Peringatan Keamanan

LD₅₀>3000 mg/kg (rat, oral)

Gonadorelin

DB00644

biotech approved investigational vet_approved

Deskripsi

Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pituitary.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Very short, initial, 2 to 10 minutes; terminal, 10 to 40 minutes

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Rapidly absorbed when injected

Metabolisme

Rapidly hydrolyzed to inactive peptide components

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

3 Data

Corifollitropin alfa	The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Gonadorelin.
Choline C 11	Gonadorelin may decrease effectiveness of Choline C 11 as a diagnostic agent.
Capromab pendetide	Gonadorelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.

Target Protein

Gonadotropin-releasing hormone receptor GNRHR

Putative gonadotropin-releasing hormone II receptor GNRHR2

Referensi & Sumber

Synthesis reference: Rainer Uhmann, Kurt Radscheit, "Process for the low-racemization preparation of peptide intermediates of the synthesis of gonadorelin and gonadorelin analogs, and new intermediates for this process." U.S. Patent US4691008, issued December, 1984.

Artikel (PubMed)

PMID: 16373418
Dungan HM, Clifton DK, Steiner RA: Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology. 2006 Mar;147(3):1154-8. Epub 2005 Dec 22.
PMID: 16621281
Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A: Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett. 2006 Jul 3;401(3):225-30. Epub 2006 Apr 18.

Contoh Produk & Brand

Produk: 8 • International brands: 7

Produk

Factrel Inj 0.5mg/vial

Powder, for solution • .5 mg / vial • Intravenous; Subcutaneous • Canada • Approved
Factrel Pws 100mcg/vial

Powder, for solution • 100 mcg / vial • Intravenous; Subcutaneous • Canada • Approved
Factrel Pws 500mcg/vial

Powder, for solution • 500 mcg / vial • Intravenous; Subcutaneous • Canada • Approved
Gonadorelin Diacetate Tetrahydrate

Powder • 1 g/1g • Not applicable • US
Lutrepulse

Powder, for solution • 3.2 mg / vial • Intravenous; Subcutaneous • Canada • Approved
Lutrepulse Pws 0.8mg/vial

Powder, for solution • 0.8 mg / vial • Intravenous; Subcutaneous • Canada • Approved
Relisorm 100 for Inj.-pws Liq-kit Sc IV

Liquid; Powder, for solution • - • Intravenous; Subcutaneous • Canada • Approved
Relisorm 500 for Inj.-pws Liq-kit IV Sc

Liquid; Powder, for solution • - • Intravenous; Subcutaneous • Canada • Approved

International Brands

Fertagyl
Gonadorelin — Intrapharm
HRF — Intrapharm
Hypocrine — Tanabe Mitsubishi Pharma
Kryptocur — Sanofi-Aventis
Lutrelef — Ferring
Relefact — Sanofi-Aventis

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.