Cisapride

DB00604

small molecule approved investigational withdrawn

Deskripsi

In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients.

Struktur Molekul 2D

Berat 465.945
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 6-12 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.

Metabolisme

Hepatic. Extensively metabolized via cytochrome P450 3A4 enzyme.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

3 Data
  • 1. Avoid grapefruit products.
  • 2. Exercise caution with St. John's Wort.
  • 3. Take before a meal. Take at least 15 minutes before meals.

Interaksi Obat

1494 Data
Phenytoin The metabolism of Cisapride can be increased when combined with Phenytoin.
Fosphenytoin The metabolism of Cisapride can be increased when combined with Fosphenytoin.
Buprenorphine Cisapride may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Hydrocodone Cisapride may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Cisapride can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Cisapride may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Cisapride may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Orphenadrine Cisapride may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Cisapride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Pramipexole Cisapride may increase the sedative activities of Pramipexole.
Ropinirole Cisapride may increase the sedative activities of Ropinirole.
Rotigotine Cisapride may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Cisapride.
Sodium oxybate Cisapride may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Cisapride may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Thalidomide Cisapride may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Cisapride may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Erythromycin The serum concentration of Cisapride can be increased when it is combined with Erythromycin.
Azithromycin The serum concentration of Cisapride can be increased when it is combined with Azithromycin.
Roxithromycin The serum concentration of Cisapride can be increased when it is combined with Roxithromycin.
Sirolimus The serum concentration of Cisapride can be increased when it is combined with Sirolimus.
Dirithromycin The serum concentration of Cisapride can be increased when it is combined with Dirithromycin.
Telithromycin The serum concentration of Cisapride can be increased when it is combined with Telithromycin.
Candicidin The serum concentration of Cisapride can be increased when it is combined with Candicidin.
Clarithromycin The serum concentration of Cisapride can be increased when it is combined with Clarithromycin.
Josamycin The serum concentration of Cisapride can be increased when it is combined with Josamycin.
Everolimus The serum concentration of Cisapride can be increased when it is combined with Everolimus.
Epothilone D The serum concentration of Cisapride can be increased when it is combined with Epothilone D.
Patupilone The serum concentration of Cisapride can be increased when it is combined with Patupilone.
6-Deoxyerythronolide B The serum concentration of Cisapride can be increased when it is combined with 6-Deoxyerythronolide B.
Ixabepilone The serum concentration of Cisapride can be increased when it is combined with Ixabepilone.
KOS-1584 The serum concentration of Cisapride can be increased when it is combined with KOS-1584.
Ridaforolimus The serum concentration of Cisapride can be increased when it is combined with Ridaforolimus.
Temsirolimus The serum concentration of Cisapride can be increased when it is combined with Temsirolimus.
AVE9633 The serum concentration of Cisapride can be increased when it is combined with AVE9633.
Coltuximab ravtansine The serum concentration of Cisapride can be increased when it is combined with Coltuximab ravtansine.
Cethromycin The serum concentration of Cisapride can be increased when it is combined with Cethromycin.
Mitemcinal The serum concentration of Cisapride can be increased when it is combined with Mitemcinal.
Brefeldin A The serum concentration of Cisapride can be increased when it is combined with Brefeldin A.
Solithromycin The serum concentration of Cisapride can be increased when it is combined with Solithromycin.
Kitasamycin The serum concentration of Cisapride can be increased when it is combined with Kitasamycin.
Carbomycin The serum concentration of Cisapride can be increased when it is combined with Carbomycin.
Doramectin The serum concentration of Cisapride can be increased when it is combined with Doramectin.
Eprinomectin The serum concentration of Cisapride can be increased when it is combined with Eprinomectin.
Oleandomycin The serum concentration of Cisapride can be increased when it is combined with Oleandomycin.
Selamectin The serum concentration of Cisapride can be increased when it is combined with Selamectin.
Tildipirosin The serum concentration of Cisapride can be increased when it is combined with Tildipirosin.
Tilmicosin The serum concentration of Cisapride can be increased when it is combined with Tilmicosin.
Tylosin The serum concentration of Cisapride can be increased when it is combined with Tylosin.
Tylvalosin The serum concentration of Cisapride can be increased when it is combined with Tylvalosin.
Bryostatin 1 The serum concentration of Cisapride can be increased when it is combined with Bryostatin 1.
Lorvotuzumab mertansine The serum concentration of Cisapride can be increased when it is combined with Lorvotuzumab mertansine.
Epofolate The serum concentration of Cisapride can be increased when it is combined with Epofolate.
Sagopilone The serum concentration of Cisapride can be increased when it is combined with Sagopilone.
Troleandomycin The serum concentration of Cisapride can be increased when it is combined with Troleandomycin.
Miocamycin The serum concentration of Cisapride can be increased when it is combined with Miocamycin.
Flurithromycin The serum concentration of Cisapride can be increased when it is combined with Flurithromycin.
Rokitamycin The serum concentration of Cisapride can be increased when it is combined with Rokitamycin.
Midecamycin The serum concentration of Cisapride can be increased when it is combined with Midecamycin.
Clindamycin The serum concentration of Cisapride can be increased when it is combined with Clindamycin.
Mepartricin The serum concentration of Cisapride can be increased when it is combined with Mepartricin.
Nelfinavir The serum concentration of Cisapride can be increased when it is combined with Nelfinavir.
Indinavir The serum concentration of Cisapride can be increased when it is combined with Indinavir.
Ritonavir The serum concentration of Cisapride can be increased when it is combined with Ritonavir.
Amprenavir The serum concentration of Cisapride can be increased when it is combined with Amprenavir.
Tipranavir The serum concentration of Cisapride can be increased when it is combined with Tipranavir.
Atazanavir The serum concentration of Cisapride can be increased when it is combined with Atazanavir.
Saquinavir The serum concentration of Cisapride can be increased when it is combined with Saquinavir.
Darunavir The serum concentration of Cisapride can be increased when it is combined with Darunavir.
Fosamprenavir The serum concentration of Cisapride can be increased when it is combined with Fosamprenavir.
Lopinavir The serum concentration of Cisapride can be increased when it is combined with Lopinavir.
Asunaprevir The serum concentration of Cisapride can be increased when it is combined with Asunaprevir.
TMC-310911 The serum concentration of Cisapride can be increased when it is combined with TMC-310911.
Amitriptyline Amitriptyline may increase the arrhythmogenic activities of Cisapride.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Cisapride.
Mifepristone The serum concentration of Cisapride can be increased when it is combined with Mifepristone.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Cisapride.
Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Cisapride.
Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Cisapride.
Cimetidine The serum concentration of Cisapride can be increased when it is combined with Cimetidine.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Cisapride.
Iloperidone The risk or severity of QTc prolongation can be increased when Cisapride is combined with Iloperidone.
Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Cisapride.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Cisapride.
Cobicistat The risk or severity of QTc prolongation and Cardiac Arrhythmia can be increased when Cobicistat is combined with Cisapride.
Nifedipine The serum concentration of Nifedipine can be increased when it is combined with Cisapride.
Simeprevir The risk or severity of QTc prolongation and Cardiac Arrhythmia can be increased when Simeprevir is combined with Cisapride.
Telaprevir The risk or severity of QTc prolongation and Cardiac Arrhythmia can be increased when Telaprevir is combined with Cisapride.
Phenindione The risk or severity of adverse effects can be increased when Cisapride is combined with Phenindione.
Tioclomarol The risk or severity of adverse effects can be increased when Cisapride is combined with Tioclomarol.
Ethyl biscoumacetate The risk or severity of adverse effects can be increased when Cisapride is combined with Ethyl biscoumacetate.
Diphenadione The risk or severity of adverse effects can be increased when Cisapride is combined with Diphenadione.
4-hydroxycoumarin The risk or severity of adverse effects can be increased when Cisapride is combined with 4-hydroxycoumarin.

