Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1.
For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen.
Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
The presence of this polymorphism in CYP2B6 is associated with reduction in efavirenz metabolism.
| Ivabradine | Ivabradine may increase the QTc-prolonging activities of Efavirenz. |
| Reserpine | Reserpine may decrease the excretion rate of Efavirenz which could result in a higher serum level. |
| Cimetidine | Cimetidine may decrease the excretion rate of Efavirenz which could result in a higher serum level. |
| Ursodeoxycholic acid | Ursodeoxycholic acid may decrease the excretion rate of Efavirenz which could result in a higher serum level. |
| Cholic Acid | Cholic Acid may decrease the excretion rate of Efavirenz which could result in a higher serum level. |
| Valinomycin | Valinomycin may decrease the excretion rate of Efavirenz which could result in a higher serum level. |
| Olmesartan | Olmesartan may decrease the excretion rate of Efavirenz which could result in a higher serum level. |
| Lenvatinib | Lenvatinib may decrease the excretion rate of Efavirenz which could result in a higher serum level. |
| Cyclosporine | The serum concentration of Cyclosporine can be decreased when it is combined with Efavirenz. |
| Pravastatin | The serum concentration of Pravastatin can be decreased when it is combined with Efavirenz. |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Efavirenz. |
| Peginterferon alfa-2b | The serum concentration of Efavirenz can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Efavirenz can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Efavirenz can be decreased when it is combined with Teriflunomide. |
| Buprenorphine | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Efavirenz. |
| Dronabinol | The serum concentration of Dronabinol can be increased when it is combined with Efavirenz. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Efavirenz. |
| Magnesium sulfate | The therapeutic efficacy of Efavirenz can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Efavirenz may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Efavirenz. |
| Mirtazapine | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Efavirenz. |
| Orphenadrine | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Pramipexole | Efavirenz may increase the sedative activities of Pramipexole. |
| Rotigotine | Efavirenz may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Efavirenz. |
| Sodium oxybate | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Efavirenz. |
| Thalidomide | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Citalopram | The serum concentration of Citalopram can be increased when it is combined with Efavirenz. |
| Clopidogrel | The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Efavirenz resulting in a loss in efficacy. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Efavirenz. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Efavirenz. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Efavirenz. |
| Fentanyl | The metabolism of Fentanyl can be decreased when combined with Efavirenz. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Efavirenz. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Efavirenz. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Efavirenz. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Efavirenz. |
| Indinavir | The serum concentration of Indinavir can be decreased when it is combined with Efavirenz. |
| Lovastatin | The serum concentration of Lovastatin can be decreased when it is combined with Efavirenz. |
| Phenytoin | The serum concentration of Efavirenz can be decreased when it is combined with Phenytoin. |
| Fosphenytoin | The serum concentration of Efavirenz can be decreased when it is combined with Fosphenytoin. |
| Isradipine | The serum concentration of Isradipine can be decreased when it is combined with Efavirenz. |
| Diltiazem | The serum concentration of Diltiazem can be decreased when it is combined with Efavirenz. |
| Trimethadione | The serum concentration of Trimethadione can be decreased when it is combined with Efavirenz. |
| Amlodipine | The serum concentration of Amlodipine can be decreased when it is combined with Efavirenz. |
| Nimodipine | The serum concentration of Nimodipine can be decreased when it is combined with Efavirenz. |
| Nisoldipine | The serum concentration of Nisoldipine can be decreased when it is combined with Efavirenz. |
| Lercanidipine | The serum concentration of Lercanidipine can be decreased when it is combined with Efavirenz. |
| Cinnarizine | The serum concentration of Cinnarizine can be decreased when it is combined with Efavirenz. |
