Peringatan Keamanan

Carbenicillin blood levels achievable are very low, and toxic reactions as a function of overdosage should not occur systematically. The oral LD50 in mice is 3,600 mg/kg, in rats 2,000 mg/kg, and in dogs is in excess of 500 mg/kg. The lethal human dose is not known. Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.

Carbenicillin

DB00578

small molecule approved investigational

Deskripsi

Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.

Struktur Molekul 2D

Berat 378.4
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1 hour
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed from the small intestine following oral administration. Oral bioavailability is 30 to 40%.

Metabolisme

Minimal.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach.

Interaksi Obat

228 Data
Methotrexate The excretion of Methotrexate can be decreased when combined with Carbenicillin.
Probenecid The excretion of Carbenicillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Penimepicycline.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Carbenicillin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Carbenicillin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Carbenicillin.
Dicoumarol Carbenicillin may increase the anticoagulant activities of Dicoumarol.
Phenindione Carbenicillin may increase the anticoagulant activities of Phenindione.
Warfarin Carbenicillin may increase the anticoagulant activities of Warfarin.
Phenprocoumon Carbenicillin may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Carbenicillin may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Carbenicillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Carbenicillin may increase the anticoagulant activities of Coumarin.
(R)-warfarin Carbenicillin may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Carbenicillin may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Carbenicillin may increase the anticoagulant activities of Fluindione.
Clorindione Carbenicillin may increase the anticoagulant activities of Clorindione.
Diphenadione Carbenicillin may increase the anticoagulant activities of Diphenadione.
Tioclomarol Carbenicillin may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Carbenicillin may increase the anticoagulant activities of (S)-Warfarin.
Diethylstilbestrol The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Carbenicillin.
Etonogestrel The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Carbenicillin.
Desogestrel The therapeutic efficacy of Desogestrel can be decreased when used in combination with Carbenicillin.
Megestrol acetate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Carbenicillin.
Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Carbenicillin.
Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Carbenicillin.
Medroxyprogesterone acetate The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Carbenicillin.
Norethisterone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Carbenicillin.
Estradiol The therapeutic efficacy of Estradiol can be decreased when used in combination with Carbenicillin.
Ethynodiol diacetate The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Carbenicillin.
Mifepristone The therapeutic efficacy of Mifepristone can be decreased when used in combination with Carbenicillin.
Norgestimate The therapeutic efficacy of Norgestimate can be decreased when used in combination with Carbenicillin.
Ethinylestradiol The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Carbenicillin.
Mestranol The therapeutic efficacy of Mestranol can be decreased when used in combination with Carbenicillin.
Drospirenone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Carbenicillin.
Estrone sulfate The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Carbenicillin.
Octylphenoxy polyethoxyethanol The therapeutic efficacy of Octylphenoxy polyethoxyethanol can be decreased when used in combination with Carbenicillin.
Cyproterone acetate The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Carbenicillin.
Trestolone The therapeutic efficacy of Trestolone can be decreased when used in combination with Carbenicillin.
Norelgestromin The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Carbenicillin.
Gestodene The therapeutic efficacy of Gestodene can be decreased when used in combination with Carbenicillin.
Hydroxyprogesterone caproate The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Carbenicillin.
Ulipristal The therapeutic efficacy of Ulipristal can be decreased when used in combination with Carbenicillin.
Dienogest The therapeutic efficacy of Dienogest can be decreased when used in combination with Carbenicillin.
Norethynodrel The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Carbenicillin.
Norgestrel The therapeutic efficacy of Norgestrel can be decreased when used in combination with Carbenicillin.
Cloprostenol The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Carbenicillin.
Gestrinone The therapeutic efficacy of Gestrinone can be decreased when used in combination with Carbenicillin.
Nomegestrol The therapeutic efficacy of Nomegestrol can be decreased when used in combination with Carbenicillin.
Lynestrenol The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Carbenicillin.
Gossypol The therapeutic efficacy of Gossypol can be decreased when used in combination with Carbenicillin.
Ormeloxifene The therapeutic efficacy of Ormeloxifene can be decreased when used in combination with Carbenicillin.
Chlormadinone The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Carbenicillin.
Norgestrienone The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Carbenicillin.
Quingestanol The therapeutic efficacy of Quingestanol can be decreased when used in combination with Carbenicillin.
Demegestone The therapeutic efficacy of Demegestone can be decreased when used in combination with Carbenicillin.
Etynodiol The therapeutic efficacy of Etynodiol can be decreased when used in combination with Carbenicillin.
Testosterone enanthate The therapeutic efficacy of Testosterone enanthate can be decreased when used in combination with Carbenicillin.
Estradiol benzoate The therapeutic efficacy of Estradiol benzoate can be decreased when used in combination with Carbenicillin.
Estradiol cypionate The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Carbenicillin.
Estradiol valerate The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Carbenicillin.
Nomegestrol acetate The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Carbenicillin.
Norethindrone enanthate The therapeutic efficacy of Norethindrone enanthate can be decreased when used in combination with Carbenicillin.
Capreomycin The serum concentration of Capreomycin can be decreased when it is combined with Carbenicillin.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Carbenicillin.
Amikacin The serum concentration of Amikacin can be decreased when it is combined with Carbenicillin.
Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Carbenicillin.
Gentamicin The serum concentration of Gentamicin can be decreased when it is combined with Carbenicillin.
Netilmicin The serum concentration of Netilmicin can be decreased when it is combined with Carbenicillin.
Neomycin The serum concentration of Neomycin can be decreased when it is combined with Carbenicillin.
Streptomycin The serum concentration of Streptomycin can be decreased when it is combined with Carbenicillin.
Kanamycin The serum concentration of Kanamycin can be decreased when it is combined with Carbenicillin.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Carbenicillin.
Ribostamycin The serum concentration of Ribostamycin can be decreased when it is combined with Carbenicillin.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Carbenicillin.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Carbenicillin.
Gentamicin C1a The serum concentration of Gentamicin C1a can be decreased when it is combined with Carbenicillin.
Neamine The serum concentration of Neamine can be decreased when it is combined with Carbenicillin.
Arbekacin The serum concentration of Arbekacin can be decreased when it is combined with Carbenicillin.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Carbenicillin.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Carbenicillin.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Carbenicillin.
Sisomicin The serum concentration of Sisomicin can be decreased when it is combined with Carbenicillin.
Plazomicin The serum concentration of Plazomicin can be decreased when it is combined with Carbenicillin.
Isepamicin The serum concentration of Isepamicin can be decreased when it is combined with Carbenicillin.
Colistin The serum concentration of Colistin can be decreased when it is combined with Carbenicillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Carbenicillin.

Target Protein

Penicillin-binding protein dacA
Beta-lactamase Toho-1 bla

Referensi & Sumber

Synthesis reference: Brain, E.G. and Nayler, J.H.C.; US. Patents 3,282,926; November 1,1966 and 3,492,291; January 27,1970; both assigned to Beecham Group Limited, England.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Carbenicillin — Polfa Tarchomin
  • Pyopen — GlaxoSmithKline

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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