Target Protein

5-hydroxytryptamine receptor 4 HTR4
5-hydroxytryptamine receptor 3A HTR3A
5-hydroxytryptamine receptor 2A HTR2A
Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2

Referensi & Sumber

Synthesis reference: Alfons Gaston Maria De Knaep, Luc Jozef Raphael Moens, Max Rey, "Synthesis of cisapride." U.S. Patent US6218542, issued January, 1988.
Artikel (PubMed)
  • PMID: 11717173
    Pearce RE, Gotschall RR, Kearns GL, Leeder JS: Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms. Drug Metab Dispos. 2001 Dec;29(12):1548-54.

Contoh Produk & Brand

Produk: 7 • International brands: 5
Produk
  • Prepulsid Sus 1mg/ml
    Suspension • 1 mg / mL • Oral • Canada • Approved
  • Prepulsid Tab 10mg
    Tablet • 10 mg / tab • Oral • Canada • Approved
  • Prepulsid Tab 20mg
    Tablet • 20 mg / tab • Oral • Canada • Approved
  • Prepulsid Tab 5mg
    Tablet • 5 mg / tab • Oral • Canada • Approved
  • Propulsid
    Tablet • 10 mg/1 • Oral • US • Approved
  • Propulsid
    Tablet • 20 mg/1 • Oral • US • Approved
  • Propulsid
    Suspension • 1 mg/1mL • Oral • US • Approved
International Brands
  • Enteropride
  • Kinestase
  • Prepulsid — Janssen-Ortho
  • Pridesia
  • Propulsid Quicksolv — Janssen-Ortho

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul