Peringatan Keamanan

Reactions to Furoxone have been reported including a fall in blood pressure, urticaria, fever, arthralgia, and a vesicular morbilliform rash. Other adverse effects can include a brown discoloration of the urine; hemolysis can occur in G6PDH-deficient patients. The drug has a monoamine oxidase (MAO) inhibitory effect and should never be given concurrently to individuals already taking MAO inhibitors.

Furazolidone

DB00614

small molecule experimental vet_approved

Deskripsi

A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)

Struktur Molekul 2D

Berat 225.16
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Radiolabeled drug studies indicate that furazolidone is well absorbed following oral administration

Metabolisme

Furazolidone is rapidly and extensively metabolized; the primary metabolic pathway identified begins with nitro-reduction to the aminofuran derivative. Two major metabolites are produced: 3-amino-2-oxazolidone (AOZ) or beta-hydroxyethylhydrazine (HEH). AOZ is responsible for monoamine oxidase inhibition. Detoxification and elimination of the drug is done primarily by conjugation with glutathione.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1324 Data
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Furazolidone.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Furazolidone.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Furazolidone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Furazolidone.
Magnesium sulfate The therapeutic efficacy of Furazolidone can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Furazolidone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Furazolidone may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Furazolidone.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Furazolidone.
Orphenadrine Furazolidone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Furazolidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Furazolidone.
Pramipexole Furazolidone may increase the sedative activities of Pramipexole.
Ropinirole Furazolidone may increase the sedative activities of Ropinirole.
Rotigotine Furazolidone may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Furazolidone.
Sodium oxybate Furazolidone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Furazolidone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Furazolidone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Furazolidone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Furazolidone.
Cyclosporine The risk or severity of hypertension can be increased when Cyclosporine is combined with Furazolidone.
Icosapent The risk or severity of hypertension can be increased when Icosapent is combined with Furazolidone.
Mesalazine The risk or severity of hypertension can be increased when Mesalazine is combined with Furazolidone.
Indomethacin The risk or severity of hypertension can be increased when Indomethacin is combined with Furazolidone.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Furazolidone.
Nabumetone The risk or severity of hypertension can be increased when Nabumetone is combined with Furazolidone.
Ketorolac The risk or severity of hypertension can be increased when Ketorolac is combined with Furazolidone.
Tenoxicam The risk or severity of hypertension can be increased when Tenoxicam is combined with Furazolidone.
Celecoxib The risk or severity of hypertension can be increased when Celecoxib is combined with Furazolidone.
Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Furazolidone.
Rofecoxib The risk or severity of hypertension can be increased when Rofecoxib is combined with Furazolidone.
Piroxicam The risk or severity of hypertension can be increased when Piroxicam is combined with Furazolidone.
Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Furazolidone.
Valdecoxib The risk or severity of hypertension can be increased when Valdecoxib is combined with Furazolidone.
Diclofenac The risk or severity of hypertension can be increased when Diclofenac is combined with Furazolidone.
Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Furazolidone.
Nicergoline The risk or severity of hypertension can be increased when Furazolidone is combined with Nicergoline.
Flurbiprofen The risk or severity of hypertension can be increased when Furazolidone is combined with Flurbiprofen.
Etodolac The risk or severity of hypertension can be increased when Furazolidone is combined with Etodolac.
Mefenamic acid The risk or severity of hypertension can be increased when Furazolidone is combined with Mefenamic acid.
Naproxen The risk or severity of hypertension can be increased when Furazolidone is combined with Naproxen.
Sulfasalazine The risk or severity of hypertension can be increased when Furazolidone is combined with Sulfasalazine.
Phenylbutazone The risk or severity of hypertension can be increased when Furazolidone is combined with Phenylbutazone.
Meloxicam The risk or severity of hypertension can be increased when Furazolidone is combined with Meloxicam.
Carprofen The risk or severity of hypertension can be increased when Furazolidone is combined with Carprofen.
Phenmetrazine The risk or severity of hypertension can be increased when Furazolidone is combined with Phenmetrazine.
Diflunisal The risk or severity of hypertension can be increased when Furazolidone is combined with Diflunisal.
Salicylic acid The risk or severity of hypertension can be increased when Furazolidone is combined with Salicylic acid.
Meclofenamic acid The risk or severity of hypertension can be increased when Furazolidone is combined with Meclofenamic acid.
Oxaprozin The risk or severity of hypertension can be increased when Furazolidone is combined with Oxaprozin.
Ketoprofen The risk or severity of hypertension can be increased when Furazolidone is combined with Ketoprofen.
Balsalazide The risk or severity of hypertension can be increased when Furazolidone is combined with Balsalazide.
