Oral LD50 Rat = 184 mg/kg, Oral LD50 Mouse = 322 mg/kg
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. PubChem
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Nicardipine is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Nicardipine is combined with Levodopa. |
| Risperidone | Nicardipine may increase the hypotensive activities of Risperidone. |
| Reserpine | Reserpine may decrease the excretion rate of Nicardipine which could result in a higher serum level. |
| Ursodeoxycholic acid | Ursodeoxycholic acid may decrease the excretion rate of Nicardipine which could result in a higher serum level. |
| Cholic Acid | Cholic Acid may decrease the excretion rate of Nicardipine which could result in a higher serum level. |
| Simeprevir | Simeprevir may decrease the excretion rate of Nicardipine which could result in a higher serum level. |
| Lenvatinib | Lenvatinib may decrease the excretion rate of Nicardipine which could result in a higher serum level. |
| Valinomycin | Valinomycin may decrease the excretion rate of Nicardipine which could result in a higher serum level. |
| Olmesartan | Olmesartan may decrease the excretion rate of Nicardipine which could result in a higher serum level. |
| Pralsetinib | The serum concentration of Pralsetinib can be increased when it is combined with Nicardipine. |
| Ceritinib | Nicardipine may increase the bradycardic activities of Ceritinib. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Nicardipine. |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Nicardipine. |
| Amifostine | Nicardipine may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Nicardipine. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Nicardipine. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Nicardipine. |
| Obinutuzumab | Nicardipine may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Nicardipine. |
| Rituximab | Nicardipine may increase the hypotensive activities of Rituximab. |
| Desmopressin | Desmopressin may decrease the antihypertensive activities of Nicardipine. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Nicardipine. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Nicardipine. |
| Dopamine | Dopamine may decrease the antihypertensive activities of Nicardipine. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Nicardipine. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Nicardipine. |
| Tyramine | Tyramine may decrease the antihypertensive activities of Nicardipine. |
| Moxisylyte | Moxisylyte may decrease the antihypertensive activities of Nicardipine. |
| Atipamezole | Atipamezole may decrease the antihypertensive activities of Nicardipine. |
| Idazoxan | Idazoxan may decrease the antihypertensive activities of Nicardipine. |
| Tramazoline | Tramazoline may decrease the antihypertensive activities of Nicardipine. |
| Fenozolone | Fenozolone may decrease the antihypertensive activities of Nicardipine. |
| Xenon | Xenon may decrease the antihypertensive activities of Nicardipine. |
| Buflomedil | Buflomedil may decrease the antihypertensive activities of Nicardipine. |
| Mefenorex | Mefenorex may decrease the antihypertensive activities of Nicardipine. |
| Quinoline Yellow WS | Quinoline Yellow WS may decrease the antihypertensive activities of Nicardipine. |
| Dutasteride | Dutasteride may decrease the antihypertensive activities of Nicardipine. |
| Naxitamab | Naxitamab may decrease the antihypertensive activities of Nicardipine. |
| Brexpiprazole | The metabolism of Brexpiprazole can be decreased when combined with Nicardipine. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Nicardipine. |
| Everolimus | The metabolism of Everolimus can be decreased when combined with Nicardipine. |
| Flibanserin | The metabolism of Flibanserin can be decreased when combined with Nicardipine. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Nicardipine. |
| Ivabradine | The metabolism of Ivabradine can be decreased when combined with Nicardipine. |
| Ivacaftor | The metabolism of Ivacaftor can be decreased when combined with Nicardipine. |
| Lurasidone | The metabolism of Lurasidone can be decreased when combined with Nicardipine. |
| Naloxegol | The metabolism of Naloxegol can be decreased when combined with Nicardipine. |
| Olaparib | The metabolism of Olaparib can be decreased when combined with Nicardipine. |
| Ranolazine | The metabolism of Ranolazine can be decreased when combined with Nicardipine. |
| Sonidegib | The metabolism of Sonidegib can be decreased when combined with Nicardipine. |
| Avanafil | The metabolism of Avanafil can be decreased when combined with Nicardipine. |
| Eplerenone | The metabolism of Eplerenone can be decreased when combined with Nicardipine. |
