Acute oral toxicity (LD50) in rats is 264 mg/kg. Cases of overdose have been reported and rarely, deaths have occurred. The following signs and symptoms may be observed following overdose: stupor, coma, diminished urine output and hypotension.
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted in vivo to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Amlodipine | Sulindac may decrease the antihypertensive activities of Amlodipine. |
| Phentermine | The risk or severity of hypertension can be increased when Phentermine is combined with Sulindac. |
| Midodrine | The risk or severity of hypertension can be increased when Midodrine is combined with Sulindac. |
| Eletriptan | The risk or severity of hypertension can be increased when Eletriptan is combined with Sulindac. |
| Isoetharine | The risk or severity of hypertension can be increased when Isoetharine is combined with Sulindac. |
| Ziprasidone | The risk or severity of hypertension can be increased when Ziprasidone is combined with Sulindac. |
| Methysergide | The risk or severity of hypertension can be increased when Methysergide is combined with Sulindac. |
| Cabergoline | The risk or severity of hypertension can be increased when Cabergoline is combined with Sulindac. |
| Zolmitriptan | The risk or severity of hypertension can be increased when Zolmitriptan is combined with Sulindac. |
| Dihydroergotamine | The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Sulindac. |
| Methylergometrine | The risk or severity of hypertension can be increased when Methylergometrine is combined with Sulindac. |
| Norepinephrine | The risk or severity of hypertension can be increased when Norepinephrine is combined with Sulindac. |
| Mirtazapine | The risk or severity of hypertension can be increased when Mirtazapine is combined with Sulindac. |
| Phenylephrine | The risk or severity of hypertension can be increased when Phenylephrine is combined with Sulindac. |
| Phenylpropanolamine | The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Sulindac. |
| Promazine | The risk or severity of hypertension can be increased when Promazine is combined with Sulindac. |
| Droperidol | The risk or severity of hypertension can be increased when Droperidol is combined with Sulindac. |
| Doxapram | The risk or severity of hypertension can be increased when Doxapram is combined with Sulindac. |
| Atropine | The risk or severity of hypertension can be increased when Atropine is combined with Sulindac. |
| Lisuride | The risk or severity of hypertension can be increased when Lisuride is combined with Sulindac. |
| Linezolid | The risk or severity of hypertension can be increased when Linezolid is combined with Sulindac. |
| Metaraminol | The risk or severity of hypertension can be increased when Sulindac is combined with Metaraminol. |
| Furazolidone | The risk or severity of hypertension can be increased when Sulindac is combined with Furazolidone. |
| Epinephrine | The risk or severity of hypertension can be increased when Sulindac is combined with Epinephrine. |
| Thioridazine | The risk or severity of hypertension can be increased when Sulindac is combined with Thioridazine. |
| Ergotamine | The risk or severity of hypertension can be increased when Sulindac is combined with Ergotamine. |
| Nicergoline | The risk or severity of hypertension can be increased when Sulindac is combined with Nicergoline. |
| Sufentanil | The risk or severity of hypertension can be increased when Sulindac is combined with Sufentanil. |
| Methoxamine | The risk or severity of hypertension can be increased when Sulindac is combined with Methoxamine. |
| Risperidone | The risk or severity of hypertension can be increased when Sulindac is combined with Risperidone. |
| Tranylcypromine | The risk or severity of hypertension can be increased when Sulindac is combined with Tranylcypromine. |
| Isoflurane | The risk or severity of hypertension can be increased when Sulindac is combined with Isoflurane. |
| Propiomazine | The risk or severity of hypertension can be increased when Sulindac is combined with Propiomazine. |
| Alfentanil | The risk or severity of hypertension can be increased when Sulindac is combined with Alfentanil. |
| Minaprine | The risk or severity of hypertension can be increased when Sulindac is combined with Minaprine. |
| Orciprenaline | The risk or severity of hypertension can be increased when Sulindac is combined with Orciprenaline. |
| Propofol | The risk or severity of hypertension can be increased when Sulindac is combined with Propofol. |
| Phenmetrazine | The risk or severity of hypertension can be increased when Sulindac is combined with Phenmetrazine. |
| Trifluoperazine | The risk or severity of hypertension can be increased when Sulindac is combined with Trifluoperazine. |
| Pseudoephedrine | The risk or severity of hypertension can be increased when Sulindac is combined with Pseudoephedrine. |
| Benzphetamine | The risk or severity of hypertension can be increased when Sulindac is combined with Benzphetamine. |
| Ritodrine | The risk or severity of hypertension can be increased when Sulindac is combined with Ritodrine. |
| Flupentixol | The risk or severity of hypertension can be increased when Sulindac is combined with Flupentixol. |
| Remifentanil | The risk or severity of hypertension can be increased when Sulindac is combined with Remifentanil. |
| Bitolterol | The risk or severity of hypertension can be increased when Sulindac is combined with Bitolterol. |
| Oxymetazoline | The risk or severity of hypertension can be increased when Sulindac is combined with Oxymetazoline. |
| Diethylpropion | The risk or severity of hypertension can be increased when Sulindac is combined with Diethylpropion. |
| Salmeterol | The risk or severity of hypertension can be increased when Sulindac is combined with Salmeterol. |
| Naratriptan | The risk or severity of hypertension can be increased when Sulindac is combined with Naratriptan. |
| Formoterol | The risk or severity of hypertension can be increased when Sulindac is combined with Formoterol. |
| Frovatriptan | The risk or severity of hypertension can be increased when Sulindac is combined with Frovatriptan. |
| Methoxyflurane | The risk or severity of hypertension can be increased when Sulindac is combined with Methoxyflurane. |
| Selegiline | The risk or severity of hypertension can be increased when Sulindac is combined with Selegiline. |
| Ergoloid mesylate | The risk or severity of hypertension can be increased when Sulindac is combined with Ergoloid mesylate. |
| Isoprenaline | The risk or severity of hypertension can be increased when Sulindac is combined with Isoprenaline. |
| Arbutamine | The risk or severity of hypertension can be increased when Sulindac is combined with Arbutamine. |
| Dutasteride | The risk or severity of hypertension can be increased when Sulindac is combined with Dutasteride. |
| Halothane | The risk or severity of hypertension can be increased when Sulindac is combined with Halothane. |
| Moclobemide | The risk or severity of hypertension can be increased when Sulindac is combined with Moclobemide. |
| Pergolide | The risk or severity of hypertension can be increased when Sulindac is combined with Pergolide. |
| Desflurane | The risk or severity of hypertension can be increased when Sulindac is combined with Desflurane. |
| Bromocriptine | The risk or severity of hypertension can be increased when Sulindac is combined with Bromocriptine. |
| Finasteride | The risk or severity of hypertension can be increased when Sulindac is combined with Finasteride. |
| Aripiprazole | The risk or severity of hypertension can be increased when Sulindac is combined with Aripiprazole. |
| Isocarboxazid | The risk or severity of hypertension can be increased when Sulindac is combined with Isocarboxazid. |
| Ergometrine | The risk or severity of hypertension can be increased when Sulindac is combined with Ergometrine. |
| Lisdexamfetamine | The risk or severity of hypertension can be increased when Sulindac is combined with Lisdexamfetamine. |
| Fenoterol | The risk or severity of hypertension can be increased when Sulindac is combined with Fenoterol. |
| Pirbuterol | The risk or severity of hypertension can be increased when Sulindac is combined with Pirbuterol. |
| Ephedra sinica root | The risk or severity of hypertension can be increased when Sulindac is combined with Ephedra sinica root. |
| Ephedrine | The risk or severity of hypertension can be increased when Sulindac is combined with Ephedrine. |
| Mephentermine | The risk or severity of hypertension can be increased when Sulindac is combined with Mephentermine. |
| Procaterol | The risk or severity of hypertension can be increased when Sulindac is combined with Procaterol. |
| Yohimbine | The risk or severity of hypertension can be increased when Sulindac is combined with Yohimbine. |
| Methotrimeprazine | The risk or severity of hypertension can be increased when Sulindac is combined with Methotrimeprazine. |
| Clenbuterol | The risk or severity of hypertension can be increased when Sulindac is combined with Clenbuterol. |
| Bambuterol | The risk or severity of hypertension can be increased when Sulindac is combined with Bambuterol. |
| MMDA | The risk or severity of hypertension can be increased when Sulindac is combined with MMDA. |
| Midomafetamine | The risk or severity of hypertension can be increased when Sulindac is combined with Midomafetamine. |
| 2,5-Dimethoxy-4-ethylamphetamine | The risk or severity of hypertension can be increased when Sulindac is combined with 2,5-Dimethoxy-4-ethylamphetamine. |
| 4-Methoxyamphetamine | The risk or severity of hypertension can be increased when Sulindac is combined with 4-Methoxyamphetamine. |
| 4-Bromo-2,5-dimethoxyamphetamine | The risk or severity of hypertension can be increased when Sulindac is combined with 4-Bromo-2,5-dimethoxyamphetamine. |
| Tenamfetamine | The risk or severity of hypertension can be increased when Sulindac is combined with Tenamfetamine. |
| Chlorphentermine | The risk or severity of hypertension can be increased when Sulindac is combined with Chlorphentermine. |
| Dextroamphetamine | The risk or severity of hypertension can be increased when Sulindac is combined with Dextroamphetamine. |
| Phendimetrazine | The risk or severity of hypertension can be increased when Sulindac is combined with Phendimetrazine. |
| Solifenacin | The risk or severity of hypertension can be increased when Sulindac is combined with Solifenacin. |
| Periciazine | The risk or severity of hypertension can be increased when Sulindac is combined with Periciazine. |
| Acepromazine | The risk or severity of hypertension can be increased when Sulindac is combined with Acepromazine. |
| Thioproperazine | The risk or severity of hypertension can be increased when Sulindac is combined with Thioproperazine. |
| Zuclopenthixol | The risk or severity of hypertension can be increased when Sulindac is combined with Zuclopenthixol. |
| Epicaptopril | The risk or severity of hypertension can be increased when Sulindac is combined with Epicaptopril. |
| Clorgiline | The risk or severity of hypertension can be increased when Sulindac is combined with Clorgiline. |
| 1-benzylimidazole | The risk or severity of hypertension can be increased when Sulindac is combined with 1-benzylimidazole. |
| Iproniazid | The risk or severity of hypertension can be increased when Sulindac is combined with Iproniazid. |
| Nialamide | The risk or severity of hypertension can be increased when Sulindac is combined with Nialamide. |
| Lysergic acid diethylamide | The risk or severity of hypertension can be increased when Sulindac is combined with Lysergic acid diethylamide. |
| Dronedarone | The risk or severity of hypertension can be increased when Sulindac is combined with Dronedarone. |
| Flibanserin | The risk or severity of hypertension can be increased when Sulindac is combined with Flibanserin. |
| Iloperidone | The risk or severity of hypertension can be increased when Sulindac is combined with Iloperidone. |