Dexmedetomidine

DB00633

small molecule approved vet_approved

Deskripsi

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Struktur Molekul 2D

Berat 200.2795
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2 hours
Volume Distribusi * 118 L
Klirens (Clearance) * 39 L/h [Healthy volunteers receiving IV infusion (0.2-0.7 mcg/kg/hr)]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic

Rute Eliminasi

A mass balance study demonstrated that after nine days an average of 95% of the radioactivity, following intravenous administration of radiolabeled dexmedetomidine, was recovered in the urine and 4% in the feces. Fractionation of the radioactivity excreted in urine demonstrated that products of N-glucuronidation accounted for approximately 34% of the cumulative urinary excretion. The majority of metabolites are excreted in the urine.

Interaksi Obat

1789 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Dexmedetomidine is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Dexmedetomidine is combined with Levodopa.
Risperidone Dexmedetomidine may increase the hypotensive activities of Risperidone.
Ceritinib Dexmedetomidine may increase the bradycardic activities of Ceritinib.
Ivabradine Dexmedetomidine may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Dexmedetomidine.
Felodipine Dexmedetomidine may decrease the antihypertensive activities of Felodipine.
Valsartan Dexmedetomidine may decrease the antihypertensive activities of Valsartan.
Ramipril Dexmedetomidine may decrease the antihypertensive activities of Ramipril.
Remikiren Dexmedetomidine may decrease the antihypertensive activities of Remikiren.
Bethanidine Dexmedetomidine may decrease the antihypertensive activities of Bethanidine.
Guanadrel Dexmedetomidine may decrease the antihypertensive activities of Guanadrel.
Olmesartan Dexmedetomidine may decrease the antihypertensive activities of Olmesartan.
Minoxidil Dexmedetomidine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Dexmedetomidine may decrease the antihypertensive activities of Treprostinil.
Amlodipine Dexmedetomidine may decrease the antihypertensive activities of Amlodipine.
Nimodipine Dexmedetomidine may decrease the antihypertensive activities of Nimodipine.
Trandolapril Dexmedetomidine may decrease the antihypertensive activities of Trandolapril.
Lercanidipine Dexmedetomidine may decrease the antihypertensive activities of Lercanidipine.
Benazepril Dexmedetomidine may decrease the antihypertensive activities of Benazepril.
Bosentan Dexmedetomidine may decrease the antihypertensive activities of Bosentan.
Enalapril Dexmedetomidine may decrease the antihypertensive activities of Enalapril.
Candoxatril Dexmedetomidine may decrease the antihypertensive activities of Candoxatril.
Losartan Dexmedetomidine may decrease the antihypertensive activities of Losartan.
Moexipril Dexmedetomidine may decrease the antihypertensive activities of Moexipril.
Nitroglycerin Dexmedetomidine may decrease the antihypertensive activities of Nitroglycerin.
Cryptenamine Dexmedetomidine may decrease the antihypertensive activities of Cryptenamine.
Candesartan cilexetil Dexmedetomidine may decrease the antihypertensive activities of Candesartan cilexetil.
Eprosartan Dexmedetomidine may decrease the antihypertensive activities of Eprosartan.
Quinapril Dexmedetomidine may decrease the antihypertensive activities of Quinapril.
Omapatrilat Dexmedetomidine may decrease the antihypertensive activities of Omapatrilat.
Telmisartan Dexmedetomidine may decrease the antihypertensive activities of Telmisartan.
Irbesartan Dexmedetomidine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Dexmedetomidine may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Dexmedetomidine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Dexmedetomidine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Dexmedetomidine may decrease the antihypertensive activities of Trimethaphan.
Bretylium Dexmedetomidine may decrease the antihypertensive activities of Bretylium.
Rescinnamine Dexmedetomidine may decrease the antihypertensive activities of Rescinnamine.
Cilazapril Dexmedetomidine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Dexmedetomidine may decrease the antihypertensive activities of Saprisartan.
Spirapril Dexmedetomidine may decrease the antihypertensive activities of Spirapril.
Mibefradil Dexmedetomidine may decrease the antihypertensive activities of Mibefradil.
Sitaxentan Dexmedetomidine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Dexmedetomidine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Dexmedetomidine may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Dexmedetomidine may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Dexmedetomidine may decrease the antihypertensive activities of Pinacidil.
Temocapril Dexmedetomidine may decrease the antihypertensive activities of Temocapril.
Riociguat Dexmedetomidine may decrease the antihypertensive activities of Riociguat.
Aliskiren Dexmedetomidine may decrease the antihypertensive activities of Aliskiren.
Manidipine Dexmedetomidine may decrease the antihypertensive activities of Manidipine.
Moxonidine Dexmedetomidine may decrease the antihypertensive activities of Moxonidine.
Rauwolfia serpentina root Dexmedetomidine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Selexipag Dexmedetomidine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Dexmedetomidine may decrease the antihypertensive activities of Angiotensin 1-7.
Rilmenidine Dexmedetomidine may decrease the antihypertensive activities of Rilmenidine.
Imidapril Dexmedetomidine may decrease the antihypertensive activities of Imidapril.
BQ-123 Dexmedetomidine may decrease the antihypertensive activities of BQ-123.
Naftopidil Dexmedetomidine may decrease the antihypertensive activities of Naftopidil.
Zofenopril Dexmedetomidine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Dexmedetomidine may decrease the antihypertensive activities of Guanoxan.
Delapril Dexmedetomidine may decrease the antihypertensive activities of Delapril.
Vincamine Dexmedetomidine may decrease the antihypertensive activities of Vincamine.
Linsidomine Dexmedetomidine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Dexmedetomidine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Dexmedetomidine may decrease the antihypertensive activities of Tolonidine.
Endralazine Dexmedetomidine may decrease the antihypertensive activities of Endralazine.
Cadralazine Dexmedetomidine may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Dexmedetomidine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Dexmedetomidine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Dexmedetomidine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Dexmedetomidine may decrease the antihypertensive activities of Guanoclor.
Candesartan Dexmedetomidine may decrease the antihypertensive activities of Candesartan.
Dexniguldipine Dexmedetomidine may decrease the antihypertensive activities of Dexniguldipine.
Tocopherylquinone Dexmedetomidine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Dexmedetomidine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Dexmedetomidine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Dexmedetomidine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Dexmedetomidine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Dexmedetomidine may decrease the antihypertensive activities of Quinaprilat.
Captopril Dexmedetomidine may decrease the antihypertensive activities of Captopril.
Levamlodipine Dexmedetomidine may decrease the antihypertensive activities of Levamlodipine.
Diazoxide Dexmedetomidine may decrease the antihypertensive activities of Diazoxide.
Buprenorphine Dexmedetomidine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
Hydrocodone Dexmedetomidine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
Magnesium sulfate The therapeutic efficacy of Dexmedetomidine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Dexmedetomidine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Dexmedetomidine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
Mirtazapine Dexmedetomidine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
Orphenadrine Dexmedetomidine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Dexmedetomidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
Pramipexole Dexmedetomidine may increase the sedative activities of Pramipexole.

