • Benzethonium Chloride and Dyclonine Hydrochloride
    Liquid • - • Topical • US • OTC
  • Benzethonium chloride and Dyclonine hydrochloride
    Liquid • - • Topical • US • OTC
  • Benzethonium Chloride and Dyclonine Hydrochloride
    Liquid • - • Topical • US • OTC
  • Benzethonium chloride Plus Dyclonine hydrochloride
    Liquid • - • Topical • US • OTC
  • Benzethonium chloride Plus Dyclonine hydrochloride
    Liquid • - • Topical • US • OTC
  • Benzethonium chloride Plus Dyclonine hydrochloride
    Liquid • - • Topical • US • OTC
Menampilkan 8 dari 57 produk.
International Brands
  • Dyclone — AstraZeneca

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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