No data are available in regard to overdosage in humans. The oral LD50 of amiloride hydrochloride (calculated as the base) is 56 mg/kg in mice and 36 to 85 mg/kg in rats, depending on the strain. The most likely signs and symptoms to be expected with overdosage are dehydration and electrolyte imbalance.
A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Amiloride is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Amiloride is combined with Levodopa. |
| Risperidone | Amiloride may increase the hypotensive activities of Risperidone. |
| Dofetilide | Amiloride may decrease the excretion rate of Dofetilide which could result in a higher serum level. |
| Aripiprazole | Aripiprazole may increase the hypotensive activities of Amiloride. |
| Aripiprazole lauroxil | Aripiprazole lauroxil may increase the hypotensive activities of Amiloride. |
| Nicorandil | Nicorandil may increase the hypotensive activities of Amiloride. |
| Digoxin | Amiloride may decrease the excretion rate of Digoxin which could result in a higher serum level. |
| Acetyldigitoxin | Amiloride may decrease the excretion rate of Acetyldigitoxin which could result in a higher serum level. |
| Deslanoside | Amiloride may decrease the excretion rate of Deslanoside which could result in a higher serum level. |
| Ouabain | Amiloride may decrease the excretion rate of Ouabain which could result in a higher serum level. |
| Digitoxin | Amiloride may decrease the excretion rate of Digitoxin which could result in a higher serum level. |
| Oleandrin | Amiloride may decrease the excretion rate of Oleandrin which could result in a higher serum level. |
| Cymarin | Amiloride may decrease the excretion rate of Cymarin which could result in a higher serum level. |
| Proscillaridin | Amiloride may decrease the excretion rate of Proscillaridin which could result in a higher serum level. |
| Metildigoxin | Amiloride may decrease the excretion rate of Metildigoxin which could result in a higher serum level. |
| Lanatoside C | Amiloride may decrease the excretion rate of Lanatoside C which could result in a higher serum level. |
| Gitoformate | Amiloride may decrease the excretion rate of Gitoformate which could result in a higher serum level. |
| Acetyldigoxin | Amiloride may decrease the excretion rate of Acetyldigoxin which could result in a higher serum level. |
| Peruvoside | Amiloride may decrease the excretion rate of Peruvoside which could result in a higher serum level. |
| Cyclosporine | The risk or severity of hyperkalemia can be increased when Amiloride is combined with Cyclosporine. |
| Icosapent | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Icosapent is combined with Amiloride. |
| Mesalazine | The risk or severity of hyperkalemia can be increased when Mesalazine is combined with Amiloride. |
| Nabumetone | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Nabumetone is combined with Amiloride. |
| Ketorolac | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ketorolac is combined with Amiloride. |
| Tenoxicam | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tenoxicam is combined with Amiloride. |
| Celecoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Celecoxib is combined with Amiloride. |
| Tolmetin | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Amiloride. |
| Rofecoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Rofecoxib is combined with Amiloride. |
| Piroxicam | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Piroxicam is combined with Amiloride. |
| Fenoprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Fenoprofen is combined with Amiloride. |
| Valdecoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Valdecoxib is combined with Amiloride. |
| Diclofenac | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diclofenac is combined with Amiloride. |
| Sulindac | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Amiloride. |
| Flurbiprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Flurbiprofen is combined with Amiloride. |
| Etodolac | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Etodolac is combined with Amiloride. |
| Mefenamic acid | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Mefenamic acid is combined with Amiloride. |
| Naproxen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Naproxen is combined with Amiloride. |
| Sulfasalazine | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulfasalazine is combined with Amiloride. |
| Phenylbutazone | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Phenylbutazone is combined with Amiloride. |
| Carprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Carprofen is combined with Amiloride. |
| Diflunisal | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Diflunisal is combined with Amiloride. |
| Salicylic acid | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salicylic acid is combined with Amiloride. |
| Meclofenamic acid | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Meclofenamic acid is combined with Amiloride. |
| Oxaprozin | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Oxaprozin is combined with Amiloride. |
| Ketoprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ketoprofen is combined with Amiloride. |
| Balsalazide | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Balsalazide is combined with Amiloride. |
| Ibuprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuprofen is combined with Amiloride. |
| Lumiracoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Lumiracoxib is combined with Amiloride. |