Target Protein

Alpha-2A adrenergic receptor ADRA2A

Referensi & Sumber

Synthesis reference: Inese Reine, Armands Zandersons, "METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS.." U.S. Patent US20100048915, issued February 25, 2010.

Contoh Produk & Brand

Produk: 124 • International brands: 2
Produk
  • Dexdor
    Injection, solution, concentrate • 100 mcg/ml • Intravenous • EU • Approved
  • Dexdor
    Injection, solution, concentrate • 100 mcg/ml • Intravenous • EU • Approved
  • Dexdor
    Injection, solution, concentrate • 100 mcg/ml • Intravenous • EU • Approved
  • Dexdor
    Injection, solution, concentrate • 100 mcg/ml • Intravenous • EU • Approved
  • Dexdor
    Injection, solution, concentrate • 100 mcg/ml • Intravenous • EU • Approved
  • Dexmedetomidine
    Injection, solution • 100 ug/1mL • Intravenous • US • Generic • Approved
  • Dexmedetomidine
    Injection, solution • 100 ug/1mL • Intravenous • US • Generic • Approved
  • Dexmedetomidine
    Injection, solution, concentrate • 100 ug/1mL • Intravenous • US • Generic • Approved
Menampilkan 8 dari 124 produk.
International Brands
  • Dexdor — Orion
  • Dexem — Themis Medicare

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul