Oral LD50 in mouse is > 10000 mg/kg, and > 4000 mg/kg in rat. Signs of overdose include those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered hypokalemia may accentuate cardiac arrhythmias.
As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of cyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Alfuzosin | Alfuzosin may increase the hypotensive activities of Cyclothiazide. |
| Amifostine | Cyclothiazide may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Cyclothiazide. |
| Forasartan | Cyclothiazide may increase the hypotensive and Electrolyte Disturbance activities of Forasartan. |
| Tasosartan | Cyclothiazide may increase the hypotensive and Electrolyte Disturbance activities of Tasosartan. |
| Saralasin | Cyclothiazide may increase the hypotensive and Electrolyte Disturbance activities of Saralasin. |
| Fimasartan | Cyclothiazide may increase the hypotensive and Electrolyte Disturbance activities of Fimasartan. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Cyclothiazide. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Cyclothiazide. |
| Obinutuzumab | Cyclothiazide may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Cyclothiazide. |
| Rituximab | Cyclothiazide may increase the hypotensive activities of Rituximab. |
| Phentermine | Phentermine may decrease the antihypertensive activities of Cyclothiazide. |
| Midodrine | Midodrine may decrease the antihypertensive activities of Cyclothiazide. |
| Eletriptan | Eletriptan may decrease the antihypertensive activities of Cyclothiazide. |
| Methysergide | Methysergide may decrease the antihypertensive activities of Cyclothiazide. |
| Cabergoline | Cabergoline may decrease the antihypertensive activities of Cyclothiazide. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Cyclothiazide. |
| Dihydroergotamine | Dihydroergotamine may decrease the antihypertensive activities of Cyclothiazide. |
| Protriptyline | Protriptyline may decrease the antihypertensive activities of Cyclothiazide. |
| Methylergometrine | Methylergometrine may decrease the antihypertensive activities of Cyclothiazide. |
| Mirtazapine | Mirtazapine may decrease the antihypertensive activities of Cyclothiazide. |
| Phenylephrine | Phenylephrine may decrease the antihypertensive activities of Cyclothiazide. |
| Promazine | Promazine may decrease the antihypertensive activities of Cyclothiazide. |
| Droperidol | Droperidol may decrease the antihypertensive activities of Cyclothiazide. |
| Nortriptyline | Nortriptyline may decrease the antihypertensive activities of Cyclothiazide. |
| Amoxapine | Amoxapine may decrease the antihypertensive activities of Cyclothiazide. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Cyclothiazide. |
| Atropine | Atropine may decrease the antihypertensive activities of Cyclothiazide. |
| Lisuride | Lisuride may decrease the antihypertensive activities of Cyclothiazide. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Cyclothiazide. |
| Trazodone | Trazodone may decrease the antihypertensive activities of Cyclothiazide. |
| Ergotamine | Ergotamine may decrease the antihypertensive activities of Cyclothiazide. |
| Nicergoline | Nicergoline may decrease the antihypertensive activities of Cyclothiazide. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Cyclothiazide. |
| Trimipramine | Trimipramine may decrease the antihypertensive activities of Cyclothiazide. |
| Risperidone | Risperidone may decrease the antihypertensive activities of Cyclothiazide. |
| Propiomazine | Propiomazine may decrease the antihypertensive activities of Cyclothiazide. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Cyclothiazide. |
| Trifluoperazine | Trifluoperazine may decrease the antihypertensive activities of Cyclothiazide. |
| Pseudoephedrine | Pseudoephedrine may decrease the antihypertensive activities of Cyclothiazide. |
| Benzphetamine | Benzphetamine may decrease the antihypertensive activities of Cyclothiazide. |
| Flupentixol | Flupentixol may decrease the antihypertensive activities of Cyclothiazide. |
| Diethylpropion | Diethylpropion may decrease the antihypertensive activities of Cyclothiazide. |
| Naratriptan | Naratriptan may decrease the antihypertensive activities of Cyclothiazide. |
| Frovatriptan | Frovatriptan may decrease the antihypertensive activities of Cyclothiazide. |
| Methoxyflurane | Methoxyflurane may decrease the antihypertensive activities of Cyclothiazide. |
| Ergoloid mesylate | Ergoloid mesylate may decrease the antihypertensive activities of Cyclothiazide. |
| Dutasteride | Dutasteride may decrease the antihypertensive activities of Cyclothiazide. |
