Peringatan Keamanan

Excessive contraction of the pupils, irritability, low blood pressure, sleepiness, slow heartbeat, sluggishness

Guanabenz

DB00629

small molecule approved investigational

Deskripsi

An alpha-2 selective adrenergic agonist used as an antihypertensive agent. PubChem

Struktur Molekul 2D

Berat 231.082
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 6 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Approximately 75% absorbed from gastrointestinal tract

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1008 Data
Deferasirox The serum concentration of Guanabenz can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Guanabenz can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Guanabenz can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Guanabenz can be decreased when it is combined with Teriflunomide.
Alfuzosin Alfuzosin may increase the hypotensive activities of Guanabenz.
Amifostine Guanabenz may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Guanabenz.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Guanabenz.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Guanabenz.
Obinutuzumab Guanabenz may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Guanabenz.
Rituximab Guanabenz may increase the hypotensive activities of Rituximab.
Phentermine Phentermine may decrease the antihypertensive activities of Guanabenz.
Angiotensin 1-7 Guanabenz may decrease the antihypertensive activities of Angiotensin 1-7.
Yohimbine Yohimbine may decrease the antihypertensive activities of Guanabenz.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Guanabenz.
Siponimod Siponimod may decrease the antihypertensive activities of Guanabenz.
Felodipine Guanabenz may decrease the antihypertensive activities of Felodipine.
Valsartan Guanabenz may decrease the antihypertensive activities of Valsartan.
Ramipril Guanabenz may decrease the antihypertensive activities of Ramipril.
Reserpine Guanabenz may decrease the antihypertensive activities of Reserpine.
Torasemide Guanabenz may decrease the antihypertensive activities of Torasemide.
Isradipine Guanabenz may decrease the antihypertensive activities of Isradipine.
Olmesartan Guanabenz may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Guanabenz may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Guanabenz may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Guanabenz may decrease the antihypertensive activities of Diltiazem.
Minoxidil Guanabenz may decrease the antihypertensive activities of Minoxidil.
Amlodipine Guanabenz may decrease the antihypertensive activities of Amlodipine.
Nimodipine Guanabenz may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Guanabenz may decrease the antihypertensive activities of Nisoldipine.
Fosinopril Guanabenz may decrease the antihypertensive activities of Fosinopril.
Trandolapril Guanabenz may decrease the antihypertensive activities of Trandolapril.
Metolazone Guanabenz may decrease the antihypertensive activities of Metolazone.
Lercanidipine Guanabenz may decrease the antihypertensive activities of Lercanidipine.
Benazepril Guanabenz may decrease the antihypertensive activities of Benazepril.
Enalapril Guanabenz may decrease the antihypertensive activities of Enalapril.
Mecamylamine Guanabenz may decrease the antihypertensive activities of Mecamylamine.
Losartan Guanabenz may decrease the antihypertensive activities of Losartan.
Moexipril Guanabenz may decrease the antihypertensive activities of Moexipril.
Furosemide Guanabenz may decrease the antihypertensive activities of Furosemide.
Eplerenone Guanabenz may decrease the antihypertensive activities of Eplerenone.
Sufentanil Sufentanil may decrease the antihypertensive activities of Guanabenz.
Lisinopril Guanabenz may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Guanabenz may decrease the antihypertensive activities of Nitroglycerin.
Isoflurane Isoflurane may decrease the antihypertensive activities of Guanabenz.
Perindopril Guanabenz may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Guanabenz may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Guanabenz may decrease the antihypertensive activities of Fenoldopam.
Eprosartan Guanabenz may decrease the antihypertensive activities of Eprosartan.
Quinapril Guanabenz may decrease the antihypertensive activities of Quinapril.
Remifentanil Remifentanil may decrease the antihypertensive activities of Guanabenz.