| Magnesium salicylate | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Magnesium salicylate is combined with Amiloride. |
| Salsalate | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Amiloride. |
| Choline magnesium trisalicylate | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Choline magnesium trisalicylate is combined with Amiloride. |
| Antrafenine | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Antrafenine is combined with Amiloride. |
| Aminophenazone | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Aminophenazone is combined with Amiloride. |
| Antipyrine | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Antipyrine is combined with Amiloride. |
| Tiaprofenic acid | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tiaprofenic acid is combined with Amiloride. |
| Etoricoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Etoricoxib is combined with Amiloride. |
| Taxifolin | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Taxifolin is combined with Amiloride. |
| Oxyphenbutazone | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Oxyphenbutazone is combined with Amiloride. |
| Licofelone | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Licofelone is combined with Amiloride. |
| Nimesulide | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Nimesulide is combined with Amiloride. |
| Benoxaprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Benoxaprofen is combined with Amiloride. |
| Metamizole | The risk or severity of hyperkalemia can be increased when Amiloride is combined with Metamizole. |
| Zomepirac | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Zomepirac is combined with Amiloride. |
| Cimicoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Cimicoxib is combined with Amiloride. |
| Lornoxicam | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Lornoxicam is combined with Amiloride. |
| Aceclofenac | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Aceclofenac is combined with Amiloride. |
| Zaltoprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Zaltoprofen is combined with Amiloride. |
| Azapropazone | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Azapropazone is combined with Amiloride. |
| Parecoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Parecoxib is combined with Amiloride. |
| Salicylamide | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salicylamide is combined with Amiloride. |
| Kebuzone | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Kebuzone is combined with Amiloride. |
| Isoxicam | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Isoxicam is combined with Amiloride. |
| Indoprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Indoprofen is combined with Amiloride. |
| Ibuproxam | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ibuproxam is combined with Amiloride. |
| Floctafenine | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Floctafenine is combined with Amiloride. |
| Fenbufen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Fenbufen is combined with Amiloride. |
| Etofenamate | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Etofenamate is combined with Amiloride. |
| Epirizole | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Epirizole is combined with Amiloride. |
| Benzydamine | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Benzydamine is combined with Amiloride. |
| Dexibuprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Dexibuprofen is combined with Amiloride. |
| Dexketoprofen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Dexketoprofen is combined with Amiloride. |
| Droxicam | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Droxicam is combined with Amiloride. |
| Tolfenamic acid | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolfenamic acid is combined with Amiloride. |
| Firocoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Firocoxib is combined with Amiloride. |
| Clonixin | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Clonixin is combined with Amiloride. |
| Morniflumate | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Morniflumate is combined with Amiloride. |
| Propacetamol | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Propacetamol is combined with Amiloride. |
| Talniflumate | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Talniflumate is combined with Amiloride. |
| Robenacoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Robenacoxib is combined with Amiloride. |
| Tepoxalin | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tepoxalin is combined with Amiloride. |
| Flunixin | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Flunixin is combined with Amiloride. |
| Polmacoxib | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Polmacoxib is combined with Amiloride. |
| Nitroaspirin | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Nitroaspirin is combined with Amiloride. |
| Indobufen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Indobufen is combined with Amiloride. |
| Ebselen | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Ebselen is combined with Amiloride. |
| Tinoridine | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tinoridine is combined with Amiloride. |
| Alclofenac | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Alclofenac is combined with Amiloride. |
| Fentiazac | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Fentiazac is combined with Amiloride. |
| Suxibuzone | The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Suxibuzone is combined with Amiloride. |