Peringatan Keamanan

Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare.

Valdecoxib

DB00580

small molecule approved investigational withdrawn

Deskripsi

Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.

Struktur Molekul 2D

Berat 314.359
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 8-11 hours
Volume Distribusi * 86 L
Klirens (Clearance) * oral cl=6 L/h * 6 – 7 L/h [In patients undergoing hemodialysis] * 6 – 7 L/h [healthy elderly subjects]

Absorpsi

Oral bioavailability is 83%.

Metabolisme

Hepatic (involves CYP3A4 and 2C9)

Rute Eliminasi

Valdecoxib is eliminated predominantly via hepatic metabolism with less than 5% of the dose excreted unchanged in the urine and feces. About 70% of the dose is excreted in the urine as metabolites, and about 20% as valdecoxib N-glucuronide.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Ingesting alcohol may increase the risk of gastrointestinal bleeding.
  • 2. Take with or without food.

Interaksi Obat

1681 Data
Amlodipine The metabolism of Valdecoxib can be decreased when combined with Amlodipine.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Valdecoxib.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Valdecoxib.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Valdecoxib.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Valdecoxib.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Valdecoxib.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Valdecoxib.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Valdecoxib.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Valdecoxib.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Valdecoxib.
Linezolid The risk or severity of hypertension can be increased when Valdecoxib is combined with Linezolid.
Metaraminol The risk or severity of hypertension can be increased when Valdecoxib is combined with Metaraminol.
Furazolidone The risk or severity of hypertension can be increased when Valdecoxib is combined with Furazolidone.
Thioridazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Thioridazine.
Nicergoline The risk or severity of hypertension can be increased when Valdecoxib is combined with Nicergoline.
Methoxamine The risk or severity of hypertension can be increased when Valdecoxib is combined with Methoxamine.
Isoflurane The risk or severity of hypertension can be increased when Valdecoxib is combined with Isoflurane.
Propiomazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Propiomazine.
Minaprine The risk or severity of hypertension can be increased when Valdecoxib is combined with Minaprine.
Orciprenaline The risk or severity of hypertension can be increased when Valdecoxib is combined with Orciprenaline.
Phenmetrazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Phenmetrazine.
Trifluoperazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Trifluoperazine.
Pseudoephedrine The risk or severity of hypertension can be increased when Valdecoxib is combined with Pseudoephedrine.
Ritodrine The risk or severity of hypertension can be increased when Valdecoxib is combined with Ritodrine.
Flupentixol The risk or severity of hypertension can be increased when Valdecoxib is combined with Flupentixol.
Remifentanil The risk or severity of hypertension can be increased when Valdecoxib is combined with Remifentanil.
Bitolterol The risk or severity of hypertension can be increased when Valdecoxib is combined with Bitolterol.
Oxymetazoline The risk or severity of hypertension can be increased when Valdecoxib is combined with Oxymetazoline.
Diethylpropion The risk or severity of hypertension can be increased when Valdecoxib is combined with Diethylpropion.
Naratriptan The risk or severity of hypertension can be increased when Valdecoxib is combined with Naratriptan.
Frovatriptan The risk or severity of hypertension can be increased when Valdecoxib is combined with Frovatriptan.
Isoprenaline The risk or severity of hypertension can be increased when Valdecoxib is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Valdecoxib is combined with Arbutamine.
Desflurane The risk or severity of hypertension can be increased when Valdecoxib is combined with Desflurane.
Isocarboxazid The risk or severity of hypertension can be increased when Valdecoxib is combined with Isocarboxazid.
Lisdexamfetamine The risk or severity of hypertension can be increased when Valdecoxib is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Valdecoxib is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Valdecoxib is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Valdecoxib is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Valdecoxib is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Valdecoxib is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Valdecoxib is combined with Procaterol.
Methotrimeprazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Valdecoxib is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Valdecoxib is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Valdecoxib is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Valdecoxib is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Valdecoxib is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Valdecoxib is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Valdecoxib is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Valdecoxib is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Valdecoxib is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Valdecoxib is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Phendimetrazine.
Periciazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Thioproperazine.
Epicaptopril The risk or severity of hypertension can be increased when Valdecoxib is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Valdecoxib is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Valdecoxib is combined with 1-benzylimidazole.
Nialamide The risk or severity of hypertension can be increased when Valdecoxib is combined with Nialamide.
Amibegron The risk or severity of hypertension can be increased when Valdecoxib is combined with Amibegron.
Naluzotan The risk or severity of hypertension can be increased when Valdecoxib is combined with Naluzotan.
Pizotifen The risk or severity of hypertension can be increased when Valdecoxib is combined with Pizotifen.
Solabegron The risk or severity of hypertension can be increased when Valdecoxib is combined with Solabegron.
Esmirtazapine The risk or severity of hypertension can be increased when Valdecoxib is combined with Esmirtazapine.
Nitrous oxide The risk or severity of hypertension can be increased when Valdecoxib is combined with Nitrous oxide.
Xylometazoline The risk or severity of hypertension can be increased when Valdecoxib is combined with Xylometazoline.
Dexmethylphenidate The risk or severity of hypertension can be increased when Valdecoxib is combined with Dexmethylphenidate.
Isometheptene The risk or severity of hypertension can be increased when Valdecoxib is combined with Isometheptene.
Levonordefrin The risk or severity of hypertension can be increased when Valdecoxib is combined with Levonordefrin.
Naphazoline The risk or severity of hypertension can be increased when Valdecoxib is combined with Naphazoline.
Tetryzoline The risk or severity of hypertension can be increased when Valdecoxib is combined with Tetryzoline.
Cinitapride The risk or severity of hypertension can be increased when Valdecoxib is combined with Cinitapride.
Tyramine The risk or severity of hypertension can be increased when Valdecoxib is combined with Tyramine.
Adrafinil The risk or severity of hypertension can be increased when Valdecoxib is combined with Adrafinil.
Isoxsuprine The risk or severity of hypertension can be increased when Valdecoxib is combined with Isoxsuprine.
Ifenprodil The risk or severity of hypertension can be increased when Valdecoxib is combined with Ifenprodil.
Hexoprenaline The risk or severity of hypertension can be increased when Valdecoxib is combined with Hexoprenaline.
Etilefrine The risk or severity of hypertension can be increased when Valdecoxib is combined with Etilefrine.
Cirazoline The risk or severity of hypertension can be increased when Valdecoxib is combined with Cirazoline.
Synephrine The risk or severity of hypertension can be increased when Valdecoxib is combined with Synephrine.
Hydracarbazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Hydracarbazine.
Benmoxin The risk or severity of hypertension can be increased when Valdecoxib is combined with Benmoxin.
Mebanazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Mebanazine.
Octamoxin The risk or severity of hypertension can be increased when Valdecoxib is combined with Octamoxin.
Pheniprazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Pheniprazine.
Phenoxypropazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Phenoxypropazine.
Pivhydrazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Pivhydrazine.
Safrazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Safrazine.
Caroxazone The risk or severity of hypertension can be increased when Valdecoxib is combined with Caroxazone.
Doxofylline The risk or severity of hypertension can be increased when Valdecoxib is combined with Doxofylline.
Iofetamine I-123 The risk or severity of hypertension can be increased when Valdecoxib is combined with Iofetamine I-123.
Racepinephrine The risk or severity of hypertension can be increased when Valdecoxib is combined with Racepinephrine.
Amitraz The risk or severity of hypertension can be increased when Valdecoxib is combined with Amitraz.
Medetomidine The risk or severity of hypertension can be increased when Valdecoxib is combined with Medetomidine.
Xylazine The risk or severity of hypertension can be increased when Valdecoxib is combined with Xylazine.
Atipamezole The risk or severity of hypertension can be increased when Valdecoxib is combined with Atipamezole.
Ractopamine The risk or severity of hypertension can be increased when Valdecoxib is combined with Ractopamine.
Romifidine The risk or severity of hypertension can be increased when Valdecoxib is combined with Romifidine.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Carbonic anhydrase 2 CA2
Carbonic anhydrase 3 CA3

Referensi & Sumber

Synthesis reference: Eswaraiah Sajja, Anumula Reddy, Aalla Sampath, Gilla Goverdhan, "Process for preparing crystalline form A of valdecoxib." U.S. Patent US20050272787, issued December 08, 2005.

Contoh Produk & Brand

Produk: 4 • International brands: 0
Produk
  • Bextra
    Tablet, film coated • 10 mg/1 • Oral • US • Approved
  • Bextra
    Tablet, film coated • 20 mg/1 • Oral • US • Approved
  • Bextra
    Tablet, film coated • 10 mg/1 • Oral • US • Approved
  • Bextra
    Tablet, film coated • 20 mg/1 • Oral • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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