Telmisartan Guanabenz may decrease the antihypertensive activities of Telmisartan.
Methyldopa Guanabenz may decrease the antihypertensive activities of Methyldopa.
Guanfacine Guanabenz may decrease the antihypertensive activities of Guanfacine.
Irbesartan Guanabenz may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Guanabenz may decrease the antihypertensive activities of Nitrendipine.
Bretylium Guanabenz may decrease the antihypertensive activities of Bretylium.
Halothane Halothane may decrease the antihypertensive activities of Guanabenz.
Desflurane Desflurane may decrease the antihypertensive activities of Guanabenz.
Captopril Guanabenz may decrease the antihypertensive activities of Captopril.
Sevoflurane Sevoflurane may decrease the antihypertensive activities of Guanabenz.
Bepridil Guanabenz may decrease the antihypertensive activities of Bepridil.
Hydralazine Guanabenz may decrease the antihypertensive activities of Hydralazine.
Cilazapril Guanabenz may decrease the antihypertensive activities of Cilazapril.
Rotigotine Rotigotine may decrease the antihypertensive activities of Guanabenz.
Nilvadipine Guanabenz may decrease the antihypertensive activities of Nilvadipine.
Azilsartan medoxomil Guanabenz may decrease the antihypertensive activities of Azilsartan medoxomil.
Riociguat Guanabenz may decrease the antihypertensive activities of Riociguat.
Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Guanabenz.
Aliskiren Guanabenz may decrease the antihypertensive activities of Aliskiren.
Efonidipine Guanabenz may decrease the antihypertensive activities of Efonidipine.
Lacidipine Guanabenz may decrease the antihypertensive activities of Lacidipine.
Moxonidine Guanabenz may decrease the antihypertensive activities of Moxonidine.
Enalaprilat Guanabenz may decrease the antihypertensive activities of Enalaprilat.
Imidapril Guanabenz may decrease the antihypertensive activities of Imidapril.
Acetylsalicylic acid Acetylsalicylic acid may decrease the antihypertensive activities of Guanabenz.
Selpercatinib Selpercatinib may decrease the antihypertensive activities of Guanabenz.
Naxitamab Naxitamab may decrease the antihypertensive activities of Guanabenz.
Levamlodipine Guanabenz may decrease the antihypertensive activities of Levamlodipine.
Amphetamine Amphetamine may decrease the antihypertensive activities of Guanabenz.
Cannabidiol The metabolism of Guanabenz can be decreased when combined with Cannabidiol.
Propofol Propofol may decrease the antihypertensive activities of Guanabenz.
Desmopressin Desmopressin may decrease the antihypertensive activities of Guanabenz.
Cyclosporine Cyclosporine may decrease the antihypertensive activities of Guanabenz.
Midodrine Midodrine may decrease the antihypertensive activities of Guanabenz.
Eletriptan Eletriptan may decrease the antihypertensive activities of Guanabenz.
Isoetharine Isoetharine may decrease the antihypertensive activities of Guanabenz.
Atomoxetine Atomoxetine may decrease the antihypertensive activities of Guanabenz.
Etomidate Etomidate may decrease the antihypertensive activities of Guanabenz.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Guanabenz.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Guanabenz.
Buspirone Buspirone may decrease the antihypertensive activities of Guanabenz.
Doxapram Doxapram may decrease the antihypertensive activities of Guanabenz.
Atropine Atropine may decrease the antihypertensive activities of Guanabenz.
Metaraminol Metaraminol may decrease the antihypertensive activities of Guanabenz.
Epinephrine Epinephrine may decrease the antihypertensive activities of Guanabenz.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Guanabenz.
Methoxamine Methoxamine may decrease the antihypertensive activities of Guanabenz.
Alfentanil Alfentanil may decrease the antihypertensive activities of Guanabenz.

Target Protein

Alpha-2A adrenergic receptor ADRA2A
Alpha-2B adrenergic receptor ADRA2B

Referensi & Sumber

Synthesis reference: British Patent 1,019,120.

Contoh Produk & Brand

Produk: 2 • International brands: 4
Produk
  • Guanabenz Acetate
    Tablet • 4 mg/1 • Oral • US • Generic • Approved
  • Guanabenz Acetate
    Tablet • 8 mg/1 • Oral • US • Generic • Approved
International Brands
  • Lisapres — Libbs
  • Rexitene — L.P.B.
  • Wytens — Alfresa Pharma
  • Wytensin — Wyeth

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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