| Aclidinium | The risk or severity of adverse effects can be increased when Nicardipine is combined with Aclidinium. |
| Mianserin | Mianserin may increase the anticholinergic activities of Nicardipine. |
| Mirabegron | The risk or severity of urinary retention can be increased when Nicardipine is combined with Mirabegron. |
| Potassium chloride | The risk or severity of gastrointestinal ulceration can be increased when Nicardipine is combined with Potassium chloride. |
| Pramlintide | The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Nicardipine. |
| Secretin porcine | The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Nicardipine. |
| Tiotropium | The risk or severity of adverse effects can be increased when Nicardipine is combined with Tiotropium. |
| Topiramate | The risk or severity of hyperthermia and oligohydrosis can be increased when Nicardipine is combined with Topiramate. |
| Umeclidinium | The risk or severity of adverse effects can be increased when Nicardipine is combined with Umeclidinium. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Nicardipine. |
| Fentanyl | The risk or severity of adverse effects can be increased when Nicardipine is combined with Fentanyl. |
| Iloperidone | The risk or severity of hypotension can be increased when Nicardipine is combined with Iloperidone. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Nicardipine. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Nicardipine. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Nicardipine. |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with Nicardipine. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Nicardipine. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with Nicardipine. |
| Cimetidine | The serum concentration of Nicardipine can be increased when it is combined with Cimetidine. |
| Clopidogrel | The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Nicardipine. |
| Efavirenz | The serum concentration of Nicardipine can be decreased when it is combined with Efavirenz. |
| Melatonin | The therapeutic efficacy of Nicardipine can be decreased when used in combination with Melatonin. |
| Nafcillin | The therapeutic efficacy of Nicardipine can be decreased when used in combination with Nafcillin. |
| Nitroprusside | Nicardipine may increase the hypotensive activities of Nitroprusside. |
| Dantrolene | The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Nicardipine. |
| Lithium citrate | The risk or severity of adverse effects can be increased when Nicardipine is combined with Lithium citrate. |
| Lithium carbonate | The risk or severity of adverse effects can be increased when Nicardipine is combined with Lithium carbonate. |
| Lithium hydroxide | The risk or severity of adverse effects can be increased when Nicardipine is combined with Lithium hydroxide. |
| Dapoxetine | Dapoxetine may increase the orthostatic hypotensive activities of Nicardipine. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Nicardipine. |
| Mifepristone | The serum concentration of Nicardipine can be increased when it is combined with Mifepristone. |
| Atomoxetine | The metabolism of Atomoxetine can be decreased when combined with Nicardipine. |
| Glycopyrronium | The risk or severity of adverse effects can be increased when Nicardipine is combined with Glycopyrronium. |
| Carvedilol | Nicardipine may increase the hypotensive activities of Carvedilol. |
| Warfarin | The serum concentration of Warfarin can be increased when it is combined with Nicardipine. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be increased when it is combined with Nicardipine. |
| (R)-warfarin | The serum concentration of (R)-warfarin can be increased when it is combined with Nicardipine. |
| R,S-Warfarin alcohol | The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Nicardipine. |
| S,R-Warfarin alcohol | The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Nicardipine. |
| (S)-Warfarin | The serum concentration of (S)-Warfarin can be increased when it is combined with Nicardipine. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Nicardipine. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Nicardipine. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Nicardipine. |
| Boceprevir | The serum concentration of Nicardipine can be increased when it is combined with Boceprevir. |
| Botulinum toxin type A | The risk or severity of adverse effects can be increased when Nicardipine is combined with Botulinum toxin type A. |
| Glucagon | Nicardipine may increase the gastrointestinal motility reducing activities of Glucagon. |
| Sulpiride | Nicardipine may increase the anticholinergic activities of Sulpiride. |