| Ethosuximide | The serum concentration of Ethosuximide can be decreased when it is combined with Efavirenz. |
| Nicardipine | The serum concentration of Nicardipine can be decreased when it is combined with Efavirenz. |
| Verapamil | The serum concentration of Verapamil can be decreased when it is combined with Efavirenz. |
| Loperamide | The metabolism of Loperamide can be decreased when combined with Efavirenz. |
| Zonisamide | The serum concentration of Zonisamide can be decreased when it is combined with Efavirenz. |
| Felodipine | The serum concentration of Felodipine can be decreased when it is combined with Efavirenz. |
| Nitrendipine | The serum concentration of Nitrendipine can be decreased when it is combined with Efavirenz. |
| Perhexiline | The serum concentration of Perhexiline can be decreased when it is combined with Efavirenz. |
| Nifedipine | The serum concentration of Nifedipine can be decreased when it is combined with Efavirenz. |
| Amiodarone | The serum concentration of Amiodarone can be decreased when it is combined with Efavirenz. |
| Carvedilol | The serum concentration of Carvedilol can be decreased when it is combined with Efavirenz. |
| Mibefradil | The serum concentration of Mibefradil can be decreased when it is combined with Efavirenz. |
| Nimesulide | The serum concentration of Nimesulide can be decreased when it is combined with Efavirenz. |
| Prenylamine | The serum concentration of Prenylamine can be decreased when it is combined with Efavirenz. |
| Cyclandelate | The serum concentration of Cyclandelate can be decreased when it is combined with Efavirenz. |
| Flunarizine | The serum concentration of Flunarizine can be decreased when it is combined with Efavirenz. |
| Fluspirilene | The serum concentration of Fluspirilene can be decreased when it is combined with Efavirenz. |
| Clevidipine | The serum concentration of Clevidipine can be decreased when it is combined with Efavirenz. |
| Methsuximide | The serum concentration of Methsuximide can be decreased when it is combined with Efavirenz. |
| Seletracetam | The serum concentration of Seletracetam can be decreased when it is combined with Efavirenz. |
| Nylidrin | The serum concentration of Nylidrin can be decreased when it is combined with Efavirenz. |
| Ziconotide | The serum concentration of Ziconotide can be decreased when it is combined with Efavirenz. |
| Dotarizine | The serum concentration of Dotarizine can be decreased when it is combined with Efavirenz. |
| Xylometazoline | The serum concentration of Xylometazoline can be decreased when it is combined with Efavirenz. |
| Nilvadipine | The serum concentration of Nilvadipine can be decreased when it is combined with Efavirenz. |
| Tranilast | The serum concentration of Tranilast can be decreased when it is combined with Efavirenz. |
| Fasudil | The serum concentration of Fasudil can be decreased when it is combined with Efavirenz. |
| Agmatine | The serum concentration of Agmatine can be decreased when it is combined with Efavirenz. |
| Fendiline | The serum concentration of Fendiline can be decreased when it is combined with Efavirenz. |
| Eperisone | The serum concentration of Eperisone can be decreased when it is combined with Efavirenz. |
| Trimebutine | The serum concentration of Trimebutine can be decreased when it is combined with Efavirenz. |
| Pinaverium | The serum concentration of Pinaverium can be decreased when it is combined with Efavirenz. |
| Aranidipine | The serum concentration of Aranidipine can be decreased when it is combined with Efavirenz. |
| Azelnidipine | The serum concentration of Azelnidipine can be decreased when it is combined with Efavirenz. |
| Benidipine | The serum concentration of Benidipine can be decreased when it is combined with Efavirenz. |
| Cilnidipine | The serum concentration of Cilnidipine can be decreased when it is combined with Efavirenz. |
| Darodipine | The serum concentration of Darodipine can be decreased when it is combined with Efavirenz. |
| Efonidipine | The serum concentration of Efonidipine can be decreased when it is combined with Efavirenz. |
| Lacidipine | The serum concentration of Lacidipine can be decreased when it is combined with Efavirenz. |
| Manidipine | The serum concentration of Manidipine can be decreased when it is combined with Efavirenz. |
| Niguldipine | The serum concentration of Niguldipine can be decreased when it is combined with Efavirenz. |
| Niludipine | The serum concentration of Niludipine can be decreased when it is combined with Efavirenz. |
| Carboxyamidotriazole | The serum concentration of Carboxyamidotriazole can be decreased when it is combined with Efavirenz. |
| Naftopidil | The serum concentration of Naftopidil can be decreased when it is combined with Efavirenz. |