Ibuprofen The risk or severity of hypertension can be increased when Furazolidone is combined with Ibuprofen.
Dutasteride The risk or severity of hypertension can be increased when Furazolidone is combined with Dutasteride.
Propafenone The risk or severity of hypertension can be increased when Furazolidone is combined with Propafenone.
Finasteride The risk or severity of hypertension can be increased when Furazolidone is combined with Finasteride.
Lumiracoxib The risk or severity of hypertension can be increased when Furazolidone is combined with Lumiracoxib.
Ephedrine The risk or severity of hypertension can be increased when Furazolidone is combined with Ephedrine.
Magnesium salicylate The risk or severity of hypertension can be increased when Furazolidone is combined with Magnesium salicylate.
Salsalate The risk or severity of hypertension can be increased when Furazolidone is combined with Salsalate.
Choline magnesium trisalicylate The risk or severity of hypertension can be increased when Furazolidone is combined with Choline magnesium trisalicylate.
Antrafenine The risk or severity of hypertension can be increased when Furazolidone is combined with Antrafenine.
Aminophenazone The risk or severity of hypertension can be increased when Furazolidone is combined with Aminophenazone.
Antipyrine The risk or severity of hypertension can be increased when Furazolidone is combined with Antipyrine.
Tiaprofenic acid The risk or severity of hypertension can be increased when Furazolidone is combined with Tiaprofenic acid.
Etoricoxib The risk or severity of hypertension can be increased when Furazolidone is combined with Etoricoxib.
Epicaptopril The risk or severity of hypertension can be increased when Furazolidone is combined with Epicaptopril.
Taxifolin The risk or severity of hypertension can be increased when Furazolidone is combined with Taxifolin.
Oxyphenbutazone The risk or severity of hypertension can be increased when Furazolidone is combined with Oxyphenbutazone.
1-benzylimidazole The risk or severity of hypertension can be increased when Furazolidone is combined with 1-benzylimidazole.
Benoxaprofen The risk or severity of hypertension can be increased when Furazolidone is combined with Benoxaprofen.
Metamizole The risk or severity of hypertension can be increased when Furazolidone is combined with Metamizole.
Zomepirac The risk or severity of hypertension can be increased when Furazolidone is combined with Zomepirac.
Dronedarone The risk or severity of hypertension can be increased when Furazolidone is combined with Dronedarone.
Cimicoxib The risk or severity of hypertension can be increased when Furazolidone is combined with Cimicoxib.
Amibegron The risk or severity of hypertension can be increased when Furazolidone is combined with Amibegron.
Nylidrin The risk or severity of hypertension can be increased when Furazolidone is combined with Nylidrin.
Solabegron The risk or severity of hypertension can be increased when Furazolidone is combined with Solabegron.
Lornoxicam The risk or severity of hypertension can be increased when Furazolidone is combined with Lornoxicam.
Aceclofenac The risk or severity of hypertension can be increased when Furazolidone is combined with Aceclofenac.
Zaltoprofen The risk or severity of hypertension can be increased when Furazolidone is combined with Zaltoprofen.
Saralasin The risk or severity of hypertension can be increased when Furazolidone is combined with Saralasin.
Azapropazone The risk or severity of hypertension can be increased when Furazolidone is combined with Azapropazone.
Parecoxib The risk or severity of hypertension can be increased when Furazolidone is combined with Parecoxib.
Salicylamide The risk or severity of hypertension can be increased when Furazolidone is combined with Salicylamide.
Tyramine The risk or severity of hypertension can be increased when Furazolidone is combined with Tyramine.
Mirabegron The risk or severity of hypertension can be increased when Furazolidone is combined with Mirabegron.
Adrafinil The risk or severity of hypertension can be increased when Furazolidone is combined with Adrafinil.
Kebuzone The risk or severity of hypertension can be increased when Furazolidone is combined with Kebuzone.
Isoxicam The risk or severity of hypertension can be increased when Furazolidone is combined with Isoxicam.
Indoprofen The risk or severity of hypertension can be increased when Furazolidone is combined with Indoprofen.
Ibuproxam The risk or severity of hypertension can be increased when Furazolidone is combined with Ibuproxam.
Floctafenine The risk or severity of hypertension can be increased when Furazolidone is combined with Floctafenine.
Fenbufen The risk or severity of hypertension can be increased when Furazolidone is combined with Fenbufen.
Etofenamate The risk or severity of hypertension can be increased when Furazolidone is combined with Etofenamate.
Etilefrine The risk or severity of hypertension can be increased when Furazolidone is combined with Etilefrine.
Epirizole The risk or severity of hypertension can be increased when Furazolidone is combined with Epirizole.
Benzydamine The risk or severity of hypertension can be increased when Furazolidone is combined with Benzydamine.
Synephrine The risk or severity of hypertension can be increased when Furazolidone is combined with Synephrine.

Target Protein

DNA

Referensi & Sumber

Synthesis reference: Drake, G.D., Gever, G. and Hayes, K.J.; U.S. Patent 2,759,931; August 21, 1956; assigned to The Norwich Pharmacal Company. Gever, G. and O'Keefe, C.J.; U.S. Patent 2,927,l IO; March 1, 1960; assigned to The Norwich Pharmacal Company.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Dependal-M — GlaxoSmithKline
  • Furoxone — Roberts Laboratories

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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