Peringatan Keamanan

Serious toxicity is unlikely following large doses of nafcillin. Acute ingestion of large doses of nafcillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses. The oral LD50 in rats is >5000mg/kg and the intravenous LD50 in rats is >1000mg/kg MSDS.

Nafcillin

DB00607

small molecule approved investigational

Deskripsi

A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections A20360.

Struktur Molekul 2D

Berat 414.475
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The serum half-life of nafcillin administered by the intravenous route ranged from 33 to 61 minutes as measured in three separate studies.
Volume Distribusi Nafcillin is reported to be widely distributed in various body fluids, including bile, pleural, amniotic and synovial fluids [FDA Label].
Klirens (Clearance) -

Absorpsi

Following intravenous administration of 500mg nafcillin, the mean plasma concentration was approximately 30 µg/mL. This value was reached after 5 minutes of injection FDA Label.

Metabolisme

Hepatic metabolism accounts for less than 30% of the biotransformation of most penicillins.

Rute Eliminasi

Nafcillin is primarily eliminated by non-renal routes, namely hepatic inactivation and excretion in the bile.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach. Food may make the absorption of oral nafcillin unpredictable.

Interaksi Obat

620 Data
Cyclosporine The metabolism of Cyclosporine can be increased when combined with Nafcillin.
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Nafcillin.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Nafcillin.
Isradipine The therapeutic efficacy of Isradipine can be decreased when used in combination with Nafcillin.
Diltiazem The therapeutic efficacy of Diltiazem can be decreased when used in combination with Nafcillin.
Trimethadione The therapeutic efficacy of Trimethadione can be decreased when used in combination with Nafcillin.
Amlodipine The therapeutic efficacy of Amlodipine can be decreased when used in combination with Nafcillin.
Nimodipine The therapeutic efficacy of Nimodipine can be decreased when used in combination with Nafcillin.
Nisoldipine The therapeutic efficacy of Nisoldipine can be decreased when used in combination with Nafcillin.
Lercanidipine The therapeutic efficacy of Lercanidipine can be decreased when used in combination with Nafcillin.
Cinnarizine The therapeutic efficacy of Cinnarizine can be decreased when used in combination with Nafcillin.
Ethosuximide The therapeutic efficacy of Ethosuximide can be decreased when used in combination with Nafcillin.
Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Nafcillin.
Magnesium sulfate The therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Nafcillin.
Verapamil The therapeutic efficacy of Verapamil can be decreased when used in combination with Nafcillin.
Zonisamide The therapeutic efficacy of Zonisamide can be decreased when used in combination with Nafcillin.
Felodipine The therapeutic efficacy of Felodipine can be decreased when used in combination with Nafcillin.
Nitrendipine The therapeutic efficacy of Nitrendipine can be decreased when used in combination with Nafcillin.
Perhexiline The therapeutic efficacy of Perhexiline can be decreased when used in combination with Nafcillin.
Nifedipine The therapeutic efficacy of Nifedipine can be decreased when used in combination with Nafcillin.
Amiodarone The therapeutic efficacy of Amiodarone can be decreased when used in combination with Nafcillin.
Carvedilol The therapeutic efficacy of Carvedilol can be decreased when used in combination with Nafcillin.
Bepridil The therapeutic efficacy of Bepridil can be decreased when used in combination with Nafcillin.
Mibefradil The therapeutic efficacy of Mibefradil can be decreased when used in combination with Nafcillin.
Nimesulide The therapeutic efficacy of Nimesulide can be decreased when used in combination with Nafcillin.
Prenylamine The therapeutic efficacy of Prenylamine can be decreased when used in combination with Nafcillin.
Cyclandelate The therapeutic efficacy of Cyclandelate can be decreased when used in combination with Nafcillin.
Flunarizine The therapeutic efficacy of Flunarizine can be decreased when used in combination with Nafcillin.
Fluspirilene The therapeutic efficacy of Fluspirilene can be decreased when used in combination with Nafcillin.
Clevidipine The therapeutic efficacy of Clevidipine can be decreased when used in combination with Nafcillin.
Methsuximide The therapeutic efficacy of Methsuximide can be decreased when used in combination with Nafcillin.
Seletracetam The therapeutic efficacy of Seletracetam can be decreased when used in combination with Nafcillin.
Nylidrin The therapeutic efficacy of Nylidrin can be decreased when used in combination with Nafcillin.
Ziconotide The therapeutic efficacy of Ziconotide can be decreased when used in combination with Nafcillin.
Dotarizine The therapeutic efficacy of Dotarizine can be decreased when used in combination with Nafcillin.
Xylometazoline The therapeutic efficacy of Xylometazoline can be decreased when used in combination with Nafcillin.