| Propafenone | Propafenone may decrease the antihypertensive activities of Cyclothiazide. |
| Pergolide | Pergolide may decrease the antihypertensive activities of Cyclothiazide. |
| Finasteride | Finasteride may decrease the antihypertensive activities of Cyclothiazide. |
| Ergometrine | Ergometrine may decrease the antihypertensive activities of Cyclothiazide. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the antihypertensive activities of Cyclothiazide. |
| Mephentermine | Mephentermine may decrease the antihypertensive activities of Cyclothiazide. |
| Yohimbine | Yohimbine may decrease the antihypertensive activities of Cyclothiazide. |
| Methotrimeprazine | Methotrimeprazine may decrease the antihypertensive activities of Cyclothiazide. |
| MMDA | MMDA may decrease the antihypertensive activities of Cyclothiazide. |
| Midomafetamine | Midomafetamine may decrease the antihypertensive activities of Cyclothiazide. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Cyclothiazide. |
| 4-Methoxyamphetamine | 4-Methoxyamphetamine may decrease the antihypertensive activities of Cyclothiazide. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Cyclothiazide. |
| Tenamfetamine | Tenamfetamine may decrease the antihypertensive activities of Cyclothiazide. |
| Chlorphentermine | Chlorphentermine may decrease the antihypertensive activities of Cyclothiazide. |
| Dextroamphetamine | Dextroamphetamine may decrease the antihypertensive activities of Cyclothiazide. |
| Phendimetrazine | Phendimetrazine may decrease the antihypertensive activities of Cyclothiazide. |
| Solifenacin | Solifenacin may decrease the antihypertensive activities of Cyclothiazide. |
| Periciazine | Periciazine may decrease the antihypertensive activities of Cyclothiazide. |
| Acepromazine | Acepromazine may decrease the antihypertensive activities of Cyclothiazide. |
| Thioproperazine | Thioproperazine may decrease the antihypertensive activities of Cyclothiazide. |
| Zuclopenthixol | Zuclopenthixol may decrease the antihypertensive activities of Cyclothiazide. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Cyclothiazide. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Cyclothiazide. |
| Lysergic acid diethylamide | Lysergic acid diethylamide may decrease the antihypertensive activities of Cyclothiazide. |
| Amineptine | Amineptine may decrease the antihypertensive activities of Cyclothiazide. |
| Dronedarone | Dronedarone may decrease the antihypertensive activities of Cyclothiazide. |
| Flibanserin | Flibanserin may decrease the antihypertensive activities of Cyclothiazide. |
| Iloperidone | Iloperidone may decrease the antihypertensive activities of Cyclothiazide. |
| Amibegron | Amibegron may decrease the antihypertensive activities of Cyclothiazide. |
| Naluzotan | Naluzotan may decrease the antihypertensive activities of Cyclothiazide. |
| Cariprazine | Cariprazine may decrease the antihypertensive activities of Cyclothiazide. |
| Mianserin | Mianserin may decrease the antihypertensive activities of Cyclothiazide. |
| Nylidrin | Nylidrin may decrease the antihypertensive activities of Cyclothiazide. |
| Pizotifen | Pizotifen may decrease the antihypertensive activities of Cyclothiazide. |
| Solabegron | Solabegron may decrease the antihypertensive activities of Cyclothiazide. |
| Asenapine | Asenapine may decrease the antihypertensive activities of Cyclothiazide. |
| Esmirtazapine | Esmirtazapine may decrease the antihypertensive activities of Cyclothiazide. |
| Vilazodone | Vilazodone may decrease the antihypertensive activities of Cyclothiazide. |
| Nitrous oxide | Nitrous oxide may decrease the antihypertensive activities of Cyclothiazide. |
| Xylometazoline | Xylometazoline may decrease the antihypertensive activities of Cyclothiazide. |
| Isometheptene | Isometheptene may decrease the antihypertensive activities of Cyclothiazide. |
| Naphazoline | Naphazoline may decrease the antihypertensive activities of Cyclothiazide. |
| Tetryzoline | Tetryzoline may decrease the antihypertensive activities of Cyclothiazide. |
| Cinitapride | Cinitapride may decrease the antihypertensive activities of Cyclothiazide. |
| Lurasidone | Lurasidone may decrease the antihypertensive activities of Cyclothiazide. |
| Tyramine | Tyramine may decrease the antihypertensive activities of Cyclothiazide. |
| Adrafinil | Adrafinil may decrease the antihypertensive activities of Cyclothiazide. |
| Ifenprodil | Ifenprodil may decrease the antihypertensive activities of Cyclothiazide. |
| Etilefrine | Etilefrine may decrease the antihypertensive activities of Cyclothiazide. |
| Butriptyline | Butriptyline may decrease the antihypertensive activities of Cyclothiazide. |