Peringatan Keamanan

LD50 = 4.8 g/kg (mouse, male)

Rifabutin

DB00615

small molecule approved investigational

Deskripsi

A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.

Struktur Molekul 2D

Berat 847.0047
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 45 (± 17) hours
Volume Distribusi -
Klirens (Clearance) * 0.69 +/- 0.32 L/hr/kg

Absorpsi

Rifabutin is readily absorbed from the gastrointestinal tract, with an absolute bioavailability averaging 20%.

Metabolisme

Hepatic. Of the five metabolites that have been identified, 25-O-desacetyl and 31-hydroxy are the most predominant. The former metabolite has an activity equal to the parent drug and contributes up to 10% to the total antimicrobial activity.

Rute Eliminasi

A mass-balance study in three healthy adult volunteers with 14C-labeled rifabutin showed that 53% of the oral dose was excreted in the urine, primarily as metabolites. About 30% of the dose is excreted in the feces.

Interaksi Makanan

1 Data
  • 1. Take with or without food. For those patients with propensity to nausea, vomiting, or other gastrointestinal upset, taking with food may be useful.

Interaksi Obat

543 Data
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Rifabutin.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Rifabutin.
Nelfinavir The serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Nelfinavir.
Indinavir The serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Indinavir.
Nevirapine The serum concentration of Rifabutin can be decreased when it is combined with Nevirapine.
Ritonavir The serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Ritonavir.
Atazanavir The serum concentration of 25-O-Desacetylrifabutin, an active metabolite of Rifabutin, can be increased when used in combination with Atazanavir.
Clopidogrel The therapeutic efficacy of Clopidogrel can be increased when used in combination with Rifabutin.
Efavirenz The metabolism of Rifabutin can be increased when combined with Efavirenz.
Elvitegravir The serum concentration of Rifabutin can be increased when it is combined with Elvitegravir.
Etravirine The serum concentration of Etravirine can be decreased when it is combined with Rifabutin.
Amprenavir The serum concentration of 25-O-Desacetylrifabutin, an active metabolite of Rifabutin, can be increased when used in combination with Amprenavir.
Fosamprenavir The serum concentration of 25-O-Desacetylrifabutin, an active metabolite of Rifabutin, can be increased when used in combination with Fosamprenavir.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Rifabutin.
Isoniazid Rifabutin may increase the hepatotoxic activities of Isoniazid.
Lopinavir The serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Lopinavir.
Perampanel The metabolism of Perampanel can be increased when combined with Rifabutin.
Raltegravir The serum concentration of Raltegravir can be decreased when it is combined with Rifabutin.
Saquinavir The serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Saquinavir.
Sofosbuvir The serum concentration of Sofosbuvir can be decreased when it is combined with Rifabutin.
Tipranavir The serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Tipranavir.
Warfarin The metabolism of Warfarin can be increased when combined with Rifabutin.
Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Rifabutin.
(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Rifabutin.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be increased when combined with Rifabutin.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be increased when combined with Rifabutin.
(S)-Warfarin The metabolism of (S)-Warfarin can be increased when combined with Rifabutin.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Rifabutin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Rifabutin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifabutin.
Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Rifabutin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Rifabutin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Rifabutin.
Pitolisant The serum concentration of Rifabutin can be decreased when it is combined with Pitolisant.
Boceprevir The serum concentration of Boceprevir can be decreased when it is combined with Rifabutin.
Darunavir The serum concentration of Rifabutin can be increased when it is combined with Darunavir.
Segesterone acetate The metabolism of Segesterone acetate can be increased when combined with Rifabutin.
Metreleptin The metabolism of Rifabutin can be increased when combined with Metreleptin.
Diethylstilbestrol The metabolism of Diethylstilbestrol can be increased when combined with Rifabutin.
Etonogestrel The metabolism of Etonogestrel can be increased when combined with Rifabutin.
Desogestrel The metabolism of Desogestrel can be increased when combined with Rifabutin.
Megestrol acetate The metabolism of Megestrol acetate can be increased when combined with Rifabutin.
Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Rifabutin.
Progesterone The metabolism of Progesterone can be increased when combined with Rifabutin.
Medroxyprogesterone acetate The metabolism of Medroxyprogesterone acetate can be increased when combined with Rifabutin.
Norethisterone The metabolism of Norethisterone can be increased when combined with Rifabutin.
Estradiol The metabolism of Estradiol can be increased when combined with Rifabutin.
Ethynodiol diacetate The metabolism of Ethynodiol diacetate can be increased when combined with Rifabutin.
Mifepristone The metabolism of Mifepristone can be increased when combined with Rifabutin.
Norgestimate The metabolism of Norgestimate can be increased when combined with Rifabutin.
Mestranol The metabolism of Mestranol can be increased when combined with Rifabutin.