Nilvadipine The therapeutic efficacy of Nilvadipine can be decreased when used in combination with Nafcillin.
Tranilast The therapeutic efficacy of Tranilast can be decreased when used in combination with Nafcillin.
Fasudil The therapeutic efficacy of Fasudil can be decreased when used in combination with Nafcillin.
Agmatine The therapeutic efficacy of Agmatine can be decreased when used in combination with Nafcillin.
Fendiline The therapeutic efficacy of Fendiline can be decreased when used in combination with Nafcillin.
Eperisone The therapeutic efficacy of Eperisone can be decreased when used in combination with Nafcillin.
Trimebutine The therapeutic efficacy of Trimebutine can be decreased when used in combination with Nafcillin.
Pinaverium The therapeutic efficacy of Pinaverium can be decreased when used in combination with Nafcillin.
Barnidipine The therapeutic efficacy of Barnidipine can be decreased when used in combination with Nafcillin.
Aranidipine The therapeutic efficacy of Aranidipine can be decreased when used in combination with Nafcillin.
Azelnidipine The therapeutic efficacy of Azelnidipine can be decreased when used in combination with Nafcillin.
Benidipine The therapeutic efficacy of Benidipine can be decreased when used in combination with Nafcillin.
Cilnidipine The therapeutic efficacy of Cilnidipine can be decreased when used in combination with Nafcillin.
Darodipine The therapeutic efficacy of Darodipine can be decreased when used in combination with Nafcillin.
Efonidipine The therapeutic efficacy of Efonidipine can be decreased when used in combination with Nafcillin.
Lacidipine The therapeutic efficacy of Lacidipine can be decreased when used in combination with Nafcillin.
Manidipine The therapeutic efficacy of Manidipine can be decreased when used in combination with Nafcillin.
Niguldipine The therapeutic efficacy of Niguldipine can be decreased when used in combination with Nafcillin.
Niludipine The therapeutic efficacy of Niludipine can be decreased when used in combination with Nafcillin.
Carboxyamidotriazole The therapeutic efficacy of Carboxyamidotriazole can be decreased when used in combination with Nafcillin.
Naftopidil The therapeutic efficacy of Naftopidil can be decreased when used in combination with Nafcillin.
Tetrahydropalmatine The therapeutic efficacy of Tetrahydropalmatine can be decreased when used in combination with Nafcillin.
Vinpocetine The therapeutic efficacy of Vinpocetine can be decreased when used in combination with Nafcillin.
Gallopamil The therapeutic efficacy of Gallopamil can be decreased when used in combination with Nafcillin.
Bencyclane The therapeutic efficacy of Bencyclane can be decreased when used in combination with Nafcillin.
Otilonium The therapeutic efficacy of Otilonium can be decreased when used in combination with Nafcillin.
Terodiline The therapeutic efficacy of Terodiline can be decreased when used in combination with Nafcillin.
Lidoflazine The therapeutic efficacy of Lidoflazine can be decreased when used in combination with Nafcillin.
Penfluridol The therapeutic efficacy of Penfluridol can be decreased when used in combination with Nafcillin.
Caroverine The therapeutic efficacy of Caroverine can be decreased when used in combination with Nafcillin.
WIN 55212-2 The therapeutic efficacy of WIN 55212-2 can be decreased when used in combination with Nafcillin.
Dexverapamil The therapeutic efficacy of Dexverapamil can be decreased when used in combination with Nafcillin.
Emopamil The therapeutic efficacy of Emopamil can be decreased when used in combination with Nafcillin.
Lomerizine The therapeutic efficacy of Lomerizine can be decreased when used in combination with Nafcillin.
Tetrandrine The therapeutic efficacy of Tetrandrine can be decreased when used in combination with Nafcillin.
Dexniguldipine The therapeutic efficacy of Dexniguldipine can be decreased when used in combination with Nafcillin.
Daclatasvir The metabolism of Daclatasvir can be increased when combined with Nafcillin.
Methotrexate The excretion of Methotrexate can be decreased when combined with Nafcillin.
Probenecid The excretion of Nafcillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Nafcillin can be decreased when used in combination with Penimepicycline.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Nafcillin.
Perampanel The metabolism of Perampanel can be increased when combined with Nafcillin.
Warfarin The metabolism of Warfarin can be increased when combined with Nafcillin.
Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Nafcillin.
(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Nafcillin.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be increased when combined with Nafcillin.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be increased when combined with Nafcillin.
(S)-Warfarin The metabolism of (S)-Warfarin can be increased when combined with Nafcillin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Nafcillin.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Nafcillin.
Rolapitant The metabolism of Rolapitant can be increased when combined with Nafcillin.

