Peringatan Keamanan

LD50=240 mg/kg (rat, oral); LD50=99 mg/kg (mouse, oral)

Metaraminol

DB00610

small molecule approved investigational

Deskripsi

An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension.

Struktur Molekul 2D

Berat 167.205
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection.

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

746 Data
Valsartan Metaraminol may decrease the antihypertensive activities of Valsartan.
Ramipril Metaraminol may decrease the antihypertensive activities of Ramipril.
Reserpine Metaraminol may decrease the antihypertensive activities of Reserpine.
Remikiren Metaraminol may decrease the antihypertensive activities of Remikiren.
Torasemide Metaraminol may decrease the antihypertensive activities of Torasemide.
Isradipine Metaraminol may decrease the antihypertensive activities of Isradipine.
Olmesartan Metaraminol may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Metaraminol may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Metaraminol may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Metaraminol may decrease the antihypertensive activities of Diltiazem.
Minoxidil Metaraminol may decrease the antihypertensive activities of Minoxidil.
Treprostinil Metaraminol may decrease the antihypertensive activities of Treprostinil.
Amlodipine Metaraminol may decrease the antihypertensive activities of Amlodipine.
Nimodipine Metaraminol may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Metaraminol may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Metaraminol may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Metaraminol may decrease the antihypertensive activities of Fosinopril.
Trandolapril Metaraminol may decrease the antihypertensive activities of Trandolapril.
Metolazone Metaraminol may decrease the antihypertensive activities of Metolazone.
Lercanidipine Metaraminol may decrease the antihypertensive activities of Lercanidipine.
Benazepril Metaraminol may decrease the antihypertensive activities of Benazepril.
Bosentan Metaraminol may decrease the antihypertensive activities of Bosentan.
Enalapril Metaraminol may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Metaraminol may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Metaraminol may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Metaraminol may decrease the antihypertensive activities of Mecamylamine.
Losartan Metaraminol may decrease the antihypertensive activities of Losartan.
Moexipril Metaraminol may decrease the antihypertensive activities of Moexipril.
Eplerenone Metaraminol may decrease the antihypertensive activities of Eplerenone.
Lisinopril Metaraminol may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Metaraminol may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Metaraminol may decrease the antihypertensive activities of Metyrosine.
Hydroflumethiazide Metaraminol may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Metaraminol may decrease the antihypertensive activities of Cryptenamine.
Perindopril Metaraminol may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Metaraminol may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Metaraminol may decrease the antihypertensive activities of Fenoldopam.
Indapamide Metaraminol may decrease the antihypertensive activities of Indapamide.
Tadalafil Metaraminol may decrease the antihypertensive activities of Tadalafil.
Eprosartan Metaraminol may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Metaraminol may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Metaraminol may decrease the antihypertensive activities of Quinapril.
Telmisartan Metaraminol may decrease the antihypertensive activities of Telmisartan.
Methyldopa Metaraminol may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Metaraminol may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Metaraminol may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Metaraminol may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Metaraminol may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Metaraminol may decrease the antihypertensive activities of Deserpidine.
Pentolinium Metaraminol may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Metaraminol may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Metaraminol may decrease the antihypertensive activities of Diazoxide.
Captopril Metaraminol may decrease the antihypertensive activities of Captopril.
Epoprostenol Metaraminol may decrease the antihypertensive activities of Epoprostenol.
Bepridil Metaraminol may decrease the antihypertensive activities of Bepridil.
Hydralazine Metaraminol may decrease the antihypertensive activities of Hydralazine.
Polythiazide Metaraminol may decrease the antihypertensive activities of Polythiazide.
Cilazapril Metaraminol may decrease the antihypertensive activities of Cilazapril.
Saprisartan Metaraminol may decrease the antihypertensive activities of Saprisartan.
Spirapril Metaraminol may decrease the antihypertensive activities of Spirapril.
Mibefradil Metaraminol may decrease the antihypertensive activities of Mibefradil.
Tienilic acid Metaraminol may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Metaraminol may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Metaraminol may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Metaraminol may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Metaraminol may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Metaraminol may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Metaraminol may decrease the antihypertensive activities of Pinacidil.
Temocapril Metaraminol may decrease the antihypertensive activities of Temocapril.
Riociguat Metaraminol may decrease the antihypertensive activities of Riociguat.
Macitentan Metaraminol may decrease the antihypertensive activities of Macitentan.
Hexamethonium Metaraminol may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Metaraminol may decrease the antihypertensive activities of Aliskiren.
Nicorandil Metaraminol may decrease the antihypertensive activities of Nicorandil.
Efonidipine Metaraminol may decrease the antihypertensive activities of Efonidipine.
Lacidipine Metaraminol may decrease the antihypertensive activities of Lacidipine.
Manidipine Metaraminol may decrease the antihypertensive activities of Manidipine.
Rauwolfia serpentina root Metaraminol may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Metaraminol may decrease the antihypertensive activities of Enalaprilat.
Selexipag Metaraminol may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Metaraminol may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Metaraminol may decrease the antihypertensive activities of Imidapril.
BQ-123 Metaraminol may decrease the antihypertensive activities of BQ-123.
Tetrahydropalmatine Metaraminol may decrease the antihypertensive activities of Tetrahydropalmatine.
Cicletanine Metaraminol may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Metaraminol may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Metaraminol may decrease the antihypertensive activities of Zofenopril.
Guanoxan Metaraminol may decrease the antihypertensive activities of Guanoxan.
Delapril Metaraminol may decrease the antihypertensive activities of Delapril.
Vincamine Metaraminol may decrease the antihypertensive activities of Vincamine.
Linsidomine Metaraminol may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Metaraminol may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Metaraminol may decrease the antihypertensive activities of Tolonidine.
Endralazine Metaraminol may decrease the antihypertensive activities of Endralazine.
Cadralazine Metaraminol may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Metaraminol may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Metaraminol may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Metaraminol may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Metaraminol may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Metaraminol may decrease the antihypertensive activities of Guanoclor.

Target Protein

D(2) dopamine receptor DRD2
Alpha-1A adrenergic receptor ADRA1A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15703094
    McDonald M, Santucci RA: Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol. Int Braz J Urol. 2004 Mar-Apr;30(2):121-2.
  • PMID: 2258979
    Koga S, Shiraishi K, Saito Y: Post-traumatic priapism treated with metaraminol bitartrate: case report. J Trauma. 1990 Dec;30(12):1591-3.
  • PMID: 3140463
    Block T, Sturm W, Ernst G, Staehler G, Schmiedt E: Metaraminol in therapy of various forms of priapism. Urologe A. 1988 Jul;27(4):225-9.

Contoh Produk & Brand

Produk: 1 • International brands: 3
Produk
  • Metaraminol Bitartrate
    Injection • 10 mg/1mL • Intramuscular; Intravenous • US • Generic • Approved
International Brands
  • Aramine — Merck
  • Metaramin
  • Pressonex

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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