Drospirenone The metabolism of Drospirenone can be increased when combined with Rifabutin.
Estrone sulfate The metabolism of Estrone sulfate can be increased when combined with Rifabutin.
Octylphenoxy polyethoxyethanol The metabolism of Octylphenoxy polyethoxyethanol can be increased when combined with Rifabutin.
Cyproterone acetate The metabolism of Cyproterone acetate can be increased when combined with Rifabutin.
Trestolone The metabolism of Trestolone can be increased when combined with Rifabutin.
Norelgestromin The metabolism of Norelgestromin can be increased when combined with Rifabutin.
Gestodene The metabolism of Gestodene can be increased when combined with Rifabutin.
Hydroxyprogesterone caproate The metabolism of Hydroxyprogesterone caproate can be increased when combined with Rifabutin.
Dienogest The metabolism of Dienogest can be increased when combined with Rifabutin.
Norethynodrel The metabolism of Norethynodrel can be increased when combined with Rifabutin.
Norgestrel The metabolism of Norgestrel can be increased when combined with Rifabutin.
Cloprostenol The metabolism of Cloprostenol can be increased when combined with Rifabutin.
Gestrinone The metabolism of Gestrinone can be increased when combined with Rifabutin.
Nomegestrol The metabolism of Nomegestrol can be increased when combined with Rifabutin.
Lynestrenol The metabolism of Lynestrenol can be increased when combined with Rifabutin.
Gossypol The metabolism of Gossypol can be increased when combined with Rifabutin.
Ormeloxifene The metabolism of Ormeloxifene can be increased when combined with Rifabutin.
Chlormadinone The metabolism of Chlormadinone can be increased when combined with Rifabutin.
Norgestrienone The metabolism of Norgestrienone can be increased when combined with Rifabutin.
Quingestanol The metabolism of Quingestanol can be increased when combined with Rifabutin.
Demegestone The metabolism of Demegestone can be increased when combined with Rifabutin.
Etynodiol The metabolism of Etynodiol can be increased when combined with Rifabutin.
Testosterone enanthate The metabolism of Testosterone enanthate can be increased when combined with Rifabutin.
Estradiol benzoate The metabolism of Estradiol benzoate can be increased when combined with Rifabutin.
Estradiol cypionate The metabolism of Estradiol cypionate can be increased when combined with Rifabutin.
Estradiol valerate The metabolism of Estradiol valerate can be increased when combined with Rifabutin.
Nomegestrol acetate The metabolism of Nomegestrol acetate can be increased when combined with Rifabutin.
Norethindrone enanthate The metabolism of Norethindrone enanthate can be increased when combined with Rifabutin.
Ulipristal The metabolism of Ulipristal can be increased when combined with Rifabutin.
Phenindione The risk or severity of bleeding can be increased when Rifabutin is combined with Phenindione.
Coumarin The risk or severity of bleeding can be increased when Rifabutin is combined with Coumarin.
Tioclomarol The risk or severity of bleeding can be increased when Rifabutin is combined with Tioclomarol.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Rifabutin is combined with Ethyl biscoumacetate.
Diphenadione The risk or severity of bleeding can be increased when Rifabutin is combined with Diphenadione.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Rifabutin is combined with 4-hydroxycoumarin.
Clorindione The risk or severity of bleeding can be increased when Rifabutin is combined with Clorindione.
Azithromycin The metabolism of Azithromycin can be increased when combined with Rifabutin.
Cephalexin The metabolism of Cephalexin can be increased when combined with Rifabutin.
Fenofibrate The metabolism of Fenofibrate can be increased when combined with Rifabutin.
Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Rifabutin.
Allylestrenol The metabolism of Allylestrenol can be increased when combined with Rifabutin.
Roflumilast The metabolism of Roflumilast can be increased when combined with Rifabutin.
Vorapaxar The metabolism of Vorapaxar can be increased when combined with Rifabutin.
Suvorexant The metabolism of Suvorexant can be increased when combined with Rifabutin.
Tasimelteon The metabolism of Tasimelteon can be increased when combined with Rifabutin.
Nintedanib The metabolism of Nintedanib can be increased when combined with Rifabutin.
Tenofovir alafenamide The metabolism of Tenofovir alafenamide can be increased when combined with Rifabutin.
Dihydroergocornine The metabolism of Dihydroergocornine can be increased when combined with Rifabutin.
Duvelisib The metabolism of Duvelisib can be increased when combined with Rifabutin.

Target Protein

DNA-directed RNA polymerase subunit alpha rpoA
DNA-directed RNA polymerase subunit beta rpoB
DNA-directed RNA polymerase subunit beta' rpoC
Heat shock protein HSP 90-alpha HSP90AA1
Endoplasmin HSP90B1

Referensi & Sumber

Contoh Produk & Brand

Produk: 12 • International brands: 3
Produk
  • Mycobutin
    Capsule • 150 mg/1 • Oral • US • Approved
  • Mycobutin
    Capsule • 150 mg/1 • Oral • US • Approved
  • Mycobutin
    Capsule • 150 mg/1 • Oral • US • Approved
  • Mycobutin
    Capsule • 150 mg • Oral • Canada • Approved
  • Mycobutin
    Capsule • 150 mg/1 • Oral • US • Approved
  • Rifabutin
    Capsule • 150 mg/1 • Oral • US • Generic • Approved
  • Rifabutin
    Capsule • 150 mg/1 • Oral • US • Generic • Approved
  • Rifabutin
    Capsule • 150 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 12 produk.
International Brands
  • Ansatipin — Pfizer
  • Ansatipine — SERB
  • Ributin — Lupin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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