Target Protein

Penicillin-binding protein 1b pbp1b
Penicillin-binding protein 2B penA
Penicillin-binding protein 2a pbp2a
Penicillin-binding protein 3 pbp3
Penicillin-binding protein 1A pbpA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 25991471
    Blumenthal KG, Parker RA, Shenoy ES, Walensky RP: Improving Clinical Outcomes in Patients With Methicillin-Sensitive Staphylococcus aureus Bacteremia and Reported Penicillin Allergy. Clin Infect Dis. 2015 Sep 1;61(5):741-9. doi: 10.1093/cid/civ394. Epub 2015 May 19.
  • PMID: 26976858
    Viehman JA, Oleksiuk LM, Sheridan KR, Byers KE, He P, Falcione BA, Shields RK: Adverse Events Lead to Drug Discontinuation More Commonly among Patients Who Receive Nafcillin than among Those Who Receive Oxacillin. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3090-5. doi: 10.1128/AAC.03122-15. Print 2016 May.
  • PMID: 24785233
    Youngster I, Shenoy ES, Hooper DC, Nelson SB: Comparative evaluation of the tolerability of cefazolin and nafcillin for treatment of methicillin-susceptible Staphylococcus aureus infections in the outpatient setting. Clin Infect Dis. 2014 Aug 1;59(3):369-75. doi: 10.1093/cid/ciu301. Epub 2014 Apr 29.
Textbook
  • ISBN: 978-0-7020-3471-8
    49. (2012). In Rang and Dale's Pharmacology (7th ed., pp. 612). Edinburgh: Elsevier/Churchill Livingstone.

Contoh Produk & Brand

Produk: 50 • International brands: 2
Produk
  • Nafcillin
    Injection • 1 g/1 • Intramuscular; Intravenous • US • Generic • Approved
  • Nafcillin
    Injection • 2 g/1 • Intramuscular; Intravenous • US • Generic • Approved
  • Nafcillin
    Injection, powder, for solution • 10 g/100mL • Intravenous • US • Generic • Approved
  • Nafcillin
    Injection, powder, for solution • 1 g/1 • Intramuscular; Intravenous • US • Generic • Approved
  • Nafcillin
    Injection, powder, for solution • 2 g/1 • Intramuscular; Intravenous • US • Generic • Approved
  • Nafcillin
    Injection, powder, for solution • 1 g/1 • Intramuscular; Intravenous • US • Generic • Approved
  • Nafcillin
    Injection, powder, for solution • 2 g/1 • Intramuscular; Intravenous • US • Generic • Approved
  • Nafcillin
    Injection, powder, for solution • 10 g/100mL • Intravenous • US • Generic • Approved
Menampilkan 8 dari 50 produk.
International Brands
  • Nallpen
  • Unipen

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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